Improved Insulin Sensitivity by Bezafibrate in Rats: Relationship to Fatty Acid Composition of Skeletal-Muscle Triglycerides

Diabetes ◽  
1997 ◽  
Vol 46 (3) ◽  
pp. 348-353 ◽  
Author(s):  
H. Matsui ◽  
K. Okumura ◽  
K. Kawakami ◽  
M. Hibino ◽  
Y. Toki ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Insulin Sensitivity ◽  
Acid Composition

Effects of physical exercise on phospholipid fatty acid composition in skeletal muscle

1998 ◽  
Vol 274 (3) ◽  
pp. E432-E438 ◽  
Author(s):  
Agneta Andersson ◽  
Anders Sjödin ◽  
Roger Olsson ◽  
Bengt Vessby
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Insulin Sensitivity ◽  
Acid Composition ◽  
The Body ◽  
Muscle Membrane ◽  
Peripheral Insulin Sensitivity ◽  
Low Intensity ◽  
Low Intensity Exercise

The effects of low-intensity exercise on the fatty acid composition in skeletal muscle and in serum were studied in 19 sedentary, middle-aged Swedish men. During a 10-wk period, all subjects were given a standardized diet with an identical fat composition. After 4 wk on this diet, they were randomly allocated to a daily exercise program (55% peak oxygen uptake) or to continue to live a sedentary life for the remaining 6 wk. Aerobic capacity (submaximal bicycle test) and peripheral insulin sensitivity (hyperinsulinemic euglycemic clamp) improved with training, whereas the body weight as well as the body composition (underwater weighing and bioimpedance) were unchanged. The proportions of palmitic acid (16:0) and linoleic acid [18:2(n-6)] and the sum of n-6 fatty acids [18:2(n-6), 20:3(n-6), 20:4(n-6)] were decreased in skeletal muscle phospholipids, whereas the proportion of oleic acid [18:1(n-9)] was increased, by training. The fatty acid profile in skeletal muscle triglycerides remained unchanged. We conclude that regular low-intensity exercise influences the fatty acid composition of the phospholipids in skeletal muscle, which hypothetically may contribute to changes of the skeletal muscle membrane fluidity and influence the peripheral insulin sensitivity.

Improved insulin sensitivity by bezafibrate in rats: relationship to fatty acid composition of skeletal-muscle triglycerides

Diabetes ◽  
1997 ◽  
Vol 46 (3) ◽  
pp. 348-353 ◽  
Author(s):  
H. Matsui ◽  
K. Okumura ◽  
K. Kawakami ◽  
M. Hibino ◽  
Y. Toki ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Insulin Sensitivity ◽  
Acid Composition

Skeletal muscle phosphatidylcholine fatty acids and insulin sensitivity in normal humans

1998 ◽  
Vol 275 (4) ◽  
pp. E665-E670 ◽  
Author(s):  
John N. Clore ◽  
Jing Li ◽  
Ranjodh Gill ◽  
Shona Gupta ◽  
Robert Spencer ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Insulin Sensitivity ◽  
Acid Composition ◽  
Vastus Lateralis ◽  
Muscle Membrane ◽  
Membrane Phospholipids ◽  
Normal Humans

The fatty acid composition of skeletal muscle membrane phospholipids (PL) is known to influence insulin responsiveness in humans. However, the contribution of the major PL of the outer (phosphatidylcholine, PC) and inner (phosphatidylethanolamine, PE) layers of the sarcolemma to insulin sensitivity is not known. Fatty acid composition of PC and PE from biopsies of vastus lateralis from 27 normal men and women were correlated with insulin sensitivity determined by the hyperinsulinemic euglycemic clamp technique at insulin infusion rates of 0.4, 1.0, and 10.0 mU ⋅ kg−1 ⋅ min−1. Significant variation in the half-maximal insulin concentration (ED50) was observed in the normal volunteers (range 24.0–146.0 μU/ml), which correlated directly with fasting plasma insulin ( r = 0.75, P < 0.0001). ED50 was inversely correlated with the degree of membrane unsaturation (C20-C22polyunsaturated fatty acids; r = 0.58, P < 0.01) and directly correlated with fatty acid elongation (ratio of 16:0 to 18:0, r = 0.45, P < 0.05) in PC. However, no relationship between fatty acid composition and insulin sensitivity was observed in PE (NS). These studies suggest that the fatty acid composition of PC may be of particular importance in the relationship between fatty acids and insulin sensitivity in normal humans.

The Relation between Insulin Sensitivity and the Fatty-Acid Composition of Skeletal-Muscle Phospholipids

1993 ◽  
Vol 328 (4) ◽  
pp. 238-244 ◽  
Author(s):  
Mark Borkman ◽  
Leonard H. Storlien ◽  
David A. Pan ◽  
Arthur B. Jenkins ◽  
Donald J. Chisholm ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Insulin Sensitivity ◽  
Acid Composition

scholarly journals Dietary fat and insulin action in humans

2000 ◽  
Vol 83 (S1) ◽  
pp. S91-S96 ◽  
Author(s):  
Bengt Vessby
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Insulin Sensitivity ◽  
Acid Composition ◽  
Δ5 Desaturase ◽  
Reduced Activity

A high intake of fat may increase the risk of obesity. Obesity, especially abdominal obesity, is an important determinant of the risk of developing insulin resistance and non-insulin-dependent diabetes mellitus. It is suggested that a high proportion of fat in the diet is associated with impaired insulin sensitivity and an increased risk of developing diabetes, independent of obesity and body fat localization, and that this risk may be influenced by the type of fatty acids in the diet. Cross-sectional studies show significant relationships between the serum lipid fatty acid composition, which at least partly mirrors the quality of the fatty acids in the diet, and insulin sensitivity. Insulin resistance, and disorders characterized by insulin resistance, are associated with a specific fatty acid pattern of the serum lipids with increased proportions of palmitic (16 : 0) and palmitoleic acids (16 : 1 n-7) and reduced levels of linoleic acid (18 : 2 n-6). The metabolism of linoleic acid seems to be disturbed with increased proportions of dihomo-gamma linolenic acid (20 : 3 n-6) and a reduced activity of the Δ5 desaturase, while the activities of the Δ9 and Δ6 desaturases appear to be increased. The skeletal muscle is the main determinant of insulin sensitivity. Several studies have shown that the fatty acid composition of the phosholipids of the skeletal muscle cell membranes is closely related to insulin sensitivity. An increased saturation of the membrane fatty acids and a reduced activity of Δ5 desaturase have been associated with insulin resistance. There are several possible mechanisms which could explain this relationship. The fatty acid composition of the lipids in serum and muscle is influenced by diet, but also by the degree of physical activity, genetic disposition, and possibly fetal undernutrition. However, controlled dietary intervention studies in humans investigating the effects of different types of fatty acids on insulin sensitivity have so far been negative.

Sign in / Sign up

Export Citation Format

Share Document