scholarly journals Differential Effects of Glucose and Lactate on Glucosensing Neurons in the Ventromedial Hypothalamic Nucleus

Diabetes ◽  
2004 ◽  
Vol 54 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Z. Song ◽  
V.H. Routh
Keyword(s):  
Hypothalamic Nucleus ◽  
Differential Effects ◽  
Ventromedial Hypothalamic Nucleus

scholarly journals Norepinephrine Regulation of Ventromedial Hypothalamic Nucleus Astrocyte Glycogen Metabolism

2021 ◽  
Vol 22 (2) ◽  
pp. 759
Author(s):  
Karen P. Briski ◽  
Mostafa M. H. Ibrahim ◽  
A. S. M. Hasan Mahmood ◽  
Ayed A. Alshamrani
Keyword(s):  
Alternative Energy ◽  
Glycogen Synthase ◽  
Glycogen Metabolism ◽  
Receptor Expression ◽  
Hypothalamic Nucleus ◽  
Control Structures ◽  
Ventromedial Hypothalamic Nucleus ◽  
Glycogen Reserve ◽  
Noradrenergic Modulation ◽  
The Brain

The catecholamine norepinephrine (NE) links hindbrain metabolic-sensory neurons with key glucostatic control structures in the brain, including the ventromedial hypothalamic nucleus (VMN). In the brain, the glycogen reserve is maintained within the astrocyte cell compartment as an alternative energy source to blood-derived glucose. VMN astrocytes are direct targets for metabolic stimulus-driven noradrenergic signaling due to their adrenergic receptor expression (AR). The current review discusses recent affirmative evidence that neuro-metabolic stability in the VMN may be shaped by NE influence on astrocyte glycogen metabolism and glycogen-derived substrate fuel supply. Noradrenergic modulation of estrogen receptor (ER) control of VMN glycogen phosphorylase (GP) isoform expression supports the interaction of catecholamine and estradiol signals in shaping the physiological stimulus-specific control of astrocyte glycogen mobilization. Sex-dimorphic NE control of glycogen synthase and GP brain versus muscle type proteins may be due, in part, to the dissimilar noradrenergic governance of astrocyte AR and ER variant profiles in males versus females. Forthcoming advances in the understanding of the molecular mechanistic framework for catecholamine stimulus integration with other regulatory inputs to VMN astrocytes will undoubtedly reveal useful new molecular targets in each sex for glycogen mediated defense of neuronal metabolic equilibrium during neuro-glucopenia.

Obese female Zucker rats (fa/fa) exhibit dendritic retraction in neurons in the ventromedial hypothalamic nucleus

2021 ◽  
Vol 113 ◽  
pp. 101919
Author(s):  
Dolores Adriana Bravo Durán ◽  
Selina Jocelyn Barreda Guzmán ◽  
Angélica Trujillo Hernández ◽  
Adriana Berenice Silva Gómez
Keyword(s):  
Hypothalamic Nucleus ◽  
Zucker Rats ◽  
Ventromedial Hypothalamic Nucleus ◽  
Obese Female

Damage to the ventromedial hypothalamic nucleus of newborn rats: Growth, ingestion, and neuroendocrine dysfunction

1981 ◽  
Vol 71 (1) ◽  
pp. 191-202 ◽  
Author(s):  
David L. Hill ◽  
C.Robert Almli ◽  
Robin S. Fisher ◽  
David Williams
Keyword(s):  
Hypothalamic Nucleus ◽  
Newborn Rats ◽  
Ventromedial Hypothalamic Nucleus
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