Transcapillary Escape Rate of Albumin in Type II Diabetic Patients: The relationship with microalbuminuria and hypertension

A low [Hb] (Hb concentration) is out-balanced by peripheral vasodilation via mechanisms that are incompletely understood. Peripheral vasodilation is influenced by NO (nitric oxide) released from vascular endothelium in response to increased vessel wall shear stress, and absorption by Hb is the main mechanism by which the bioactivity of NO is disarmed. Thus we propose that graded NO absorption is the mechanism through which a low [Hb] is related to peripheral vasodilation. In the present study, we examined the relationship between [Hb] and FMD (flow-mediated vasodilation; 5 min of cuff ischaemia) of the radial and brachial arteries in 33 normal subjects and in 13 patients with Type II diabetes, known to have impaired NO-mediated vasodilation. The smaller radial artery provided the more sensitive test, as it had a 2-fold larger FMD than the brachial artery (22±18% compared with 9±18% respectively, in normal subjects; means±S.D., P<0.05). FMD of the radial artery had a negative correlation with [Hb] (r2=−0.66, P<0.05; n=27). In subjects with [Hb] below and above the median of 14.1 g/dl, the radial artery FMD was 30±22% compared with 13±12% respectively (P<0.05). In diabetic patients, FMD was lower and a co-variation with [Hb] could not be established. Thus, in normal subjects, NO-mediated endothelium-related vasodilation at least partly out-balanced the ‘added burden’ of a low [Hb] during post-ischaemic reperfusion.

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Changes in Blood Pressure, Body Fluids, Circulating Angiotensin II and Aldosterone, with Improved Diabetic Control

Clinical Science ◽

10.1042/cs063415s ◽

1982 ◽

Vol 63 (s8) ◽

pp. 415s-418s ◽

Cited By ~ 23

Author(s):

J. A. O'hare ◽

J. B. Ferriss ◽

B. M. Twomey ◽

H. Gonggrijp ◽

D. J. O'sullivan

Keyword(s):

Blood Pressure ◽

Angiotensin Ii ◽

Metabolic Control ◽

Plasma Volume ◽

Diabetic Control ◽

Escape Rate ◽

Diabetic Patients ◽

Exchangeable Sodium ◽

Poor Metabolic Control ◽

Transcapillary Escape Rate

1. We studied 12 normotensive non-ketotic diabetic patients during poor metabolic control, with sustained hyperglycaemia, and again, after an interval of 3 weeks, when metabolic control was improved. On each occasion we measured blood pressure, total exchangeable sodium, plasma volume, transcapillary escape rate of albumin, and plasma concentrations of angiotensin II and aldosterone. 2. With improved diabetic control there was a small but significant fall in arterial pressure. Total exchangeable sodium was normal when control was poor but rose significantly to above normal with improved control. 3. Plasma volume also rose significantly with improved control, and the transcapillary escape rate of albumin fell and the intravascular mass of albumin rose. 4. Plasma angiotensin II and aldosterone concentrations were significantly above normal during poor metabolic control, but fell to normal with improved control. 5. These findings indicate a resetting of the relationship between blood pressure and exchangeable sodium when diabetic control improves. The association between exchangeable sodium and concentrations of angiotensin II and aldosterone also appears altered in diabetic patients. These changes associated with varying metabolic control must be considered when studying cardiovascular disease in diabetic patients.

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The Relationship of Illness Perception and Medication Adherence in Patients With Diabetes Mellitus Type II

10.21203/rs.3.rs-426152/v1 ◽

2021 ◽

Author(s):

Sina Sabeti Bilondi ◽

Ali Delshad Noghabi ◽

Hosein Aalami

Keyword(s):

Medication Adherence ◽

Type Ii Diabetes ◽

Pearson Correlation ◽

Illness Perception ◽

Personal Control ◽

Diabetic Patients ◽

Type Ii ◽

Diabetes Clinic ◽

The Mean ◽

The Relationship

Abstract Background: One of the most well-known chronic diseases in the world is diabetes. Disease perception is the patient's organized cognitive representation of his or her illness and can affect treatment adherence. The aim of this study was to investigate the relationship between illness perception and adherence to the medical regimen in patients with type II diabetes. Methods: This descriptive-analytical cross-sectional study was performed on 260 patients with type II diabetes referred to Gonabad Diabetes Clinic by systematic random sampling in 2019. Data collection tools were demographic questionnaire, Morisky medication Adherence Scale (MMAS-8), and Brief illness Perception Questionnaire (BIPQ). Data were analyzed by SPSS 20 software. And using descriptive statistics, Pearson correlation coefficient. P < 0.05 was considered significant. Results: The results showed that the mean score of illness perception of type II diabetes was 46.39 ± 9.45 (range 0-70) and the mean score of medication Adherence was 2.93 ± 1.9 (range 0-8). The results of Pearson correlation test showed a significant relationship between illness perception and medication Adherence (P <0.001, r = 0.199). Also, the regression model showed that the dimensions of disease comprehension and personal control from illness perception were significantly related to medication Adherence of type II diabetic patients (P <0.001). Conclusion: By measuring the level of illness perception, the degree of medication Adherence can be predicted. Therefore, strengthening the illness perception in order to medication Adherence seems to be an important therapeutic strategy in educational interventions. Keywords: illness perception, medication Adherence, type II diabetes

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The relationship between Fear of Hypoglycemia and Sleep Quality among type II Diabetic Patients

10.21203/rs.2.10880/v1 ◽

2019 ◽

Author(s):

Leili Yekefallah ◽

Farzaneh Talebi ◽

Ali Razaghpoor ◽

Mohammmad Hossein Mafi

Keyword(s):

Sleep Quality ◽

Significant Relationship ◽

Diabetic Patients ◽

Poor Sleep ◽

Type Ii ◽

Poor Sleep Quality ◽

Fear Of Hypoglycemia ◽

The Mean ◽

The Relationship

Abstract Introduction and Objective Fear of hypoglycemia can result in anxiety, stress, anger, depression and severe avoidance behaviors that it affects the sleep quality of diabetic patients. Therefore, the present study was conducted with the aim of investigating the relationship between fear of hypoglycemia and sleep quality among type II diabetic patients. Methods The present cross-sectional study was conducted on 400 type II diabetic patients referred to endocrinology clinic of Velayat Hospital and Boali Hospital in Qazvin, in 2018. Data were collected using a checklist for demographic variables, the Fear of Hypoglycemia Survey (FHS-W), and the Pittsburgh sleep quality index (PSQI). Descriptive statistics and Spearman correlation test were performed for data analysis using SPSS v24. Results In this study, the mean age of diabetic patients was 55.75±10.31. The majority of the participants were female (n=299, 74.8%) and were treated with oral anti-diabetic drugs (n=174, 43.5%). The mean score of sleep quality in patients was 8.98±3.64 and the fear of hypoglycemia was 21.27±11.92. The results of this study showed that there was a significant relationship between the fear of hypoglycemia and the poor sleep quality among patients (p<0.001, r=0.305). Conclusion The fear of hypoglycemia has a direct and significant relationship with poor sleep quality in diabetic patients; so that this fear reduces the quality of sleep in diabetic patients. Therefore, in order to provide adequate sleep to prevent inappropriate sleep complications, great attention should be paid to the issue of fear of hypoglycemia, and consider some actions to reduce this fear.

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Lack of effect of fish oil supplementation on coagulation and transcapillary escape rate of albumin in insulin-dependent diabetic patients with diabetic nephropathy

Scandinavian Journal of Clinical and Laboratory Investigation ◽

10.1080/00365510118549 ◽

2001 ◽

Vol 61 (5) ◽

pp. 349-356

Author(s):

B. Myrup, P. Rossing, T. Jensen, H.

Keyword(s):

Diabetic Nephropathy ◽

Fish Oil ◽

Escape Rate ◽

Diabetic Patients ◽

Transcapillary Escape Rate ◽

Insulin Dependent ◽

Insulin Dependent Diabetic ◽

Fish Oil Supplementation

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The Relationship Between Periodontal Disease And Blood Glucose Level Among Type II Diabetic Patients

The Journal of Contemporary Dental Practice ◽

10.5005/jcdp-2-4-1 ◽

2001 ◽

Vol 2 (4) ◽

pp. 1-6 ◽

Cited By ~ 11

Author(s):

Khalid Almas ◽

Mohammed Al-Qahtani ◽

Marzouk Al-Yami ◽

Nazeer Khan

Keyword(s):

Blood Glucose ◽

Periodontal Disease ◽

Blood Glucose Level ◽

Glucose Level ◽

Oral Hygiene ◽

Healthy Subjects ◽

Diabetic Patients ◽

Type Ii ◽

Hygiene Practices ◽

The Relationship

Abstract The aim of this study was to determine the relationship between periodontal disease and the blood glucose level among type II non-insulin dependent diabetic mellitus (NIDDM) subjects. Forty subjects, 20 in each group, of healthy and diabetic subjects, ages ranged 20-70 years, were examined at King Saud University, College of Dentistry. Clinical examination included frequency of oral hygiene practices, periodontal status by using the Community Periodontal Index of Treatment Needs (CPITN), fasting blood glucose level (FBGL), and random blood glucose level (RBGL). Unstandardized orthopantomograms (OPGs) were taken for radiographic findings. The number of missing teeth (tooth loss) was assessed from the radiographs. The results showed that periodontal disease severity was high among diabetic subjects. Diabetic subjects brushed less frequently, and they had a higher blood glucose level than healthy subjects. The mean CPITN score was compared with mean blood glucose level and the severity of periodontal disease. There was a steady increase in blood glucose level with increase in CPITN scores, i.e., CPITN score 13.5 to 19.12 corresponded with 142 mg/dl and 173.2 mg/dl FBGL, and 184.2 and 199.12 mg/dl RBGL among diabetic subjects. The study indicated that diabetic subjects should improve their oral hygiene practices and control of blood glucose levels should be emphasized. Further studies are needed among diabetics and healthy subjects from the general population with better sampling techniques and a larger sample size. Citation Almas K, Al-Qahtani M, Al-Yami M, Khan N. The Relationship Between Periodontal Disease And Blood Glucose Level Among Type II Diabetic Patients. J Contemp Dent Pract 2001 Nov;(2)4: 018-025.

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