scholarly journals Serum Galectin-3 and Subsequent Risk of Coronary Heart Disease in Subjects With Childhood-Onset Type 1 Diabetes: A Cohort Study

2021 ◽  
Author(s):  
Maryam Saeed ◽  
German Tapia ◽  
Inger Ariansen ◽  
Lars C. Stene ◽  
Ingebjørg Seljeflot ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Type 1 Diabetes ◽  
Heart Disease ◽  
High Sensitivity ◽  
Childhood Onset ◽  
Onset Type ◽  
Galectin 3 ◽  
Conventional Risk Factors

<a><i>Objective:</i></a> To study whether serum galectin-3 and other biomarkers of inflammation predict coronary heart disease (CHD) in subjects with longstanding childhood-onset type 1 diabetes. <p><i>Research, design and methods:</i> A population-based nation-wide cohort of 299 subjects with type 1 diabetes diagnosed in Norway at age <15 years during 1973-1982. They were examined in 2002-2003 at mean age of 33 years (range 21-44), with mean diabetes duration of 24 years (range 19-30). Subjects were followed through December 31, 2017 for their first CHD event registered by a hospitalization or cause of death using nation-wide registries. Stored serum samples were available for 296 subjects and analyzed for interleukin (IL)-6, IL-6 receptor, IL-18, high sensitivity-C-reactive protein, matrix metalloproteinases-9, tissue inhibitor of metalloproteinase-1, galectin-3 and high sensitivity troponin T (hs-TNT). Adjusted hazard ratios (aHR) for CHD per standard deviation increase in biomarker were estimated using Cox regression. </p> <p><i>Results:</i> Of 295 subjects, 40 (13.6%) had documented CHD event during mean follow-up of 14.4 years (range 0.5 - 16). IL-6 (aHR 1.32, 95% CI: 1.07 – 1.63), galectin-3 (aHR 1.44, 95% CI: 1.09 – 1.80) and TIMP-1 (aHR 1.37, 95% CI 1.04 – 1.81) were significant predictors of CHD after adjustment for conventional risk factors. </p> <p><i>Conclusion:</i><b> </b>Galectin-3 was significantly associated with future CHD in subjects with type 1 diabetes, and if the results are replicated in larger studies it may aid in prediction together with conventional risk factors for CHD. <b><br> </b></p>

scholarly journals Serum Galectin-3 and Subsequent Risk of Coronary Heart Disease in Subjects With Childhood-Onset Type 1 Diabetes: A Cohort Study

2021 ◽  
Author(s):  
Maryam Saeed ◽  
German Tapia ◽  
Inger Ariansen ◽  
Lars C. Stene ◽  
Ingebjørg Seljeflot ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Type 1 Diabetes ◽  
Heart Disease ◽  
High Sensitivity ◽  
Childhood Onset ◽  
Onset Type ◽  
Galectin 3 ◽  
Conventional Risk Factors

<a><i>Objective:</i></a> To study whether serum galectin-3 and other biomarkers of inflammation predict coronary heart disease (CHD) in subjects with longstanding childhood-onset type 1 diabetes. <p><i>Research, design and methods:</i> A population-based nation-wide cohort of 299 subjects with type 1 diabetes diagnosed in Norway at age <15 years during 1973-1982. They were examined in 2002-2003 at mean age of 33 years (range 21-44), with mean diabetes duration of 24 years (range 19-30). Subjects were followed through December 31, 2017 for their first CHD event registered by a hospitalization or cause of death using nation-wide registries. Stored serum samples were available for 296 subjects and analyzed for interleukin (IL)-6, IL-6 receptor, IL-18, high sensitivity-C-reactive protein, matrix metalloproteinases-9, tissue inhibitor of metalloproteinase-1, galectin-3 and high sensitivity troponin T (hs-TNT). Adjusted hazard ratios (aHR) for CHD per standard deviation increase in biomarker were estimated using Cox regression. </p> <p><i>Results:</i> Of 295 subjects, 40 (13.6%) had documented CHD event during mean follow-up of 14.4 years (range 0.5 - 16). IL-6 (aHR 1.32, 95% CI: 1.07 – 1.63), galectin-3 (aHR 1.44, 95% CI: 1.09 – 1.80) and TIMP-1 (aHR 1.37, 95% CI 1.04 – 1.81) were significant predictors of CHD after adjustment for conventional risk factors. </p> <p><i>Conclusion:</i><b> </b>Galectin-3 was significantly associated with future CHD in subjects with type 1 diabetes, and if the results are replicated in larger studies it may aid in prediction together with conventional risk factors for CHD. <b><br> </b></p>

scholarly journals Serum Galectin-3 and Subsequent Risk of Coronary Heart Disease in Subjects With Childhood-Onset Type 1 Diabetes: A Cohort Study

Diabetes Care ◽  
2021 ◽  
pp. dc201712
Author(s):  
Maryam Saeed ◽  
German Tapia ◽  
Inger Ariansen ◽  
Lars C. Stene ◽  
Ingebjørg Seljeflot ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Type 1 Diabetes ◽  
Cohort Study ◽  
Heart Disease ◽  
Childhood Onset ◽  
Onset Type ◽  
Galectin 3 ◽  
Subsequent Risk

scholarly journals The incidences of and risk factors for severe retinopathy requiring photocoagulation and albuminuria in Japanese patients with childhood-onset type 1 diabetes

2017 ◽  
Vol 9 (2) ◽  
pp. 121-128
Author(s):  
Hiroko Takaike ◽  
◽  
Yasuko Uchigata ◽  
Nobuo Matsuura ◽  
Nozomu Sasaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Japanese Patients ◽  
Childhood Onset ◽  
Onset Type

scholarly journals Factors of raised C-reactive protein as a potential determinant of Diabetic patients and Risk factor for Coronary Heart Disease

2018 ◽  
Vol 5 (3) ◽  
pp. 3656-3661
Author(s):  
Sharma Sushil Kumar ◽  
Rastogi Parag
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Type 1 Diabetes ◽  
Heart Disease ◽  
Research Work ◽  
Islet Autoimmunity ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein

Elevated C-reactive protein (CRP) levels have previously been described before the onset of type 1 diabetes and gestational diabetes. We hypothesized that inflammation, as reflected by elevated CRP levels, can help predict development of islet autoimmunity or type 1 diabetes. The outcome of this research is to establish potential determinants of raised CRP concentrations in type 1 diabetic patients. Sensitive assay showed ‘low-level’ CRP concentrations in 147 type 1 patients (83M, 64F, median age 30 years, range 13–67). We have done step by step variant examination to relate these CRP levels to known cardiovascular risk factors and demographic data. Only four patients had established Coronary Heart Disease (median CRP 3.43 mg/l vs. 0.85 mg/l, p=0.035). In subjects without overt CHD, multivariate analysis revealed increase in subject age (p=0.0027), BMI (p=0.001) and HbA1 (p=0.013) to be associated with a higher CRP concentration, as was female sex (p=0.025) and a history of CHD in a first-degree relative (p=0.018, n=58). Elevated CRP levels were positively associated with cardiovascular and renal risk factors: age, body mass index, blood pressure, serum cholesterol level, smoking, plasma glucose level and elevated urinary albumin excretion and presence of hypertension were unrelated. This research work advises that certain of the risk factors connected with CHD in type 1 patients are also individually predictive of high CRP concentrations. The reasons for this, and whether intervention would prove valuable, require further analysis

scholarly journals A population-based study of risk factors for severe hypoglycaemia in a contemporary cohort of childhood-onset type 1 diabetes

Diabetologia ◽  
2013 ◽  
Vol 56 (10) ◽  
pp. 2164-2170 ◽  
Author(s):  
Matthew N. Cooper ◽  
Susan M. O’Connell ◽  
Elizabeth A. Davis ◽  
Timothy W. Jones
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Severe Hypoglycaemia ◽  
Population Based ◽  
Childhood Onset ◽  
Population Based Study ◽  
Onset Type

scholarly journals Early deaths from ischaemic heart disease in childhood-onset type 1 diabetes

2018 ◽  
Vol 103 (10) ◽  
pp. 981-983 ◽  
Author(s):  
Trina C Evans-Cheung ◽  
H Jonathan Bodansky ◽  
Roger C Parslow ◽  
Richard G Feltbower
Keyword(s):  
Type 1 Diabetes ◽  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Clinical Validation ◽  
Death Certification ◽  
Childhood Onset ◽  
Children And Young People ◽  
Onset Type ◽  
Standardised Mortality Ratios

AimsThe risk of ischaemic heart disease (IHD) death in early type 1 diabetes onset was assessed using death certification data.MethodsThe Yorkshire Register of type 1 Diabetes in Children and Young People was linked to clinically validated death certification data for those diagnosed under 15 years. Standardised mortality ratios (SMRs) were calculated using the England and Wales population and IHD death rates between 1978 and 2014 by 5-year age group and sex.ResultsThe cohort included 4382 individuals (83 097 person years). Of 156 deaths, nine were classed as IHD deaths before clinical validation. After clinical validation, 14 IHD deaths were classified, with an SMR of 13.8 (95% CI 8.2 to 23.3) and median age at death of 35.1 years (range 21.9–47.9 years).ConclusionsThere is an early emergence of death from IHD in early onset type 1 diabetes. Underascertainment of IHD deaths was present without clinical validation of death certification.

Vascular risk factors in coronary heart disease (CHD) associated with type 1 diabetes mellitus

1991 ◽  
Vol 90 (2-3) ◽  
pp. 223
Author(s):  
P WINOCOUR ◽  
P DURRINGTON ◽  
D BHATNAGAR ◽  
A MBEWU ◽  
M ISHOLA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Type 1 Diabetes ◽  
Heart Disease ◽  
Type 1 Diabetes Mellitus ◽  
Vascular Risk Factors ◽  
Vascular Risk

Psychiatric disorders during early adulthood in those with childhood onset type 1 diabetes: Rates and clinical risk factors from population-based follow-up

2016 ◽  
Vol 18 (7) ◽  
pp. 599-606 ◽  
Author(s):  
M. N. Cooper ◽  
A. Lin ◽  
G. A. Alvares ◽  
N. H. de Klerk ◽  
T. W. Jones ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Psychiatric Disorders ◽  
Early Adulthood ◽  
Population Based ◽  
Clinical Risk Factors ◽  
Childhood Onset ◽  
Onset Type
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