scholarly journals Long-Term Occupational Consequences for Families of Children With Type 1 Diabetes: The Mothers Take the Burden

2021 ◽  
Author(s):  
Andrea Dehn-Hindenberg ◽  
Heike Saßmann ◽  
Verena Berndt ◽  
Torben Biester ◽  
Bettina Heidtmann ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Children ◽  
Financial Burden ◽  
Working Hours ◽  
Age At Diagnosis ◽  
First Year ◽  
Diabetes Diagnosis ◽  
Negative Consequences

<b>OBJECTIVE</b> <p>To investigate the occupational and financial consequences for parents following the onset of type 1 diabetes in their child. </p> <p><b>RESEARCH DESIGN AND METHODS</b> </p> <p>A questionnaire assessing occupational and financial situations before and in the first year after the onset of diabetes was distributed to all families with a child ≤14 years of age at diagnosis with a diabetes duration of at least 12 months in nine German pediatric diabetes centers. </p> <p><b>RESULTS</b></p> <p>Data of 1,144 children (mean age at diagnosis 6.7 (3.6) years, 46.5% female) and their families were obtained. Mothers’ occupational status reflected in paid working hours was significantly reduced in the first year after their child's diabetes diagnosis (<i>P</i> < 0.001). Overall, 15.1% of mothers stopped working, and 11.5% reduced working hours. Mothers of preschool children were particularly affected. Fathers’ working status hardly changed (<i>P</i> = 0.75). Nearly half of the families (46.4%) reported moderate to severe financial losses. Compared to an earlier similar study in 2003, significant negative occupational consequences for mothers and financial burden on families remain unchanged in 2018 (<i>P</i> = 0.59 & 0.31, respectively).</p> <p><b>CONCLUSIONS</b></p> <p>Mothers of young children with newly diagnosed diabetes experienced negative consequences in their occupational situation. This inequality for mothers can have long-term negative consequences for their mental health and future economic situation. There is an urgent need for action to reduce the burden on families and to provide professional, social, and regulatory support especially for mothers of young children with diabetes. </p>

scholarly journals Long-Term Occupational Consequences for Families of Children With Type 1 Diabetes: The Mothers Take the Burden

2021 ◽  
Author(s):  
Andrea Dehn-Hindenberg ◽  
Heike Saßmann ◽  
Verena Berndt ◽  
Torben Biester ◽  
Bettina Heidtmann ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Children ◽  
Financial Burden ◽  
Working Hours ◽  
Age At Diagnosis ◽  
First Year ◽  
Diabetes Diagnosis ◽  
Negative Consequences

<b>OBJECTIVE</b> <p>To investigate the occupational and financial consequences for parents following the onset of type 1 diabetes in their child. </p> <p><b>RESEARCH DESIGN AND METHODS</b> </p> <p>A questionnaire assessing occupational and financial situations before and in the first year after the onset of diabetes was distributed to all families with a child ≤14 years of age at diagnosis with a diabetes duration of at least 12 months in nine German pediatric diabetes centers. </p> <p><b>RESULTS</b></p> <p>Data of 1,144 children (mean age at diagnosis 6.7 (3.6) years, 46.5% female) and their families were obtained. Mothers’ occupational status reflected in paid working hours was significantly reduced in the first year after their child's diabetes diagnosis (<i>P</i> < 0.001). Overall, 15.1% of mothers stopped working, and 11.5% reduced working hours. Mothers of preschool children were particularly affected. Fathers’ working status hardly changed (<i>P</i> = 0.75). Nearly half of the families (46.4%) reported moderate to severe financial losses. Compared to an earlier similar study in 2003, significant negative occupational consequences for mothers and financial burden on families remain unchanged in 2018 (<i>P</i> = 0.59 & 0.31, respectively).</p> <p><b>CONCLUSIONS</b></p> <p>Mothers of young children with newly diagnosed diabetes experienced negative consequences in their occupational situation. This inequality for mothers can have long-term negative consequences for their mental health and future economic situation. There is an urgent need for action to reduce the burden on families and to provide professional, social, and regulatory support especially for mothers of young children with diabetes. </p>

scholarly journals Continuous Glucose Monitoring Initiation Within First Year of Type 1 Diabetes Diagnosis Is Associated With Improved Glycemic Outcomes: 7-Year Follow-Up Study

2022 ◽  
Author(s):  
Anagha Champakanath ◽  
Halis Kaan Akturk ◽  
G. Todd Alonso ◽  
Janet K Snell-Bergeon ◽  
Viral N Shah
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Monitoring ◽  
First Year ◽  
Diabetes Diagnosis ◽  
One Year ◽  
Glycemic Outcomes ◽  
Design And Methods

Objective: To evaluate long-term glycemic outcomes of CGM initiation within the first year of type 1 diabetes. <p>Research Design and Methods: 396 patients with type 1 diabetes were divided into three groups; 1) CGM [CGM use within one year of diabetes and continued through the study], 2) no-CGM [no CGM use throughout the study], 3) new-CGM [CGM use after 3 years of diabetes] and were followed up to 7-years. </p> <p>Results: A1c was significantly lower in CGM compared to no-CGM group throughout 7 years of follow-up [LS mean A1cs (%): 6-month 7.3 vs 8.1, 1-year 7.4 vs 8.6, 2-year 7.7 vs 9.1, 3-year 7.6 vs 9.3, 4-year 7.4 vs 9.6, 5-year 7.6 vs 9.7, 6-year 7.5 vs 10.0 and 7-year 7.6 vs 9.8, all p<0.001] adjusting for age at diagnosis, sex, and insulin delivery method. </p> <p>Conclusion: CGM initiation within first year of type 1 diabetes results in long-term improvement in A1c. </p>

scholarly journals Continuous Glucose Monitoring Initiation Within First Year of Type 1 Diabetes Diagnosis Is Associated With Improved Glycemic Outcomes: 7-Year Follow-Up Study

2022 ◽  
Author(s):  
Anagha Champakanath ◽  
Halis Kaan Akturk ◽  
G. Todd Alonso ◽  
Janet K Snell-Bergeon ◽  
Viral N Shah
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Monitoring ◽  
First Year ◽  
Diabetes Diagnosis ◽  
One Year ◽  
Glycemic Outcomes ◽  
Design And Methods

Objective: To evaluate long-term glycemic outcomes of CGM initiation within the first year of type 1 diabetes. <p>Research Design and Methods: 396 patients with type 1 diabetes were divided into three groups; 1) CGM [CGM use within one year of diabetes and continued through the study], 2) no-CGM [no CGM use throughout the study], 3) new-CGM [CGM use after 3 years of diabetes] and were followed up to 7-years. </p> <p>Results: A1c was significantly lower in CGM compared to no-CGM group throughout 7 years of follow-up [LS mean A1cs (%): 6-month 7.3 vs 8.1, 1-year 7.4 vs 8.6, 2-year 7.7 vs 9.1, 3-year 7.6 vs 9.3, 4-year 7.4 vs 9.6, 5-year 7.6 vs 9.7, 6-year 7.5 vs 10.0 and 7-year 7.6 vs 9.8, all p<0.001] adjusting for age at diagnosis, sex, and insulin delivery method. </p> <p>Conclusion: CGM initiation within first year of type 1 diabetes results in long-term improvement in A1c. </p>

scholarly journals Continuous Glucose Monitoring Initiation Within First Year of Type 1 Diabetes Diagnosis Is Associated With Improved Glycemic Outcomes: 7-Year Follow-Up Study

2022 ◽  
Author(s):  
Anagha Champakanath ◽  
Halis Kaan Akturk ◽  
G. Todd Alonso ◽  
Janet K Snell-Bergeon ◽  
Viral N Shah
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Monitoring ◽  
First Year ◽  
Diabetes Diagnosis ◽  
One Year ◽  
Glycemic Outcomes ◽  
Design And Methods

Objective: To evaluate long-term glycemic outcomes of CGM initiation within the first year of type 1 diabetes. <p>Research Design and Methods: 396 patients with type 1 diabetes were divided into three groups; 1) CGM [CGM use within one year of diabetes and continued through the study], 2) no-CGM [no CGM use throughout the study], 3) new-CGM [CGM use after 3 years of diabetes] and were followed up to 7-years. </p> <p>Results: A1c was significantly lower in CGM compared to no-CGM group throughout 7 years of follow-up [LS mean A1cs (%): 6-month 7.3 vs 8.1, 1-year 7.4 vs 8.6, 2-year 7.7 vs 9.1, 3-year 7.6 vs 9.3, 4-year 7.4 vs 9.6, 5-year 7.6 vs 9.7, 6-year 7.5 vs 10.0 and 7-year 7.6 vs 9.8, all p<0.001] adjusting for age at diagnosis, sex, and insulin delivery method. </p> <p>Conclusion: CGM initiation within first year of type 1 diabetes results in long-term improvement in A1c. </p>

scholarly journals Continuous Glucose Monitoring Initiation Within First Year of Type 1 Diabetes Diagnosis Is Associated With Improved Glycemic Outcomes: 7-Year Follow-Up Study

Diabetes Care ◽  
2022 ◽  
Author(s):  
Anagha Champakanath ◽  
Halis Kaan Akturk ◽  
G. Todd Alonso ◽  
Janet K. Snell-Bergeon ◽  
Viral N. Shah
Keyword(s):  
Type 1 Diabetes ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
First Year ◽  
Diabetes Diagnosis ◽  
Glycemic Outcomes ◽  
Design And Methods

OBJECTIVE To evaluate long-term glycemic outcomes of continuous glucose monitoring (CGM) initiation within the first year of type 1 diabetes diagnosis. RESEARCH DESIGN AND METHODS Patients with type 1 diabetes (N = 396) were divided into three groups: 1) CGM (CGM use within 1 year of diabetes diagnosis and continued through the study); 2) no-CGM (no CGM use throughout the study); and 3) new-CGM (CGM use after 3 years since diabetes diagnosis). Patients were followed up to 7 years. RESULTS A1c was significantly lower in the CGM compared with the no-CGM group throughout 7 years of follow-up (least squares mean A1c values: 6 months, 7.3% vs. 8.1%; 1 year, 7.4% vs. 8.6%; 2 years, 7.7% vs. 9.1%; 3 years, 7.6% vs. 9.3%; 4 years, 7.4% vs. 9.6%; 5 years, 7.6% vs. 9.7%; 6 years, 7.5% vs. 10.0%; and 7 years, 7.6% vs. 9.8%; for all, P &lt; 0.001) adjusting for age at diagnosis, sex, and insulin delivery method. CONCLUSION CGM initiation within first year of type 1 diabetes diagnosis results in long-term improvement in A1c.

Long-term use of insulin pump vs pens in treating young children with type 1 diabetes

2015 ◽  
Author(s):  
Ashraf Soliman ◽  
Fawzia Alkhalaf ◽  
Mahmoud Alzyoud ◽  
Noura Alhumaidi ◽  
Ahmed Elawwa ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Children ◽  
Insulin Pump

scholarly journals Non-immune-mediated versus immune-mediated type 1 diabetes: diagnosis and long-term differences—retrospective analysis

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Diana Catarino ◽  
Diana Silva ◽  
Joana Guiomar ◽  
Cristina Ribeiro ◽  
Luísa Ruas ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Retrospective Analysis ◽  
Diabetes Diagnosis ◽  
Immune Mediated

Body Mass Index Changes in Youth in the First Year after Type 1 Diabetes Diagnosis

2015 ◽  
Vol 166 (5) ◽  
pp. 1265-1269.e1 ◽  
Author(s):  
Brigid Gregg ◽  
Crystal G. Connor ◽  
Katrina J. Ruedy ◽  
Roy W. Beck ◽  
Craig Kollman ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Type 1 Diabetes ◽  
Body Mass ◽  
First Year ◽  
Diabetes Diagnosis ◽  
Index Changes

scholarly journals Specific type 1 diabetes risk genes underpin age-at-diagnosis and indicate joint defects in immunity, beta-cell fragility and responses to viral infections in early-onset disease

2019 ◽  
Author(s):  
Jamie R.J. Inshaw ◽  
Antony J. Cutler ◽  
Daniel J.M. Crouch ◽  
Linda S. Wicker ◽  
John A. Todd
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cells ◽  
Viral Infections ◽  
Multinomial Logistic Regression ◽  
Age At Diagnosis ◽  
Diabetes Diagnosis ◽  
Logistic Regression Models ◽  
Risk Alleles ◽  
Hla Haplotypes

AbstractObjectiveImmunohistological analyses of pancreata from patients with type 1 diabetes suggest a stratification of islet pathology of both B and T lymphocyte islet inflammation common in children diagnosed at <7 years (<7 group), whereas B cells are rare in those diagnosed age ≥13 (≥13 group). Based on these observations, we sought to identify differences in genetic susceptibility between these age-at-diagnosis groups, to inform on the aetiology of the most aggressive form of type 1 diabetes that initiates in the first years of life.Research Design and MethodsUsing multinomial logistic regression models, we tested if known type 1 diabetes loci (17 within the HLA region and 55 non-HLA regions) had significantly stronger effect sizes in the <7 group compared to the ≥13 group, using genotype data from 27,075 individuals (18,488 controls, 3,109 cases diagnosed at <7, 3,754 at 7-13 and 1,724 at ≥13).ResultsSix HLA haplotypes/classical alleles and seven non-HLA regions, one of which functions specifically in beta cells (GLIS3), and the other six likely affecting key T cell (IL2RA, IL10, SIRPG, IKZF3, THEMIS), thymus (THEMIS) and B cell development/functions (IKZF3, IL10) or in both immune and beta cells (CTSH) had stronger effects in the <7 group.ConclusionsIn newborn children with the greatest load of certain risk alleles, dysregulated response of immune and beta cells to environmental stresses such as virus infection, combine to cause a rapid loss of insulin production, driving down the age of type 1 diabetes diagnosis.

scholarly journals Factors Associated with Decline of C-peptide in a Cohort of Young Children Diagnosed with Type 1 Diabetes

2020 ◽  
Author(s):  
Andrea K Steck ◽  
Xiang Liu ◽  
Jeffrey P Krischer ◽  
Michael J Haller ◽  
Riitta Veijola ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Children ◽  
Area Under The Curve ◽  
Age At Diagnosis ◽  
Z Score ◽  
C Peptide ◽  
Factors Associated ◽  
Female Sex ◽  
Younger Age

Abstract Context Understanding factors involved in the rate of C-peptide decline is needed to tailor therapies for type 1 diabetes (T1D). Objective Evaluate factors associated with rate of C-peptide decline after T1D diagnosis in young children. Design Observational study. Setting Academic centers. Participants 57 participants in The Environmental Determinants of Diabetes in the Young (TEDDY) enrolled at 3 months of age and followed until T1D and 56 age-matched children diagnosed with T1D in the community. Intervention A mixed meal tolerance test was used to measure the area under the curve (AUC) C-peptide at 1, 3, 6, 12 and 24 months post-diagnosis. Outcome Factors associated with rate of C-peptide decline during the first 2 years post-diagnosis were evaluated using mixed effects models adjusting for age at diagnosis and baseline C-peptide. Results Adjusted slopes of AUC C-peptide decline did not differ between TEDDY subjects and community controls (p=0.21), although the former had higher C-peptide baseline levels. In univariate analyses combining both groups (n=113), younger age, higher weight and BMI z-scores, female sex, increased number of islet autoantibodies, and IA-2A or ZnT8A positivity at baseline were associated with higher rate of C-peptide loss. Younger age, female sex and higher weight z-score remained significant in multivariate analysis (all p&lt;0.02). At three months after diagnosis, higher HbA1c became an additional independent factor associated with higher rate of C-peptide decline (p&lt;0.01). Conclusion Younger age at diagnosis, female sex, higher weight z-score, and HbA1c were associated with higher rate of C-peptide decline after T1D diagnosis in young children.

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