scholarly journals Use of Overkill Half-Cycle Qualification Data to Support Reduction of Exposure Time in Validated Ethylene Oxide Sterilization Cycles

2020 ◽  
Vol 54 (s1) ◽  
pp. 40-44
Author(s):  
Scott Weiss ◽  
Phil Cogdill ◽  
Joyce M. Hansen
Keyword(s):  
Ethylene Oxide ◽  
Medical Device ◽  
Exposure Time ◽  
Half Cycle ◽  
Additional Time ◽  
Conservative Nature ◽  
Medical Device Manufacturers ◽  
Using Data ◽  
Ethylene Oxide Sterilization

Abstract This article details the evaluation conducted for the potential to reduce ethylene oxide (EO) exposure times using data from currently validated EO sterilization cycles. The candidate cycles used the overkill half-cycle approach detailed in Annex B of ANSI/AAMI/ISO 11135:2014. The overkill half-cycle approach is conservative and has been the method of choice with medical device manufacturers because of its ease of understanding. The analysis presented provides an understanding of the extent of this conservative nature. Based on the analysis, exposure time can be reduced and rapidly implemented. The reduction in the exposure time may improve the product EO residuals and allow for additional time for the EO processing chamber to be utilized and/or for additional off-gassing for the product, if needed.

scholarly journals Center-Based Child Care and Differential Improvements in the Child Development Outcomes of Disadvantaged Children

2021 ◽  
Author(s):  
Sarah Anne Reynolds
Keyword(s):  
Child Care ◽  
Child Development ◽  
Economic Status ◽  
Value Added ◽  
Additional Time ◽  
Nationally Representative ◽  
Using Data ◽  
Development Outcomes ◽  
One Year ◽  
The Impact

Abstract Background Research finds center-based child care typically benefits children of low socio-economic status (SES) but few studies have examined if it also reduces inequalities in developmental disadvantage. Objective I test if the length of time in center-based care between ages one and three years associates with child development scores at age three years, focusing on the impact for groups of children in the lower tercile of child development scores and in the lower SES tercile. Method Using data from 1,606 children collected in a nationally representative Chilean survey, I apply a value-added approach to measure gains in child development scores between age one and three years that are associated with length of time in center-based child care. Results Disadvantages at age one year were associated with lower child development scores at age three years. No benefits of additional time in center-based care were found for the non-disadvantaged group, but positive associations were found between more time in center-based care and child development outcomes for children with the SES disadvantage only. Center-based care was not associated with child development trajectories of children with lower child development scores at age one year, no matter their SES status. Conclusions There is evidence that Chilean center-based child care reduces SES inequality in child development scores between ages one and three years, but only if children already were not low-scorers at age one year.

Ethylene oxide sterilization at 37 °C

1988 ◽  
Vol 11 (3) ◽  
pp. 294-295
Author(s):  
M. Colard ◽  
J.J. Haxhe
Keyword(s):  
Ethylene Oxide ◽  
Ethylene Oxide Sterilization

scholarly journals Ethylene oxide sterilization of bone grafts: Residual gas concentration and fibroblast toxicity

1994 ◽  
Vol 65 (6) ◽  
pp. 640-642 ◽  
Author(s):  
Takeshi Arizono ◽  
Yukihide Iwamoto ◽  
Kiyotaka Okuyama ◽  
Yoichi Sugioka
Keyword(s):  
Ethylene Oxide ◽  
Bone Grafts ◽  
Gas Concentration ◽  
Residual Gas ◽  
Ethylene Oxide Sterilization

Lessons to be learnt from the PIP saga

2012 ◽  
Vol 94 (3) ◽  
pp. 82-83
Author(s):  
Norman Williams
Keyword(s):  
Medical Device ◽  
Professional Lives ◽  
Surgical Implants ◽  
Medical Device Manufacturers ◽  
Surgical Career

In the course of my surgical career I have witnessed many groundbreaking developments that have dramatically improved and saved patients' lives and been truly transformational. Such breakthroughs have invariably occurred from a combination of science, surgical ingenuity and skill underpinned by the enthusiasm and drive of a variety of surgical innovators and medical device manufacturers. We should all be proud of the progress that has been made and the lives that have been saved and improved. However, from time to time I have also witnessed scandals involving surgical implants that have marred the reputation of not only the manufacturers but also, on occasion, the surgeons involved. These scandals have a significant impact on the specialty and can often inhibit progress, cause suffering to patients and destroy professional lives.

Microwave cavity spectrometer for process monitoring of ethylene oxide sterilization

1993 ◽  
Vol 64 (1) ◽  
pp. 103-108 ◽  
Author(s):  
Z. Zhu ◽  
C. Gibson ◽  
A. H. Samuel ◽  
I. P. Matthews
Keyword(s):  
Ethylene Oxide ◽  
Process Monitoring ◽  
Microwave Cavity ◽  
Ethylene Oxide Sterilization

scholarly journals Microbiological Aspects of Ethylene Oxide Sterilization

1970 ◽  
Vol 19 (1) ◽  
pp. 146-151 ◽  
Author(s):  
K. Kereluk ◽  
R. A. Gammon ◽  
R. S. Lloyd
Keyword(s):  
Ethylene Oxide ◽  
Ethylene Oxide Sterilization ◽  
Microbiological Aspects
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