scholarly journals Diagnostic and prognostic value of cancer stem cell marker CD44 and soluble CD44 in the peripheral Blood of patients with oral Squamous cell carcinoma

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Aya K. Khamis ◽  
Hamed A. Fouad ◽  
Hanaa S. Raslan ◽  
Mohamed M. Fata ◽  
Amira I. Fayad
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Peripheral Blood ◽  
Prognostic Value ◽  
Stem Cell Marker ◽  
Soluble Cd44 ◽  
Poorly Differentiated ◽  
Diagnostic And Prognostic Value

BackgroundHead and neck cancer is a major health problem. Recent studies on the pathobiology of oral squamous cell carcinoma (OSCC) have led to the discovery of a small population of cancer cells with a consistent behavior with the features of cancer stem cells (CSCs).  CSCs are required and responsible for initiation, maintenance and recurrence of disease. Molecular markers are commonly used for the identification of CSCs. CD44 is the most reported CSC marker in OSCC.The aim of the study was to evaluate and correlate the expression of CD44 in different histopathological grades of OSCC, as well as to assess the diagnostic and prognostic value of soluble CD44 (CD44sol) in peripheral blood of patients.Materials and methodsFifteen patients with OSCC were included; biopsies were histologically evaluated using haematoxylin and eosin. Serial sections were immunohistochemically stained by monoclonal antibody to CD44. The intensity of immunostaining of CD44 was calculated. Enzyme-linked immunosorbent assay (ELISA) method was used to determine the concentration of CD44sol in the blood serum.ResultsAll grades of OSCC showed membranous immunosignaling of CD44. The well, moderately and poorly differentiated OSCC cases showed weak, moderate and intense positive membranous immunosignaling of CD44 respectively.CD44sol levels were significantly higher in OSCC patients than they were in control groups. Soluble CD44 serum levels were significantly higher in poorly differentiated than they were in moderately and well differentiated.ConclusionCSCs detection in fixed human tissue and CD44sol detection in peripheral blood using ELISA seemed to be a promising method and may have a diagnostic and prognostic value in management of OSCC.

Diagnostic and prognostic value of serum miR-99a expression in oral squamous cell carcinoma

2018 ◽  
Vol 23 (3) ◽  
pp. 333-339 ◽  
Author(s):  
Liang Chen ◽  
Jing Hu ◽  
Lina Pan ◽  
Xiaochun Yin ◽  
Qibao Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Diagnostic And Prognostic Value

Negative regulation of natural killer cell in tumor tissue and peripheral blood of oral squamous cell carcinoma

Cytokine ◽  
2015 ◽  
Vol 76 (2) ◽  
pp. 123-130 ◽  
Author(s):  
Anupam Dutta ◽  
Arunabha Banerjee ◽  
Nabajyoti Saikia ◽  
Jyotirmoy Phookan ◽  
Munindra Narayan Baruah ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Natural Killer Cell ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Natural Killer ◽  
Squamous Cell ◽  
Peripheral Blood ◽  
Tumor Tissue ◽  
Killer Cell ◽  
Negative Regulation

scholarly journals The prognostic value of immune checkpoints in oral squamous cell carcinoma

Oral Diseases ◽  
2018 ◽  
Vol 25 (6) ◽  
pp. 1435-1445 ◽  
Author(s):  
Meri Sieviläinen ◽  
Rabeia Almahmoudi ◽  
Ahmed Al‐Samadi ◽  
Tuula Salo ◽  
Matti Pirinen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Immune Checkpoints

scholarly journals Prognostic value of CAIX expression in oral squamous cell carcinoma: a systematic review and meta-analysis

2020 ◽  
Vol 35 (1) ◽  
pp. 1258-1266 ◽  
Author(s):  
Alejandro I. Lorenzo-Pouso ◽  
Mercedes Gallas-Torreira ◽  
Mario Pérez-Sayáns ◽  
Cintia M. Chamorro-Petronacci ◽  
Oscar Alvarez-Calderon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Caix Expression

scholarly journals Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Qunxing Li ◽  
Xiangqi Liu ◽  
Dikan Wang ◽  
Yanqiong Wang ◽  
Huanzi Lu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cells ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nk Cells ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Lymphoid Structures ◽  
Infiltrating Lymphocytes

Abstract Tertiary lymphoid structures (TLS) are ectopic lymphoid structures in cancers that are largely associated with favourable prognosis. However, the prognostic value of TLSs in oral squamous cell carcinoma (OSCC) is largely unknown, and the association between tumour infiltrating lymphocytes (TILs) and TLSs has been rarely explored in OSCC. In this study, associated markers of TLS, including peripheral node address (PNAd) in high endothelial venules, CD20 in B cells and CD3 in T cells, were examined in 168 OSCC patients, and survival analysis was performed between TLS-positive and TLS-negative cohorts. We detected the presence of TILs by staining CD8+ cytotoxic T cells and CD57+ NK cells as well. TLSs appeared as highly organized structures in 45 (26.8%) cases. TLS-positive patients had a better 5-year overall survival (OS) rate (88.9% vs. 56.1%, P < 0.001) and relapse-free survival (RFS) rate (88.9% vs. 63.4%, P = 0.002). Moreover, the presence of TLS was an independent prognostic factor for both the 5-year OS rate (hazard ratio [HR] = 3.784; 95% confidence interval [CI], 1.498–9.562) and RFS rate (HR = 3.296; 95% CI, 1.279–8.490) in multivariate analysis. Furthermore, a higher density of CD8+ T cells and CD57+ NK cells was found in TLS-positive sections than in TLS-negative counterparts (P < 0.001), and their combination provided a higher predictive accuracy (AUC = 0.730; 95% CI, 0.654–0.805). In conclusion, our results suggest that TLS is an independent positive prognostic factor for OSCC patients. These findings provide a theoretical basis for the future diagnostic and therapeutic value of TLSs in OSCC treatment.

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