scholarly journals Effect of Diode Laser on Gingival Crevicular Fluid Stromal Derived Factor – 1 Alpha Level in Chronic Periodontitis Patients- A Randomized Clinical Trial

2019 ◽  
Vol 1 (5) ◽  
Author(s):  
Rakesh M.P. ◽  
Krishna Kripal ◽  
Deepthi R. ◽  
Sandeep S. Prabhu ◽  
Shanmugapriya P.A.
Keyword(s):  
Periodontal Disease ◽  
Diode Laser ◽  
Gingival Crevicular Fluid ◽  
Immune Defense ◽  
Clinical Parameters ◽  
Scaling And Root Planing ◽  
Root Planing ◽  
Group 2 ◽  
Crevicular Fluid ◽  
Group 1

Background: SDF-1α may be involved in the immune defense pathway activated during periodontal disease. Upon development of disease, SDF-1α levels increase and may recruit host defensive cells into sites of inflammation. This suggests that SDF-1α may be a useful biomarker for the identification of periodontal disease progression. Previous studies suggested that diode laser using as an adjunct to SRP in clinical and biochemical benefits. Aims and objectives: The aim of the present study was to assess the effect of diode laser on gingival crevicular fluid stromal derived factor – 1 alpha (SDF-1α) level in chronic generalized periodontitis patients.  Materials and methods: A total of 30 patients were divided in two groups based on inclusion and exclusion criteria as follows: Group 1:  15 chronic generalized periodontitis patients who received treatment with scaling and root planing. Group 2: 15 chronic generalized periodontitis patients who received treatment with scaling and root planing and diode laser. Each GCF samples were collected at baseline, 15 days and 21 days after treatment. Clinical parameters like gingival index, probing pocket depth and clinical attachment level were recorded and GCF samples also collected. Results: All the clinical parameters (GI, PPD, CAL) and the concentration of SDF-1α level in GCF were found to be significantly reduced in the group 2 compared to group 1 after 21 days. The mean values of GI, PPD, CAL parameters at different time intervals was found statistically significant in both the groups (p<0.001). Conclusion: Within the limitations of the present study, we conclude that diode laser used as an adjunct to SRP provides greater improvement in clinical and biochemical benefits over conventional mechanical treatment during medium term of observation.

Efficacy of subgingivally delivered atorvastatin and simvastatin as an adjunct to scaling and root planing

2015 ◽  
Vol 30 (4) ◽  
Author(s):  
Sai M. Surve ◽  
Anirudh B. Acharya ◽  
Srinath L. Thakur
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Local Delivery ◽  
Control Group ◽  
Clinical Parameters ◽  
Scaling And Root Planing ◽  
Root Planing ◽  
Significant Difference ◽  
Group 2 ◽  
Crevicular Fluid

AbstractThe current understanding of the pathogenesis of periodontal disease has resulted in adjunctive use of various pharmacologic agents in periodontal therapy. The objective of this investigation was to assess the efficacy of atorvastatin and simvastatin (because of their pleiotropic properties) as an adjunct to dental scaling and root planing (SRP) by local delivery, i.e. placing them subgingivally, in the treatment of chronic periodontitis.Local delivery systems for atorvastatin and simvastatin were prepared in sodium alginate suspension to be administered with calcium chloride solution. Patients diagnosed with chronic periodontitis were grouped as group 1, receiving SRP only (control), group 2, receiving SRP with subgingival delivery of 1.2% simvastatin, and group 3, receiving SRP with subgingival delivery of 1.2% atorvastatin. Clinical parameters and interleukin (IL) 1α levels in the gingival crevicular fluid (GCF) were assessed.All three groups showed significant reductions in clinical parameters and IL-1α levels in the GCF (p<0.05). However, the test groups did not show any statistically significant difference when compared with control.Subgingivally delivered atorvastatin and simvastatin as an adjunct to SRP is efficacious but did not demonstrate any added benefit as compared with SRP alone.

scholarly journals A COMPARATIVE EVALUATION OF C-REACTIVE PROTEIN GCF LEVEL IN PERIODONTITIS PATIENTS AFTER SCALING AND ROOT PLANING WITH AND WITHOUT DIODE LASER

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Sangeeta Roy ◽  
C.S. Joshi ◽  
Pradeep Shukla ◽  
Gaurav Malhotra ◽  
Prerna Kataria ◽  
...  
Keyword(s):  
Diode Laser ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Periodontal Therapy ◽  
Type I ◽  
Scaling And Root Planing ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Root Planing ◽  
Crevicular Fluid

Background and Objectives: C?reactive protein (CRP) is a type I acute phase reactant. A number of studies have reported elevated gingival crevicular fluid (GCF) CRP levels in periodontitis subjects, which decrease following periodontal therapy. Effect of diode laser as an adjuct to Scaling & Root planing is also well stablished. The aim of the present study was to evaluate the effect of periodontal treatment SRP with diode laser, on CRP levels in GCF in patients with chronic periodontitis. Materials and Methods: A total of 40 subjects with moderate periodontitis based on community periodontal index scores, were included in the study. Periodontal therapy was performed dividing each side of jaw as a group (Split mouth); one side SRP alone & another Diode laser with SRP. GCF was collected from each subject at Baseline (prior to treatment) and 1 month after periodontal therapy. The collected sample was subjected to biochemical analysis to detect CRP levels by using a commercially available highly sensitive kit. Results: The present study demonstrated that the mean CRP values at baseline were found to be 0.11043mg/l in side-I (side treated with SRP alone); 0.11042mg/l in side-II (side treated with SRP & laser) of the patient, which reduced to 0.4148 mg/L in side I and 0.3985mg/L in side II after treatment, which are highly significant according to statistical analysis but the changes between two sides were non- significant statistically. Interpretation and Conclusion: Within the limitations of this study, it can be concluded that periodontal therapy is able to reduce the GCF C reactive protein level significantly, but there was no statistically significant result in CRP level, between sides treated with SRP & SRP with laser. Key words: Chronic periodontitis, C?reactive protein, gingival crevicular fluid, Scaling and root planing, Diode laser

scholarly journals Effect of Non-Surgical Periodontal Therapy on Interleukin-29 Levels in Gingival Crevicular Fluid of Chronic Periodontitis and Aggressive Periodontitis Patients

2013 ◽  
Vol 34 (1) ◽  
pp. 1-7 ◽  
Author(s):  
B. M. Shivaprasad ◽  
A. R. Pradeep
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Aggressive Periodontitis ◽  
Periodontal Therapy ◽  
Scaling And Root Planing ◽  
Group 3 ◽  
The Mean ◽  
Group 2 ◽  
Crevicular Fluid ◽  
Group 1

Recently discovered interleukin 29 (IL-29) has antiviral properties and its production is induced by herpes viruses. This study was aimed at analyzing the effect of non-surgical periodontal treatment on IL-29 levels in gingival crevicular fluid (GCF) of chronic and aggressive periodontitis patients. A total of 60 participants were divided into healthy group (group 1;n= 20), chronic periodontitis group (group 2;n= 20), and aggressive periodontitis group (group 3;n= 20). GCF samples collected from each subject at baseline and 6–8 weeks after scaling and root planing were quantified for IL-29 levels using ELISA. The mean IL-29 concentration in GCF was found to be highest in group 3 (92.37 pg/μl). The mean IL-29 level in group 1 and group 2 was 36.88 pg/μl and 69.35 pg/μl respectively. After scaling and root planing, the mean concentration of IL-29 in GCF was increased to 85.99 pg/μl in group 2 and to 114.64 pg/μl in group 3. Results of the present study indicate that antiviral IL-29 level was highest in GCF of aggressive periodontitis patients and least in subjects with healthy periodontium, while that of chronic periodontitis lying in between. After non-surgical periodontal therapy, IL-29 levels increased both in chronic and aggressive periodontitis patients and deserve further investigation as a potential therapeutic agent in treating periodontitis.

“Gingival Crevicular Fluid Levels of Interleukin-35 in Periodontal Health, Chronic Periodontitis & the Effect of Scaling & Root Planning on Interleukin-35 Levels in Chronic Periodontitis – A Randomized Controlled Clinical Study”

2021 ◽  
Vol 13 (2) ◽  
pp. 7-15
Author(s):  
Dr. Ammu Varghese ◽  
Dr. Harsha Mysore Babu ◽  
Dr. Archana R Naik ◽  
Dr. Savita A M ◽  
Dr. Pallavi Nanaiah Kukkera
Keyword(s):  
Chronic Periodontitis ◽  
T Regulatory Cells ◽  
Gingival Crevicular Fluid ◽  
Scaling And Root Planing ◽  
Regulatory Cells ◽  
Periodontal Health ◽  
Root Planing ◽  
Crevicular Fluid ◽  
Fluid Levels ◽  
Group 1

Background & Objectives: Interleukin-35 (IL-35) is a newly identified anti-inflammatory cytokine generated by T regulatory cells. They are most effective at high inflammation sites and are a potent activator of T regulatory cells. Hence this study aimed to assess gingival crevicular fluid levels of IL-35 in healthy subjects and chronic periodontitis patients and to compare the levels of IL-35, before and after scaling and root planing in chronic periodontitis patients. Methods: Forty subjects were selected and categorised into 3 groups. Group 1: Periodontally healthy individuals, Group 2A: Chronic periodontitis patients and Group 2B: Group 2A patients who were evaluated 6 weeks after scaling and root planing. Gingival bleeding index, probing pocket depth and clinical attachment level were recorded. Gingival crevicular fluid samples were collected and stored at -800 C till they were subjected to analysis by Enzyme Linked Immunosorbent Assay (ELISA). Results: On intergroup comparison, the difference in mean IL-35 levels and clinical parameters were highly statistically significant between Group 1 and Group 2A while between Group 1 and Group 2B were not significant. On comparing Group 2A and Group 2B, the mean differences were highly statistically significant P (<0.001). Significant reductions in all parameters were noted in Group 2B. Conclusion: Significant reduction of IL-35 levels in chronic periodontitis patients, 6-8 weeks after scaling and root planing and their presence in periodontally healthy subjects suggest the role of IL-35 in controlling the inflammation and their protective role in maintaining periodontal health. Key message: IL-35 has an effective role in controlling the inflammation and in maintaining periodontal health. IL-35 can be considered as a promising prognostic biomarker in periodontal diseases.

scholarly journals COMPARATIVE EVALUATION OF EFFICACY OF SCALING AND ROOT PLANING WITH AND WITHOUT CHLORHEXIDINE CHIP AND DIODE LASER IN CHRONIC PERIODONTITIS PATIENTS

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Reya Shree ◽  
Varun Dahiya ◽  
Pradeep Shukla ◽  
Prerna Kataria ◽  
Mona Dagar
Keyword(s):  
Diode Laser ◽  
Chronic Periodontitis ◽  
Control Group ◽  
Clinical Parameters ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Root Planing ◽  
Before And After ◽  
Laser Group

Introduction: The motive of the present study is to comparatively measure the competence and effectiveness of diode laser and chlorhexidine chip as adjuncts to the scaling and root planing procedure, in patients with chronic periodontitis. Aim: To evaluate the efficacy of diode laser and chlorhexidine chip before and after scaling and root planing in the management of chronic periodontitis. The objective is to compare the efficacy of chlorhexidine chip and diode laser before and after scaling and root planning on clinical parameters. Study and design: Randomized clinical trial with split mouth design done in the Department of Periodontics and Implantology. Materials and methods: Twenty chronic periodontitis patients having a probing pocket depth of 5mm-7mm on at least one interproximal site in each quadrant of the mouth were selected in the study. After initial treatment, four sites in each patient were randomly subjected to scaling and root planing (control), chlorhexidine chip application (CHX chip group), diode laser (810 nm) decontamination (Diode laser group) or combination of both (Diode laser and chip group). All subjects received a clinical periodontal examination by single examiner who recorded all the variables by manual procedure. Clinical parameters namely Plaque index (PI), Gingival Index (GI), probing pocket depth (PPD) and clinical attachment level (CAL) were assessed at baseline, one month and three months. Results were statistically analysed using one-way ANOVA followed by Post Hoc Analysis. Results: The differences in PPD reduction and CAL gain between control group and CHX chip and combination groups were statistically significant (p<0.05) at three months, whereas, the diode laser group did not show any significant difference from the control group. Conclusion: Within the limitations in the present study, the following conclusions were derived, i.e., chlorhexidine local delivery alone or in combination with diode laser decontamination is effective in improving oral hygiene, reducing gingival inflammation, reducing probing pocket depth and improving clinical attachment levels when used as adjuncts to scaling and root planing in non-surgical periodontal therapy of patients with chronic periodontitis. Keywords: Diode laser decontamination, Local drug delivery, Scaling and root planing.

scholarly journals Effect of Scaling and Root Planing on Detection of Tannerella forsythia in Chronic Periodontitis

2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
Ritesh B. Wadhwani ◽  
Minal S. Chaudhary ◽  
Dipti A. Tharani ◽  
Shweta A. Chandak
Keyword(s):  
Chronic Periodontitis ◽  
Scaling And Root Planing ◽  
Tannerella Forsythia ◽  
Root Planing ◽  
Detection Frequency ◽  
Probing Depth ◽  
Periodontal Destruction ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim. This study was aimed to determine the prevalence of Tannerella forsythia in subgingival plaque samples of chronic periodontitis patients having different level of periodontal destruction and to assess the effect of scaling and root planing (SRP) on prevalence of T. forsythia. Materials and Methods. Study included 3 groups: group 1 were healthy individuals, group 2 had periodontitis with probing depth ≤ 5 mm, and group 3 had periodontitis with probing depth > 5 mm. Subjects in groups 2 and 3 exhibited both healthy and diseased periodontal sites. Prevalence of T. forsythia was determined using polymerase chain reaction. Subjects in groups 2 and 3 received SRP and were reevaluated three months after SRP. Results. T. forsythia was not detected in group 1. It was found in diseased sites in 40% and 73.33% of patients from groups 2 and 3, respectively. It was also found in healthy sites in 6.67% and 13.33% of patients from groups 2 and 3, respectively. The detection frequency of T. forsythia after SRP was 6.67% and 13.33% in groups 2 and 3, respectively. Conclusion. The results indicate a possible association between periodontal disease and presence of T. forsythia. Also, the detection frequency of T. forsythia was reduced after SRP.

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