scholarly journals NON-ENZYMATIC NATURAL REACTIVE OXYGEN SCAVENGERS (ROS): A REVIEW ON STRUCTURES AND MODE OF ACTION

2019 ◽  
Vol 6 (2) ◽  
pp. 103-112
Author(s):  
Tanveer Ahamad ◽  
Waseem Ahmad Ansari ◽  
Devendra Singh Negi ◽  
Mohammad Faheem Khan
Keyword(s):  
Mode Of Action ◽  
Reactive Oxygen ◽  
Oxygen Scavengers

scholarly journals Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

2004 ◽  
Vol 167 (3) ◽  
pp. 457-468 ◽  
Author(s):  
Julián Pardo ◽  
Alberto Bosque ◽  
Reina Brehm ◽  
Reinhard Wallich ◽  
Javier Naval ◽  
...  
Keyword(s):  
Cell Death ◽  
Target Cell ◽  
Ex Vivo ◽  
Reactive Oxygen ◽  
Phosphatidyl Serine ◽  
Oxygen Scavengers ◽  
Cell Death Pathways ◽  
Physiological Relevance ◽  
Apoptotic Pathways ◽  
Tumor Target Cell

Purified cytolytic T lymphocyte (CTL) proteases granzyme (gzm)A and gzmB with sublytic dose of perforin (perf) initiate distinct proapoptotic pathways. Their physiological relevance in CTL-mediated target cell apoptosis is elusive. Using ex vivo virus-immune CD8+ T cells from mice deficient in perf, gzmA and/or gzmB, and the Fas-resistant EL4.F15 tumor target cell, we show that (a) CTL from gzmA−/− or gzmB−/− mice similarly induced early proapoptotic features, such as phosphatidyl serine (PS) exposure on plasma membrane, ΔΨm loss, and reactive oxygen radical generation, though with distinct kinetics; (b) CTL from gzmA−/− but not from gzmB−/− mice activate caspase 3 and 9; (c) PS exposure induced by CTL from gzmA−/− or gzmB−/− mice is prevented, respectively, by caspase inhibitors or by reactive oxygen scavengers without interfering with target cell death; and (d) all gzm-induced apoptotic features analyzed depend critically on perf. Thus, perf is the principal regulator in CTL-mediated and gzm-facilitated intracellular processes. The ability of gzmA and gzmB to induce multiple independent cell death pathways may be the hosts response to circumvent evasion strategies of pathogens and tumors.

A novel insight into the mode of action of glufosinate: how reactive oxygen species are formed

2020 ◽  
Vol 144 (3) ◽  
pp. 361-372 ◽  
Author(s):  
Hudson K. Takano ◽  
Roland Beffa ◽  
Christopher Preston ◽  
Philip Westra ◽  
Franck E. Dayan
Keyword(s):  
Reactive Oxygen Species ◽  
Mode Of Action ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Insight Into

scholarly journals Generation of reactive oxygen species is the primary mode of action and cause of survivin suppression by sepantronium bromide (YM155)

2021 ◽  
Author(s):  
Tasaduq Hussain Wani ◽  
Goutam Chowdhury ◽  
Anindita Chakrabarty
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Mode Of Action ◽  
Reactive Oxygen ◽  
Cancer Drug ◽  
Oxygen Species ◽  
Secondary Effects ◽  
Primary Mode ◽  
Anti Cancer ◽  
Sepantronium Bromide

The anti-cancer drug YM155's primary mode of action is generation of reactive oxygen species, while survivin suppression and DNA damage are secondary effects.

scholarly journals Movable Hollow Nanoparticles as Reactive Oxygen Scavengers

Chem ◽  
2019 ◽  
Vol 5 (9) ◽  
pp. 2378-2387 ◽  
Author(s):  
Meiling Lian ◽  
Zhenjie Xue ◽  
Xuezhi Qiao ◽  
Cong Liu ◽  
Shuo Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen ◽  
Oxygen Scavengers ◽  
Hollow Nanoparticles

Polydopamine Coated Au-Pt Nanorods: Enhanced Photothermal Properties and Efficient Reactive Oxygen Scavengers

2021 ◽  
pp. 112247
Author(s):  
Qianqian Duan ◽  
Jialin Wang ◽  
Boye Zhang ◽  
Xiaoyuan Wang ◽  
Juanjuan Xue ◽  
...  
Keyword(s):  
Reactive Oxygen ◽  
Oxygen Scavengers

scholarly journals Both metal-chelating and free radical-scavenging synthetic pentapeptides as efficient inhibitors of reactive oxygen species generation

Metallomics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1220-1229 ◽  
Author(s):  
Gizella Csire ◽  
Laetitia Canabady-Rochelle ◽  
Marie-Christine Averlant-Petit ◽  
Katalin Selmeczi ◽  
Loic Stefan
Keyword(s):  
Reactive Oxygen Species ◽  
Free Radical ◽  
Mode Of Action ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Free Radical Scavenging ◽  
Oxygen Species ◽  
Metal Chelating

The very first Fe(iii)-peptide chelators exhibiting antioxidant properties thanks to an unprecedented dual direct/indirect mode of action.

scholarly journals Unifying Mechanism for Nutrients as Anticancer Agents: Electron Transfer, Reactive Oxygen Species and Oxidative Stress

2017 ◽  
Vol 9 (8) ◽  
pp. 66 ◽  
Author(s):  
Peter Kovacic ◽  
Ratnasamy Somanathan
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Electron Transfer ◽  
Anticancer Agents ◽  
Mode Of Action ◽  
Recent Article ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Bactericidal Action ◽  
And Oxidative Stress

A recent article deals with various nutrients in relation to bactericidal action. The present article focuses on a unifying mode of action for the nutrients, namely, resveratrol, epigallocatechin, polyene-ß-carotene, polyene lycopene, piperine, curcumin, genistein, luteolin, sulforaphane and pomegranate extract. The mechanism is based on electron transfer, reactive oxygen species and oxidative stress, which comprises an extension of earlier reports involving agents. Most of the compounds are precursors of electron transfer quinones, whereas others fit into the polyene category. The nutrients are better known as antioxidants. The dichotomy is addressed.

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