scholarly journals The role of microorganism association in the development of chronic purulent maxillary sinusitis in patients with type 1 diabetes mellitus

2021 ◽  
Vol 25 (3 (99)) ◽  
pp. 61-70
Author(s):  
O. Мazur ◽  
O. Plaksyvyi ◽  
I. Kalutskyi ◽  
K. Yakovets
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Maxillary Sinusitis ◽  
Population Level ◽  
Control Group ◽  
Candida Spp ◽  
Microbial Associations ◽  
Maxillary Sinuses

Aim – to study the species composition and population level of the microbiota of the content of the maxillary sinuses and the role of associations of microorganisms in the development and course of chronic purulent maxillary sinusitis (CPMS) in patients with type 1 diabetes.Material and methods. A microbiological examination of 97 samples of the contents of the cavity of the maxillary sinuses was carried out. The main group consisted of 50 patients with CPMS with type 1 diabetes at the age of 20-67 years (10 patients at the age of 20-31 years, 14 patients - 31-45 years old and 26 - at the age of 45-67 years). Among the patients of the main group, endocrinologists established the course of type 1 diabetes mellitus of moderate severity in 39 patients, and a severe course in 11 patients. The control group consisted of 47 CPMS patients of the same age without type 1 diabetes mellitus (DM).Results. Bacteriological and mycological methods in the content of maxillary sinuses of patients with maxillary sinusitis associated with type 1 diabetes mellitus (DM) 175 strains of different kinds of microorganisms were isolated and identified, belonging to 24 various taxonomic groups which form different by their qualitative content microbial associations in the biotope which consist of three different kinds in 58% of patients, consist of four kinds – in 34,0% and five various taxa – in 8,0% of patients. Chronic purulent maxillary sinusitis in patients with type 1 DM disrupts microbial associations. In patients with CPMS with type 1 DM in comparison with the control group, the number of associations consist of three kinds increases by 2,7 times, but the number of associations composed of 4 types of microorganisms decreases by 11.76%. The number of associations consisting of 5 types in patients is reduced by 3.5 times. The above may indicate the influence of not only the etiological agent but also a certain association of microorganisms on the severity of the course of CPMS associated with type 1 diabetes. All leading pathogens persist in the biotope in association. Associates, depending on their role in normobiocenosis, can inhibit the pathogenetic activity of the leading pathogen or, conversely, activate its pathogenetic role, which must be taken into account when choosing a therapeutic tactics.Conclusions. Chronic purulent maxillary sinusitis in patients with type 1 diabetes disrupts microbial associations. In the content of the cavity of the maxillary sinuses of patients with chronic purulent maxillary sinusitis, combined with type 1 diabetes mellitus, 175 strains of various types of microorganisms belonging to 24 different taxonomic groups were isolated and identified, which in the biotope form microbial associations of different qualitative composition, consisting of 3 different species in 58% of patients, out of 4 species in 34.0% and from five different taxa - in 8.0% of patients. Among the most numerous associations, consisting of 3 types of pathogenic and opportunistic autochthonous facultative microorganisms, associations of the following representatives are more common: M. catarrhalis, S. aureus and Bacteroides spp.; Prevotella spp., S. viridans and S. salivarius; M. catarrhalis, Prevotella spp. and S. epidermitidis; H. influenzae, Prevotella spp. and S. epidermitidis. Associations consisting of 4 species were found in 34% of patients and consist of S. pneumoniae, M. catarrhalis, S. pyogenes, Fusobacterium spp; S. pneumoniae, E. coli, S. aureus and Candida spp.; S. pneumoniae, E. coli Hly +, S. viridans and Candida spp. In patients with chronic purulent maxillary sinusitis, combined with type 1 diabetes mellitus with a severe course, there were associations consisting of S. pneumoniae, M. catarrhalis, Candida spp. and S. epidermitidis; S. pneumoniae, M. catarrhalis, S. pyogenes, S. epidermitidis; Bacteroides spp., H. influenzae, S. pyogenes, Enterobacter freundii spp.; Bacteroides spp., H. influenzae, S. pyogenes, Candida spp. In patients with chronic purulent maxillary sinusitis, against the background of a severe course of type 1 diabetes mellitus, associations of microorganisms, consisting of 5 types, were found. Their composition was different, but in all the pathogen S. pneumoniae was isolated and identified at a high population level, opportunistic obligate anaerobic bacteria of the genus Bacteroides and Prevotella, Fusobacterium, streptococci, and Staphylococcus aureus. All leading pathogens persist in the biotope in association, which must be taken into account when choosing therapeutic tactics.

scholarly journals Species composition and population level of the microbiota of the contents of the maxillary sinuses and oropharynx in patients with chronic purulent maxillary sinusitis with type 1 diabetes mellitus

2021 ◽  
Vol 25 (3 (99)) ◽  
pp. 52-60
Author(s):  
O. Mazur
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Maxillary Sinusitis ◽  
Population Level ◽  
Opportunistic Pathogens ◽  
E Coli ◽  
Obligate Anaerobic ◽  
Maxillary Sinuses

Aim – to study the species composition and population level of the microbiota of the contents of the maxillary sinuses and oropharynx in patients with chronic purulent maxillary sinusitis (CPMS), which arose on the background of type 1 diabetes mellitus (DM).Material and methods. A microbiological examination of 97 samples of the contents of the maxillary sinus cavity was performed. The main group consisted of 50 patients with CPMS with type 1 diabetes aged 20-67 years (10 patients aged 20-31 years, 14 patients aged 31-45 years and 26 aged 45-67 years). Among patients of the main group, endocrinologists found in 39 patients the course of type 1 diabetes of moderate severity, in 11 - severe course. The control group consisted of 47 people of the same age, who during the last 6 months did not suffer from any diseases and considered themselves practically healthy.Results. The leading pathogens in CPMS in patients with type 1 (DM) are S. pneumoniae (34% of patients), H. influenzae (24%), M. catarrhalis (24%), S. aureus (10.0%), S. pyogenes (6.0%), E. coli Hly + (2.0%). It is established that the purulent-inflammatory process in the maxillary sinuses in patients with type 1 diabetes develops against the background of the formed dysbiosis of the oropharynx: 1st degree in 6.0%, 2nd degree - in 28% of patients and 3rd degree - in 66% of patients, which is characterized by a pronounced deficiency of indigenous obligate anaerobic and aerobic bacteria and contamination of the habitat with pathogenic and opportunistic pathogens and other microorganisms.Conclusions. The leading causative agents of chronic purulent maxillary sinusitis in patients with type 1 diabetes mellitus at the present stage are: S.pneumoniae (32.0%), H.influenzae (26.0%), M.catarrhalis (24.0%), S. pyogenes (10.0%), S. aureus (6.0%) and E. coli Hly + (2.0%). Patients with chronic purulent maxillary sinusitis, which developed on the background of type 1 diabetes mellitus, are eliminated from the habitat of bifidobacteria, lactococci and S. mutans, which are important for their multifunctional role in the microbiocenosis; the number of physiologically useful lactobacilli is significantly reduced by 2 orders of magnitude, salivary streptococci by 92.91%, S.viridans by 25.17%, S.sanguis by 86.17%, S.mitis by 45.33%, M.luteus-25.35%. Against this background, the number of opportunistic pathogens increases significantly by 84.59%, fusobacteria by 69.33%, pyogenic streptococcus - by 50.5%, hemophilic bacteria - by 55.71%, moraxella - by 74.01%, yeast-like fungi of the genus Candida - by 25.63%. Bacteria that contaminate the oropharynx and the contents of the cavities of the maxillary sinuses reach a high population level (from 4.33 ± 0.14 to 5.69 ± 0.09 lg KUO \ ml). In chronic purulent sinusitis in patients with type 1 diabetes mellitus in the contents of the oropharyngeal cavity are associations of autochthonous obligate and facultative opportunistic and allochthonous microorganisms, consisting of 3 types of microorganisms in 3 (6%) patients, out of 4 in 41 ( 82%) and out of 5 in 6 (12%) patients. Chronic purulent process in the maxillary sinus in patients with type 1 diabetes mellitus develops against the background of the formed dysbacteriosis / dysbiosis of the oropharynx I degree in 6.0%, II degree - in 28.0% of patients and III degree - in 66.0% of patients with chronic purulent maxillary sinusitis, characterized by elimination or severe deficiency of autochthonous obligate anaerobic and aerobic bacteria (bacteria of the genus Bifidobacterium, Lactobacillus, Streptococcus (S.salivarius, S.sanguis, S.mitis, S.mutans, L.lactis, M.luteus) biotope contamination by pathogenic and conditionally pathogenic S.pneumoniae, S.pyogenes, H.influenzae, M.catarrhalis, E.coli, E.coli Hly+, Enterobacter freundii., Klebsiella oxytoca, S.aureus and others.

Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus

Open Medicine ◽  
2009 ◽  
Vol 4 (4) ◽  
pp. 415-422
Author(s):  
Kamile Gul ◽  
Ihsan Ustun ◽  
Yusuf Aydin ◽  
Dilek Berker ◽  
Halil Erol ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Statistical Significance ◽  
Control Group ◽  
Acid Decarboxylase ◽  
Thyroid Peroxidase ◽  
The Difference ◽  
Type 1 Dm

AbstractThe aim of the study was to determine the frequency and titers of anti-thyroid peroxidase (Anti-TPO), anti-thyroglobulin (Anti-TG), and anti-glutamic acid decarboxylase (Anti-GAD) antibodies in Turkish patients with type 1 diabetes mellitus (DM), and to compare the frequency of anti-TPO and anti-TG titers in the presence or absence of anti-GAD. A total of 104 patients including 56 males and 48 females with type 1 DM and their age-, gender-, and body mass index-matched control group, including 31 males and 27 females, 58 cases in total with an age range of 15-50 years, were recruited into this study. In patients with type 1 DM, positive anti-GAD was detected in 30.8% (n=32). In patients with positive anti-GAD, rate of positive anti-TPO was 37.5%; however, in patients with negative anti-GAD, the rate of positive anti-TPO was 9.7% and the difference was statistically significant (p=0.001). In patients with positive anti-GAD, the rate of positive anti-TG was 18.8%. In patients with negative anti-GAD, the rate of positive anti-TG was 2.8%, and the difference between them was statistically significant (p=0.005). In patients with positive and negative anti-GAD, rates of both positive anti-TPO and anti-TG were 15.6% and 1.4%, respectively, with the difference showing statistical significance (p=0.004). Thyroid autoimmunity in type 1 DM patients with positive anti-GAD was apparently higher; therefore, these patients should be followed more frequently and carefully.

scholarly journals Impact of ELKa, the Electronic Device for Prandial Insulin Dose Calculation, on Metabolic Control in Children and Adolescents with Type 1 Diabetes Mellitus: A Randomized Controlled Trial

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Agnieszka Kowalska ◽  
Katarzyna Piechowiak ◽  
Anna Ramotowska ◽  
Agnieszka Szypowska
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Metabolic Control ◽  
Electronic Device ◽  
Intervention Group ◽  
Insulin Dosage ◽  
Control Group ◽  
Prandial Insulin

Background. The ELKa system is composed of computer software, with a database of nutrients, and a dedicated USB kitchen scale. It was designed to automatize the everyday calculations of food exchanges and prandial insulin doses. Aim. To investigate the influence of the ELKa on metabolic control in children with type 1 diabetes mellitus (T1DM). Methods. A randomized, parallel, open-label clinical trial involved 106 patients aged <18 years with T1DM, HbA1C≤10%, undergoing intensive insulin therapy, allocated to the intervention group, who used the ELKa (n=53), or the control group (n=53), who used conventional calculation methods. Results. After the 26-week follow-up, the intention-to-treat analysis showed no differences to all endpoints. In per protocol analysis, 22/53 (41.5%) patients reporting ELKa usage for >50% of meals achieved lower HbA1C levels (P=0.002), lower basal insulin amounts (P=0.049), and lower intrasubject standard deviation of blood glucose levels (P=0.023) in comparison with the control. Moreover, in the intervention group, significant reduction of HbA1C level, by 0.55% point (P=0.002), was noted. No intergroup differences were found in the hypoglycemic episodes, BMI-SDS, bolus insulin dosage, and total daily insulin dosage. Conclusions. The ELKa system improves metabolic control in children with T1DM under regular usage. The trial is registered at ClinicalTrials.gov, number NCT02194517.

Electrocardiographic data of children with type 1 diabetes mellitus

2021 ◽  
pp. 1-5
Author(s):  
Mehmet Türe ◽  
Alper Akın ◽  
Edip Unal ◽  
Ahmet Kan ◽  
Suat Savaş
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Sudden Death ◽  
Type 1 Diabetes Mellitus ◽  
Qt Dispersion ◽  
Control Group ◽  
Haemoglobin A1c ◽  
Duration Of Diabetes ◽  
And Gender

Abstract Background: Adult patients diagnosed with type 1 diabetes mellitus are at risk for ventricular arrhythmias and sudden cardiac death. Aim: The objective of our study is to evaluate the electrocardiographic data of children diagnosed with type 1 diabetes mellitus and to determine the possibility of arrhythmia in order to prevent sudden death. Methods: Electrocardiographic data of 60 patients diagnosed with type 1 diabetes mellitus and 86 controls, who were compatible with the patient group in terms of age and gender, were compared. Results: The duration of diabetes in our patients with type 1 diabetes mellitus was 5.23 ± 1.76 years, and the haemoglobin A1c levels were 9.63% ± 1.75%. The heart rate, QRS, QT maximum, QT dispersion, QTc minimum, QTc maximum, QTc dispersion, Tp-e maximum, Tp-e maximum/QTc maximum and the JTc were significantly higher compared to the control group. There was no significant correlation between the duration of type 1 diabetes mellitus and HbA1c levels and the electrocardiographic data. Conclusion: We attributed the lack of a significant correlation between the duration of type 1 diabetes mellitus and the haemoglobin A1c levels and the electrocardiographic data to the fact that the duration of diabetes was short, since our patients were children. We believe that patients with type 1 diabetes mellitus should be followed up closely in terms of sudden death, as they have electrocardiographic changes that may cause arrhythmias compared to the control group. However, more studies with longer follow-up periods are necessary to support our data.

scholarly journals Risk of Urticaria in Children with Type 1 Diabetes Mellitus: A Nationwide Cohort Study

2019 ◽  
Vol 17 (1) ◽  
pp. 176
Author(s):  
Shih-Yi Lin ◽  
Cheng-Li Lin ◽  
Cheng-Chieh Lin ◽  
Wu-Huei Hsu ◽  
Chung-Y. Hsu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Hazard Ratio ◽  
Control Group ◽  
Case Group ◽  
Research Database ◽  
Increased Risk ◽  
Type 1 Dm

Type 1 diabetes mellitus (T1DM) has been linked to many autoimmune problems. The association between T1DM and urticaria warrants investigation. Data were extracted from the National Health Insurance Research Database (NHIRD) of Taiwan. Participants with T1DM were recruited as the case group, and that group was matched by sex and age at a ratio of 1:4 to the control group comprising those without T1DM. The study period was 1998–2011. All participants were followed up to the diagnosis of urticaria, withdrawal from the insurance program, death, or the end of the study. A multivariable Cox proportional hazard model was used to calculate the adjusted and crude hazard ratios for urticaria. A total of 5895 participants (1179 in the case group and 4716 in the control group) were followed up in the study. The total incidence rate of urticaria in patients with type 1 DM was 26.6 per 1000 person-years, and that in controls was 6.85 per 1000 person-years. Compared with the control group, the hazard ratio of urticaria in the case group was 2.84 (95% CI = 2.27–3.56). Compared with age-matched participants without T1DM, patients with type 1 DM aged <18 years had a 3.62-fold higher risk of urticaria (95% CI = 2.85–4.59). The hazard ratio in patients with an adjusted Diabetes Complications Severity Index (aDCSI) score of 1.01–2.00 per year was 2.57 (95% CI = 1.18–5.57), and that in patients with an aDCSI score of >2.00 per year was 4.47 (95% CI = 2.68–7.47). T1DM patients aged <18 years had an increased risk of urticaria, but a similar phenomenon was not observed among T1DM patients older than 18 years.

scholarly journals Can HbA1c predict quality of life in children with type 1 diabetes mellitus?

2020 ◽  
Author(s):  
Katharina Schiller ◽  
Markus Kofler ◽  
Martin Frühwirth ◽  
Michaela Fantur ◽  
Markus Rauchenzauner
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Sensory Nerve ◽  
Self Esteem ◽  
Control Group ◽  
Fitness Level

Abstract BackgroundThe aim of this study was to examine a possible association of HbA1c, quality of life (QoL), fitness, and electrophysiological parameters in children with type 1 diabetes mellitus (T1DM).MethodsThe study population (n = 34) consisted of patients with T1DM (n = 17) and an age- and BMI-matched healthy control group (n = 17). HbA1c was obtained from patients with T1DM at time of diagnosis (T0), at 6 months (T6), at 12 months (T12), and at time of study inclusion (Tstudy). QoL was determined with a standardized questionnaire (KINDL-R). All children completed a 6-minute walk test (6MWT) to evaluate their fitness level. Electrodiagnostic studies established upper and lower limb motor and sensory nerve conduction velocities (NCV).ResultsHigher HbA1c (Tstudy) was associated with lower QoL showing in the subscales self-esteem, friends and school. Higher HbA1c (T6) and (T12) was associated with lower QoL in the subscale self-esteem. Based on various subscales, perceived problem areas differed significantly between children and their parents. No differences in fitness level and NCV were found between patients and controls except for a significantly slower median motor NCV in patients. HbA1c was not associated with NCVs at this early stage of disease.ConclusionsGood metabolic control reflected by adequate HbA1c values seems to be important for a good QoL in children with T1DM. Early HbA1c analysis serves as predictor for QoL during follow-up.Trial registration: Retrospectively registered

scholarly journals The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus

2010 ◽  
Vol 13 (3) ◽  
pp. 25-31
Author(s):  
Tatiana Vasil'evna Nikonova ◽  
Pavel Vasil'evich Apanovich ◽  
Elena Vladimirovna Pekareva ◽  
Vera Anatol'evna Gorelysheva ◽  
Sergey Alexandrovich Prokof'ev ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
T Lymphocytes ◽  
Type 1 Diabetes Mellitus ◽  
Functional Activity ◽  
Risk Group ◽  
Control Group ◽  
Suppressor Activity ◽  
Foxp3 Gene

Type 1 diabetes mellitus (DM1) is associated with compromised (defective) immunologic tolerance to autoantigens and selective destruction of pancreatic B-cells by CD4+ (effector) and CD8 (cytotoxic) lymphocytes. The mechanisms of autotolerance involve CD4+CD25+high T-regulatory cells (Treg) whose suppressor activity depends on the expression of the FoxP3 gene. Aim. Detection of quantitative and functional alterations at the level of regulation of immunity in subjects at risk of DM1 and patients with different duration of DM1. Materials and methods. 116 patients (67 men and 49 women) with different duration of DM1. The risk group was comprised of 33 subjects (10 men and 23 women), control group included 16 subjects. In all cases, HLA genotyping was performed, autoantibodies to GDC, insulin and tyrosine phosphatase, islet cell antigens were determined, subpopulation composition of CD3+, CD4+, CD8+, CD38+, HLA DR+, CD25+, CD4+25+ lymphocytes and their functional activities (FoxP3 gene expression) studied, C-peptie and HbA1c levels measured. Results. A tendency toward a rise in Cd25+ and CD4+25+ T-lymphocytes and a decrease in FoxP3 expression was documented in the risk group compared with control (p0.05) but their functional activity was lower (p

scholarly journals Effectiveness of a nutrition education package on glycaemic control among children with type 1 diabetes mellitus aged 3-14 years in Uganda: study protocol for a cluster-randomized trial

2020 ◽  
Author(s):  
NICHOLAS BARI NDAHURA ◽  
JUDITH MUNGA ◽  
JUDITH KIMIYWE ◽  
EZEKIEL MUPERE
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycaemic Control ◽  
Medical Care ◽  
Type 1 Diabetes Mellitus ◽  
Nutrition Education ◽  
Control Group ◽  
Routine Medical Care ◽  
Level Of Knowledge

Introduction: Inadequate dietary management practices among children with type 1 diabetes mellitus (T1DM) often result in preventable complications, disability, and premature deaths, and yet strict glycaemic control can help reduce the long-term complications. Furthermore, parental caregiving has also been shown to have an impact on glycaemic control and yet often a gap exists between recommended care and provided care, resulting in failure of children with T1DM meeting their treatment targets. In Uganda, no published study has been conducted to find out if nutrition education has an effect on glycaemic control and caregivers level of knowledge on general and diabetes-specific nutrition for children with T1DM. Methods: The study will be a cluster randomised controlled trial with 10 health facilities randomised to control or intervention at a ratio of 1:1. A total of 100 caregiver-child pairs will be recruited. The participants in the control group will continue to receive routine medical care, while those in the intervention group will receive routine medical care and a nutrition education package. The primary outcome is glycated hemoglobin (HbA1c) values. Secondary outcomes will be caregivers level of knowledge on general and diabetes-specific nutrition knowledge, childrens dietary diversity score and childrens mean intake of energy, protein, and fat. Discussion: The findings of this study will be used in improving nutrition education in T1DM among children attending diabetes clinics in Uganda. Trial registration number: The trial is registered with The Pan African Clinical Trials Registry (PACTR201902548129842).

scholarly journals Relationships between parameters of cardiorespiratory function and bioimpedance analysis in young patients with type 1 diabetes mellitus

2021 ◽  
Vol 36 (3) ◽  
pp. 78-86
Author(s):  
O. I. Vengrzhinovskaya ◽  
I. Z. Bondarenko ◽  
O. A. Shatskaya ◽  
R. S. Kosharnaya ◽  
M. V. Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Cardiovascular Diseases ◽  
Type 1 Diabetes Mellitus ◽  
Body Mass ◽  
Anaerobic Threshold ◽  
Exercise Tolerance ◽  
Control Group ◽  
Vo2 Max

Type 1 diabetes mellitus (T1DM) triggers disruption of oxygen transport system in patients. The maximum oxygen consumption (VO2 max) during spiroergometry depends on the functional capabilities and composition of the body. Moreover, VO2 max may be considered a predictor of pathological changes in cardiovascular system.Aim. The purpose of the study was to investigate the compositional body characteristics and functional cardiorespiratory parameters in T1DM patients.Material and Methods. The study comprised 30 patients with T1DM (average age of 25.5 ± 8.1 years) and 10 patients of control group (average age of 27 ± 9 years). Patients received spiroergometry examination according to B. Bruce protocol and bioimpedansometry using the Inbody 770 apparatus. The study showed that T1DM patients reached anaerobic threshold faster (p = 0.032) and had significantly lower VO2 max and carbon dioxide emission compared to patients without diabetes (p = 0.021; p = 0.034) whereas exercise tolerance did not significantly differ compared with the corresponding value in control group. Patients with higher muscle mass i.e. muscle tissue weight (kg) according to bioimpedance measurements had higher values of VO2 max (L) in control group (p = 0.017) and in group of T1DM patients (p = 0.028).Conclusions: Young T1DM patients without cardiovascular diseases had significantly less effective cardiorespiratory system compared with that in people without diabetes even in those with high exercise tolerance. Rapid achievement of anaerobic threshold with preserved performance efficiency was a sign of unfavorable prognosis. Body mass index and lean body mass did not significantly affect the performance parameters in young T1DM patients. Screening of spiroergometry parameters may be used for identification of young T1DM patients at high risk of unfavorable cardiovascular diseases including chronic heart failure.

scholarly journals Short-term use of continuous glucose monitoring system adds to glycemic control in young type 1 diabetes mellitus patients in the long run: A clinical trial

2011 ◽  
Vol 68 (8) ◽  
pp. 650-654 ◽  
Author(s):  
Gordana Bukara-Radujkovic ◽  
Dragan Zdravkovic ◽  
Sinisa Lakic
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Glucose Monitoring ◽  
Control Group ◽  
Short Term ◽  
Experimental Group

Background/Aim. Balancing strict glycemic control with setting realistic goals for each individual child and family can optimize growth, ensure normal pubertal development and emotional maturation, and control long term complications in children with type 1 diabetes (T1DM). The aim of this study was to evaluate the efficacy of short-term continuous glucose monitoring system (CGMS) application in improvement of glycemic control in pediatric type 1 diabetes mellitus (T1DM) patients. Methods. A total of 80 pediatric T1DM patients were randomly assigned into the experimental and the control group. The experimental group wore CGMS sensor for 72 hours at the beginning of the study. Self-monitored blood glucose (SMBG) levels and hemoglobin A1c (HbA1c) levels were obtained for both groups at baseline, and at 3 and 6 months. Results. There was a significant improvement in HbA1c (p < 0.001), in both the experimental and the control group, without a significant difference between the groups. Nevertheless, after 6 months the improvement of mean glycemia was noticed only in the experimental group. This finding was accompanied with a decrease in the number of hyperglycemic events and no increase in the number of hypoglycemic events in the experimental group. Conclusions. The results suggest that the CGMS can be considered as a valuable tool in treating pediatric T1DM patients, however further research is needed to more accurately estimate to what extent, if any, it outperforms intensive self-monitoring of blood glucose.

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