scholarly journals Diffuse melanosis secondary to metastatic melanoma in a Nelore bull

2021 ◽  
Vol 14 (3) ◽  
pp. 191-198
Author(s):  
Jacqueline de Jesus ◽  
◽  
Andrieli Bortolini ◽  
Gabriela de Almeida ◽  
Bárbara de Oliveira ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Urinary Bladder ◽  
Antibiotic Therapy ◽  
Lymph Nodes ◽  
Metastatic Melanoma ◽  
Clinical Signs ◽  
Metastatic Malignant Melanoma ◽  
Dark Urine ◽  
Spleen And Lymph Nodes ◽  
Black Discoloration

We report a case of diffuse melanosis secondary to metastatic malignant melanoma in a Nelore bull. Clinical signs included isolation from the herd, epistaxis, hyperthermia, pale ocular membranes, mucoid diarrhea and dark urine. Despite anti-inflammatory and antibiotic therapy, the bull died 45 days after the onset of the clinical signs. The most striking lesion was diffuse black discoloration to the visceral organs including liver, spleen, lungs, lymph nodes, and kidneys; all these affect organs were moderately enlarged”. The urine was black. Histologically, 50-80% of the parenchyma of the liver, spleen and lymph nodes was obliterated by aggregates of melanin-loaded neoplastic melanocytes. Those neoplastic cells also occurred within capillaries of the liver, spleen, lymph nodes, urinary bladder, lungs and kidneys. Immunohistochemistry of neoplastic melanocytes was positive for Melan A and PNL2 markers. Abundant brown to black pigment was found in melanophages in the lungs, confirmed by IBA1 immunohistochemistry.

Combination Chemotherapy with 1-Methyl-1-Nitrosourea and Cyclophosphamide in Metastatic Melanoma

1978 ◽  
Vol 64 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Krsto Kolarić ◽  
Anton Roth ◽  
Vera Fuss
Keyword(s):  
Body Weight ◽  
Malignant Melanoma ◽  
Antitumor Activity ◽  
Lymph Nodes ◽  
Metastatic Melanoma ◽  
Combination Chemotherapy ◽  
Tumor Regression ◽  
Objective Response ◽  
Metastatic Malignant Melanoma ◽  
Melanoma Metastasis

Twenty one patients with advanced metastatic melanoma were treated with a combination of 1-methyl-1-nitrosourea (MNU) and cyclophosphamide. AH the patients had not previously been treated with cytostatics. MNU in the dose of 4 mg/kg and cyclophosphamide in the dose of 8 mg/kg body weight was administered daily. The drugs were given in 6 day cycles. Objective response (> 50% tumor regression) was obtained in 8 (38%) of the 21 treated patients, with 2 complete and 6 partial remissions. The duration of remission was 2–12 months (M = 6.2 months). Injections of MNU caused nausea and vomiting in approximately all the treated patients. Combination of these drugs, however, produced myelodepression in 33% of treated patients. This combination of drugs showed antitumor activity in metastatic malignant melanoma, particularly in melanoma metastasis of the lung, brain and lymph nodes and needs further investigation.

scholarly journals Diffuse Melanosis and Ascites due to Metastatic Malignant Melanoma

2008 ◽  
Vol 8 ◽  
pp. 556-557 ◽  
Author(s):  
Elena Sendagorta ◽  
Angel Pizarro ◽  
Marta Feito ◽  
Matias Mayor ◽  
Paloma Ramírez ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Melanoma ◽  
Female Patient ◽  
Metastatic Malignant Melanoma ◽  
Current Evidence ◽  
Rare Entity ◽  
Skin Hyperpigmentation

We present a female patient who developed mucosal and skin hyperpigmentation due to metastatic malignant melanoma. Diffuse cutaneus melanosis is a rare entity that complicates a small percentage of metastatic melanomas, confering a fatal prognosis. We discuss briefly the current evidence on pathogenesis of melanosis arising from metastatic melanoma.

Cryptosporidiosis, coccidiosis, and total colonic mucosal collapse in an immunosuppressed puppy

1999 ◽  
Vol 35 (5) ◽  
pp. 405-409 ◽  
Author(s):  
MD Willard ◽  
D Bouley
Keyword(s):  
Renal Failure ◽  
Antibiotic Therapy ◽  
Lymph Nodes ◽  
Cause Of Death ◽  
Chronic Diarrhea ◽  
Opportunistic Pathogens ◽  
Lymphoid Follicles ◽  
Colonic Lesion ◽  
Ultimate Cause ◽  
Spleen And Lymph Nodes

An eight-week-old puppy with chronic diarrhea was diagnosed with simultaneous opportunistic pathogens (i.e., cryptosporidiosis, coccidiosis) and total colonic mucosal collapse. Lack of lymphoid follicles in the spleen and lymph nodes suggested a primary underlying immunosuppression that most likely permitted infection with these pathogens. Intensive antibiotic therapy was most likely responsible for the severe colonic lesion, and bismuth subsalicylate administration in this severely dehydrated puppy may have contributed to renal failure as the ultimate cause of death.

TATTOO PIGMENT IN LYMPH NODES MIMICKING METASTATIC MALIGNANT MELANOMA

2003 ◽  
Vol 111 (6) ◽  
pp. 2120-2122 ◽  
Author(s):  
Tal Friedman ◽  
Melvin Westreich ◽  
Sharon Nofech Mozes ◽  
Arie Dorenbaum ◽  
Oscar Herman
Keyword(s):  
Malignant Melanoma ◽  
Lymph Nodes ◽  
Metastatic Malignant Melanoma ◽  
Tattoo Pigment

scholarly journals Nivolumab Induced Lethal Aplastic Anemia in a Patient with Metastatic Melanoma

2019 ◽  
Vol 12 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Keren Rouvinov ◽  
Karen Nalbandyan ◽  
Victor Kozlov ◽  
Nir Peled ◽  
Alexander Yakobson
Keyword(s):  
Malignant Melanoma ◽  
Aplastic Anemia ◽  
Metastatic Melanoma ◽  
Active Treatment ◽  
Melanoma Patient ◽  
Case Reports ◽  
Metastatic Malignant Melanoma ◽  
Line Treatment ◽  
Metastatic Melanoma Patient ◽  
Advanced Line

Nivolumab is an active treatment in patients with metastatic melanoma. We report a case of a patient with metastatic malignant melanoma who was given nivolumab as an advanced-line treatment. She received nivolumab 3 mg/kg every 2 weeks for 4 cycles and developed aplastic anemia. To the best of our knowledge, there are only three published case reports that have shown aplastic anemia in patients who have been treated by immunotherapy. This is the first report of a lethal aplastic anemia during nivolumab monotherapy in a metastatic melanoma patient.

Metastatic malignant melanoma of the larynx

2001 ◽  
Vol 115 (11) ◽  
pp. 925-927 ◽  
Author(s):  
H. Pau ◽  
S. De ◽  
M. G. Spencer ◽  
P. R. M. Steele
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Melanoma ◽  
Surgical Excision ◽  
Metastatic Malignant Melanoma ◽  
Cutaneous Malignant Melanoma ◽  
Diagnosis And Treatment ◽  
Metastatic Tumour ◽  
Previously Treated

Metastatic malignant melanoma of the larynx is considered to be extremely rare by most authors. This paper describes a 78-year-old patient, previously treated for cutaneous malignant melanoma and intestinal fibrosarcoma, who presented with stridor due to a metastatic melanoma in the larynx. It was a pedunculated lesion and surgical excision of the lesion was accomplished with a tonsillar snare. This paper further discusses the evolving history, diagnosis and treatment of this metastatic tumour, and reviews the literature regarding previously reported cases.

scholarly journals Effective Immunotherapy in Bone Marrow Metastatic Melanoma Presenting with Disseminated Intravascular Coagulopathy

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Bolanle Gbadamosi ◽  
Daniel Ezekwudo ◽  
Bhadresh Nayak ◽  
Zhou Yu ◽  
Sandra Gjorgova-Gjeorgjievski ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Malignant Melanoma ◽  
Metastatic Melanoma ◽  
Checkpoint Inhibitors ◽  
Treatment Options ◽  
Metastatic Malignant Melanoma ◽  
Critically Ill Patient ◽  
Low Grade ◽  
Disseminated Intravascular Coagulopathy ◽  
Intravascular Coagulopathy

Malignant melanoma is responsible for the majority of skin cancer deaths and is increasing in prevalence. Bone marrow (BM) involvement by melanoma is rare in the absence of widespread visceral disease. Here, we report the case of a 30-year-old female who presented to the hospital with back pain, low-grade fever, and easy bruising. She was found to be bicytopenic and in disseminated intravascular coagulopathy (DIC). Surprisingly, BM biopsy showed extensive involvement by metastatic malignant melanoma in the absence of visceral or brain metastasis. The unique presentation of this case and the challenge of management of a potentially treatable cancer in a critically ill patient are discussed, alongside a review of published cases of metastatic melanoma in the BM and an exploration of currently available treatment options. The excellent response of our patient to combined immune checkpoint inhibitors has yet to be paralleled in the available literature.

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