scholarly journals Dissomic disorders associated with juvenile rheumatoid arthritis: impact on quality of life

2020 ◽  
Author(s):  
AA Elezarov ◽  
AS Kucheryavyy ◽  
LN Gumenyuk ◽  
LE Sorokina ◽  
SR Arifdzhanova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Juvenile Rheumatoid Arthritis ◽  
Healthy Children ◽  
Excessive Sleepiness ◽  
Quality Scale ◽  
Gender And Age ◽  
Life Model ◽  
Pedsql 4.0

Dyssomnic disorders (DD) associated with juvenile rheumatoid arthritis (JRA) are some of the most common conditions that are difficult to endure and that lead to deconditioning. This study aimed to assess prevalence and structure of DD, their relationship with clinical picture peculiarities and contribution to deterioration of the quality of lives of JRA patients. At the 1st stage, we assessed prevalence of DD in a continuous sample of JRA patients and healthy children aged 8–16 years. At the 2nd stage, we assessed DD structure, features associated with gender and age, connections to the key clinical characteristics of JRA and quality of life of the patients. In the context of the study, we used the SDSC sleep quality scale, the PedsQL 4.0 quality of life model, and the Ritchie index. DD develop in JRA patients 3.3 times more often than in healthy children (in 178 (72.3%) and 93 (22.2%) children, respectively). The DD registered were sleep initiation and maintenance disorders (54 cases, 22.0%), respiratory disorders (32 cases, 13.0%), sleep-to-wakefulness transition disorders (31 cases, 12.6%), excessive sleepiness disorders (38 cases, 15.4%), combinations thereof (23, 9.3%). Girls had sleep initiation and maintenance disorders more pronounced (p = 0.003), boys were more prone to excessive sleepiness (p = 0.008). The severity of DD increases with patients' age (r = 0.69; p = 0.001) and JRA onset age (r = 0.71; p = 0.001); they are also more severe in polyarticular JRA patients (r = 0.32; p = 0.048). We have clarified the relationship between DD and indicators of inflammatory (r = 0.56; p = 0.001) and Ritchie indices (r = 0.44; p = 0.005), duration of morning stiffness (r = 0.49; p = 0.029). The proven connection between DD and JRA entails the need for routine checks for DD in such patients, and, when discovered, DD should call for personalized therapeutic and diagnostic approach rather than be regarded as one of the JRA syndromes.

scholarly journals Quality of Life among Children with Juvenile Rheumatoid Arthritis

2018 ◽  
Vol 14 (1) ◽  
pp. 117-131
Author(s):  
Faransa Ahmed ◽  
Safaa Mahmoud ◽  
Shimaa elrehem ◽  
Alameldin allah
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Juvenile Rheumatoid Arthritis

scholarly journals ASSOCIATION OF CLINICAL, PSYCHOEMOTIONAL STATUS AND THE PATHOGENETIC THERAPY WITH THE DEVELOPMENT OF REMISSION IN ADULT PATIENTS WITH JUVENILE RHEUMATOID ARTHRITIS

2018 ◽  
Vol 14 (1-2) ◽  
pp. 24-33
Author(s):  
M.B. Dzhus
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Femoral Neck ◽  
Juvenile Rheumatoid Arthritis ◽  
Adult Patients ◽  
Group I ◽  
Sf 36 ◽  
Pathogenetic Therapy ◽  
Active Disease

Relevance. The study of the frequency of remission in adult patients  with JRA treated in accordance with the "Unified clinical protocol for medical care for patients with juvenile rheumatoid arthritis" is relevant. Objective. The aim of our study was to evaluate the association of the clinical, psycho-emotional state and the pathogenetic therapy with the development of remission in adult patients with JRA. Materials and methods. 168 adult patients with JRA were examined at the transition period of the health care and adolescents. A retrospective analysis of medical records was performed to evaluate clinical symptoms and laboratory data in childhood and evaluated the clinical status, duration of the disease, activity on the JADAS and DAS-28 scales, quality of life, depression and alexithymia by scales SF-36, PHQ-9, TAS- 20, bone mineral density and methods of treatment in childhood and in adulthood. Results. All patients were divided into 2 groups: Group I - 138 patients (82.1%) with active disease at the time of examination, and II group - 30 patients (17.9%) who achieved remission. Patients who achieved remission did not differ by age at the time of the study, although the prevalence of women (58.1%) in the I group was determined, compared with 31.0% in the II group. Patients in both groups did not differ in height, however, patients with remission had a greater body weight (p <0.01) and BMI (p <0.01). There were no differences between the groups in the level of RF and A-CCP, ANA and the presence of HLA-B27, as well as in total cholesterol, LDL-cholesterol, glucose as risk factors for atherosclerosis (all p> 0.05). Patients with active disease had lower BMD in femoral neck and in ultradistal forearm area (all p <0.05). There were no difference in the the appointment of the IBT in doth groups. However, patients with remission more often did not receive GC in history (p <0.001) and at the time of examination (p <0.001), which is explained by less activity in the onset of the disease (p <0.05). Both groups did not differ in either the duration of the DMARD therapy, nor on the doses of methotrexate and sulfosalazine. Of the 53 patients with RF(+)/RF(-) polyarthritis - the most prognostically unfavorable variant of JRA, had arthritis > 3 joints (p <0.01), symmetrical arthritis (p <0.05), higher ESR ( p <0,05) compared patients with remission, and the absence of differences in the levels of CRP and JADAS. Conclusions. Patients with JRA in adulthood in 82.1% continue to have an active disease of varying degrees. The negative influence of the active disease on the BMD is found, mainly in the area of ​​femoral neck and ultradistal forearm in adult patients with active JRA compared with patients in remission. The significant influence of active disease in adulthood on the quality of life according to the SF-36 questionnaire was determined such as physical well-being, physical, role and social functioning, bodily pain, general health, and mental health compared with the group of patients in remission. An increase level of depression was found by PHQ-9 questionnaire in the I group compared to II group, although they did not differ in the level of Alexithymia. Patients who achieved remission compared with patients with active polyarthritis, were less likely to take GC in adulthood and reseived a higher dose of methotrexate.

scholarly journals Health-related quality of life in Iranian adolescents: a psychometric evaluation of the self-report form of the PedsQL 4.0 and an investigation of gender and age differences

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Habib Hadianfard ◽  
Behnaz Kiani ◽  
Mahla Azizzadeh Herozi ◽  
Fatemeh Mohajelin ◽  
John T. Mitchell
Keyword(s):  
Quality Of Life ◽  
Psychometric Properties ◽  
Internal Consistency ◽  
Convergent Validity ◽  
Age Effects ◽  
Self Report ◽  
Gender And Age ◽  
Pedsql 4.0 ◽  
Test Retest Reliability

Abstract Background Research on the psychometric properties of the Persian self-report form of the Pediatric Quality of Life Inventory Version 4.0 (PedsQL 4.0) in adolescents has several gaps (e.g., convergent validity) that limit its clinical application and therefore the cross-cultural impact of this measure. This study aimed at investigating the psychometric properties of the PedsQL 4.0 and the effects of gender and age on quality of life in Iranian adolescents. Method The PedsQL 4.0 was administered to 326 adolescents (12–17 years). A subsample of 115 adolescents completed the scale two weeks after the first assessment. Confirmatory Factor Analysis (CFA), correlation of the PedsQL 4.0 with the Weiss Functional Impairment Rating Scale-Self-report (WFIRS-S), and Item Response Theory (IRT) analysis were conducted to examine validity. Cronbach’s alpha, McDonald’s Omega, and Intra class correlation (ICC) were calculated as well to examine reliability. Gender and age effects were also evaluated. Results Internal consistency and test–retest reliability of the total PedsQL 4.0 scale was .92 and .87, respectively. The PedsQL 4.0 scores showed negative moderate to strong correlations with the WFIRS-S total scale. The four-factor model of the PedsQL 4.0 was not fully supported by the CFA—the root mean square error of approximation and the comparative fit index showed a mediocre and poor fit, respectively. IRT analysis indicated that all items of the PedsQL 4.0 fit with the scale and most of them showed good discrimination. The items and total scale provided more information in the lower levels of the latent trait. Males showed significantly higher scores than females in physical and emotional functioning, psychosocial health, and total scale. Adolescents with lower ages showed better quality of life than those with higher ages in all scores of the PedsQL 4.0. Conclusion The PedsQL 4.0 showed good psychometric properties with regard to internal consistency, test–retest reliability, and convergent validity in Iranian adolescents, which supports its use in clinical settings among Persian-speaking adolescents. However, factor structure according to our CFA indicates that future work should address how to improve fit. In addition, studies that include PedsQL 4.0 should consider gender and age effects were reported.

scholarly journals The Influence of Sanatorium-Resort Rehabilitation on the Cytokine Profile and Quality of Life Parameters in Juvenile Rheumatoid Arthritis

2021 ◽  
Vol 20 (4) ◽  
pp. 22-27
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Juvenile Rheumatoid Arthritis ◽  
Cytokine Profile ◽  
Control Group ◽  
Functional Disorders ◽  
Quality Of Life Indicators ◽  
Tnf Α ◽  
Anti Inflammatory

Aim. To study was to assess the dynamics of cytokine profile indicators and quality of life in patients with juvenile rheumatoid arthritis under the influence of the standard sanatorium-resort rehabilitation complex. Material and methods. At the stage of sanatorium rehabilitation, 112 patients aged from 8 to 17 years (mean age 13.2±3.7) with juvenile rheumatoid arthritis were examined. The dynamics of the main quality of life indicators were assessed using the CHAQ questionnaire (pediatric version). Changes in proinflammatory (TNF-α, IL-1, IL-6) and anti-inflammatory cytokines (IL-4, IL-10) were evaluated in correlation with quality of life indices. The control group consisted of 25 healthy equals in age. Results. In juvenile rheumatoid arthritis, the cytokine profile changes, expressed in significantly higher indices of both pro- and antiinflammatory cytokines associated with functional disorders and, as a consequence, lower quality of life indicators as compared with healthy equals in age. Under the influence of sanatorium-resort treatment, functional disorders decreased, quality of life increased, levels of TNF-α, IL-1 as well as anti-inflammatory cytokine IL-4 significantly (p<0,05) decreased. As for other both pro- and antiinflammatory cytokines, only non-significant tendency to decrease was registered. Conclusion. It has been established that before the beginning of sanatorium-resort treatment, the quality of life parameters were lower in patients with juvenile rheumatoid arthritis (JRA), while the values of both proinflammatory (TNF-α, IL-1, IL-6) and anti-inflammatory (IL-4, IL-10) cytokines were significantly (p<0,01) higher than in the control group. At the same time, changes in the studied parameters correlated with the activity of the inflammatory process and the severity of the functional insufficiency of the joints. There were noted the positive influence of the standard complex of sanatorium-resort treatment on the examined quality of life parameters and the tendency to normalization of cytokine profile indexes in patients with JRA.

Health Related Quality of Life, Disease Activity, Severity and Coping in Juvenile Rheumatoid Arthritis

2006 ◽  
Vol 6 (4) ◽  
pp. 561-568 ◽  
Author(s):  
Fatma A. Shaaban . ◽  
Iman M. Metwally . ◽  
Samia M. Samy . ◽  
Iman I. Salama . ◽  
Amal I. Hassanin .
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Juvenile Rheumatoid Arthritis ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
And Coping

Quality-of-Life Measurements in Juvenile Rheumatoid Arthritis Patients Treated with Etanercept

2003 ◽  
Vol 23 (8) ◽  
pp. 511-518 ◽  
Author(s):  
Renee F Robinson ◽  
Milap C Nahata ◽  
John R Hayes ◽  
Robert Rennebohm ◽  
Gloria Higgins
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Juvenile Rheumatoid Arthritis ◽  
Quality Of Life Measurements

Profile of Daily Life in Children With Brain Tumors: An Assessment of Health-Related Quality of Life

2005 ◽  
Vol 23 (24) ◽  
pp. 5493-5500 ◽  
Author(s):  
Sundeep R. Bhat ◽  
Tress L. Goodwin ◽  
Tasha M. Burwinkle ◽  
Meagan F. Lansdale ◽  
Gary V. Dahl ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Grade Glioma ◽  
Cns Tumors ◽  
Low Grade ◽  
Healthy Children ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Pedsql 4.0

Purpose The survival of children with CNS tumors approaches 70%, yet health-related quality of life (HRQOL) has not been investigated rigorously in this population. We aimed to show that universal assessment of HRQOL could be obtained easily by using the PedsQL 4.0 and to provide a composite profile of their daily lives. Patients and Methods The PedsQL was administered to all patients seen in the neuro-oncology clinic at Lucile Packard Children's Hospital (Palo Alto, CA) from December 2001, to September 2002. Patients were compared with healthy controls by using two-sided t tests to evaluate statistically significant differences. Results One hundred thirty-four patients (73 male; mean age ± standard deviation, 11.8 ± 5.4 years; 55 had low-grade glioma, 32 had medulloblastoma/primitive neuroectodermal tumor/embryonal tumor, 17 had malignant astrocytoma, nine had germ-cell tumor, and 21 had other types of tumors) were assessed, each in less than 20 minutes. Scores on both child and parent-proxy reports for the total HRQOL, psychosocial, physical, emotional, social, and school-functioning scales were all significantly lower than controls (P < .01). Patients with low-grade glioma were reported to have the highest total HRQOL. Children receiving radiation therapy (XRT) but no chemotherapy had significantly lower total, psychosocial, emotional, and social functioning than those receiving other treatments, including XRT plus chemotherapy. Conclusion The PedsQL can be used to assess HRQOL rapidly and easily in children with CNS tumors, who have significantly worse HRQOL than healthy children. Children receiving XRT fare worse overall; chemotherapy added to XRT does not seem to worsen HRQOL. Assessment of HRQOL should be included as an outcome in future clinical trials.

scholarly journals ASSOCIATION OF CLINICAL, PSYCHOEMOTIONAL STATUS AND THE PATHOGENETIC THERAPY WITH THE DEVELOPMENT OF REMISSION IN ADULT PATIENTS WITH JUVENILE RHEUMATOID ARTHRITIS

2018 ◽  
Vol 14 (1-2) ◽  
pp. 24-33
Author(s):  
M.B. Dzhus
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Femoral Neck ◽  
Juvenile Rheumatoid Arthritis ◽  
Adult Patients ◽  
Group I ◽  
Sf 36 ◽  
Pathogenetic Therapy ◽  
Active Disease

Relevance. The study of the frequency of remission in adult patients  with JRA treated in accordance with the "Unified clinical protocol for medical care for patients with juvenile rheumatoid arthritis" is relevant. Objective. The aim of our study was to evaluate the association of the clinical, psycho-emotional state and the pathogenetic therapy with the development of remission in adult patients with JRA. Materials and methods. 168 adult patients with JRA were examined at the transition period of the health care and adolescents. A retrospective analysis of medical records was performed to evaluate clinical symptoms and laboratory data in childhood and evaluated the clinical status, duration of the disease, activity on the JADAS and DAS-28 scales, quality of life, depression and alexithymia by scales SF-36, PHQ-9, TAS- 20, bone mineral density and methods of treatment in childhood and in adulthood. Results. All patients were divided into 2 groups: Group I - 138 patients (82.1%) with active disease at the time of examination, and II group - 30 patients (17.9%) who achieved remission. Patients who achieved remission did not differ by age at the time of the study, although the prevalence of women (58.1%) in the I group was determined, compared with 31.0% in the II group. Patients in both groups did not differ in height, however, patients with remission had a greater body weight (p <0.01) and BMI (p <0.01). There were no differences between the groups in the level of RF and A-CCP, ANA and the presence of HLA-B27, as well as in total cholesterol, LDL-cholesterol, glucose as risk factors for atherosclerosis (all p> 0.05). Patients with active disease had lower BMD in femoral neck and in ultradistal forearm area (all p <0.05). There were no difference in the the appointment of the IBT in doth groups. However, patients with remission more often did not receive GC in history (p <0.001) and at the time of examination (p <0.001), which is explained by less activity in the onset of the disease (p <0.05). Both groups did not differ in either the duration of the DMARD therapy, nor on the doses of methotrexate and sulfosalazine. Of the 53 patients with RF(+)/RF(-) polyarthritis - the most prognostically unfavorable variant of JRA, had arthritis > 3 joints (p <0.01), symmetrical arthritis (p <0.05), higher ESR ( p <0,05) compared patients with remission, and the absence of differences in the levels of CRP and JADAS. Conclusions. Patients with JRA in adulthood in 82.1% continue to have an active disease of varying degrees. The negative influence of the active disease on the BMD is found, mainly in the area of ​​femoral neck and ultradistal forearm in adult patients with active JRA compared with patients in remission. The significant influence of active disease in adulthood on the quality of life according to the SF-36 questionnaire was determined such as physical well-being, physical, role and social functioning, bodily pain, general health, and mental health compared with the group of patients in remission. An increase level of depression was found by PHQ-9 questionnaire in the I group compared to II group, although they did not differ in the level of Alexithymia. Patients who achieved remission compared with patients with active polyarthritis, were less likely to take GC in adulthood and reseived a higher dose of methotrexate.

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