CLINICAL, PATHOGENIC AND THERAPEUTIC ASPECTS OF THE COMORBIDITY OF ATOPIC DERMATITIS AND BRONCHIAL ASTHMA IN CHILDREN

2021 ◽  
Vol 100 (3) ◽  
pp. 146-151
Author(s):  
I.I. Balabolkin ◽  
◽  
V.A. Bulgakova ◽  
T.I. Eliseeva ◽  
◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Literature Review ◽  
Data Management ◽  
Bronchial Asthma ◽  
Therapeutic Strategies ◽  
Treatment Efficiency ◽  
Improve Treatment ◽  
Asthma In Children

The literature review covered clinical, pathogenic and therapeutic aspects of comorbidity of atopic dermatitis (AD) and bronchial asthma (BA) in children. On the basis of data on pathogenesis of diseases, characteristics of AD in children with BA it is justified that there is a need to use common therapeutic strategies in data management of comorbid patients, which can reduce pharmacological load and improve treatment efficiency.

scholarly journals Genetic markers of bronchial asthma in children with atopic dermatitis

2007 ◽  
pp. 37-40 ◽  
Author(s):  
L. M. Ogorodova ◽  
O. S. Fedorova ◽  
E. Yu. Bragina ◽  
M. B. Freidin ◽  
M. I. Petrovskaya
Keyword(s):  
Early Childhood ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Atopic Disease ◽  
Preventive Therapy ◽  
Allergic Disorder ◽  
Genotype Combination ◽  
Interleukin 5 ◽  
Asthma In Children ◽  
And Control

The aim of the study was to evaluate the usefulness of the -703С/Т polymorphism in IL-5 gene, Q551R polymorphism in IL-4RA gene, and GSTM1 and GSTТ1 gene polymorphism as biological markers of bronchial asthma (BA) in children with atopic dermatitis (AD). We genotyped children with AD (n = 72; mean age, 9.4 ± 0.28 years), children with AD in combination with BA (n = 68; mean age, 7.5 ± 0.7 years) and control subjects (n = 147; mean age, 9.9 ± 0.42 years). We found the associations between BA and the -703С allele of the interleukin-5 (IL-5) gene (OR = 1.73, p = 0.013) and -703СС / 551RR genotype combination (OR = 3.15; p = 0.015) in children with AD; between the 551RR genotype of the IL-4RA gene and atopy (p < 0.05). -703CT / GSТТ1 0/0 genotype combination was found rarer in children with BA than in controls (OR = 0.15; p = 0.049). Thus, -703С/Т allele of the IL-5 gene and -703СС / 551RR genotype combination were associated with BA and could be used as valuable markers of the disease in children with AD, whereas the Q551R polymorphism in the IL-4RA gene was associated with predisposition to atopic disease and could be used for administration of preventive therapy of allergic disorder in early childhood. The -703CT / GSТТ1 0/0 genotype combination can prevent BA occurrence in children with AD.

Combination of atopic dermatitis and bronchial asthma in children: new treatment options

2019 ◽  
Vol 14 (2) ◽  
pp. 61-67
Author(s):  
V.A. Revyakina ◽  
◽  
I.A. Larkova ◽  
E.D. Kuvshinova ◽  
V.A. Mukhortykh ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Treatment Options ◽  
Asthma In Children ◽  
New Treatment

Atopic dermatitis: new horizons of therapy

2019 ◽  
Vol 1 (7) ◽  
pp. 29-32 ◽  
Author(s):  
L. S. Kruglova ◽  
E. M. Gensler
Keyword(s):  
Blood Pressure ◽  
Immune Response ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Targeted Therapy ◽  
Inflammatory Response ◽  
Bronchial Asthma ◽  
New Horizons ◽  
The Past

Over the past decades, the first breakthrough milestone in the treatment of severe forms of atopic dermatitis (AD) has been targeted therapy aimed at inhibiting IL-4 and IL-13. This was made possible thanks to advances in the understanding of the pathogenesis of AD, the driver of which is the Th2-type immune response, which also underlies such manifestations of atopy as bronchial asthma, allergic rhinitis, and polynosis. In the case of the Th2-type immune response, cytokines IL-4 and IL-13 are secreted, which are the main promoters of the inflammatory response in AD. Inhibition of IL-4 and IL-13 leads to the prevention of inflammation and is an effective approach to therapy. The use of therapy aimed at inhibition of cytokines allows you to effectively cope with the manifestations of severe and moderately severe blood pressure.

The effect of pentoxifylline (trental) on the production of cytokines with sensitized t-lymphocytes in bronchial asthma in children

2018 ◽  
Vol 2018 (1) ◽  
pp. 26-32
Author(s):  
V. G. Chernusky ◽  
◽  
M. M. Popov ◽  
O. L. Govalenkova ◽  
G. V. Letyago ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Bronchial Asthma ◽  
Asthma In Children
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