scholarly journals The minimum inhibitory concentration and exposure time of the combination of quaternary ammonium compound with ethylendiamintetraacetic acid (EDTA) against methicillin-resistant Staphylococcus Aureus

2009 ◽  
Vol 21 (1) ◽  
Author(s):  
Swasty Dwirayunita
Keyword(s):  
Staphylococcus Aureus ◽  
Minimum Inhibitory Concentration ◽  
Exposure Time ◽  
Quaternary Ammonium ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Inhibitory Concentration ◽  
Quaternary Ammonium Compound ◽  
Dilution Method ◽  
Ammonium Compound ◽  
Methicillin Resistant

The aim of this study was to determine The Minimum Inhibitory Concentration (MIC) and the exposure time of the combination of quaternary ammonium compound with ethylenediaminetetraacetic acid (EDTA) towards Methicillin-resistant Staphylococcus aureus so that the combination can be applied as a disinfectant against MRSA.The tested bacteria MRSA was isolated from the RSGM of the Faculty of Dentistry Padjadjaran University. This laboratory experimental study was conducted based on a serial dilution method. The combination of quaternary ammonium compound with EDTA was diluted in 1/1000, 1/2000, 1/4000, 1/8000, 1/16000, 1/32000, 1/64000, and 1/128000 concentration.The result showed that the combination of quaternary ammonium compound with EDTA inhibited the MRSA on 1/1000, 1/2000 and 1/4000 concentrations. The effective exposure time to reduce the number of MRSA colonies are 2.5 and 3 minutes with 1/1000 concentration from the combination. In conclusion that the MIC of the combination of quaternary ammonium compound with EDTA is in 1/4000 concentration and the effective exposure time is more than 3 minutes.

scholarly journals Minimum inhibitory concentration of the combination of quaternary ammonium compound with ethylenediaminetetra-acetic acid (EDTA) towards hand isolated Staphylococcus Epidermidis

2009 ◽  
Vol 21 (1) ◽  
Author(s):  
Dyah Ika Maria
Keyword(s):  
Acetic Acid ◽  
Minimum Inhibitory Concentration ◽  
Quaternary Ammonium ◽  
Staphylococcus Epidermidis ◽  
Inhibitory Concentration ◽  
Antibacterial Effect ◽  
Quaternary Ammonium Compound ◽  
Dilution Method ◽  
Ammonium Compound ◽  
Serial Dilution Method

The aim of this study was to determine the Minimum Inhibitory Concentration (MIC) of the combination of Quaternary ammonium compound with Ethylenediaminetetra-acetic acid (EDTA) towards hand isolated Staphylococcus epidermidis for preventing the cross infection. The Minimum Inhibitory Concentration was determined based on a serial dilution method in 1/1000, 1/2000, 1/4000, 1/8000, 1/16000, 1/32000, 1/64000, 1/128000 concentration with two repetitions. The result showed that the 1/4000 concentration of the combination of Quaternary ammonium compound with Ethylenediaminetetra-acetic acid was the MIC. In conclusion, the combination of Quaternary ammonium compound with Ethylenediaminetetra-acetic acid had an antibacterial effect towards Staphylococcus epidermidis with the MIC in 1/4000 concentration.

scholarly journals Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2758 ◽  
Author(s):  
Rawan Alnufaie ◽  
Hansa Raj KC ◽  
Nickolas Alsup ◽  
Jedidiah Whitt ◽  
Steven Andrew Chambers ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Minimum Inhibitory Concentration ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Inhibitory Concentration ◽  
Fatality Rate ◽  
Pyrazole Derivatives ◽  
Methicillin Resistant ◽  
Antimicrobial Studies ◽  
Mrsa Strains

In this paper, synthesis and antimicrobial studies of 31 novel coumarin-substituted pyrazole derivatives are reported. Some of these compounds have shown potent activity against methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration (MIC) as low as 3.125 µg/mL. These molecules are equally potent at inhibiting the development of MRSA biofilm and the destruction of preformed biofilm. These results are very significant as MRSA strains have emerged as one of the most menacing pathogens of humans and this bacterium is bypassing HIV in terms of fatality rate.

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