А сlinical case report of mediastinal teratoma in an adolescent patient with Klinefelter syndrome

Teratoma is a germ cell tumor, which consists of derivatives of three germ layers and has various malignant potentials – from benign mature forms to immature embryonic forms with a somatic type of malignancy. Even the mature type of teratoma is biologically unpredictable providing for an ability to grow locally with invasion. Necessity for complete removal of tumors, wherever they are located, is explained by the fact that there is a risk of a possible development of growing teratoma syndrome or transformation into malignant tumors. This article describes the clinical case of growing teratoma syndrome of mediastinal localization in a teenager with Klinefelter syndrome, also as an example of the multidisciplinary approach of pediatric oncologists, surgeons, radiotherapists and pathomorphologists in decision-making for optimal treatment. The patients' parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.

Download Full-text

Klinefelter Syndrome in preschool children: the importance of an early multidisciplinary approach for patients and families

Minerva Pediatrica ◽

10.23736/s0026-4946.16.04412-1 ◽

2019 ◽

Vol 71 (5) ◽

Cited By ~ 2

Author(s):

Claudia Rigamonti ◽

Paola Vizziello ◽

Federico Monti ◽

Francesca Dall'ara ◽

Paola F. Ajmone ◽

...

Keyword(s):

Preschool Children ◽

Multidisciplinary Approach ◽

Klinefelter Syndrome

Download Full-text

Rare localization of renal cell carcinoma metastases in the paranasal sinuses and breast: a case report

Medical Visualization ◽

10.24835/1607-0763-2018-6-13-22 ◽

2019 ◽

Vol 22 (6) ◽

pp. 13-22

Author(s):

E. V. Kryaneva ◽

N. A. Rubtsova ◽

A. V. Levshakova ◽

A. I. Khalimon ◽

A. V. Leontyev ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Paranasal Sinuses ◽

Renal Cell ◽

Clinical Case ◽

Clear Cell ◽

Malignant Tumors ◽

Metastatic Potential ◽

Cell Renal Cell Carcinoma ◽

Metastatic Lesions

This article presents a clinical case demonsratinga high metastatic potential of clear cell renal cell carcinoma combined with atypical metastases to breast and paranasal sinuses. The prevalence of metastatic lesions to the breast and paranasal sinuses in various malignant tumors depending on their morphological forms is analyzed. The authors present an analysis of data published for the last 30 years. The optimal diagnostic algorithms to detect the progression of renal cell carcinoma and to evaluate the effectiveness of the treatment are considered.

Download Full-text

Rheumatic Immune-Related Adverse Events—A Consequence of Immune Checkpoint Inhibitor Therapy

Biology ◽

10.3390/biology10060561 ◽

2021 ◽

Vol 10 (6) ◽

pp. 561

Author(s):

Anca Bobircă ◽

Florin Bobircă ◽

Ioan Ancuta ◽

Alesandra Florescu ◽

Vlad Pădureanu ◽

...

Keyword(s):

Immune System ◽

Adverse Events ◽

Immune Checkpoint ◽

Multidisciplinary Approach ◽

Malignant Tumors ◽

Checkpoint Inhibitors ◽

Treatment Options ◽

Cancer Cell Growth ◽

Inhibitory Mechanisms ◽

Checkpoint Inhibitor Therapy

The advent of immunotherapy has changed the management and therapeutic methods for a variety of malignant tumors in the last decade. Unlike traditional cytotoxic chemotherapy, which works by interfering with cancer cell growth via various pathways and stages of the cell cycle, cancer immunotherapy uses the immune system to reduce malignant cells’ ability to escape the immune system and combat cell proliferation. The widespread use of immune checkpoint inhibitors (ICIs) over the past 10 years has presented valuable information on the profiles of toxic adverse effects. The attenuation of T-lymphocyte inhibitory mechanisms by ICIs results in immune system hyperactivation, which, as expected, is associated with various adverse events defined by inflammation. These adverse events, known as immune-related adverse events (ir-AEs), may affect any type of tissue throughout the human body, which includes the digestive tract, endocrine glands, liver and skin, with reports of cardiovascular, pulmonary and rheumatic ir-AEs as well. The adverse events that arise from ICI therapy are both novel and unique compared to those of the conventional treatment options. Thus, they require a multidisciplinary approach and continuous updates on the diagnostic approach and management.

Download Full-text

Multiple recurrence of granulosa cell tumor of the ovary: A case report and literature review

10.1055/s-0039-1685319 ◽

2016 ◽

Author(s):

Varkha Chandra ◽

Sandhya Jain ◽

Neerja Goel ◽

Bindia Gupta ◽

Shalini Rajaram

Keyword(s):

Case Report ◽

Granulosa Cell ◽

Adnexal Mass ◽

Malignant Tumors ◽

Abdominal Mass ◽

Pelvic Mass ◽

Granulosa Cell Tumor ◽

Cell Tumor ◽

Surgical Staging ◽

Granulosa Cell Tumors

Introduction: Granulosa cell tumors comprise approximately 5% of all ovarian malignancy and account for 70% of malignant sex cord stromal tumors. Granulosa cell tumors have been diagnosed from infancy, the peak incidence being perimenopausal age. The potential of malignancy of these tumors is low, recurrences are often late and found in 10-33% of cases. Case Report: A 32-year-old P1L1 presented with large abdominal mass for which she underwent staging laparotomy with debulking surgery. She was a known case of granulosa cell tumor in the past and had undergone three laparotomies, along with chemotherapy. At the age of 13 yrs, she was diagnosed with a stage IA granulosa cell tumor (GCT) of the ovary first time. She underwent surgical staging and removal of left sided adnexal mass, after which she was asymptomatic for 7 years. In 2003 she again presented with lump abdomen for which she underwent resection of adnexal mass, histopathology was consistent with recurrent GCT. After second surgery she also received two cycles of chemotherapy. Despite adjuvant chemotherapy, patient presented again after three years in 2006 with adnexal mass and was found to have a third recurrence. At that time, she received 6 cycles of chemotherapy and the mass regressed. Meanwhile she got married and had one child. After four year in 2010 she again presented with lump abdomen and she underwent surgical staging, total abdominal hysterectomy with right salphingo ophorectomy along with removal of mass. After five year in 2015 she again presented with lump abdomen; there was a large pelvic mass which was removed and patient referred for chemotherapy. Discussion: GCTS which a rare malignant tumors of ovary tend to be associated with late recurrences. Although most recurrences occurs within 10 years after initial diagnosis, there are occasional reports of recurrences after10 years. We experienced the rare case of a patient who relapsed multiple times over 20 years, despite surgical and targeted treatment. Conclusion: The long history of granulosa cell tumor highlights the importance of extended follow up of the patient.

Download Full-text

Hormone-producing ovarian tumors in children (a clinical case of managing a patient with a granulosa cell tumor of the juvenile type)

Problemy reproduktsii ◽

10.17116/repro20212705148 ◽

2021 ◽

Vol 27 (5) ◽

pp. 48

Author(s):

L.V. Adamyan ◽

E.V. Sibirskaya ◽

S.A. Korotkova ◽

E.A. Karapetyan ◽

E.I. Polyakova ◽

...

Keyword(s):

Granulosa Cell ◽

Clinical Case ◽

Granulosa Cell Tumor ◽

Cell Tumor ◽

Ovarian Tumors ◽

Juvenile Type

Download Full-text

Endoscopic Transnasal Resection of Ectopic Esthesioneuroblastoma in the Pterygopalatine Fossa: Technical Case Report

Operative Neurosurgery ◽

10.1227/01.neu.0000346268.69786.88 ◽

2009 ◽

Vol 65 (suppl_6) ◽

pp. onsE112-onsE113 ◽

Cited By ~ 6

Author(s):

Satoru Kodama ◽

Toshiaki Kawano ◽

Masashi Suzuki

Keyword(s):

Clinical Presentation ◽

Malignant Tumors ◽

Malignant Neoplasm ◽

Complete Removal ◽

Pterygopalatine Fossa ◽

Open Approach ◽

Transnasal Approach ◽

Olfactory Neuroepithelium ◽

Endoscopic Transnasal Approach ◽

Left Maxillary Sinus

Abstract Objective: Esthesioneuroblastoma is a rare, malignant neoplasm arising from the olfactory neuroepithelium in the upper nasal cavity. Even more rare is ectopic esthesioneuroblastoma developing from the region outside the olfactory epithelium. In addition, tumors occurring in the pterygopalatine fossa (PPF) are uncommon, and the endoscopic transnasal approach for the resection of malignant tumors in this region is also uncommon. Clinical Presentation: We describe an esthesioneuroblastoma arising from the left maxillary sinus and PPF. The tumor was resected using the endoscopic transnasal approach, followed by treatment with radiotherapy. The patient showed no evidence of recurrence 12 months postoperatively. Technique: The endoscopic transnasal approach could be successfully used for the complete removal of malignant tumors in the PPF. Conclusion: The PPF is an anatomic area that is difficult to access. The endoscopic transnasal approach improves access and visualization; it also has the potential to reduce complications compared with the open approach. The endoscopic transnasal approach might become the treatment of choice for malignant tumors in the PPF.

Download Full-text

Leiomyosarcoma of Prostate

Health Sciences ◽

10.15342/hs.1.178 ◽

2020 ◽

Vol 1 (1) ◽

Author(s):

Abdeljalil Heddat ◽

Younes Houry ◽

Redouane Rabii

Keyword(s):

Therapeutic Approach ◽

Multidisciplinary Approach ◽

Malignant Tumors ◽

Survival Rates ◽

Multicenter Trial ◽

Advanced Stage ◽

Rare Tumor ◽

Actuarial Survival ◽

Term Survival

Prostate leiomyosarcoma is an extremely rare and very aggressive neoplasm that represents less than 0.1% of primary malignant tumors of the prostate. We present a patient with primary leiomyosarcoma of prostate and examine the cases reported in the literature to discuss the clinical, diagnostic and therapeutic aspects of this rare tumor. Median survival was estimated at 17 months (95% CI 20.7–43.7 months) and the actuarial survival rates at 1, 3 and 5 years were 68%, 34% and 26%, respectively. The only predictors of long-term survival were negative surgical margins and the absence of metastatic disease at presentation. A multidisciplinary approach is necessary for the proper management of this terrible entity. Surgery with or without chemotherapy seems to be the main therapeutic method for operable leimyosarcomas, but in general there is no consensus on the best therapeutic approach. Most cases are diagnosed at an advanced stage of the disease. A global multicenter trial is needed to find therapies that would improve the prognosis.

Download Full-text

Multidisciplinary approach in intensive care of massive obstetric blood loss: a clinical case

EMERGENCY MEDICINE ◽

10.22141/2224-0586.7.86.2017.116888 ◽

2017 ◽

Vol 0 (7.86) ◽

pp. 101-105

Author(s):

V.A. Sedinkin ◽

А.М. Dokunina ◽

V.О. Drozdova ◽

E.V. Маksimova ◽

М.N. Palega ◽

...

Keyword(s):

Intensive Care ◽

Blood Loss ◽

Clinical Case ◽

Multidisciplinary Approach

Download Full-text

Intracardiac extension of the inferior vena cavaLeiomyosarcoma with Budd-Chiari syndrome presentation: A case report

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1502071m ◽

2015 ◽

Vol 143 (1-2) ◽

pp. 71-73

Author(s):

Predrag Matic ◽

Goran Vucurevic ◽

Srdjan Babic ◽

Slobodan Tanaskovic ◽

Branko Lozuk ◽

...

Keyword(s):

Inferior Vena Cava ◽

Inferior Vena ◽

Malignant Tumors ◽

Vena Cava ◽

Complete Removal ◽

Term Result ◽

Short Term ◽

Short Term Result ◽

Chiari Syndrome ◽

Intracardiac Extension

Introduction. Leiomyosarcomas of the inferior vena cava are rare malignant tumors. A limited number of these cases have been described so far. Only few of them have intracardiac propagation and surgery is rarely undertaken for their treatment. Case Outline. We present a 52-year-old female patient in whom leiomyosarcoma of the inferior vena cava with intracardiac propagation was diagnosed. The patient underwent successful surgical treatment with complete removal of the tumor and direct suture of the inferior vena cava. No additional modalities of therapy were undertaken. Conclusion. Surgery, without radiation therapy can be a successful option for the treatment of inferior vena cava leiomyosarcoma with a good short-term result.

Download Full-text