scholarly journals DIFFERENCES OF LIVER FUNCTION TESTS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH AND WITHOUT CORONARY ARTERY DISEASE

2018 ◽  
Vol 24 (3) ◽  
pp. 266
Author(s):  
Hendra Saputra ◽  
Burhanuddin Nasution ◽  
Santi Syafril
Keyword(s):  
Diabetes Mellitus ◽  
Liver Function ◽  
Total Bilirubin ◽  
Liver Function Tests ◽  
Arterial Disease ◽  
Direct Bilirubin ◽  
Coronary Arterial Disease ◽  
Type 2 Dm ◽  
Significant Difference

One of the macroangiopathic complications of Diabetes Mellitus (DM) is Coronary Arterial Disease (CAD). Several studies showed that the liver was one of the organs involved in the pathological development of diabetes.The aim of this study was to find the differences of liver function in type 2 DM patients with CAD and without CAD. This was an analytical observational study with cross-sectional design. Forty-four type 2 DM patients with and without CAD at the Adam Malik Hospital Medan who came during June - August 2016 were studied for liver function (total bilirubin, direct bilirubin, AST and ALT). In this study, the average values of total bilirubin and direct bilirubin level in patients with CAD were found to be lower than without CAD. Statistically a significant difference revealed a total bilirubin (p < 0.001) and direct bilirubin (p = 0.001) in type 2 DM patients with and without CAD. There was a significant difference in liver function tests in DM type 2 patients with, and without coronary arterial disease, these data suggested that total billirubin and direct billirubin levels in type 2 DM patients with CAD were found lower than those without CAD. 

scholarly journals Relationship between homocysteine and non-dipper pattern in patients with type 2 diabetes mellitus

2012 ◽  
Vol 56 (5) ◽  
pp. 285-290 ◽  
Author(s):  
Serdal Korkmaz ◽  
Abdulkerim Yilmaz ◽  
Gürsel Yildiz ◽  
Fatih Kiliçli ◽  
Serhat Içağasioğlu
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Control Group ◽  
Diabetic Patients ◽  
Nocturnal Blood Pressure ◽  
Type 2 Dm ◽  
Significant Difference

OBJECTIVE: The rate of reduction of nocturnal blood pressure (NBP) is lesser than normal in patients with type 2 diabetes mellitus (type 2 DM). Hyperhomocysteinemia (HHC) disrupts vascular structure and function, no matter the underlying causes. The risk of development of vascular disease is greater in diabetic patients with hyperhomocysteinemia than in patients with normal homocystein levels. The aim of the study was to investigate whether there are differences of homocystein levels in dipper and non-dippers patients with type 2 DM. SUBJECTS AND METHODS: We compared 50 patients (33 females, 17 males) with type 2 DM and 35 healthy individuals (18 females, 17 males ) in a control group. Ambulatory blood pressure monitoring (ABPM) was performed and homocysteine levels were measured in all patients. RESULTS: We found that the percentage of non-dipper pattern was 72% in patients with type 2 DM and 57% in control group. In diabetic and control individuals, homocystein levels were higher in non-dipper (respectively 13.4 ± 8.1 µmol/L and 11.8 ± 5 µmol/L) than in dipper subjects (respectively, 11.8 ± 5.8 µmol/L and 10.1 ± 4.2 µmol/L), but there was no significant difference between the two groups (respectively, p = 0.545, p = 0.294). CONCLUSION: In both groups, homocystein levels were higher in non-dipper than in dipper participants, but there was no significant difference between the groups. High homocystein levels and the non-dipper pattern increases cardiovascular risk. Therefore, the relationship between nocturnal blood pressure changes and homocystein levels should be investigated in a larger study.

Utility of Platelet Indices in Assessing the Risk of Coronary Artery Disease in Patients of Diabetes Mellitus

2020 ◽  
Author(s):  
Ayesh Khatoon ◽  
Shakti Kumar Yadav ◽  
Sompal Singh ◽  
Harsh Vardhan Singh ◽  
Namrata Sarin
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Diabetic Patients ◽  
Platelet Volume ◽  
Distribution Width ◽  
Type 2 Dm ◽  
Significant Difference ◽  
Artery Disease

Abstract Background: Platelet volume indices (PVI) such as mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (P-LCR), are the indicators of increased platelet activity which may play a role in development of vascular complications in diabetic patients. This study was performed to evaluate and compare the platelet volume indices such as MPV, PDW, P-LCR in patients of type 2 diabetes mellitus (DM) with and without manifested coronary artery disease in order to identify their usefulness in determining the risk for development of coronary complications.Methods: Analytical cross - sectional study included 150 patients of which 100 patients were diagnosed as type 2 DM and 50 apparently healthy controls. The study cases were divided into two groups based on presence or absence of coronary artery disease. Group A included 50 cases of type 2 DM without manifested coronary artery disease and group B included 50 cases of type 2 DM with manifested coronary artery disease. PVI was obtained using automated cell counter.Results: MPV, PDW, P-LCR were significantly higher in diabetics as compared to controls subjects (P < 0.001 for all). However, no statistically significant difference was found between diabetics with and without manifested coronary artery disease.Conclusions: The study showed higher PVI in diabetic subjects when compared to control subjects, but no difference between patients with and without manifested coronary artery disease suggesting that various other factors might be associated with the pathogenesis of CAD in patients of DM.

scholarly journals Cardiac Function in Uncomplicated Type 2 Diabetes Mellitus

2019 ◽  
Vol 18 (2) ◽  
pp. 211-215
Author(s):  
Bimal K Agrawal ◽  
Parul Jain ◽  
Saurabh Marwaha ◽  
Richa Goel ◽  
Himanshu D Kumar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiac Function ◽  
Cardiac Dysfunction ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Coronary Arterial Disease ◽  
Type 2 Dm

Objective: Diabetic cardiomyopathy (DC) is a myocardial disease characterized by myocyte hypertrophy, interstitial fibrosis, protein glycosylation and intra-myocardial micro-angiopathy due to prolonged exposure of myocardial tissues to hyperglycemia in diabetes mellitus (DM) patients. Alteration in cardiac function can be non-invasively assessed via echocardiography. The early recognition of cardiac dysfunction can prevent the symptomatic heart failure in DM patients. The study aimed at evaluating cardiac function in uncomplicated type 2 diabetes mellitus. Materials And Methods: Sixty Type 2 DM patients without any feature of the coronary arterial disease (CAD), hypertension, nephropathy and respiratory illness were enrolled in the study and compared with the sixty age matched healthy controls. Echocardiographic assessment was done in all subjects to evaluate the cardiac function. Results: Diastolic dysfunction was more common in diabetic patients when compared with normal healthy population. Systolic dysfunction progresses with age of the diabetic patient. Conclusion: Echocardiography is a simple noninvasive cost effective test for detecting cardiac dysfunction in Type 2 DM patients and should be applied to detect early Left ventricular(LV) dysfunction so that corrective measures may be initiated early and cardiac functions may be preserved for long. Bangladesh Journal of Medical Science Vol.18(2) 2019 p.211-215

Investigation of Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in type 2 diabetes mellitus

2007 ◽  
Vol 98 (07) ◽  
pp. 186-191 ◽  
Author(s):  
Béla Nagy ◽  
Éva Csongrádi ◽  
Harjit Pal Bhattoa ◽  
István Balogh ◽  
György Blaskó ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Diabetic Patients ◽  
Type 2 Dm ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Soluble P ◽  
Overweight Subjects ◽  
Contradictory Data

SummaryIncreased levels of soluble P-selectin (sP-selectin) have been shown in a number of different disorders, e.g. diabetes mellitus (DM) and cardiovascular disease (CVD). Several studies have attempted to demonstrate the association of the most intensively examined variant of P-selectin gene polymorphism (Thr715Pro) with sP-selectin levels in healthy subjects and in CVD, but contradictory data have been reported.To clarify the effect of Pro715 allele on the sP-selectin levels in type 2 DM, we analysed this polymorphism in diabetic patients and compared these data with sP-selectin levels. Type 2 DM patients (n=119), 48 BMImatched non diabetic individuals – consisting mostly of overweight subjects – and 57 healthy volunteers were included in the study.TheThr715Pro polymorphism was analysed by PCR-RFLP, while sP-selectin levels were measured by ELISA. Significantly elevated sP-selectin levels were found in both DM and in overweight subjects compared to healthy controls. We confirmed previous reports that in healthy Pro715 allele carriers lower sP-selectin levels could be measured; however, this difference was only significant in case of lean subjects. No significant difference was detected in sP-selectin level among DM and overweight individuals according to this genotype. However, significant difference was observed in sP-selectin levels in older DM patients compared to younger ones,but these levels were not accounted for by the Thr715Pro polymorphism.We suggest that in type 2 DM individuals, the significantly elevated sP-selectin levels are not due to the Thr715Pro P-selectin gene polymorphism.

scholarly journals The Effects of Tai Chi on Type 2 Diabetes Mellitus: A Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Mengyao Chao ◽  
Chunyan Wang ◽  
Xiaosheng Dong ◽  
Meng Ding
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Tai Chi ◽  
Meta Analysis ◽  
Postprandial Blood Glucose ◽  
Type 2 Dm ◽  
Significant Difference

Objective. To investigate the effects of Tai chi in type 2 diabetes mellitus (type-2 DM) patients using systematic review and meta-analysis. Methods. Seven electronic resource databases were searched, and randomized controlled trials on the role of Tai chi in type-2 DM patients were retrieved. The meta-analysis was performed with RevMan 5.3, and research quality evaluation was conducted with the modified Jadad scale. Results. Fourteen studies, with 798 individuals related to the intervention of Tai chi on diabetes, were included. The results showed that, compared with nonexercise, Tai chi had the effect of lowering fasting blood glucose [MD = −1.39, 95% CI (−1.95, −0.84), P<0.0001] and the subgroup effect size decreased with the increase of total exercise amount, there is no significant difference between Tai chi and other aerobic exercises [MD = −0.50, 95% CI (−1.02, 0.02), P=0.06]; compared with nonexercise, Tai chi could reduce HbA1c [MD = −0.21, 95% CI (−0.61, 0.19), P=0.31], and the group effect size decreased with the increase of total exercise amount. The reducing HbA1c effect of Tai chi was better than that of other aerobic exercises, but the difference was at the margin of statistical significance [MD = −0.19, 95% CI (−0.37, 0.00), P=0.05]; compared with nonexercise, Tai chi had the effect of reducing 2 h postprandial blood glucose [MD = −2.07, 95% CI (−2.89, −1.26), P=0.0002], there is no significant difference between Tai chi and other aerobic exercises in reducing 2 h postprandial blood glucose [MD = −0.44, 95% CI (−1.42, 0.54), P=0.38]. Conclusion. Tai chi can effectively affect the management of blood glucose and HbA1c in type-2 DM patients. Long-term adherence to Tai chi has a better role in reducing blood glucose and HbA1c levels in type 2 DM patients.

scholarly journals Hand functions in type 1 and type 2 diabetes mellitus

2017 ◽  
Vol 145 (11-12) ◽  
pp. 584-588
Author(s):  
Pinar Akpinar ◽  
Afitap Icagasioglu ◽  
Esra Selimoglu ◽  
Banu Mesci
Keyword(s):  
Diabetes Mellitus ◽  
Grip Strength ◽  
Control Group ◽  
Hand Functions ◽  
Type 2 Dm ◽  
Significant Difference ◽  
Hand Disability ◽  
Type 1 Dm

Introduction/Objective. Hand functions have an enormous impact on activities of daily living in patients with diabetes mellitus (DM), such as self-care, administering insulin injections, and preparing and eating meals. The aim of the study was to evaluate hand functions and grip strength in patients with type 1 and type 2 DM. Methods. This was an observational case-control study investigating the hand functions and grip strength in patients with type 1 and type 2 DM. The study comprised 41 patients with type 1 DM aged 25?50 years sex- and age-matched, 40 non-diabetic controls, and 91 patients with type 2 DM aged 40?65 years sex- and age-matched 60 non-diabetic controls. Patients with documented history of diabetic sensorimotor neuropathy and adhesive capsulitis were excluded. The Duruoz Hand Index was used to assess the functional hand disability. Grip strength was tested with a calibrated Jamar dynamometer. Results. The Duruoz Hand Index scores in patients with type 2 DM were significantly higher than in persons in the control group (p < 0.01), but there was no significant difference between the type 1 DM and the control group (p > 0.05). Grip strength values of patients with type 1 DM were significantly lower compared to those in the control group (p < 0.05), whereas there was no significant difference between patients with type 2 DM and their control group. There was a negatively significant correlation between grip strength and the Duruoz Hand Index scores in patients with both type 1 and type 2 DM (p < 0.05). Conclusion. Patients with type 1 DM and type 2 DM have different degrees of hand disability as compared to healthy control groups.

The Variation of Platelet Function in Gestational Diabetes Mellitus.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3957-3957
Author(s):  
Yiqing Li ◽  
Songmei Yin ◽  
Danian Nie ◽  
Xiuju Wang ◽  
Shuangfeng Xie ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Platelet Activation ◽  
Platelet Function ◽  
Normal Pregnancy ◽  
Special Role ◽  
Type 2 Dm ◽  
Significant Difference

Abstract Gestational diabetes mellitus (GDM) was as glucose intolerance of different severity that onset or first recognition during the current pregnancy. GDM was a special complication of pregency and the most common cause of fetal and maternal mortality and morbidity. The etiology of this disease is not clear. Increased platelet function was common in normal pregnancy or type 2 diabetes mellitus (DM) patients in the last decade. However, when pregnancy plus type 2 DM, that is, the GDM, was the platelet function still changed? In the current study, we tested blood platelet function including platelet counts (PC), mean platelet volume (MPV) and granule membrane protein-140 (GMP-140, also known as P-selectin, CD62P) in pregnant women with GDM. CD62P was a sensitive index to evaluate platelet activation. PC and MPV would alter when platelets had been destructed significantly, so they were sensitive indexes for platelet activation too. PC was (206.02±60.23)×109/L in GDM, (228.76±56.24)×109/L in normal pregnancy, (219.76±58.14)×109/L in type 2 DM without pregnancy. MPV was 9.53±1.64fl in GDM, 8.74±1.59fl in normal pregnancy, 9.16±1.23fl in type 2 DM without pregnancy. The PC and MPV had no significant difference among GDM, normal pregnancy and type 2 DM without pregnancy (P&gt;0.05). The expression of CD62P was higher than that of normal pregnancy or type 2 DM (41.82±12.95% vs. 26.21±7.09% or 24.18±8.79% P&lt;0.05). These results indicate that there were much more platelet activation in GDM compared with normal pregnancy or type 2 DM, but the platelet destruction was not increased. Inhibition of activated platelet may be a new therapeutic strategy for the treatment of GDM. However, whether there was special role affecting platelet activation directly in GDM was unknown. The concrete mechanism underlying GDM platelet dysfunction need more elucidated.

scholarly journals Association of HbA1c with Urinary ACR & eGFR in Type-2 Diabetes Mellitus

Pulse ◽  
2014 ◽  
Vol 5 (1) ◽  
pp. 6-11 ◽  
Author(s):  
Nazmin Haque ◽  
Bidhan Chandra Debnath ◽  
Mohammad Ibrahim ◽  
Khondaker Sirajuddin ◽  
Monojit Majumder ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vascular Complication ◽  
Urinary Albumin ◽  
Accurate Estimation ◽  
Urine Collection ◽  
Cross Sectional ◽  
Spot Urine ◽  
Type 2 Dm ◽  
Significant Difference

Background Diabetic nephropathy is a chronic micro vascular complication of poorly controlled diabetes mellitus (DM), leading to end stage renal disease (ESRD). Control of DM is monitored by HbA1c. There are two early markers - to assess early renal impairment: Microalbuminuria (MA) & Glomerular Filtration Rate (GFR). Estimation of MA - needs 24 hours collection of urine. GFR is clinically assessed by creatinine clearance rate (CCR) at the same time for accurate estimation of GFR which also needs 24 hours urine collection. Faulty timing and non compliance for 24 hours urine collection - may give erroneous results. MA is better reflected by spot urine urinary albumin-creatinine ratio (ACR). Some formula based calculation of GFR, called estimated GFR (eGFR) are well correlated with CCR which needs only single blood sample for S.Creatinine (S.Cr). For example one such formula is Cockroft-Gault (C-G) formula. Objective To evaluate the association of HbA1c with urinary ACR and eGFR in Type 2DM. Design It was a cross sectional study carried out in the department of Biochemistry, Sylhet MAG Osmani Medical College, from July 2010 to June 2011. Methods Fifty (50) known type 2 DM patients of 40-60 years age were evaluated dividing them on the basis of HbA1c (<8%,>8%), duration of DM (>5 years, <5 years), normotensives or hypertensives. FBS, S.Cr, Urinary Albumin & Creatinine were estimated. eGFR and urinary ACR were calculated. Results were expressed as mean ± SD. Data were analyzed with SPSS software version (12.0). Unpaired ’t’ test and Pearson’s correlation tests were performed as tests of significance. Value of ‘p’<0.05 was the level of significance. Results Significant difference of S.Cr & HbA1c was found between study groups on HbA1c<8% and >8%. DBP was significantly raised in hypertensive type 2 DM. Duration of DM did not show significant correlation with renal functional parameters. Serum Creatinine & U.ACR had significant positive correlation with HbA1c>8% and only with ACR but not with S.Cr in study subjects having HbA1c<8%. DOI: http://dx.doi.org/10.3329/pulse.v5i1.20183 Pulse Vol.5 January 2011 p.6-11

Differences in lipid transfers to HDL between patients with coronary arterial disease with or without type 2 diabetes mellitus

2017 ◽  
Vol 263 ◽  
pp. e217
Author(s):  
Raul Cavalcante Maranhao ◽  
Thauany Martins Tavoni ◽  
Oscar Giese Laverdy Neto ◽  
Marília Da Costa Oliveira Sprandel ◽  
Roberto Kalil Filho ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Arterial Disease ◽  
Coronary Arterial Disease
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