scholarly journals Regioselective Green Synthesis and Antimicrobial properties of full fused non mixed Heterocyclic Systems

2017 ◽  
Vol 13 (2) ◽  
pp. 6006-6020
Author(s):  
Amira A. El-Sayed ◽  
Maher El-HAshash ◽  
Sameh Rizk
Keyword(s):  
Antimicrobial Activity ◽  
Green Synthesis ◽  
Elemental Analysis ◽  
Spectroscopic Data ◽  
Heterocyclic Compounds ◽  
Antimicrobial Properties ◽  
One Pot ◽  
One Pot Synthesis ◽  
Electrophilic Reagents

One pot synthesis and reaction of triazinthione and triazinohydrazide derivatives with different electrophilic reagents in ordered to synthesis of some interesting non-mixed heterocyclic compounds. Structures of thiazolotriazine, triazolotriazine, pyrimidinyltriazine, and triazinotriazine derivatives were established via spectroscopic data and elemental analysis. The synthesized compounds were screened for their antimicrobial activity.

scholarly journals Green Synthesis andIn VitroBiological Evaluation of Heteroaryl Chalcones and Pyrazolines of Medicinal Interest

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Vishal Banewar
Keyword(s):  
Green Synthesis ◽  
Elemental Analysis ◽  
Broad Spectrum ◽  
Spectroscopic Data ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Biological Evaluation ◽  
Active Compounds

Pyrazolines are well known and important nitrogen containing 5-membered heterocyclic compounds. In the present investigation, a series of various heteroaryl chalcones and pyrazolines were synthesized by condensing formylquinolines with diverse ketones. The newly synthesized 2-pyrazolines were characterized on the basis of elemental analysis and spectroscopic data. All of the newly synthesized target compounds were selected by the NCI forin vitrobiological evaluation. These active compounds exhibited broad spectrum of various biological activities. Most of the compounds showed potent activity.

scholarly journals Toward the Identification of Novel Antimicrobial Agents: One-Pot Synthesis of Lipophilic Conjugates of N-Alkyl d- and l-Iminosugars

Marine Drugs ◽  
2020 ◽  
Vol 18 (11) ◽  
pp. 572
Author(s):  
Anna Esposito ◽  
Daniele D’Alonzo ◽  
Stefano D’Errico ◽  
Eliana De Gregorio ◽  
Annalisa Guaragna
Keyword(s):  
Antimicrobial Activity ◽  
Succinic Acid ◽  
Bacterial Cell ◽  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One ◽  
High Yields

In the effort to improve the antimicrobial activity of iminosugars, we report the synthesis of lipophilic iminosugars 10a–b and 11a–b based on the one-pot conjugation of both enantiomeric forms of N-butyldeoxynojirimycin (NBDNJ) and N-nonyloxypentyldeoxynojirimycin (NPDNJ) with cholesterol and a succinic acid model linker. The conjugation reaction was tuned using the established PS-TPP/I2/ImH activating system, which provided the desired compounds in high yields (94–96%) by a one-pot procedure. The substantial increase in the lipophilicity of 10a–b and 11a–b is supposed to improve internalization within the bacterial cell, thereby potentially leading to enhanced antimicrobial properties. However, assays are currently hampered by solubility problems; therefore, alternative administration strategies will need to be devised.

Polyoxometalate based ionic crystal: dual applications in selective colorimetric sensor for hydrated ZnCl2 and antimicrobial activity

2021 ◽  
Vol 45 (12) ◽  
pp. 5576-5588
Author(s):  
C. Sabarinathan ◽  
M. Karthikeyan ◽  
R. M. Murugappan ◽  
Savarimuthu Philip Anthony ◽  
Bhaskaran Shankar ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Ionic Crystal ◽  
Colorimetric Sensor ◽  
Icp Oes ◽  
One Pot ◽  
One Pot Synthesis ◽  
Acidic Conditions

One-pot synthesis of POM-salt ([Himi]4[SiMo12O40] (1)) was achieved by mixing silicomolybdic acid and imidazole in acidic conditions and characterized by FTIR, TGA, SEM, EDX, ICP-OES and XPS.

scholarly journals Synthesis of New Furothiazolo Pyrimido Quinazolinones from Visnagenone or Khellinone and Antimicrobial Activity

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2793 ◽  
Author(s):  
Ameen Abu-Hashem
Keyword(s):  
Antimicrobial Activity ◽  
Growth Inhibition ◽  
Spectral Data ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Heterocyclic Compounds ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Bacteria And Fungi ◽  
New Compounds

Substituted-6-methyl-1-thioxo-1,2-dihydro-3H-furo[3,2-g]pyrimido[1,6-a]quinazolin-3-ones (5a,b) were synthesized from condensation of visnagenone (2a) or khellinone (2b) with 6-amino-thiouracil (3) in dimethylformamide or refluxing of (4a) or (4b) in dimethylformamide. Hence, compounds (5a,b) were used as the starting materials for preparing many new heterocyclic compounds such as; furo[3,2-g]pyrimido[1,6-a]quinazoline (6a,b), furo[3,2-g]thiazolo[2′,3′:2,3]pyrimido[1,6-a]quinazolinone (7a,b), substituted-benzylidene-furo[3,2-g]thiazolo[2′,3′:2,3]pyrimido[1,6-a]quinazoline-3,5-dione (8a–f), 3-oxo-furo[3,2-g]pyrimido[1,6-a]quinazoline-pentane-2,4-dione (9a,b), 1-(pyrazole)-furo[3,2-g]pyrimido[1,6-a]quinazolinone (10a,b), 2-(oxo or thioxo)-pyrimidine-furo[3,2-g]pyrimido[1,6-a]quinazolinone (11a–d), 1-(methylthio)-furo[3,2-g]pyrimido[1,6-a]quinazolinone (12a,b), 1-(methyl-sulfonyl)-furo[3,2-g]pyrimido[1,6-a]quinazolinone (13a,b) and 6-methyl-1-((piperazine) or morpholino)-3H-furo[3,2-g]pyrimido[1,6-a]quinazolin-3-one (14a–d). The structures of the prepared compounds were elucidated on the basis of spectral data (IR, 1H-NMR, 13C-NMR, MS) and elemental analysis. Antimicrobial activity was evaluated for the synthesized compounds against Gram-positive, Gram-negative bacteria and fungi. The new compounds, furothiazolo pyrimido quinazolines 8a–f and 11a–d displayed results excellent for growth inhibition of bacteria and fungi.

One-Pot Synthesis ofN-Heterocyclic Compounds from Cyclopropenethione Derivatives

2000 ◽  
Vol 65 (11) ◽  
pp. 3341-3345 ◽  
Author(s):  
Noboru Matsumura ◽  
Yoshio Yagyu ◽  
Masamichi Ito ◽  
Tomohiro Adachi ◽  
Kazuhiko Mizuno
Keyword(s):  
Heterocyclic Compounds ◽  
One Pot ◽  
One Pot Synthesis

An efficient one-pot synthesis of pyrazolyl-thiazolidinedione hybrid analogues and evaluation of their antimicrobial activity

2020 ◽  
Vol 29 ◽  
pp. 100507
Author(s):  
Sivaganesh Tummalacharla ◽  
Pannala Padmaja ◽  
Pedavenkatagari Narayana Reddy
Keyword(s):  
Antimicrobial Activity ◽  
One Pot ◽  
One Pot Synthesis

One-pot synthesis, theoretical study and antimicrobial activity of 5,5′-(1,4-phenylenebis-(methanylylidene))Bis(3-Aryl(Alkyl)-2-thioxoimidazolidin-4-one) derivatives

2019 ◽  
Vol 194 (1-2) ◽  
pp. 147-155
Author(s):  
Raafat M. Shaker ◽  
Hisham A. Abd El-Naby ◽  
Essam Kh. Ahmed ◽  
Mahmoud A. A. Ibrahim ◽  
Sageda A. Gedamy
Keyword(s):  
Antimicrobial Activity ◽  
Theoretical Study ◽  
One Pot ◽  
One Pot Synthesis

Solvent-free one-pot synthesis of polysubstituted tetrahydropyrimidines and their antioxidant and antimicrobial properties

2015 ◽  
Vol 42 (2) ◽  
pp. 923-937 ◽  
Author(s):  
Shailaja Myadaraboina ◽  
Manjula Alla ◽  
Arunadevi Parlapalli ◽  
Sarangapani Manda
Keyword(s):  
Antimicrobial Properties ◽  
Solvent Free ◽  
One Pot ◽  
One Pot Synthesis

One-pot green synthesis and antimicrobial activity of exfoliated Ag NP-loaded quaternized chitosan/clay nanocomposites

RSC Advances ◽  
2013 ◽  
Vol 3 (25) ◽  
pp. 9714 ◽  
Author(s):  
Bo Liu ◽  
Suqin Shen ◽  
Jiwen Luo ◽  
Xiaoying Wang ◽  
Runcang Sun
Keyword(s):  
Antimicrobial Activity ◽  
Green Synthesis ◽  
Clay Nanocomposites ◽  
One Pot ◽  
Quaternized Chitosan
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