Levels of Î²2-Microglobulin and Association of ACE Gene I/D Polymorphism with Type 2 Diabetes Mellitus patients

BackgroundDiabetes mellitus is a metabolic ailment which is an outcome of defect in insulin secretion, insulin action, or both. The ACEgene systematizes Angiotensin Converting Enzyme (ACE) and is the most profoundly studied gene because of its crucial role in the renin-angiotensin system (RAS). The insertion/ deletion (I/D) of a 287bp long Alu repetitive sequence in intron 16 is responsible for three genotypes, DD and II homozygotes and ID heterozygotes.ACE levels differ in carriers with respect to their genotype; DD carriers have twice the levels of ACE than that found in II genotype individuals. The main purpose of this study is to investigate the association ofACE gene I/Dpolymorphism in Pakistani Type 2 Diabetes Mellitus (T2DM) patients primarily from Lahore.Methods:Hundred patients (T2DM) and fifty healthy controls were enrolled in this study. The ACE I/D polymorphism, located in intron 16, was analyzed by a triple primer method called nested-PCR and subsequently the results were analyzed by gel electrophoresis.Urine samples were also collected from patients suffering from diabetic nephropathy for the determination of beta-2 microglobulin.Results: The frequency of ACE genotypes DD, ID and II among the patients with type 2 diabetes mellitus was found to be 76%, 10%, 14% whereas in control subjects, 38% , 4% , 8% respectively. Other clinical parameters like blood sugar level and body mass index were also evaluated to find an association with genotype. The findings showed a non-significant association of ACE genotype with Blood Sugar Level (BSL) and Body Mass Index (BMI).Of the hundred T2DM patients enrolled in the study ten (10%) were of diabetic nephropathy. Beta-2-microglobulin was measured in the urine of these patients as well as healthy controls. A significant association between Î²2-microglobulin and T2DM was found by Fischerâ€™s exact test. Serum creatinine values were noted and correlation was found. The results showed a positive correlation but non-significant between creatinine and beta-2-microglobulin.Conclusion:In the present study, no significant association was found between ACE gene I/D polymorphism and T2DM. Gender of the T2DM patients showed null effect on genotype.Â Other clinical parameters like blood sugar level and body mass index also revealed a non-significant association with the ACE gene genotype.

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Association of Body Mass Index, Blood Sugar and Glycated Hemoglobin Levels with Types of Macular Edema in Patients with Type-2 Diabetes Mellitus

JOJ Ophthalmology ◽

10.19080/jojo.2020.08.555741 ◽

2020 ◽

Vol 8 (4) ◽

Author(s):

Akansha Sharma

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Body Mass Index ◽

Type 2 Diabetes Mellitus ◽

Macular Edema ◽

Blood Sugar ◽

Body Mass ◽

Glycated Hemoglobin

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Is Bariatric Surgery Effective for Chinese Patients with Type 2 Diabetes Mellitus and Body Mass Index < 35 kg/m2? A Systematic Review and Meta-analysis

Obesity Surgery ◽

10.1007/s11695-021-05520-9 ◽

2021 ◽

Author(s):

Yichen Li ◽

Yijie Gu ◽

Yujia Jin ◽

Zhongqi Mao

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Type 2 Diabetes ◽

Bariatric Surgery ◽

Body Mass Index ◽

Type 2 Diabetes Mellitus ◽

Body Mass ◽

Meta Analysis ◽

Chinese Patients

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Incongruence in body image and body mass index: A surrogate risk marker in Black women for type 2 diabetes mellitus

African Journal of Primary Health Care & Family Medicine ◽

10.4102/phcfm.v5i1.496 ◽

2013 ◽

Vol 5 (1) ◽

Author(s):

Rynal Devanathan ◽

Viveka Devanathan ◽

Tonya M. Esterhuizen

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Body Mass Index ◽

Body Image ◽

Type 2 Diabetes Mellitus ◽

Black Women ◽

Body Mass ◽

Risk Marker ◽

Diabetes Group

Background: Excess weight contributes to the development and progression of Type 2 diabetes mellitus (T2DM). Distorted body image amongst urban Black women and the perception that thinness is linked with HIV, may however be compounding the problem, particularly in areas with a high HIV burden.Objectives: This study aimed to compare the perception of body image in urban Black women with and without T2DM.Methods: A cross-sectional comparative study was conducted on 328 Black women systematically sampled into two groups (with and without T2DM). Body mass index (BMI) (weight [kg]/height[m2]) was determined and the adapted Stunkard Body Image Silhouettes for Black women was used to determine perceived body image (PBI).Results: Seventy-two per cent had T2DM and in this group 89% were obese, with a mean BMI of 39.5 kg/m2 (s.d. ± 8.5). In the non-diabetes group (NDG) 44% were obese, with a mean BMIof 31.3 kg/m2 (s.d. ± 9.0) Black women underestimated their body image across all weight categories (p < 0.05). Both groups (99% of the study group) also perceived thinness as being associated with HIV.Conclusions: This study identified an incongruence between PBI and actual BMI amongst urban Black women. This, combined with their belief that thinness is associated with HIV, places those with T2DM at risk of secondary complications arising from diabetes mellitus, and those without diabetes mellitus at a higher risk of developing T2DM. A discrepancy between PBI and BMI may therefore serve as a risk marker to alert clinicians to use a more ethno-cultural specific approach in engaging with urban Black women regarding weight loss strategies in the future.

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