Heart-type fatty acid-binding protein after ultramarathon running and relationship with high-sensitivity troponin I

2016 ◽  
Vol 17 ◽  
pp. e252-e253 ◽  
Author(s):  
Giuseppe Lippi ◽  
Mariella Dipalo ◽  
Rosalia Aloe ◽  
Gian Luca Salvagno ◽  
Federico Schena
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Troponin I ◽  
Binding Protein ◽  
High Sensitivity ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
High Sensitivity Troponin

Role of heart fatty acid binding protein in early detection of non ST-elevation myocardial infarct and its comparison with other cardiac markers

2020 ◽  
pp. 1-12
Author(s):  
Syed Muhammad Salman Habib ◽  
Abdul Rasheed Khan ◽  
Sultana Habib ◽  
Syed Zia Ullah ◽  
Riffat Sultana ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Troponin I ◽  
Binding Protein ◽  
St Elevation Myocardial Infarction ◽  
Cardiac Markers ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
St Elevation

Abstract Objectives: To determine the role of heart fatty acid-binding protein in early detection of non-ST-elevation myocardial infarction and its comparison with two other cardiac markers. Methods: The cross-sectional study was conducted at Abbasi Shaheed Hospital, Karachi, from June 2012 to June 2014, and comprised patients presenting at the emergency department within two hours of chest pain and who were subsequently referred to the cardiology department with a provisional diagnosis of either unstable angina or non-ST-elevation myocardial infarction.  Relevant history was taken on a specific proforma and electrocardiogram as well as routine investigations were done in the emergency department. Blood samples from the subjects were tested for the diagnosis of myocardial infarction through detection of heart fatty acid-binding protein, Troponin-I and Creatine kinase-myocardial band. Sensitivity and specificity of the three markers were calculated keeping coronary angiography as the gold standard. Data was analysed using SPSS 17. Results: Out of 250 patients, 153(61.2%) were males. The overall mean age was 54.45±13.92 years. Sensitivity and specificity of heart fatty acid-binding protein were 80.6% and 78.5% (p<0.05), for Troponin-I, 37.7% and 75% (p>0.05), and for Creatine Kinase-myocardial band, 29.5% and 67.8% (p>0.05). Conclusion: Heart fatty acid-binding protein was found to be a good diagnostic tool for the detection of non-ST-elevation myocardial infarction. Key Words: Non ST-elevation myocardial infarct, Cardiac markers, Heart fatty acid-binding protein, Troponin-I, Creatine kinase isoenzyme MB, Angiography. Continuous...

scholarly journals Heart-type fatty acid-binding protein (H-FABP), pentraxin-3 (PTX-3) and thrombomodulin in bovine traumatic pericarditis

2019 ◽  
Vol 67 (4) ◽  
pp. 505-516 ◽  
Author(s):  
Ramazan Yildiz ◽  
Mahmut Ok ◽  
Merve Ider ◽  
Ugur Aydogdu ◽  
Alper Ertürk
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Troponin I ◽  
Binding Protein ◽  
Clinical Signs ◽  
Control Group ◽  
Pentraxin 3 ◽  
Cardiac Damage ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

The aim of this study was to evaluate the biomarkers of cardiac damage such as heart-type fatty acid-binding protein (H-FABP), pentraxin-3 (PTX-3), and thrombomodulin (TM) for the detection and prognosis of bovine traumatic pericarditis (TP). Spontaneous TP was diagnosed on the basis of history, clinical signs, complete blood count, glutaraldehyde test, ultrasonography, and pericardiocentesis findings. H-FABP, PTX-3 and TM levels in serum were compared between 25 Holstein cows diagnosed with spontaneous TP and 10 healthy control cows using bovine-specific ELISA kits. Serum H-FABP in cattle with TP was significantly (P < 0.05) higher than in the control group and positively correlated with cardiac troponin-I (cTnI), creatine kinase myocardial band (CK-MB), PTX-3 and TM (r = 0.683, 0.342, 0.448 and 0.424, respectively; P < 0.05). The serum levels of PTX-3 (P < 0.05) and TM (P < 0.05) in cattle with TP were significantly higher than in the control group. Cardiac damage biomarkers H-FABP, PTX-3 and TM may be useful in the diagnosis of bovine TP.

scholarly journals Diagnostic Value of Heart-type Fatty Acid Binding Protein in Group of Patients with NSTEMI at the Time of Application for Medical Care

2021 ◽  
pp. 70-74
Author(s):  
Yevhen Sid ◽  
Oleksandr Kulbachuk
Keyword(s):  
Fatty Acid ◽  
Early Detection ◽  
Fatty Acid Binding Protein ◽  
Troponin I ◽  
Binding Protein ◽  
Diagnostic Value ◽  
Cardiac Marker ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
First Contact

The relevance of the early detection of myocardial necrosis is due to the difficulties of differential diagnosis in the first hours of the development of acute coronary syndrome. Therefore, the doctors of the first contact, as before, are interested in an early cardiac marker and the presence of tests based on it. Heart fatty acid binding protein (h-FABP) is a cardiac marker that increases in the blood to diagnostic values after just one hour from the beginning of clinical manifestations. The objective: to determine the diagnostic value of heart fatty acid binding protein in group of patients with NSTEMI. Materials and methods. We examined 280 patients with STEMI, 91 patients with NSTEMI, 76 with stable angina pectoris. Blood samples were taken from all patients at the first contact to determine troponin I, a heart fatty acid binding protein and CPK-MB. Patients with NSTEMI were divided into three subgroups: the first – up to 3 hours from the onset of symptoms, the second – from 3 to 6, the third from 6 to 12. The level of heart fatty acid binding protein in plasma was determined by enzyme immunoassay. Results. The early detection of AMI in people visiting primary care doctors with chest pain continues to be a challenge. Undoubtedly, cardiac troponins are the “gold standard” for the diagnosis of AMI, but early detection of these can give a negative result. The results of the studies show a high diagnostic efficacy of h-FABP in the early diagnosis of AMI, and it is superior in sensitivity (in the first hours from the onset of the disease) to cardiac troponins. So, for example, in the subgroup of patients with the onset of symptom manifestation up to 3 hours for h-FABP with a cut-off >0,48 ng/ml, the sensitivity was 92.7 % and specificity was 97,3 % (AUC=0,99; 95 % CI AUC 0,942–0,998). In the same subgroup, troponin I had a specificity of  22,0 %, with cut off >0,84 ng/ml (AUC=0,71; 95 % CI AUC 0,615–0,787). Conclusions. The level of cardiac protein that binds fatty acids is significantly increased in patients with acute myocardial infarction compared with stable coronary heart disease.

scholarly journals The Prognostic and Risk-Stratified Value of Heart-Type Fatty-Acid-Binding Protein in Community Acquired Pneumonia in Emergency Department

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Yun-Xia Chen ◽  
Chun-Sheng Li
Keyword(s):  
Emergency Department ◽  
Fatty Acid ◽  
Roc Curve ◽  
Fatty Acid Binding Protein ◽  
Troponin I ◽  
Binding Protein ◽  
Pneumonia Severity Index ◽  
Community Acquired Pneumonia ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Objective.To evaluate the prognostic and risk stratified ability of heart-type fatty-acid-binding protein (H-FABP) in patients with community acquired pneumonia (CAP) in emergency department (ED) and to compare it with Pneumonia Severity Index (PSI) and CURB-65.Methods.Consecutive adult CAP patients admitted to the ED of Beijing Chao-Yang Hospital were enrolled. Circulating H-FABP and troponin I were measured. PSI and CURB-65 were calculated in all patients. The differences in 28-day mortality and requirement for mechanical ventilation (MV) or a vasopressor within 6 h after ED arrival were compared in patients with positive H-FABP (≥7 ng/mL) and negative ones (<7 ng/mL). Receiver operating characteristic (ROC) curve and logistic regression were used to assess the predictive value of H-FABP.Results.From August to November 2012, 229 CAP patients were enrolled. The 28-day mortality, PSI, CURB-65, and incidence of using MV or a vasopressor were much higher in H-FABP-positive patients than in negative ones (P<0.01). H-FABP was an independent predictor of the 28-day mortality. The area under the ROC curve (AUC) of H-FABP was 0.751. Combination of H-FABP and CURB-65 (AUC = 0.824) or H-FABP and PSI (AUC = 0.820) improved their prognostic performance.Conclusions.H-FABP was valuable for prognosis and risk stratification in CAP patients in ED.

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