Simple F Tests for Main Effects and Interactions in 2 × 2 × k Contingency Tables
A method of controlling for the effects of a nuisance variable in testing the significance of treatment effects on a discrete binary response is described. Proportions of “success” responses in two treatment groups are standardized relative to an estimate of the sampling variance at each level of the concomitant variable, and an unweighted-means analysis of variance is used to test the main effect for treatments and the interaction of treatments × levels. Exact calculations and Monte Carlo results are presented which show the proposed F tests to have actual Type I error probabilities that are closer to the nominal alpha level than is true for alternative tests. The actual Type I error rates are less seriously affected by differences in marginal probabilities of “success” and “failure” responses than is true for other tests, and in the face of small cell frequencies the standardized-means analysis of variance appears to have substantially greater power than the other tests most commonly used with 2 × 2 × k contingency tables.