Environment is not the Most Important Variable in Determining Oral Morphine Consumption in Wistar Rats

1996 ◽  
Vol 78 (2) ◽  
pp. 391-400 ◽  
Author(s):  
B. F. Petrie
Keyword(s):  
Wistar Rats ◽  
Oral Morphine ◽  
Strain Differences ◽  
Important Variable ◽  
Morphine Consumption ◽  
Standard Laboratory ◽  
Differential Housing

The role of differential housing on sucrose-morphine consumption in outbred Wistar rats was investigated in two studies. The results of earlier research, indicating rats housed in a quasinatural colony drank significantly less sucrose-morphine than rats isolated in standard laboratory cages, could not be replicated, as the consumption of sucrose-morphine by the isolated animals in the present two studies was reduced. It is possible that during a colony conversion the supplier inadvertently introduced strain differences making the present rats more resistant to xenobiotic consumption. Discussion documents the role of genetics in morphine consumption.

Effects of maternal oral morphine consumption on neural tube development in Wistar rats

2005 ◽  
Vol 159 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Shiva Nasiraei-Moghadam ◽  
Hedayat Sahraei ◽  
Hossein Bahadoran ◽  
Mehrangiz Sadooghi ◽  
Seyed Hossein Salimi ◽  
...  
Keyword(s):  
Neural Tube ◽  
Wistar Rats ◽  
Oral Morphine ◽  
Morphine Consumption ◽  
Neural Tube Development

scholarly journals Time-Dependent Effect of Oral Morphine Consumption on the Development of Cytotrophoblast and Syncytiotrophoblast Cells of the Placental Layers during the Three Different Periods of Pregnancy in Wistar Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Leila Dehghani ◽  
Hedayat Sahraei ◽  
Rokhsareh Meamar ◽  
Masoomeh Kazemi
Keyword(s):  
Wistar Rats ◽  
Oral Morphine ◽  
Time Dependent ◽  
Morphine Consumption ◽  
Male Rats ◽  
Dependent Manner ◽  
Control Groups ◽  
Female Wistar Rats ◽  
Time Dependent Effect ◽  
Surface Thickness

Previous studies have shown that morphine abuse during pregnancy cancause a delay in the development of the placenta and embryo and also bring about birth defects. The present study investigates the effect of the duration of maternal morphine consumption during pregnancy, as well as the impacts of morphine abuse on the development of placental layers during the three different periods of pregnancy in Wistar rats.Materials and Methodology. Female Wistar rats have been used in the present study. Experimental groups received morphine (0.05 mg/mL of drinking water) after one night of coupling with male rats for mating. On 9th, 10th, and 14th days of pregnancy, pregnant animals were killed, and placentas were removed and fixed. The cells of the placentas layers were calculated by light microscope and MOTIC and SPSS software.Results. The maternal surface thickness of the placenta was significantly increased, whereasthe fetal surface thickness of placenta was significantly decreased with morphine consumption with a time-dependent manner in experimental groups, compared to control groups. Moreover, the number of trophoblast cells increased in both maternal and fetal surfaces of placenta with respect to the duration of morphine consumption which was overt in the experimental groups compared to the control groups.Conclusion. In general, the time-dependent effects of oral morphine consumption can inhibit the development and natural functioning of cytotrophoblast and syncytiotrophoblast cells of the placental layers.

Role of cytokines in anti-implantation activity of H2receptor blockers in albino wistar rats

2009 ◽  
Vol 00 (00) ◽  
pp. 090930024626018-7
Author(s):  
Shyam S. Agrawal ◽  
Sibi P. Ittiyavirah
Keyword(s):  
Wistar Rats

scholarly journals The Role of High Fat Diets and Liver Peptidase Activity in the Development of Obesity and Insulin Resistance in Wistar Rats

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 636
Author(s):  
Germán Domínguez-Vías ◽  
Ana Belén Segarra ◽  
Manuel Ramírez-Sánchez ◽  
Isabel Prieto
Keyword(s):  
Glucose Metabolism ◽  
Wistar Rats ◽  
Metabolic Disorders ◽  
Peptidase Activity ◽  
High Fat ◽  
Β Cell ◽  
High Fat Diets ◽  
Glutamyl Transferase ◽  
Fat Diets

High-fat diets (HFD) have been widely associated with an increased risk of metabolic disorders and overweight. However, a high intake of sources that are rich in monounsaturated fatty acids has been suggested as a dietary agent that is able to positively influence energy metabolism and vascular function. The main objective of this study was to analyze the role of dietary fats on hepatic peptidases activities and metabolic disorders. Three diets: standard (S), HFD supplemented with virgin olive oil (VOO), and HFD supplemented with butter plus cholesterol (Bch), were administered over six months to male Wistar rats. Plasma and liver samples were collected for clinical biochemistry and aminopeptidase activities (AP) analysis. The expression of inducible nitric oxide synthase (iNOS) was also determined by Western blot in liver samples. The diet supplement with VOO did not induce obesity, in contrast to the Bch group. Though the VOO diet increased the time that was needed to return to the basal levels of plasma glucose, the fasting insulin/glucose ratio and HOMA2-%B index (a homeostasis model index of insulin secretion and valuation of β-cell usefulness (% β-cell secretion)) were improved. An increase of hepatic membrane-bound dipeptidyl-peptidase 4 (DPP4) activity was found only in VOO rats, even if no differences in fasting plasma glucagon-like peptide 1 (GLP-1) were obtained. Both HFDs induced changes in hepatic pyroglutamyl-AP in the soluble fraction, but only the Bch diet increased the soluble tyrosyl-AP. Angiotensinase activities that are implicated in the metabolism of angiotensin II (AngII) to AngIV increased in the VOO diet, which was in agreement with the higher activity of insulin-regulated-AP (IRAP) in this group. Otherwise, the diet that was enriched with butter increased soluble gamma-glutamyl transferase (GGT) and Leucyl-AP, iNOS expression in the liver, and plasma NO. In summary, VOO increased the hepatic activity of AP that were related to glucose metabolism (DPP4, angiotensinases, and IRAP). However, the Bch diet increased activities that are implicated in the control of food intake (Tyrosine-AP), the index of hepatic damage (Leucine-AP and GGT), and the expression of hepatic iNOS and plasma NO. Taken together, these results support that the source of fat in the diet affects several peptidases activities in the liver, which could be related to alterations in feeding behavior and glucose metabolism.

The Role of Group Work in Classroom Second Language Acquisition

1985 ◽  
Vol 7 (2) ◽  
pp. 233-248 ◽  
Author(s):  
Teresa Pica ◽  
Catherine Doughty
Keyword(s):  
Second Language ◽  
Second Language Acquisition ◽  
Language Acquisition ◽  
Group Work ◽  
Classroom Interaction ◽  
Empirical Support ◽  
Important Variable ◽  
Classroom Organization ◽  
Interaction Task

The shift in language classroom organization from teacher-fronted to student group work has received a growing amount of theoretical and empirical support (cf. Long, 1983; Long, Adams, McLean, and Castanos, 1976; Taylor, 1982). However, this practice is becoming so popular that it is in danger of turning into yet another ESL bandwagon. The following study was conducted, therefore, to evaluate the role of group work in the classroom, specifically in regard to its possible effects on classroom second language acquisition. Comparisons were made of three ESL classrooms during group vs. teacher-fronted classroom interaction on decision-making tasks.Analysis focused on three broad categories: (1) grammaticality of input, (2) negotiation of input, and (3) individual input/production. Significant differences between the two participation patterns were indicated only in the increased amount of input and production for individual students during group interaction. Task, rather than participation pattern was shown to be a more important variable with regard to parameters (1) and (2). These results suggested that group work has a useful but somewhat restricted role in classroom second language acquisition.

scholarly journals Impact of Entrepreneurial Education on Entrepreneurial Intentions of Pakistani Students

2015 ◽  
Vol 2 (1) ◽  
pp. 43 ◽  
Author(s):  
Altaf Hussain ◽  
Dr. Norashidah
Keyword(s):  
Business Students ◽  
Entrepreneurial Intention ◽  
Important Variable ◽  
Entrepreneurial Intentions ◽  
Theoretical Knowledge ◽  
Network Development ◽  
Entrepreneurial Education ◽  
Entrepreneurship Research ◽  
Study Results

Why an individual prefer to become an entrepreneur and what factor motivated his intentions for becoming an entrepreneur is considered important question in entrepreneurship research. Entrepreneurial education is considered an important variable which effect on entrepreneurial intentions. However, empirical research results on entrepreneurial education and entrepreneurial intention yielded mixed results. To investigate further this question from developing countries perspective, this paper looks at the role of entrepreneurial education in developing the entrepreneurial intentions for becoming entrepreneur. The sample for this study composed of final year business students from Pakistan. The result of this study supports the entrepreneurial intentions model based on the theory of planned behavior. The results further suggested significant influence of entrepreneurial education on entrepreneurial intentions of the students. Moreover, this study results also showed that theoretical knowledge of entrepreneurship (know-what) and knowledge of social network development (know-who) component are vital for imparting entrepreneurial education.

Ouabain- and central sodium-induced hypertension depend on the ventral anteroventral third ventricle region

1999 ◽  
Vol 276 (1) ◽  
pp. H63-H70 ◽  
Author(s):  
Shereeni J. Veerasingham ◽  
Frans H. H. Leenen
Keyword(s):  
Hypertonic Saline ◽  
Wistar Rats ◽  
Third Ventricle ◽  
Cardiovascular Responses ◽  
Ibotenic Acid ◽  
Air Jet ◽  
Artificial Cerebrospinal Fluid ◽  
Induced Hypertension ◽  
Chronic Infusion

To examine the role of the ventral anteroventral third ventricle (vAV3V) in the hypertension induced by chronic subcutaneous ouabain and intracerebroventricular hypertonic saline, neurons in this area were destroyed by microinjection of an excitotoxin, ibotenic acid. Sham-operated or lesioned Wistar rats were administered ouabain (50 μg/day) or placebo for 3 wk from subcutaneously implanted controlled release pellets or artificial cerebrospinal fluid (CSF) or CSF containing 0.8 mol/l NaCl (5 μl/h) infused intracerebroventricularly for 2 wk. At the end of the experiment, mean arterial pressure (MAP) and heart rate at rest and in response to ganglionic blockade by intravenous hexamethonium (30 mg/kg) were assessed. In rats infused with hypertonic saline, responses to air jet stress were also assessed. Baseline MAP in sham-operated rats receiving intracerebroventricular hypertonic saline or subcutaneous ouabain was significantly higher than in control rats (115 ± 1 vs. 97 ± 3 and 121 ± 3 vs. 103 ± 3 mmHg, respectively). vAV3V lesions abolished the increase in MAP elicited by chronic infusion of hypertonic saline or administration of ouabain. Sham-operated rats treated with hypertonic saline or ouabain exhibited significantly enhanced decreases in MAP to hexamethonium, but lesioned rats did not. Rats infused with hypertonic saline demonstrated enhanced responses to air jet stress that were similar in sham-operated and lesioned rats. These results demonstrate that neurons in the vAV3V are essential for the hypertension induced by intracerebroventricular hypertonic saline and subcutaneous ouabain, possibly by increasing sympathetic tone. Cardiovascular responses to air jet stress appear not to be mediated by the vAV3V.

Sign in / Sign up

Export Citation Format

Share Document