scholarly journals The New Changes In The 7th Ajcc/Uicc Staging System Of Gastric Carcinomas

2013 ◽  
Vol 59 (3) ◽  
pp. 165-168 ◽  
Author(s):  
Ioana Hălmaciu ◽  
Simona Gurzu ◽  
B A Suciu ◽  
S I Comișel ◽  
L Dénes ◽  
...  
Keyword(s):  
Stage Iv ◽  
Staging System ◽  
Cancer Staging ◽  
Signet Ring Cell ◽  
Gastric Carcinomas ◽  
Staging Systems ◽  
Signet Ring ◽  
Ring Cell ◽  
Uicc Staging System ◽  
New System

Abstract Objective: The aim of this study was to analyze in parallel the 6th and the newest 7th AJJCC/UICC (American Joint Committee on Cancer/ International Union Against Cancer) staging system in order to highlight changes brought by the new staging system. Methods: We analyzed data obtained retrospectively from 134 hospitalized patients diagnosed with gastric carcinomas, who underwent surgery at the Surgery Clinics of the County Emergency Clinical Hospital of Tîrgu Mureș, Romania between 2008-2010. The data have been obtained from histopathology reports, and the analyzed parameters were the following: age, gender and pTNM staging. For all cases included in the study restaging was performed according to the 7th AJJCC/UICC staging system. Results: 71.66% of cases were adenocarcinomas, 7.46% mucinous adenocarcinoma, 14.17% signet ring cell carcinoma, and 6.71% undifferentiated carcinoma. The signet ring cell carcinomas predominated before 65 years of age (p = 0.003). Compared to the 6th staging system, in the new system pT2 percentages decreased significantly from 38.8% to 6.71%, and pT4 increases from 11.19% to 55.97% (p <0.0001). The pN3 cases increased from 20.9% to 45.52%, because all cases classified as pN2 in the old staging system, became pN3 in the new system. Some of the pN1 cases turned into pN2 in the new system (p = 0.004). Stage IV cases also decreased from 29.85% to 14.94%, due to regrouping of stage III. Conclusions: There are significant changes between the two staging systems. The new staging system aims to achieve a better postoperative follow-up.

scholarly journals Colorectal Signet Ring Cell Carcinoma in a Young Pregnant Woman

2020 ◽  
Vol 13 (1) ◽  
pp. 182-187
Author(s):  
Francisco Ibargüengoitia Ochoa ◽  
Gerardo Miranda Dévora ◽  
Leonardo Silva Lino ◽  
Cintia Sepulveda Rivera ◽  
Diego González Vázquez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Carcinoma ◽  
Stage Iv ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
High Morbidity ◽  
Cancer Stage ◽  
Signet Ring ◽  
Histologic Differentiation ◽  
Ring Cell

Colorectal cancer during pregnancy is one of the less common neoplasms with an incidence of 0.8 in 100,000 pregnancies. Primary colonic signet ring cell carcinoma is a weird variety, characterized by a poor histologic differentiation, with a high morbidity-mortality rate. The case of a 24-year-old patient with a 22-week-old pregnancy and colorectal cancer stage IV in palliative state is presented, with a devastating result. Early diagnosis represents a challenge because of the presentation form and the histologic aggressiveness of this disease. We suggest that colorectal cancer during pregnancy must be treated by a multidisciplinary team.

scholarly journals Risk Factors of Lymph Node Metastasis in Patients with Early Pure and Mixed Signet Ring Cell Gastric Carcinomas

2019 ◽  
Vol 10 (5) ◽  
pp. 1124-1131 ◽  
Author(s):  
Qingqing Hu ◽  
Raymond Dekusaah ◽  
Shouli Cao ◽  
Taohong Pang ◽  
Yi Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Signet Ring Cell ◽  
Gastric Carcinomas ◽  
Node Metastasis ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Clinical Outcomes of Mucinous Gastric Carcinomas Compared with Non-mucinous and Signet Ring Cell Carcinomas

2020 ◽  
Vol 76 (6) ◽  
pp. 297-303
Author(s):  
Honggeun Ahn ◽  
Woo Chul Chung ◽  
Yeon-Ji Kim ◽  
Seongyul Ryu ◽  
Eunsun Lim
Keyword(s):  
Clinical Outcomes ◽  
Signet Ring Cell ◽  
Gastric Carcinomas ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Pericardial Biopsy Revealed Gastric Signet-Ring Cell Cancer

2015 ◽  
Vol 8 (1) ◽  
pp. 174-178 ◽  
Author(s):  
Yu Hashimoto ◽  
Yoshifumi Iwata ◽  
Ryusho Sangen ◽  
Daisuke Usuda ◽  
Tsugiyasu Kanda ◽  
...  
Keyword(s):  
Cell Cancer ◽  
Supportive Therapy ◽  
Stage Iv ◽  
Best Supportive Care ◽  
Signet Ring Cell ◽  
Clear Fluid ◽  
Cardiothoracic Ratio ◽  
Large Pericardial Effusion ◽  
Signet Ring ◽  
Ring Cell

We describe the case of an 85-year-old man who presented with a large pericardial effusion. The patient was admitted because of anorexia and general malaise. Chest X-ray revealed an increased cardiothoracic ratio and a small amount of bilateral pleural effusion. Two-dimensional ultrasonographic echocardiography showed pericardial effusions with atrial and right ventricular early diastolic collapse, establishing the diagnosis of cardiac tamponade. Signet-ring cell cancer with pericardial involvement was diagnosed by subxiphoid pericardiostomy. The clear fluid was removed through pericardial drainage. The signet-ring cell carcinoma of the stomach was revealed by gastric fiberscope examination after pericardial biopsy proved malignancy. Virchow lymph node metastasis was also found. We diagnosed the patient with gastric cancer stage IV and suggested him the best supportive therapy. He died of cardiac arrest 1 month after best supportive care.

scholarly journals Development and Validation of a Prognostic Nomogram for Gastric Signet Ring Cell Carcinoma: A Multicenter Population-Based Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Shuairan Zhang ◽  
Yang Liu ◽  
Zihan Jiao ◽  
Zenan Li ◽  
Jin Wang ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Staging System ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Seer Database ◽  
Kaplan Meier ◽  
Signet Ring ◽  
Ajcc Staging System ◽  
Ring Cell ◽  
Ajcc Staging

BackgroundGastric signet ring cell carcinoma (GSRCC) is a rare disease associated with poor prognosis. A prognostic nomogram was developed and validated in this study to assess GSRCC patients’ overall survival (OS).MethodsPatients diagnosed with GSRCC from the Surveillance, Epidemiology, and End Results (SEER) database (2004–2016) and the First Hospital of China Medical University (CMU1h) were enrolled in this retrospective cohort study. Univariate and multivariate COX analysis was used to determine independent prognostic factors to construct the prognostic nomogram. Predictions were evaluated by the C-index and calibration curve. In addition, the receiver operating characteristic (ROC) curve, decision curve analysis (DCA), and Kaplan-Meier analysis were employed to assess the clinical utility of the survival prediction model.ResultsPatients were classified into two cohorts. We randomly divided patients in the SEER database and CMU1h cohort into a training group (n=3068, 80%) and a validation group (n=764, 20%). Age, race, T stage, N stage, M stage, therapy, and tumor size were significantly associated with the prognosis of GSRCC patients. On this basis, a nomogram was constructed, with a C-index in the training and the validation cohorts at 0.772 (95% CI: 0.762–0.782) and 0.774 (95% CI: 0.752–0.796), respectively. The accuracy of the generated nomogram was verified through calibration plots. Similarly, compared with the traditional AJCC staging system, the results of the area under curve (AUC) calculated by ROC, DCA, and Kaplan-Meier curves, demonstrated a good predictive value of the constructed nomogram, compared to the traditional AJCC staging system.ConclusionIn the present study, seven independent prognostic factors of GSRCC were screened out. The established nomogram models based on seven variables provided a visualization of each prognostic factor’s risk and assisted clinicians in predicting the 1-, 3-, and 5-year OS of GSRCC.

Metastatic patterns and prognostic significance of signet ring cell carcinoma of the colon: Retrospective analysis of SEER database.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 488-488 ◽  
Author(s):  
John Khoury ◽  
Rebecca Chacko ◽  
David Macari ◽  
Bolanle Gbadamosi ◽  
Daniel Ezekwudo ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Survival Rates ◽  
Stage Iv ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Seer Database ◽  
Carcinoma Of The Colon ◽  
Signet Ring ◽  
Metastatic Patterns ◽  
Ring Cell

488 Background: Signet ring cell carcinoma of the colon (SRCC) represents less than 1% of all colon carcinomas. We retrospectively examined the metastatic patterns and prognosis of SRCC in comparison to adenocarcinoma (AC) of the colon. Methods: A total of 763 patients diagnosed with SRCC and 42,875 patients with AC of the colon from 2010 to 2012 were identified from the Surveillance, Epidemiology and End Results (SEER) database. Age, race, gender, primary site, grade, stage, metastatic site and survival data were collected. Results: Out of 43,638 patients, 78.7% were white, 12.5% black and 8.8% other races. Median age of diagnosis was 67.5 years for SRCC as compared to 69.1 years for AC . SRCC was more likely to be grade III or IV (92% vs 21.6%; p < 0.001), to be found in the right colon (63.7% vs 49.4%; p < 0.001) and to present as advanced stage (40.2% vs 29.4% for stage III and 37.1% vs 22.3% for stage IV; p < 0.001). SRCC was more likely to present with metastases to the brain (11.0% vs 1.3%; p < 0.001) and bone (6.4% vs 4.1%; p < 0.001), while AC subjects were more likely to present with metastases to the liver (77.0% vs 22.1%; p < 0.001) and lung (21.2% vs 5.8%; p < 0.001). The 5 year overall survival rate (5-YSR) was 28.2% (CI, 24.5% to 32.4%) for SRCC compared to 50.8% (CI, 50.1% to 51.6%) for AC (Hazard ratio for death, 1.38; CI, 1.26 to 1.52; P < 0.001). The differences in stage specific 5-year survival rates for SRCC and AC were not statistically significant for stage I and stage II. However, SRCC had a lower 5-YSR for stage III (34.5% vs 55.4%) and stage IV (3.3% vs 10.8%). Conclusions: SRCC of the colon has worse survival rates for advanced stages when compared to AC. SRCC presents at earlier age, with advanced tumor grade and stage at diagnosis. The metastatic behavior of SRCC is different than AC with a higher incidence of brain and bone metastases at diagnosis.

scholarly journals Liver and Pancreatic Injury in Response to ALK Inhibitors in a Patient with Primary Signet Ring Cell Carcinoma of the Lung: A Case Report

2021 ◽  
pp. 107-111
Author(s):  
Ibrahim Yildiz
Keyword(s):  
Acute Pancreatitis ◽  
Case Report ◽  
Stage Iv ◽  
Signet Ring Cell ◽  
Alk Inhibitors ◽  
Anaplastic Lymphoma ◽  
First Case ◽  
Platinum Based Chemotherapy ◽  
Signet Ring ◽  
Ring Cell

We report a patient with stage IV anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (primary lung signet ring cell adenocarcinoma) who received serial crizotinib, chemotherapy, and lorlatinib over more than 4 years. The patient discontinued crizotinib after approximately 4 months due to crizotinib-associated hepatotoxicity. Twenty-five days later, when transaminases had normalized, crizotinib was resumed. However, the patient’s liver enzymes rapidly increased again, and crizotinib was discontinued. After 6 cycles of platinum-based chemotherapy, lorlatinib was initiated. Hepatotoxicity did not recur with lorlatinib, a next-generation ALK inhibitor, but grade 4 hypertriglyceridemia and acute pancreatitis were induced by lorlatinib after 4 months. To our knowledge, this is the first case report of acute pancreatitis with lorlatinib. Additionally, stereotactic body radiation therapy (SBRT) was performed for residual small primary lesions in the lung without stopping lorlatinib. Given the rarity of radiation pneumonitis, especially with the relatively small fields treated by SBRT, we suspect that lorlatinib enhanced the pulmonary toxicity. Physicians should be aware that ALK inhibitors, such as lorlatinib and crizotinib, have potentially lethal side effects.

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