scholarly journals Changes in Distortion Product Otoacoustic Emission Caused by Contralateral Broadband Noise

2015 ◽  
Vol 39 (1) ◽  
pp. 125-138 ◽  
Author(s):  
Edward Ozimek ◽  
Andrzej Wicher
Keyword(s):  
Otoacoustic Emission ◽  
Acoustic Stimulation ◽  
Wide Frequency Range ◽  
Broadband Noise ◽  
Distortion Product Otoacoustic Emission ◽  
Frequency Range ◽  
Distortion Product ◽  
Stimulation Level ◽  
Contralateral Acoustic Stimulation ◽  
The Mean

Abstract The main purpose of this investigation was to measure the effect of contralateral acoustic stimulation (CAS) on distortion product otoacoustic emission (DPOAE) in twenty human ears, for a ratio of primary tones f2/f1 = 1.22 and a wide frequency range of f2 (1.4-9 kHz), for two intensity levels of primary tones (L1 = 60 dB SPL; L2 = 50 dB SPL and L1 = 70 dB SPL; L2 = 60 dB SPL) and two intensity levels of CAS (50 and 60 dB SPL). It was found that in the presence of CAS, in the majority of cases the DPOAE level decreased (suppression), but it might also increase (enhancement) or remain unchanged depending on the frequency. The mean suppression level of the component of the frequency fDP = 2f1 f2 might be approximated by a linearly decreasing function of the f2 frequency of primary tones. The slope of this function was negative and increased with an increase of the contralateral stimulation level. The higher was the contralateral noise level the greater was the suppression. For the fDP level below about 15 dB SPL, suppression was observed in a substantial number of measurement cases (in about 85% of all measured cases on average). When the fDP level was higher than 15 dB SPL, only suppression (not enhancement) was observed.

scholarly journals Correlation and Reliability of Behavioral and Otoacoustic-Emission Estimates of Contralateral Medial Olivocochlear Reflex Strength in Humans

2021 ◽  
Vol 15 ◽  
Author(s):  
Miriam I. Marrufo-Pérez ◽  
Peter T. Johannesen ◽  
Enrique A. Lopez-Poveda
Keyword(s):  
Otoacoustic Emission ◽  
Acoustic Stimulation ◽  
Broadband Noise ◽  
Distortion Product Otoacoustic Emission ◽  
Detection Thresholds ◽  
Medial Olivocochlear Reflex ◽  
Distortion Product ◽  
Healthy Humans ◽  
Medial Olivocochlear ◽  
Tone Detection

The roles of the medial olivocochlear reflex (MOCR) in human hearing have been widely investigated but remain controversial. We reason that this may be because the effects of MOCR activation on cochlear mechanical responses can be assessed only indirectly in healthy humans, and the different methods used to assess those effects possibly yield different and/or unreliable estimates. One aim of this study was to investigate the correlation between three methods often employed to assess the strength of MOCR activation by contralateral acoustic stimulation (CAS). We measured tone detection thresholds (N = 28), click-evoked otoacoustic emission (CEOAE) input/output (I/O) curves (N = 18), and distortion-product otoacoustic emission (DPOAE) I/O curves (N = 18) for various test frequencies in the presence and the absence of CAS (broadband noise of 60 dB SPL). As expected, CAS worsened tone detection thresholds, suppressed CEOAEs and DPOAEs, and horizontally shifted CEOAE and DPOAE I/O curves to higher levels. However, the CAS effect on tone detection thresholds was not correlated with the horizontal shift of CEOAE or DPOAE I/O curves, and the CAS-induced CEOAE suppression was not correlated with DPOAE suppression. Only the horizontal shifts of CEOAE and DPOAE I/O functions were correlated with each other at 1.5, 2, and 3 kHz. A second aim was to investigate which of the methods is more reliable. The test–retest variability of the CAS effect was high overall but smallest for tone detection thresholds and CEOAEs, suggesting that their use should be prioritized over the use of DPOAEs. Many factors not related with the MOCR, including the limited parametric space studied, the low resolution of the I/O curves, and the reduced numbers of observations due to data exclusion likely contributed to the weak correlations and the large test–retest variability noted. These findings can help us understand the inconsistencies among past studies and improve our understanding of the functional significance of the MOCR.

The relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions

2017 ◽  
Vol 131 (11) ◽  
pp. 1017-1025 ◽  
Author(s):  
H Keppler ◽  
S Degeest ◽  
I Dhooge
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Otoacoustic Emission ◽  
Homeostatic Plasticity ◽  
Distortion Product Otoacoustic Emissions ◽  
Chronic Tinnitus ◽  
Distortion Product Otoacoustic Emission ◽  
Frequency Range ◽  
Distortion Product ◽  
The Relationship

AbstractObjectives:Chronic tinnitus is associated with reduced auditory input, which results in changes in the central auditory system. This study aimed to examine the relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. For audiometry, the parameters represented the edge frequency of hearing loss, the frequency of maximum hearing loss and the frequency range of hearing loss. For distortion product otoacoustic emissions, the parameters were the frequency of lowest distortion product otoacoustic emission amplitudes and the frequency range of reduced distortion product otoacoustic emissions.Method:Sixty-seven patients (45 males, 22 females) with subjective chronic tinnitus, aged 18 to 73 years, were included.Results:No correlation was found between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. However, tinnitus pitch fell mostly within the frequency range of hearing loss.Conclusion:The current study seems to confirm the relationship between tinnitus pitch and the frequency range of hearing loss, thus supporting the homeostatic plasticity model.

Clinical characteristics and audiological significance of spontaneous otoacoustic emissions in tinnitus patients with normal hearing

2010 ◽  
Vol 125 (3) ◽  
pp. 246-250 ◽  
Author(s):  
D-K Kim ◽  
S-N Park ◽  
K-H Park ◽  
H G Choi ◽  
E-J Jeon ◽  
...  
Keyword(s):  
Otoacoustic Emissions ◽  
Early Stage ◽  
Otoacoustic Emission ◽  
Normal Hearing ◽  
Control Group ◽  
Study Group ◽  
Distortion Product Otoacoustic Emission ◽  
Spontaneous Otoacoustic Emissions ◽  
Distortion Product ◽  
The Mean

AbstractObjective:To define the clinical and audiological features of normal-hearing tinnitus patients with spontaneous otoacoustic emissions, and to evaluate the role of spontaneous otoacoustic emissions in tinnitus generation.Materials and methods:Thirty-two patients with spontaneous otoacoustic emissions were compared with 29 patients without spontaneous otoacoustic emissions, regarding clinical and audiological aspects.Results:The mean age of the study group subjects was significantly lower, and they experienced the kindling effect less frequently than the control group. The mean tinnitus handicap inventory score of the study group was considerably higher than that of the controls, although the difference was not statistically significant. The study group had significantly quieter tinnitus, and higher transient evoked and distortion product otoacoustic emission responses, compared with the control group.Conclusions:Normal-hearing tinnitus patients with spontaneous otoacoustic emissions have different clinical and audiological characteristics, compared with those without spontaneous otoacoustic emissions. Appropriate evaluation and treatment should be considered at an early stage in these patients.

Pengaruh sisplatin dosis tinggi terhadap penurunan fungsi sel rambut luar koklea

2013 ◽  
Vol 40 (2) ◽  
Author(s):  
Asti Kristianti ◽  
Teti Madiadipoera ◽  
Bogi Soeseno
Keyword(s):  
Hair Cells ◽  
Malignant Neoplasm ◽  
Otoacoustic Emission ◽  
Outer Hair Cells ◽  
High Dose ◽  
Distortion Product Otoacoustic Emission ◽  
Inclusion Criteria ◽  
Cochlear Hair Cells ◽  
Distortion Product ◽  
Bilateral Sensorineural Hearing Loss

Background: Chemotherapy is worldwide used nowadays, and its toxicity still remain a problemespecially toxicity to the ear (ototoxicity). Cisplatin (cis-diamminedichloroplatinum) is one of themost commonly used chemotherapy and highly potent in treating epithelial malignancies. Ototoxicitycaused by cisplatin is irreversible, progressive, bilateral, sensorineural hearing loss especially on highfrequency (4-8 KHz) accompanied by tinnitus. Purpose: To observe the cochlear outer hair cells damagein malignancies patients treated with cisplatin. Methods: This study is an observational analytic studywith prospective design to determine the influence of high dose cisplatin on cochlear outer hair cellsfunction. The research was carried out at the ENT-HNS Department, Hasan Sadikin General HospitalBandung, from November 2007 until June 2008. Audiometry, tympanometry, and distortion productotoacoustic emission (DPOAE) examinations were conducted before chemotherapy and DPOAE, andtimpanometry was again measured three days after first and second cycles of cisplatin administration. McNemar test was performed to calculate the effects of high-dose cisplatin to the cochlear outer haircells function. To compare pre and post-cisplatin on alteration of cochlear hair cells function, Wilcoxontest was used. Results: In this study 60 ears from 30 subjects that meet the inclusion criteria, consistedof 25 man (83.3%) and 5 women (16.7%). The prevalence of damaged cochlear outer hair cells were63% at first cycle and 70% at second cycle of cisplatin administration. The decline of cochlear outerhair cells function was significant (p<0.001). Conclusion: High-dose cisplatin decreases cochlear outerhair cells function in patients with malignant neoplasm. Abstrak : Latar belakang: Kemoterapi sekarang rutin digunakan secara klinis di seluruh dunia. Sejalan denganhal tersebut toksisitas kemoterapi, khususnya terhadap telinga saat ini menjadi perhatian. Sisplatin(cis-diamminedichloroplatinum) adalah salah satu obat kemoterapi yang paling banyak digunakandan paling manjur untuk terapi keganasan epitelial. Efek ototoksik sisplatin yaitu terjadi gangguandengar sensorineural yang irreversible, progresif, bilateral pada frekuensi tinggi (4-8 kHz), dan disertaidengan tinitus. Tujuan: Untuk menilai penurunan fungsi sel rambut luar koklea pada penderita tumorganas sesudah pemberian sisplatin dosis tinggi dengan menggunakan DPOAE. Metode: Studi analitikobservasional dengan rancangan prospektif di Bagian IK. THT-KL RS. Hasan Sadikin Bandung mulaibulan November 2007 sampai dengan Juni 2008. Pada penelitian ini dilakukan pemeriksaan audiometrinada murni, timpanometri, dan distortion product otoacoustic emission (DPOAE) prakemoterapi, kemudianDPOAE dan timpanometri diulang tiga hari sesudah siklus pertama dan kedua kemoterapi sisplatin. Datayang diperoleh diuji dengan uji McNemar dan uji Wilcoxon. Hasil: Dari penelitian didapat 60 telingadari 30 subjek penelitian yang memenuhi kriteria inklusi yang terdiri dari 25 laki-laki (83,3%) dan 5perempuan (16,7%). Insidens penurunan fungsi sel rambut luar koklea sebesar 63% (38 kasus) sesudahsiklus pertama dan 70% (42 kasus) sesudah siklus kedua. Hubungan penurunan fungsi sel rambut luarkoklea memberikan nilai yang sangat bermakna sejak pemberian siklus pertama (p<0,001). Kesimpulan:Pemberian sisplatin dosis tinggi pada penderita tumor ganas menyebabkan penurunan fungsi sel rambutluar koklea.Kata kunci: kemoterapi, sisplatin dosis tinggi, sel rambut luar koklea.

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