scholarly journals Solitary Fibrous Tumor of Adrenal Gland and Review of the Literature

PRILOZI ◽  
2021 ◽  
Vol 42 (3) ◽  
pp. 63-69
Author(s):  
Martina Ambardjieva ◽  
Skender Saidi ◽  
Rubens Jovanovic ◽  
Josif Janculev ◽  
Viktor Stankov ◽  
...  

Abstract Solitary fibrous tumor (SFT) is a rare and still controversial entity. This type of tumor first appeared in the literature as a pleural lesion, but, over the last decades, it has been reported in many extrathoracic sites. As a tumor of the adrenal gland, SFT is still rare and very uncommon, thus extensive research among the English language literature has been performed. We present here a case report of an adrenal SFT which is compared to 11 other known cases. Our case report is from a patient with SFT on the left adrenal gland, followed by mild symptoms of abdominal discomfort and hypertension. Physical examination, laboratory, and radiological tests were performed. The patient underwent surgery and the material was sent for histopathologic analysis for a definite diagnosis. Regular follow up appointments were performed over the course of two years. No recurrence of the tumor has been detected. We explain the symptoms, diagnosis, treatment, and additionally we describe the results and implications of the findings reported in the literature. Correct diagnosis is mandatory for optimal management of solitary fibrous tumor patients.

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Hailu Wondimu Gebresellassie ◽  
Yusuf Mohammed ◽  
Brahenu Kotiso ◽  
Bereket Amare ◽  
Aemero Kebede

Author(s):  
Saeed Sohrabpour ◽  
Reza Erfanian ◽  
Ebrahim Karimi ◽  
Farrokh Heidari

A Solitary Fibrous Tumor (SFT) is a soft tissue tumor that appears exceedingly rare in the parotid gland. The literature review suggested that approximately 12%-22% of these cases behave aggressively. Besides, only 4 cases of histological malignant parotid gland SFT are reported in the English literature. We presented a 65-year-old cigarette-smoker man with a fix and tender mass over the left parotid and submandibular areas. On physical examination, the marginal branch of the facial nerve was paralyzed. The left total parotidectomy and neck dissection levels 1 and 2 were performed with preoperative embolization procedure and adjuvant radiotherapy for the patient. The results of the follow-up examination were unremarkable after 11 months. In this case report, we aimed to increase awareness on SFTs, although rare, among clinicians and pathologists. Accordingly, it should be considered in the differential diagnosis of soft-tissue tumors in the major salivary glands for better management.


2002 ◽  
Vol 47 (4) ◽  
pp. 395
Author(s):  
Mi Hye Paeng ◽  
Do Youn Kim ◽  
Byung Chul Kang ◽  
Seung Yon Baek

2012 ◽  
Vol 103 (3) ◽  
pp. 573-577
Author(s):  
Kazumi Hashizume ◽  
Seiji Matsumoto ◽  
Syusaku Nakazono ◽  
Gaku Tamaki ◽  
Tadasu Motoya ◽  
...  

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
S. E. Huisman ◽  
I. Verlinden ◽  
P. van Battum ◽  
J. W. A. Leijtens

Abstract Introduction A solitary fibrous tumor (SFT) is an uncommon neoplasm of mesenchymal and probably fibroblastic origin, occurring mainly in the extremities, and pleura. However, a primary involvement of endocrine organs is rare and even exceptional when found in the adrenal gland. Hereby, we describe the 10th report of an adrenal SFT. Case presentation A 77-year old man was diagnosed with a lesion in the right adrenal gland during a urologic indicated computed tomography (CT). No symptoms and laboratory anomalies were reported indicating any endocrine activity. Follow up CT-scans showed progressive growth of the nodule for which the patient underwent laparoscopic right adrenalectomy. Histological examination showed a hypercellular spindle cell neoplasm with elongated nuclei and a low mitotic index. The vessels were arranged in a hemangiopericytoma-like pattern with a slight sclerosing appearance. Immunohistochemistry showed a positive staining of neoplastic cells for STAT6, CD-34 and Bcl-2. Translocation analysis using RT-PCR showed no NAB2-STAT6 fusion. The specimen was confirmed as a hypercellular variant of an adrenal SFT. Discussion SFT is a rare neoplasm when occurring in the adrenal gland. Differential diagnosis can be broad because of no defined pathognomonic morphological characteristics. However, NAB2-STAT6 gene fusions are considered a molecular hallmark of SFTs. Therefore, STAT6 immunohistochemistry is a valuable diagnostic tool in differentiating between SFT and histologic mimics. After diagnosing SFT, its biological behavior is difficult to predict. SFTs are mostly benign tumors. Nonetheless, a histological benign-appearing SFT can show malignant clinical characteristics impeding assessment of proper follow up. However, malignancy has not been previously reported in any adrenal SFT case report.


2020 ◽  
pp. 030089162097476
Author(s):  
Michele Manica ◽  
Marco Roscigno ◽  
Richard Naspro ◽  
Mario Sodano ◽  
Laura Milesi ◽  
...  

Background: Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm described initially in visceral pleura but can occasionally involve other sites such as the urinary tract. Extrapleural localizations are often indolent but some malignant SFTs have been described. The treatment and the most important prognostic factor for SFT seem to be complete resection of the neoplasm. Case report: We report the 10-year history of a retroperitoneal SFT, which recurred twice after conservative management, and was eventually treated with en bloc resection of the mass, the bladder, and the prostate, and urinary diversion by ileal conduit. To our knowledge, this case has the longest follow-up in the literature. Conclusion: Extrapleural SFTs often have indolent but unpredictable behavior as they can recur even after many years. Some histologic features are associated with the malignancy of these tumors. Complete resection of the neoplasm is the most important prognostic factor. Patients with SFT should be considered for a very long follow-up after the surgery due to the risk of possible late recurrences.


2019 ◽  
Vol 21 (4) ◽  
pp. 421 ◽  
Author(s):  
Hong Chang ◽  
Ya-Ting Liu ◽  
Fei-Xue Song ◽  
Lin Xiang

2021 ◽  
Vol 25 ◽  
pp. 200530
Author(s):  
Amintas Samuel ◽  
Laurent Elodie ◽  
Gros Audrey ◽  
Sesboue Come ◽  
Merlio Jean-Philippe ◽  
...  

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Kozue Matsuishi ◽  
Kojiro Eto ◽  
Atsushi Morito ◽  
Hirokazu Hamasaki ◽  
Keisuke Morita ◽  
...  

Abstract Background Solitary fibrous tumor (SFT) is a relatively rare mesenchymal tumor that mainly affects adults. Its prognosis is good after curative resection, but distant recurrences after 10 years or longer have been reported. Recurrent SFT usually arises as a local lesion; distant metastasis is rarely reported. Here, we report lung metastases that recurred a decade after excising a retroperitoneal primary SFT. Case presentation A 44-year-old woman had an SFT resected from her right retroperitoneum at our hospital. Ten years later, at age 54, she underwent a lung resection after CT showed three suspected metastases in her left lung. All three were histologically diagnosed as lung metastases from the retroperitoneal SFT. However, whereas the primary SFT had 1–2 mitotic cells/10 high power fields (HPF), the metastatic lesion increased malignancy, at 50/10 HPF. Conclusion Patients who have had resected SFTs should be carefully followed up, as malignancy may change in distant metastasis, as in this case.


2021 ◽  
Author(s):  
Ali Sheikhy ◽  
Aida Fallahzadeh ◽  
Seyed Hossein Ahmadi‐Tafti ◽  
Kaveh Hosseini ◽  
Reza Mohseni‐Badalabadi ◽  
...  

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