scholarly journals The multidisciplinary team for gastroenteropancreatic neuroendocrine tumours: the radiologist’s challenge

2019 ◽  
Vol 53 (4) ◽  
pp. 373-387 ◽  
Author(s):  
Vincenza Granata ◽  
Roberta Fusco ◽  
Sergio Venanzio Setola ◽  
Elisabetta de Lutio di Castelguidone ◽  
Luigi Camera ◽  
...  
Keyword(s):  
Multidisciplinary Team ◽  
Neuroendocrine Tumours ◽  
Clinical Symptoms ◽  
Neuroendocrine Tumour ◽  
Imaging Techniques ◽  
Critical Role ◽  
Nuclear Imaging ◽  
Distant Metastases ◽  
Gastroenteropancreatic Neuroendocrine Tumours ◽  
Effective Diagnosis

Abstract Background Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are a heterogeneous group of tumours. An effective diagnosis requires a multimodal approach that combines evaluation of clinical symptoms, hormonelevels, radiological and nuclear imaging, and histological confirmation. Imaging plays a critical role in NETs diagnosis, prognosis and management, so the radiologists are important members of the multidisciplinary team. During diagnostic work-up two critical issues are present: firstly the need to identify tumor presence and secondly to define the primary site and assess regional and distant metastases. Conclusions The most appropriate imaging technique depends on the type of neuroendocrine tumour and the availability of specialized imaging techniques and expertise. There is no general consensus on the most efficient imaging pathway, reflecting the challenge in reliably detection of these tumours.

Nurse developments in neuroendocrine tumour management.

2003 ◽  
pp. 487-488 ◽  
Author(s):  
C Bouvier
Keyword(s):  
Multidisciplinary Team ◽  
Significant Contribution ◽  
Neuroendocrine Tumours ◽  
Neuroendocrine Tumour ◽  
Nurse Specialist ◽  
Royal Free Hospital ◽  
The Past ◽  
Standards Of Practice ◽  
High Standards ◽  
Set Up

Nurse developments in the management of neuroendocrine tumours have changed significantly over the past three years. At the Royal Free Hospital we set up the nurse specialist role due to the expansion of patients being referred to the specialist unit, and the obvious need for a nursing input into their care. The nurse specialist can make a significant contribution within the context of a multidisciplinary team especially in the production of guidelines and policies to ensure and maintain high standards of practice, education for the patient, and the provision of expertise and security that the patient requires when diagnosed with a rare disease.

Marked improvement in hyperammonaemic encephalopathy from multimodal treatment of metastatic neuroendocrine tumour

2021 ◽  
Vol 14 (6) ◽  
pp. e241191
Author(s):  
Alexander Davis ◽  
Stephen Clarke ◽  
Sally Ayesa ◽  
David L Chan
Keyword(s):  
Poor Prognosis ◽  
Neuroendocrine Tumours ◽  
Treatment Approach ◽  
Neuroendocrine Tumour ◽  
Multimodality Treatment ◽  
Peptide Receptor ◽  
The Poor ◽  
Heterogenous Group ◽  
Gastroenteropancreatic Neuroendocrine Tumours ◽  
New Diagnosis

Gastroenteropancreatic neuroendocrine tumours (GEPNETs) are a heterogenous group of tumours which are rising in incidence. Morbidity and mortality related to these tumours is dependent on the location of metastatic spread. Hyperammonaemia and subsequent encephalopathy has previously been described in GEPNET and is typically associated with a poor prognosis. We describe a case of a 55-year-old woman with hyperammonaemic encephalopathy and a new diagnosis of GEPNET. Given the poor prognosis and the outcomes in this patient group we feel this case highlights the benefit of a multimodality treatment approach including peptide receptor radionucleotide therapy and transarterial chemoembolisation.

scholarly journals Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters

2010 ◽  
Vol 17 (4) ◽  
pp. 909-918 ◽  
Author(s):  
Martin B Niederle ◽  
Monika Hackl ◽  
Klaus Kaserer ◽  
Bruno Niederle
Keyword(s):  
Digestive Tract ◽  
Neuroendocrine Tumours ◽  
Neuroendocrine Tumour ◽  
Tnm Staging ◽  
Incidence Rates ◽  
Neuroendocrine Cells ◽  
Malignant Tumours ◽  
Main Site ◽  
Well Differentiated ◽  
Gastroenteropancreatic Neuroendocrine Tumours

As incidence data on gastroenteropancreatic neuroendocrine tumours (GEP-NETs) have so far only been retrospectively obtained and based on inhomogeneous material, we conducted a prospective study in Austria collecting all newly diagnosed GEP-NETs during 1 year. Using the current WHO classification, the tumor, nodes, metastases (TNM) staging and Ki67 grading and the standard diagnostic procedure proposed by the European Neuroendocrine Tumor Society (ENETS), GEP-NETs from 285 patients (male: 148; female: 137) were recorded. The annual incidence rates were 2.51 per 100 000 inhabitants for men, 2.36 per 100 000 for women. The stomach (23%) was the main site, followed by appendix (21%), small intestine (15%) and rectum (14%). Patients with appendiceal tumours were significantly younger than patients with tumours in any other site. About 46.0% were classified as benign, 15.4% as uncertain, 31.9% as well differentiated malignant and 6.7% as poorly differentiated malignant. Patients with benign or uncertain tumours were significantly younger than patients with malignant tumours. Among the malignant tumours of the digestive tract, 1.49% arose from neuroendocrine cells. For malignant gastrointestinal NETs, the incidence was 0.80 per 100 000: 40.9% were ENETS stage I, 23.8% stage II, 11.6% stage III and 23.8% stage IV. The majority (59.7%) were grade 1, 31.2% grade 2 and 9.1% grade 3. NETs of the digestive tract are more common than previously reported; the majority show benign behaviour, are located in the stomach and are well differentiated. G3 tumours are very rare.

Whole brain atlas-based diffusion kurtosis imaging parameters for evaluation of minimal hepatic encephalopathy

2021 ◽  
pp. 197140092110269
Author(s):  
Prateek Gupta ◽  
Sameer Vyas ◽  
Teddy Salan ◽  
Chirag Jain ◽  
Sunil Taneja ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Clinical Symptoms ◽  
Early Stage ◽  
Imaging Techniques ◽  
Clinical Stage ◽  
Minimal Hepatic Encephalopathy ◽  
Brain Atlas ◽  
Diffusion Kurtosis Imaging ◽  
Whole Brain ◽  
Diffusion Kurtosis

Background and purposes Minimal hepatic encephalopathy (MHE) has no recognizable clinical symptoms, but patients have cognitive and psychomotor deficits. Hyperammonemia along with neuroinflammation lead to microstructural changes in cerebral parenchyma. Changes at conventional imaging are detected usually at the overt clinical stage, but microstructural alterations by advanced magnetic resonance imaging techniques can be detected at an early stage. Materials and methods Whole brain diffusion kurtosis imaging (DKI) data acquired at 3T was analyzed to investigate microstructural parenchymal changes in 15 patients with MHE and compared with 15 age- and sex-matched controls. DKI parametric maps, namely kurtosis fractional anisotropy (kFA), mean kurtosis (MK), axial kurtosis (AK) and radial kurtosis (RK), were evaluated at 64 white matter (WM) and gray matter (GM) regions of interest (ROIs) in the whole brain and correlated with the psychometric hepatic encephalopathy score (PHES). Results The MHE group showed a decrease in kFA and AK across the whole brain, whereas MK and RK decreased in WM ROIs but increased in several cortical and deep GM ROIs. These alterations were consistent with brain regions involved in cognitive function. Significant moderate to strong correlations (–0.52 to –0.66; 0.56) between RK, MK and kFA kurtosis metrics and PHES were observed. Conclusion DKI parameters show extensive microstructural brain abnormalities in MHE with minor correlation between the severity of tissue damage and psychometric scores.

Accuracy of visual assessments of proliferation indices in gastroenteropancreatic neuroendocrine tumours

2013 ◽  
Vol 66 (8) ◽  
pp. 700-704 ◽  
Author(s):  
Helen T M Young ◽  
Norman J Carr ◽  
Bryan Green ◽  
Charles Tilley ◽  
Vidhi Bhargava ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Proliferation Indices ◽  
Gastroenteropancreatic Neuroendocrine Tumours ◽  
Visual Assessments
Sign in / Sign up

Export Citation Format

Share Document