Adsorption and release of terbinafine hydrochloride: Effects of adsorbents, additives, pH, and temperature

2009 ◽  
Vol 63 (3) ◽  
Author(s):  
Zuzana Vitková ◽  
Jarmila Oremusová ◽  
Oľga Greksáková
Keyword(s):  
Drug Release ◽  
Ph Value ◽  
Methyl Cellulose ◽  
Hydroxypropyl Cellulose ◽  
Dosage Forms ◽  
View Point ◽  
Factors Affecting ◽  
Terbinafine Hydrochloride ◽  
Topical Dosage ◽  
Topical Dosage Forms

AbstractThe paper describes results obtained within the study of factors affecting the process of an antifungal drug — terbinafine hydrochloride adsorption on two different adsorbents — charcoal and silicagel. The effects of the adsorbent area, pH value, temperature and additives (polymers — methyl cellulose and hydroxypropyl cellulose) were analyzed and their impact on the adsorption of terbinafine was derived. The increase of pH and temperature, and the presence of additives decreased the amount of terbinafine adsorbed on the adsorbents. Terbinafine is currently applied both perorally and topically. Hydrogels, i.e. compositions of a drug, additives and water, are, due to their advantageous properties, preferred topical dosage forms. Mass fraction of additives of 1 % to 4 % were studied from the view point of drug release. This study shows that both the sort and the concentration of polymers influence the drug release from hydrogels significantly.

scholarly journals Formulation and evaluation of different topical dosage forms for wound healing properties

2020 ◽  
Vol 11 (1) ◽  
pp. 730-746
Author(s):  
Dandasi Jayachandra Dev ◽  
Jayaprakash J S ◽  
Kulkarni P K ◽  
Akhila A R ◽  
Namratha S Saraf
Keyword(s):  
Particle Size ◽  
Wound Healing ◽  
Drug Release ◽  
Dosage Forms ◽  
Cyclodextrin Complexes ◽  
In Vitro Drug Release ◽  
Topical Dosage ◽  
Topical Dosage Forms ◽  
Wound Healing Activity

The aim of the present work was to compare the wound healing efficacy of different topical dosage forms such as β cyclodextrin complex gel, liposomal gel, and ointment on the rat model. Simvastatin was used as a drug, β cyclodextrin was used as a complexing agent to enhance solubility, L α Phosphatidylcholine as a phospholipid, and cholesterol as a stabilizing agent. Liposomes were prepared by thin-film hydration method, β cyclodextrin complexes of simvastatin were prepared by spray drying technique, and the ointment was prepared in simple method. Beta cyclodextrin gels and liposomal gels were prepared by direct incorporation of spray-dried products and lyophilized liposomes into Carbopol gel. The gel was evaluated for drug content, particle size, viscosity, spreadability, surface morphology, in-vitro drug release studies, skin irritation study, and wound healing activity studies. FTIR and DSC studies showed no chemical interaction between the drug and excipients. The particle size of β cyclodextrin complexes was in the range of 0.5 μm to 2.5 μm and for liposomes 163 nm to 725 nm. The in-vitro drug release was 96.7 % at the end of the sixth hour for β cyclodextrin gel, 29.7 % at the end of the sixth hour for liposomal gel, and 96.2 % at the end of 3 hours for ointment. Wound healing activity studies were carried out for 21 days on albino wrister rats, a period of epithelization, and rate of wound contraction was measured on 4, 8, 14, 16, and 21 days. Simvastatin ointment showed a significant effect on wound healing in the rat model compared to β-cyclodextrin gel and liposomal gel. Hence, Simvastatin ointment could be a potential dosage form for clinical utility on wound healing.

Topical Lipid Based Drug Delivery Systems for Skin Diseases: A Review

2020 ◽  
Vol 15 (4) ◽  
pp. 283-298
Author(s):  
Suresh Kumar Sahu ◽  
Rakesh Raj ◽  
Pooja Mongia Raj ◽  
Ram Alpana
Keyword(s):  
Drug Delivery ◽  
Skin Diseases ◽  
Topical Therapy ◽  
Skin Layer ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Systemic Side Effects ◽  
Transcutaneous Delivery ◽  
Topical Dosage ◽  
Topical Dosage Forms

Treatment of skin ailments through systemic administration is limited due to toxicity and patients discomfort. Hence, lower risk of systemic side effects from topical dosage forms like ointments, creams, emulsions and gels is more preferred for the treatment of skin disease. Application of lipid based carriers in drug delivery in topical formulations has recently become one of the major approaches to improve drug permeation, safety, and effectiveness. These delivery systems include liposomes, ethosomes, transfersomes, Nanoemulsions (NEs), Solid Lipid Nanoparticles (SLNs) Nanostructured Lipid Carriers (NLCs) and micelles. Most of the liposomes and SLNs based products are in the market while some are under investigation. Transcutaneous delivery of therapeutics to the skin layer by novel lipid based carriers has enhanced topical therapy for the treatment of skin ailments. This article covers an overview of the lipid-based carriers for topical uses to alleviate skin diseases.

scholarly journals ORGANOGELS AS A POTENTIAL TOPICAL DRUG DELIVERY SYSTEM

2018 ◽  
Vol 1 (2) ◽  
pp. 49-58
Author(s):  
Shubhendra Jha ◽  
Sheo Datta Maurya
Keyword(s):  
Organic Liquid ◽  
Three Dimensional ◽  
Systemic Effect ◽  
Dosage Forms ◽  
External Application ◽  
Self Assembled ◽  
Bioactive Agents ◽  
Topical Dosage ◽  
Semi Solid ◽  
Topical Dosage Forms

Semisolid preparations for external application to skin have gained much demand, since it is easily absorbed through the skin layers. Many novel topical dosage forms have been discovered, among which organogels appears to play an important role. Interest in organogels has increased in a wide variety of fields including chemistry, biotechnology and pharmaceutics. Organogels are thermodynamically stable, biocompatible, isotropic gel, which not only give localized effect, but also systemic effect through percutaneous absorption. Organogels are semi-solid systems, in which an organic liquid phase is immobilized by a three-dimensional network composed of self assembled, intertwined gelator fibers. The apolar phase gets immobilized within spaces of the three-dimensional networked structure formed due to the physical interactions amongst the self assembled structures of compounds regarded as gelators. Organogels have been explored as matrices for the delivery of bioactive agents. Compared to conventional topical dosage forms, these novel formulations are found to be more advantageous and efficient. In future, organogels can give way to many promising discoveries in the field of topical dosage forms. The current review aims at giving an idea about organogels, its applications and importance in topical delivery.

Evaluation of the in vitro release and permeation of Cordia verbenacea DC essential oil from topical dosage forms

2019 ◽  
Vol 53 ◽  
pp. 101173 ◽  
Author(s):  
Jéssica Domingos da Silva ◽  
Márcio Vinícius Gomes ◽  
Lucio Mendes Cabral ◽  
Valeria Pereira de Sousa
Keyword(s):  
Essential Oil ◽  
In Vitro Release ◽  
Dosage Forms ◽  
Topical Dosage ◽  
Vitro Release ◽  
Topical Dosage Forms

Determination of bisphenol diglycidyl ethers in topical dosage forms

2006 ◽  
Vol 40 (2) ◽  
pp. 322-330 ◽  
Author(s):  
Tue Søeborg ◽  
Steen Honoré Hansen ◽  
Bent Halling-Sørensen
Keyword(s):  
Dosage Forms ◽  
Topical Dosage ◽  
Topical Dosage Forms
Sign in / Sign up

Export Citation Format

Share Document