Topical Lipid Based Drug Delivery Systems for Skin Diseases: A Review

Treatment of skin ailments through systemic administration is limited due to toxicity and patients discomfort. Hence, lower risk of systemic side effects from topical dosage forms like ointments, creams, emulsions and gels is more preferred for the treatment of skin disease. Application of lipid based carriers in drug delivery in topical formulations has recently become one of the major approaches to improve drug permeation, safety, and effectiveness. These delivery systems include liposomes, ethosomes, transfersomes, Nanoemulsions (NEs), Solid Lipid Nanoparticles (SLNs) Nanostructured Lipid Carriers (NLCs) and micelles. Most of the liposomes and SLNs based products are in the market while some are under investigation. Transcutaneous delivery of therapeutics to the skin layer by novel lipid based carriers has enhanced topical therapy for the treatment of skin ailments. This article covers an overview of the lipid-based carriers for topical uses to alleviate skin diseases.

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Recent advancement in topical drug delivery for psoriasis: Clinical Pertinence and Potential Market

Current Drug Targets ◽

10.2174/1389450122666210412124256 ◽

2021 ◽

Vol 22 ◽

Author(s):

Rakhi Kumari ◽

Jitu Halder ◽

Amit Sharma ◽

Vineet Kumar Rai

Keyword(s):

Drug Delivery ◽

Skin Inflammation ◽

World Market ◽

Dosage Forms ◽

Severe Form ◽

Global Market ◽

Market Potential ◽

Chronic Skin ◽

Topical Dosage ◽

Topical Dosage Forms

: Psoriasis is an immune-mediated chronic skin inflammation. This disease can be associated with several manifestation like red flaks, silver scale, patches, plaques and silvery-white squams. Approximately 70% of the patients treated with topical dosage forms have a mild-to-moderate form of psoriasis, whereas a moderate-to-severe form of psoriasis is treated with systemic, photo, and biological therapies. Considering the big fraction that topicals cover, we present the current market potential, clinical relevance, and recent advances in the topical delivery of the drug for psoriasis. Though we witnessed several advancements in the recent few decades, delivering new immunomodulatory and biological molecules for topical psoriatic treatment have been proved efficient and safe option for the large percentage of patients for whom systemic therapy is not indicated. This article enumerates the promising topical dosage forms at present under assessment for their clinical pertinence. The competency of conventional topicals to reach and transform the world market is enumerated in terms of their success rate after proving the clinical pertinence against psoriasis. However, the entrance of novel drug delivery systems based advanced topical products in the global market is highly anticipated as they have immense potential to precedent tremendous impact on psoriasis treatment in near future.

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Comprehensive review on additives of topical dosage forms for drug delivery

Drug Delivery ◽

10.3109/10717544.2013.879355 ◽

2014 ◽

Vol 22 (8) ◽

pp. 969-987 ◽

Cited By ~ 36

Author(s):

Tarun Garg ◽

Goutam Rath ◽

Amit K. Goyal

Keyword(s):

Drug Delivery ◽

Dosage Forms ◽

Comprehensive Review ◽

Topical Dosage ◽

Topical Dosage Forms

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Development of Innovative Orally Fast Disintegrating Film Dosage Forms: A Review

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2012.5.2.2 ◽

2012 ◽

Vol 5 (2) ◽

pp. 1666-1674 ◽

Cited By ~ 3

Author(s):

Bibhu Prasad Panda ◽

N.S Dey ◽

M.E.B. Rao

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Dosage Form ◽

Geriatric Patients ◽

Dosage Forms ◽

Delivery Systems ◽

Design And Development ◽

Innovative Drug ◽

Potential Benefits ◽

Pharmaceutical Industries

Over the past few decades, there has been an increased interest for innovative drug delivery systems to improve safety, efficacy and patient compliance, thereby increasing the product patent life cycle. The discovery and development of new chemical entities is not only an expensive but also time consuming affair. Hence the pharmaceutical industries are focusing on the design and development of innovative drug delivery systems for existing drugs. One such delivery system is the fast disintegrating oral film, which has gained popularity among pediatric and geriatric patients. This fast disintegrating film with many potential benefits of a fast disintegrating tablet but devoid of friability and risk of choking is more acceptable to pediatric and geriatric patients. Formulation of fast disintegrating film can be achieved by various techniques, but common methods of preparation include spraying and casting. These film forming techniques use hydrophilic film former in combination with suitable excipients, which allow the film to disintegrate or dissolve quickly in the mouth within a few seconds without the administration of water. In view of the advantages of the fast disintegrating films over the fast disintegrating tablets and other dosage forms, it has the potential for commercial exploitation. The oral film dosage form not only has certain advantages of other fast disintegrating systems but also satisfies the unmet needs of the market. The present review emphasizes on the potential benefits, design and development of robust, stable, and innovative orally fast- disintegrating films and their future scenarios on a global market as a pharmaceutical dosage form.

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FAST DISSOLVING DRUG DELIVERY SYSTEMS: FORMULATION, PREPARATION TECHNIQUES AND EVALUATION

Universal Journal of Pharmaceutical Research ◽

10.22270/ujpr.v3i4.185 ◽

2018 ◽

Author(s):

Satbir Singh ◽

Tarun Virmani ◽

Reshu Virmani ◽

Geeta Mahlawat ◽

Pankaj Kumar

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Dosage Forms ◽

Delivery Systems ◽

Oral Dosage ◽

Oral Drug ◽

Self Medication ◽

Onset Of Action ◽

Fast Disintegrating Tablets

The Fast Dissolving Drug Delivery Systems sets a new benchmark was an expansion that came into existence in the early 1980’s and combat over the use of the different dosage form like tablets, suspension, syrups, capsules which are the other oral drug delivery systems. Fast Dissolving Drug Delivery System (FDTS) has a major advantage over the conventional dosage forms since the drug gets rapidly disintegrated and dissolves in the saliva without the use of water .In spite of the downside lack of immediate onset of action; these oral dosage forms have valuable purposes such as self medication, increased patient compliance, ease of manufacturing and lack of pain. Hence Fast Disintegrating Tablets (FDTS) technology has been gaining importance now-a-days with wide variety of drugs serving many purposes. Fast Disintegrating Tablets (FDTS) has ever increased their demand in the last decade since they disintegrate in saliva in less than a minute that improved compliance in pediatrics and geriatric patients, who have difficulty in swallowing tablets or liquids. As fast dissolving tablet provide instantaneous disintegration after putting it on tongue, thereby rapid drug absorption and instantaneous bioavailability, whereas Fast dissolving oral films are used as practical alternative to FDTS. These films have a potential to deliver the drug systemically through intragastric, sublingual or buccal route of administration and also has been used for local action. In present review article different aspects of fast dissolving tablets and films like method of preparations, latest technologies, evaluation parameters are discussed. This study will be useful for the researchers for their lab work.

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ORGANOGELS AS A POTENTIAL TOPICAL DRUG DELIVERY SYSTEM

International Journal of Drug Regulatory Affairs ◽

10.22270/ijdra.v1i2.110 ◽

2018 ◽

Vol 1 (2) ◽

pp. 49-58

Author(s):

Shubhendra Jha ◽

Sheo Datta Maurya

Keyword(s):

Organic Liquid ◽

Three Dimensional ◽

Systemic Effect ◽

Dosage Forms ◽

External Application ◽

Self Assembled ◽

Bioactive Agents ◽

Topical Dosage ◽

Semi Solid ◽

Topical Dosage Forms

Semisolid preparations for external application to skin have gained much demand, since it is easily absorbed through the skin layers. Many novel topical dosage forms have been discovered, among which organogels appears to play an important role. Interest in organogels has increased in a wide variety of fields including chemistry, biotechnology and pharmaceutics. Organogels are thermodynamically stable, biocompatible, isotropic gel, which not only give localized effect, but also systemic effect through percutaneous absorption. Organogels are semi-solid systems, in which an organic liquid phase is immobilized by a three-dimensional network composed of self assembled, intertwined gelator fibers. The apolar phase gets immobilized within spaces of the three-dimensional networked structure formed due to the physical interactions amongst the self assembled structures of compounds regarded as gelators. Organogels have been explored as matrices for the delivery of bioactive agents. Compared to conventional topical dosage forms, these novel formulations are found to be more advantageous and efficient. In future, organogels can give way to many promising discoveries in the field of topical dosage forms. The current review aims at giving an idea about organogels, its applications and importance in topical delivery.

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Fluid gels: A systematic review towards their application in pharmaceutical dosage forms and drug delivery systems

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2021.102947 ◽

2021 ◽

pp. 102947

Author(s):

Muhammad Syakir Mohd Shahrizan ◽

Zul Hadif Abd Aziz ◽

Haliza Katas

Keyword(s):

Systematic Review ◽

Drug Delivery ◽

Drug Delivery Systems ◽

Dosage Forms ◽

Delivery Systems ◽

Pharmaceutical Dosage Forms

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Evaluation of the in vitro release and permeation of Cordia verbenacea DC essential oil from topical dosage forms

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2019.101173 ◽

2019 ◽

Vol 53 ◽

pp. 101173 ◽

Cited By ~ 2

Author(s):

Jéssica Domingos da Silva ◽

Márcio Vinícius Gomes ◽

Lucio Mendes Cabral ◽

Valeria Pereira de Sousa

Keyword(s):

Essential Oil ◽

In Vitro Release ◽

Dosage Forms ◽

Topical Dosage ◽

Vitro Release ◽

Topical Dosage Forms

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Stealth Coating of Nanoparticles in Drug-Delivery Systems

Nanomaterials ◽

10.3390/nano10040787 ◽

2020 ◽

Vol 10 (4) ◽

pp. 787 ◽

Cited By ~ 18

Author(s):

See Yee Fam ◽

Chin Fei Chee ◽

Chean Yeah Yong ◽

Kok Lian Ho ◽

Abdul Razak Mariatulqabtiah ◽

...

Keyword(s):

Drug Delivery ◽

Blood Circulation ◽

Delivery Systems ◽

Mononuclear Phagocyte ◽

Polymer Chains ◽

Cancer Therapies ◽

Drug Actions ◽

Coating Characteristics ◽

Systemic Side Effects ◽

Poly Ethylene

Nanoparticles (NPs) have emerged as a powerful drug-delivery tool for cancer therapies to enhance the specificity of drug actions, while reducing the systemic side effects. Nonetheless, NPs interact massively with the surrounding physiological environments including plasma proteins upon administration into the bloodstream. Consequently, they are rapidly cleared from the blood circulation by the mononuclear phagocyte system (MPS) or complement system, resulting in a premature elimination that will cause the drug release at off-target sites. By grafting a stealth coating layer onto the surface of NPs, the blood circulation half-life of nanomaterials can be improved by escaping the recognition and clearance of the immune system. This review focuses on the basic concept underlying the stealth behavior of NPs by polymer coating, whereby the fundamental surface coating characteristics such as molecular weight, surface chain density as well as conformations of polymer chains are of utmost importance for efficient protection of NPs. In addition, the most commonly used stealth polymers such as poly(ethylene glycol) (PEG), poly(2-oxazoline) (POx), and poly(zwitterions) in developing long-circulating NPs for drug delivery are also thoroughly discussed. The biomimetic strategies, including the cell-membrane camouflaging technique and CD47 functionalization for the development of stealth nano-delivery systems, are highlighted in this review as well.

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