Synthesis of new antimicrobial 4-aminosubstituted 3-nitrocoumarins

2010 ◽  
Vol 64 (3) ◽  
Author(s):  
Biljana Dekić ◽  
Vidoslav Dekić ◽  
Niko Radulović ◽  
Rastko Vukićević ◽  
Radosav Palić
Keyword(s):  
Antimicrobial Activity ◽  
Klebsiella Pneumoniae ◽  
Ethyl Acetate ◽  
Disk Diffusion ◽  
Coumarin Derivatives ◽  
Similar Activity ◽  
In Vitro Antimicrobial Activity ◽  
Yeast Strains ◽  
Wide Range

AbstractA series of new coumarin derivatives has been synthesized by condensation of 4-chloro-3-nitrocoumarin and the appropriate arylamine and sulfonamide in ethyl acetate in the presence of triethylamine. The synthesized compounds were screened for their in vitro antimicrobial activity against thirteen strains of bacteria and three fungal/yeast strains using disk diffusion assays. They were shown to possess a wide range of activities from almost completely inactive compounds to medium active ones. (4-[(5-Chloropyridin-2-yl)amino]-3-nitro-2H-chromen-2-one) showed similar activity against Klebsiella pneumoniae as tetracycline.

scholarly journals In vitro antimicrobial activity of the organic extract of Cladonia substellata Vainio and usnic acid against Staphylococcus spp. obtained from cats and dogs

2017 ◽  
Vol 37 (4) ◽  
pp. 368-378 ◽  
Author(s):  
Jusciêne B. Moura ◽  
Agueda C. de Vargas ◽  
Gisele V. Gouveia ◽  
João J. de S. Gouveia ◽  
Juracy C. Ramos-Júnior ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activities ◽  
Meca Gene ◽  
Usnic Acid ◽  
Organic Extract ◽  
In Vitro Antimicrobial Activity ◽  
Low Concentrations ◽  
Wide Range ◽  
Staphylococcus Spp

ABSTRACT: Cladonia substellata Vainio is a lichen found in different regions of the world, including the Northeast of Brazil. It contains several secondary metabolites with biological activity, including usnic acid, which has exhibited a wide range of biological activities. The aim of this study was to evaluate the in vitro antimicrobial activity of the organic extract of C. substellata and purified usnic acid. Initially, Staphylococcus spp., derived from samples of skin and ears of dogs and cats with suspected pyoderma and otitis, were isolated and analyzed. In antimicrobial susceptibility testing against Staphylococcus spp., 77% (105/136) of the isolates were resistant to the antimicrobials tested. In the assessment of biofilm production, 83% (113/136) were classified as producing biofilm. In genetic characterization, 32% (44/136) were positive for blaZ, no isolate (0/136) was positive for the mecA gene, and 2% (3/136) were positive for the icaD gene. The in vitro antimicrobial activity of the organic extract of C. substellata and purified usnic acid against Staphylococcus spp. ranged from 0.25mg/mL to 0.0019mg/mL, inhibiting bacterial growth at low concentrations. The substances were more effective against biofilm-producing bacteria (0.65mg/mL-0.42mg/mL) when compared to non-biofilm producing bacteria (2.52mg/mL-2.71mg/mL). Usnic acid and the organic extract of C. substellata can be effective in the treatment of pyoderma and otitis in dogs and cats caused by Staphylococcus spp.

IN VITRO ANTIMICROBIAL ACTIVITY OF CYNODON DACTYLON (L.) PERS. LEAF EXTRACTS. ANTIMICROBIAL ACTIVITY BY ZONE OF INHIBITION ESTIMATION

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (04) ◽  
pp. 37-41
Author(s):  
S. M Pawaskar ◽  
◽  
K. C. Sasangan
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Ethyl Acetate ◽  
Petroleum Ether ◽  
Cynodon Dactylon ◽  
Diffusion Method ◽  
Zone Of Inhibition ◽  
Leaf Extracts ◽  
In Vitro Antimicrobial Activity

The present study was undertaken to evaluate in vitro antimicrobial activity of the successive leaf extracts of Cynodon dactylon in petroleum ether, ethyl acetate, acetone, ethanol, methanol and water, against various gram positive & gram negative bacterial strains using zone of inhibition. Both Agar well diffusion method & Agar disc diffusion method were used to evaluate the antibacterial efficacy. The microorganisms used in the test were – Escherichia coli, Proteus vulgaris, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Shigella flexneri, Salmonella typhi, Salmonella paratyphi A, Salmonella paratyphi B, Bacillus subtilis, Streptococcus pyogenes, Vibrio cholerac and Enterobacter aerogenes. Two fungal strains - Candida albicans and Saccharomyces cerevisiae were also tested to evaluate the antifungal potential of the said plant extract. The reference antibiotics chloramphenicol & ampicillin (antibacterial); nystatin & clotrimazole and (antifungal) were also tested against these standard microorganisms used in the assay and the results were compared with that of the plant extracts.The results of the study revealed that all the seven successive extracts of the leaf powder of Cynodon dactylon ( L.) Pers. exhibited prominent antimicrobial and antifungal activity against all microorganisms used in the study. The nonpolar extracts i.e. petroleum ether, ethyl acetate and acetone showed the most significant antibacterial and antifungal activity against all tested organisms. The petroleum ether and ethyl acetate extracts showing maximum inhibition in the range of 8 mm - 15 mm. This was closely followed by, acetone extract, which showed the inhibition in the range of 9 mm - 13 mm.

RO 23-6240 (AM-833), a new fluoroquinolone: In vitro antimicrobial activity and tentative disk diffusion interpretive criteria

1987 ◽  
Vol 7 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Peter C. Fuchs ◽  
Ronald N. Jones ◽  
Arthur L. Barry ◽  
Leona W. Ayers ◽  
Thomas L. Gavan ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Disk Diffusion ◽  
In Vitro Antimicrobial Activity

scholarly journals In Vitro Antimicrobial Activity of a New Cephalosporin, Ceftaroline, and Determination of Quality Control Ranges for MIC Testing

2008 ◽  
Vol 53 (3) ◽  
pp. 1271-1274 ◽  
Author(s):  
Steven D. Brown ◽  
Maria M. Traczewski
Keyword(s):  
Antimicrobial Activity ◽  
Quality Control ◽  
Disk Diffusion ◽  
Bacterial Isolates ◽  
In Vitro Antimicrobial Activity ◽  
Reference Strains ◽  
Phenotypic Groups

ABSTRACT The spectrum of activity of ceftaroline was evaluated against 1,247 bacterial isolates representing 44 different species or phenotypic groups. For the majority of species, the activity of ceftaroline was comparable or superior to that of ceftriaxone. MIC and/or disk diffusion quality control ranges of ceftaroline were determined for five standard ATCC reference strains.

scholarly journals In vitro antimicrobial screening of Lycoperdon lividium and determination of the ethanol extract composition by gas chromatography/mass spectrometry

2016 ◽  
Vol 11 (2) ◽  
pp. 389 ◽  
Author(s):  
Kerem Canli ◽  
Ergin Murat Altuner ◽  
Ilgaz Akata ◽  
Yavuz Turkmen ◽  
Ugur Uzek
Keyword(s):  
Antimicrobial Activity ◽  
Video Clip ◽  
Ethanol Extract ◽  
Disk Diffusion ◽  
Gas Chromatography Mass Spectrometry ◽  
Diffusion Method ◽  
Disk Diffusion Method ◽  
Disk Diffusion Test ◽  
Wide Range

<p class="Abstract">The aim of this study was to investigate the antimicrobial activity of <em>Lycoperdon lividium</em> against 17 bacterial and 1 fungal strains and analyse the composition of ethanol extracts by GC/MS. The in vitro antimicrobial activity of <em>L. lividium</em> extracts having 15 mg/mL concentration was assessed against a wide range of strains by disk diffusion method. The ethanol extract of <em>L. lividium</em> had antimicrobial activity against several microorganism tested, but it was active especially against <em>S. carnosus</em>. The results obtained herein indicate that <em>L. lividium</em> contains several active metabolites.</p><p class="Abstract">Video clip</p><p><a href="https://youtube.com/v/ymWOQBeNN84">Disk diffusion test</a>: 7 min 11 sec</p>

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