Introduction to methods of describing the forecast on the risk of failure to the means of transport

2012 ◽  
Vol 30 (1) ◽  
pp. 119-127
Author(s):  
Henryk Tomaszek ◽  
Ryszard Kaleta ◽  
Mariusz Zieja
Keyword(s):  
Long Range ◽  
Failure Rate ◽  
Risk Of Failure ◽  
The Relationship ◽  
Preliminary Description

The paper is an attempt to describe the forecast on the risk of damages resulting from failures to the means of transport. It has been assumed that the product of the probability of failure (fault) occurrence and measures of effects thereof are to be used to estimate the risk. The below presented dependences that describe the risk of damages have been based on the failure rate. With the available literature as the basis, a preliminary description of the probability of a failure (fault) and the level of losses has been proposed. The paper gives dependences on short- and long-range risk forecasts. To determine the relationship for the probability of a failure (fault), the failure rate has been used.

scholarly journals Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Carlos G. Acevedo-Rocha ◽  
Aitao Li ◽  
Lorenzo D’Amore ◽  
Sabrina Hoebenreich ◽  
Joaquin Sanchis ◽  
...  
Keyword(s):  
Long Range ◽  
Fitness Landscape ◽  
Conformational Dynamics ◽  
P450 Monooxygenase ◽  
Access Channel ◽  
Long Range Interactions ◽  
Limited Protein ◽  
Dynamics Simulations ◽  
The Relationship ◽  
Single Enzyme

AbstractMultidimensional fitness landscapes provide insights into the molecular basis of laboratory and natural evolution. To date, such efforts usually focus on limited protein families and a single enzyme trait, with little concern about the relationship between protein epistasis and conformational dynamics. Here, we report a multiparametric fitness landscape for a cytochrome P450 monooxygenase that was engineered for the regio- and stereoselective hydroxylation of a steroid. We develop a computational program to automatically quantify non-additive effects among all possible mutational pathways, finding pervasive cooperative signs and magnitude epistasis on multiple catalytic traits. By using quantum mechanics and molecular dynamics simulations, we show that these effects are modulated by long-range interactions in loops, helices and β-strands that gate the substrate access channel allowing for optimal catalysis. Our work highlights the importance of conformational dynamics on epistasis in an enzyme involved in secondary metabolism and offers insights for engineering P450s.

LONG-RANGE CORRELATIONS IN THE PHASE-SHIFTS OF NUMERICAL SIMULATIONS OF BIOCHEMICAL OSCILLATIONS AND IN EXPERIMENTAL CARDIAC RHYTHMS

1999 ◽  
Vol 07 (02) ◽  
pp. 113-130 ◽  
Author(s):  
I. M. DE LA FUENTE ◽  
L. MARTINEZ ◽  
J. M. AGUIRREGABIRIA ◽  
J. VEGUILLAS ◽  
M. IRIARTE
Keyword(s):  
Phase Shift ◽  
Periodic Solutions ◽  
Long Range ◽  
Phase Shifts ◽  
Long Range Correlations ◽  
Rescaled Range ◽  
Biochemical Oscillations ◽  
Phase Shift Data ◽  
Relationship Of ◽  
The Relationship

In biochemical dynamical systems during each transition between periodical behaviors, all metabolic intermediaries of the system oscillate with the same frequency but with different phase-shifts. We have studied the behavior of phase-shift records obtained from random transitions between periodic solutions of a biochemical dynamical system. The phase-shift data were analyzed by means of Hurst's rescaled range method (introduced by Mandelbrot and Wallis). The results show the existence of persistent behavior: each value of the phase-shift depends not only on the recent transitions, but also on previous ones. In this paper, the different kind of periodic solutions were determined by different small values of the control parameter. It was assessed the significance of this results through extensive Monte Carlo simulations as well as quantifying the long-range correlations. We have also applied this type of analysis on cardiac rhythms, showing a clear persistent behavior. The relationship of the results with the cellular persistence phenomena conditioned by the past, widely evidenced in experimental observations, is discussed.

scholarly journals Decomposition of M/M/1 With Unreliable Service and a Working Vacation

2020 ◽  
Vol 9 (1) ◽  
pp. 63
Author(s):  
Joshua Patterson ◽  
Andrzej Korzeniowski
Keyword(s):  
Closed Form ◽  
Failure Rate ◽  
Waiting Time ◽  
Queue Length ◽  
Service Failure ◽  
Working Vacation ◽  
Stationary Queue Length ◽  
Stationary Waiting Time ◽  
Relationship Of ◽  
The Relationship

We use the stationary distribution for the M/M/1 with Unreliable Service and aWorking Vacation (M/M/1/US/WV) given explicitly in (Patterson & Korzeniowski, 2019) to find a decomposition of the stationary queue length N. By applying the distributional form of Little's Law the Laplace-tieltjes Transform of the stationary customer waiting time W is derived. The closed form of the expected value and variance for both N and W is found and the relationship of the expected stationary waiting time as a function of the service failure rate is determined.

scholarly journals The relationship between oxide-ion conductivity and cation vacancy order in the hybrid hexagonal perovskite Ba3VWO8.5

2020 ◽  
Vol 8 (32) ◽  
pp. 16506-16514 ◽  
Author(s):  
Asma Gilane ◽  
Sacha Fop ◽  
Falak Sher ◽  
Ronald I. Smith ◽  
Abbie C. Mclaughlin
Keyword(s):  
Ionic Conductivity ◽  
Long Range ◽  
Cation Vacancy ◽  
Ion Conductivity ◽  
Cation Ordering ◽  
Oxygen Diffusivity ◽  
Oxide Ion Conductivity ◽  
The Relationship ◽  
Oxide Ion

Cation ordering in Ba3VWO8.5 disrupts long-range oxygen diffusivity parallel to the c-axis resulting in reduced ionic conductivity.

The hazard and vitality measures of ageing

1989 ◽  
Vol 26 (03) ◽  
pp. 532-542 ◽  
Author(s):  
Joseph Kupka ◽  
Sonny Loo
Keyword(s):  
Sudden Death ◽  
Failure Rate ◽  
Residual Life ◽  
Ageing Process ◽  
Mean Residual Life ◽  
Absolutely Continuous ◽  
Intrinsic Interest ◽  
Increasing Failure Rate ◽  
Time Period ◽  
The Relationship

A new measure of the ageing process called the vitality measure is introduced. It measures the ‘vitality' of a time period in terms of the increase in average lifespan which results from surviving that time period. Apart from intrinsic interest, the vitality measure clarifies the relationship between the familiar properties of increasing hazard and decreasing mean residual life. The main theorem asserts that increasing hazard is equivalent to the requirement that mean residual life decreases faster than vitality. It is also shown for general (i.e. not necessarily absolutely continuous) distributions that the properties of increasing hazard, increasing failure rate, and increasing probability of ‘sudden death' are all equivalent.

scholarly journals Predictors of Failure for Nonoperative Management of Spinal Epidural Abscess

2019 ◽  
Vol 11 (1) ◽  
pp. 6-12
Author(s):  
Sarah Hunter ◽  
Robert Cussen ◽  
Joseph F. Baker
Keyword(s):  
Cell Count ◽  
Failure Rate ◽  
Epidural Abscess ◽  
Nonoperative Management ◽  
White Cell Count ◽  
White Cell ◽  
Spinal Epidural Abscess ◽  
Lumbar Region ◽  
Risk Of Failure ◽  
Spinal Epidural

Study Design: Retrospective cohort study. Objectives: The aim of this study is to identify predictive factors associated with failure of nonoperative management of spinal epidural abscess (SEA). Methods: Between January 2007 and January 2017, there were 97 patients 18 years or older treated for SEA at a tertiary referral center. Of these, 58 were initially managed nonoperatively. Details on presenting complaint, laboratory parameters, radiographic evaluation, demographics, comorbidities, and neurologic status (Frankel grades A-E) were collected. Success of treatment was defined as eradication of infection with no requirement for further antimicrobial therapy. Diagnosis of SEA was made via evaluation of imaging and intraoperative findings. Patients with repeat presentation of SEA, children, and those who were transferred for immediate surgical decompression were excluded. Results: Fifty-eight patients initially treated nonoperatively were included. Of these, 21 failed nonoperative management and required surgical intervention. The mean age was 60 years, 66% male, and 19% of Maori ethnicity. Abscess location was predominantly dorsal, and in the lumbar region (53%). Multivariate analysis identified Maori ethnicity, multifocal sepsis, and elevated white cell count as predictors of failure of nonoperative management. With 1 predictor the risk of failure was 44%. In the presence of 2 predictive variables, failure rate increased to 60%, and if all 3 variables were present, patients had a 75% risk of failure. Conclusion: Thirty-six percent of patients treated nonoperatively failed nonoperative management—the failure rate was significantly increased in patients with multifocal sepsis, in patients with elevated white cell count, and in patients of Maori ethnicity.

ROLLER-COASTER FAILURE RATES AND MEAN RESIDUAL LIFE FUNCTIONS WITH APPLICATION TO THE EXTENDED GENERALIZED INVERSE GAUSSIAN MODEL

2010 ◽  
Vol 25 (1) ◽  
pp. 103-118 ◽  
Author(s):  
Ramesh C. Gupta ◽  
Weston Viles
Keyword(s):  
Failure Rate ◽  
Generalized Inverse ◽  
Residual Life ◽  
Gaussian Model ◽  
Change Points ◽  
Mean Residual Life ◽  
Additional Parameter ◽  
Inverse Gaussian ◽  
Generalized Inverse Gaussian ◽  
The Relationship

The investigation in this article was motivated by an extended generalized inverse Gaussian (EGIG) distribution, which has more than one turning point of the failure rate for certain values of the parameters. In order to study the turning points of a failure rate, we appeal to Glaser's eta function, which is much simpler to handle. We present some general results for studying the reationship among the change points of Glaser's eta function, the failure rate, and the mean residual life function (MRLF). Additionally we establish an ordering among the number of change points of Glaser's eta function, the failure rate, and the MRLF. These results are used to investigate, in detail, the monotonicity of the three functions in the case of the EGIG. The EGIG model has one additional parameter, δ, than the generalized inverse Gaussian (GIG) model's three parameters; see Jorgensen [7]. It has been observed that the EGIG model fits certain datasets better than the GIG of Jorgensen [7]. Thus, the purpose of this article is to present some general results dealing with the relationship among the change points of the three functions described earlier. The EGIG model is used as an illustration.

The relationship between ozone, peroxyacetylnitrate and precursors in long range transport of photooxidants to Scandinavia

1997 ◽  
Vol 31 (17) ◽  
pp. 2853-2869 ◽  
Author(s):  
Øystein Hov ◽  
Frode Flatoy ◽  
Terje Krognes ◽  
Norbert Schmidbauer ◽  
Niels Z. Heidam ◽  
...  
Keyword(s):  
Long Range ◽  
Long Range Transport ◽  
Range Transport ◽  
The Relationship

Long-range transport of aerosol particles and precursors - determining the relationship between emissions and observed concentration levels

2000 ◽  
Vol 31 ◽  
pp. 560-561
Author(s):  
A. Semb ◽  
M. Lazaridis ◽  
S. Larssen ◽  
L. Tarrason ◽  
S. Tsyro
Keyword(s):  
Long Range ◽  
Aerosol Particles ◽  
Long Range Transport ◽  
Range Transport ◽  
The Relationship ◽  
Concentration Levels
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