scholarly journals The relationship of the brainstem ischemia and chronicity of lumboischialgia

2015 ◽  
Vol 22 (3) ◽  
pp. 54-59
Author(s):  
D. G. Smolko ◽  
K. T. Aliev ◽  
E. V. Bondarenko ◽  
D. A. Lobatsevich ◽  
O. T. Makarova ◽  
...  
Keyword(s):  
Vertebral Artery ◽  
Pain Intensity ◽  
Blood Vessels ◽  
Low Dose ◽  
Intervertebral Disks ◽  
Prolonged Pain ◽  
Clinically Significant ◽  
Relationship Of ◽  
The Relationship ◽  
Herniated Discs

We analyzed 60 patients aged from 30 up to 75 years with any of low-lumbar herniated intervertebral disks. Pain intensity was compared with the concomitant presence of chronic circulatory failure in the vertebral-basilar basin as a result of clinically significant abnormalities of blood vessels in the form of hypoplasia of vertebral artery and its tortuosity. We investigated dynamics of patient's pain under the influence of low-dose treatment by Cortexin (neurocytoprotector). In patients with chronic brainstem ischemia the herniated discs cause more intense and prolonged pain (radicular and local). More effective in these patients is a treatment with inclusion of Cortexin 20 mg intramuscularly within 10 days.

scholarly journals Investigation of the Correlation between Postherpetic Itch and Neuropathic Pain over Time

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Rie Ishikawa ◽  
Masako Iseki ◽  
Rie Koga ◽  
Eiichi Inada
Keyword(s):  
Neuropathic Pain ◽  
Herpes Zoster ◽  
Pain Intensity ◽  
Visual Analog Scale ◽  
Analog Scale ◽  
Paindetect Questionnaire ◽  
Relationship Of ◽  
The Relationship ◽  
Over Time

Postherpetic itch (PHI), or herpes zoster itch, is an intractable and poorly understood disease. We targeted 94 herpes zoster patients to investigate their pain and itch intensities at three separate stages of the condition (acute, subacute, and chronic). We used painDETECT questionnaire (PDQ) scores to investigate the correlation between PHI and neuropathic pain. Seventy-six patients were able to complete follow-up surveys. The prevalence of PHI was 47/76 (62%), 28/76 (37%), and 34/76 (45%) at the acute, subacute, and chronic stages, respectively. PHI manifestation times and patterns varied. We investigated the relationship of PHI with neuropathic pain using the visual analog scale (VAS), which is a measure of pain intensity, and the PDQ, which is a questionnaire used to evaluate the elements of neuropathic pain. The VAS and PDQ scores did not differ significantly between PHI-positive and PHI-negative patients. A large neuropathic component was not found for herpes zoster itch, suggesting that neuropathic pain treatments may not able to adequately control the itch. Accordingly, we suggest that a more PHI-focused therapy is required to address this condition.

EVALUATION OF THE VESSEL AGE BY APPLYING THE ACCELERATION PLETHYSMOGRAM ANALYSIS

2021 ◽  
pp. 61-67
Author(s):  
Елизавета Александровна Молчанова ◽  
Петр Вячеславович Лужнов
Keyword(s):  
Blood Vessels ◽  
Pulse Wave ◽  
Vascular System ◽  
Vascular Wall ◽  
Second Derivative ◽  
Contour Analysis ◽  
Physiological Factors ◽  
Vascular Age ◽  
Relationship Of ◽  
The Relationship

В работе приведены понятия жесткости, эластичности и тонуса сосудов, а также же их взаимосвязь с общим состоянием сосудистой стенки. Описан индекс, объединяющий влияние вышеперечисленных факторов на состояние сосудистой системы и дающий представление о возрасте сосудов пациента, а также показана связь этого индекса с возрастом человека. Представлен обзор способов определения возраста сосудов с помощью контурного анализа пульсовой волны. Среди предложенных способов был выделен подход на основе контурного анализа сигнала пульсовой волны, а также ее второй производной. В данном исследовании проводилась разработка алгоритма расчета показателя возраста сосудов (VA), базирующаяся на анализе сигнала и его второй производной. При этом особое внимание уделялось физической интерпретации параметров, входящих в состав расчетной формулы. С помощью представленного алгоритма в группе из трех испытуемых был определен сосудистый возраст. Из анализа полученных результатов было выявлено влияние физиологических факторов на значение возраста сосудов. Предложены методики, позволяющие исключить влияние этих факторов на значения показателя VA и тем самым получить более точные результаты. Также представлены стратегии дальнейшего развития исследований в этом направлении In The paper presents the concepts of rigidity, elasticity and tone of blood vessels, as well as their relationship with the general state of the vascular wall. An index is described that combines the influence of the above factors on the state of the vascular system and gives an idea of the age of the patient's vessels, and also shows the relationship of this index with the age of a person. An overview of the methods for determining the age of blood vessels using the contour analysis of the pulse wave is presented. Among the proposed methods, an approach based on the contour analysis of the pulse wave signal, as well as its second derivative, was singled out. In this study, an algorithm was developed for calculating the indicator of vascular age (VA), based on the analysis of the signal and its second derivative. In this case, special attention was paid to the physical interpretation of the parameters included in the calculation formula. Using the presented algorithm, vascular age was determined in a group of three subjects. From the analysis of the results obtained, the influence of physiological factors on the value of the age of the vessels was revealed. Methods are proposed that allow to exclude the influence of these factors on the values of the VA indicator and thereby obtain more accurate results. Also presented are strategies for the further development of research in this direction

scholarly journals MICROCIRCULATORY SYSTEM OF THE SKIN (DEMONSTRATION MATERIALS OF STUDENTS AND YOUNG SCIENTISTS)

2021 ◽  
Vol 1 (4) ◽  
Author(s):  
Veronika Bocharova ◽  
Mariia Kushnir ◽  
Daria Pedchenko
Keyword(s):  
Blood Vessels ◽  
Scientific Literature ◽  
Structural Components ◽  
Microcirculatory System ◽  
The Subject ◽  
Relationship Of ◽  
The Relationship

The subject of research – the structure of the microcirculatory tract of the skin. The purpose of the work is to provide demonstration materials of students and young scientists of the microcirculatory system of the skin. Even in the modern scientific literature there are many contradictions about the relationship of structural components that form the microcirculatory system of the skin, which dictates the need for further research on the relationship of various blood vessels with other components of the so-called microcirculatory system.Key words: microcirculatory system of skin, demonstration materials.

scholarly journals What Is the Relationship of Fear Avoidance to Physical Function and Pain Intensity in Injured Athletes?

2018 ◽  
Vol 476 (4) ◽  
pp. 754-763 ◽  
Author(s):  
Stefan F. Fischerauer ◽  
Mojtaba Talaei-Khoei ◽  
Rens Bexkens ◽  
David C. Ring ◽  
Luke S. Oh ◽  
...  
Keyword(s):  
Pain Intensity ◽  
Physical Function ◽  
Fear Avoidance ◽  
Relationship Of ◽  
The Relationship ◽  
Injured Athletes

scholarly journals The structure, nature and intensity of painin various forms of external genital endometriosis

2016 ◽  
Vol 65 (2) ◽  
pp. 24-30 ◽  
Author(s):  
Tatiana O Efimenko
Keyword(s):  
Neuropathic Pain ◽  
Pain Intensity ◽  
Nociceptive Pain ◽  
Visual Analogue Scale Pain ◽  
Ovarian Cysts ◽  
Microsoft Excel ◽  
Analogue Scale Pain ◽  
Severe Degree ◽  
Relationship Of ◽  
The Relationship

Background. The study of the relationship of severity of endometriosis, localization and intensity of pelvic pain is a significant scientific interest. Aim of the study was to determine the structure of pain in women with external genital endometriosis (EGE) varying forms of distribution. Materials and methods. 124 patients were examined. Degree exam proliferation was assessed by endoscopy. Recovered: superficial endometriosis; endometrioid ovarian cysts; infiltrative forms of endometriosis; combined forms of endometriosis. Pain intensity was determined in accordance with a 10-point visual-analogue scale. Pain Detect scale was used to determine the nature of the pain. Statistical analysis of the material was carried out using the Microsoft Excel 2013 (Microsoft Corp., USA) applications and Stastistica 10.0 for Windows. Results. Light degree of pain intensity in patients with superficial forms EGE (92.11 %, 35 cases) is 21 times higher than that in patients with infiltrative forms (4.35 %, 1 case). Severe degree of pain intensity and with the same frequency is found at infiltrative (56.52 %, 13 cases), combined forms of endometriosis (57.14 %, 8 cases) and in patients with bilateral endometrioid cysts (47.37 %, 9 cases). Nociceptive pain is typical for patients with superficial forms EGE (73.68 %, 28 cases). Neuropathic pain occurs 4.5 times more frequently in patients with infiltrative (86.96 %, 20 cases) and combined forms of endometriosis (92.86 %, 13 cases). Conclusions. Light degree of pain intensity corresponds to the surface form of endometriosis, moderate and severe degree of pain equally common in infiltrative forms and endometrioid ovarian cysts, severe degree of intensity of the most common in infiltrative endometriosis and associated forms. By the nature of pain in superficial forms of endometriosis is dominated by complaints typical for nociceptive pain, neuropathic pain is more common in infiltrative endometriosis and associated forms.

UGT1A1 promoter genotype correlates with pharmacokinetics but not toxicity in patients receiving protracted irinotecan (IRN)

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 3078-3078 ◽  
Author(s):  
C. F. Stewart ◽  
J. C. Panetta ◽  
M. O’Shaughnessy ◽  
S. Throm ◽  
T. Liu ◽  
...  
Keyword(s):  
Promoter Region ◽  
Low Dose ◽  
Dosage Adjustment ◽  
Hematological Toxicity ◽  
Dosing Schedule ◽  
Female Patients ◽  
The Difference ◽  
Clinically Significant ◽  
The Relationship ◽  
Low Dosage

3078 Background: Recent USFDA recommendations include a dosage adjustment for patients who are homozygous for the UGT1A1*28 allele (i.e., 7 TA repeats in the promoter) due to an increase in neutropenia when those patients receive IRN. However, this recommendation was based upon data from adults treated with high IRN dosage (e.g., 350 mg/m2). This study evaluates the relationship between UGT1A1 promoter genotype and phenotype (i.e., SN-38 glucuronidation and IRN toxicity) in patients treated with low-dose, protracted IRN. Methods: 31 children treated on 2 institutional protocols received low dosage (20 to 60 mg/m2) i.v. IRN daily for 5 days of 2 consecutive weeks. PK sampling and UGT1A1 genotyping were performed during cycle 1. Patients were designated as 6/6, 6/7, or 7/7 depending on the number of TA repeats in the UGT1A1 promoter region. All patients were evaluable for gastrointestinal and hematological toxicity, primarily grades 3 and 4 neutropenia and diarrhea. Results: The frequencies of 6/6, 6/7, and 7/7 genotypes were 9/31 (29%), 15/31 (48%), and 7/31 (23%), respectively. Patients with 7/7 genotype had a statistically greater baseline bilirubin than patients with 6/6 or 6/7 genotype (p<0.03), but the difference was not considered clinically significant. In females, the SN-38:IRN AUC ratio was greater in patients with 7/7 vs. 6/6 or 6/7 genotype (0.15 vs. 0.05 vs. 0.09;p<0.005). Similarly the SN-38G:SN-38 ratio was less in females with 7/7 vs. 6/6 or 6/7 genotype (1.5 vs. 4.1 vs. 3.5;p<0.03). Patients with 7/7 genotype did not have a greater incidence of diarrhea (0/7) or neutropenia (0/7) than patients with 6/6 (3/9 with diarrhea, 2/9 with neutropenia) or 6/7 (3/15 with diarrhea, 1/15 with neutropenia) genotype. Conclusions: Although female patients with a 7/7 genotype did have altered SN-38 disposition, toxicity was not increased in patients with the 7/7 genotype treated with a low dose protracted schedule of irinotecan. Therefore, no dosage adjustment for genotype is indicated with this IRN dosing schedule. No significant financial relationships to disclose.

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