EVALUATION OF THE VESSEL AGE BY APPLYING THE ACCELERATION PLETHYSMOGRAM ANALYSIS

2021 ◽  
pp. 61-67
Author(s):  
Елизавета Александровна Молчанова ◽  
Петр Вячеславович Лужнов
Keyword(s):  
Blood Vessels ◽  
Pulse Wave ◽  
Vascular System ◽  
Vascular Wall ◽  
Second Derivative ◽  
Contour Analysis ◽  
Physiological Factors ◽  
Vascular Age ◽  
Relationship Of ◽  
The Relationship

В работе приведены понятия жесткости, эластичности и тонуса сосудов, а также же их взаимосвязь с общим состоянием сосудистой стенки. Описан индекс, объединяющий влияние вышеперечисленных факторов на состояние сосудистой системы и дающий представление о возрасте сосудов пациента, а также показана связь этого индекса с возрастом человека. Представлен обзор способов определения возраста сосудов с помощью контурного анализа пульсовой волны. Среди предложенных способов был выделен подход на основе контурного анализа сигнала пульсовой волны, а также ее второй производной. В данном исследовании проводилась разработка алгоритма расчета показателя возраста сосудов (VA), базирующаяся на анализе сигнала и его второй производной. При этом особое внимание уделялось физической интерпретации параметров, входящих в состав расчетной формулы. С помощью представленного алгоритма в группе из трех испытуемых был определен сосудистый возраст. Из анализа полученных результатов было выявлено влияние физиологических факторов на значение возраста сосудов. Предложены методики, позволяющие исключить влияние этих факторов на значения показателя VA и тем самым получить более точные результаты. Также представлены стратегии дальнейшего развития исследований в этом направлении In The paper presents the concepts of rigidity, elasticity and tone of blood vessels, as well as their relationship with the general state of the vascular wall. An index is described that combines the influence of the above factors on the state of the vascular system and gives an idea of the age of the patient's vessels, and also shows the relationship of this index with the age of a person. An overview of the methods for determining the age of blood vessels using the contour analysis of the pulse wave is presented. Among the proposed methods, an approach based on the contour analysis of the pulse wave signal, as well as its second derivative, was singled out. In this study, an algorithm was developed for calculating the indicator of vascular age (VA), based on the analysis of the signal and its second derivative. In this case, special attention was paid to the physical interpretation of the parameters included in the calculation formula. Using the presented algorithm, vascular age was determined in a group of three subjects. From the analysis of the results obtained, the influence of physiological factors on the value of the age of the vessels was revealed. Methods are proposed that allow to exclude the influence of these factors on the values of the VA indicator and thereby obtain more accurate results. Also presented are strategies for the further development of research in this direction

scholarly journals The Relationship of Modifiable Risk Factors with Indicators of Arterial Stiffness and Vascular Age in Patients with Arterial Hypertension

2021 ◽  
Vol 17 (1) ◽  
pp. 42-48
Author(s):  
A. M. Tuktarov ◽  
T. S. Kazanceva ◽  
A. E. Filippov ◽  
A. G. Obrezan
Keyword(s):  
Risk Factors ◽  
Arterial Stiffness ◽  
Arterial Hypertension ◽  
Pulse Wave ◽  
Modifiable Risk Factors ◽  
Hypertensive Patients ◽  
Vascular Age ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship

Aim. To study the relationship of modifiable risk factors (RF) with indicators of arterial stiffness and vascular age based on the contour analysis of the pulse wave velocity in hypertensive patients.Material and methods. The material of the study was the data from a survey of patients undergoing clinical observation at the polyclinic of MMC SOGAZ. A total of 107 patients were examined, in which 70 were men and 37 were women. The average age was 52.3±18.29. Photoplethysmography was used as a special research method, performed using the AngioScan-01 diagnostic complex. The main indicators used to evaluate the stiffness of large vessels were: stiffness index (SI), reflection index (RI), augmentation index (Alp75), age index (AGI), pulse wave types (PV) and vascular age (VA).Results. The mean values of arterial stiffness indices in patients with essential arterial hypertension (AH) and healthy individuals (control) had significant differences. The mean SI, Alp75, and VA values in the group of patients with AH were 7.8±1.03, 7.0±14.44 and 50.8±15.93 versus 7.2±1.73, 0.5±18.02 and 43.8±16.94, respectively (p< 0.05). In both groups, a strong inverse correlation of passport age with C-type PV was revealed (r=0.74, p< 0.01), which reflected the dynamics of a gradual age-dependent decrease in vascular compliance. The average VA value in the control group was 63.1±16.99 years with an average passport age of 59.5±8.79 years, which significantly differed from VA in hypertensive patients (p< 0,05). Overweight, hypercholesterolemia, elevated low-density lipoprotein levels, lack of adequate antihypertensive control, and left ventricular diastolic dysfunction were significantly associated with early vascular (arterial) aging.Conclusion. Patients with hypertension, in addition to high blood pressure, significantly differ from normotensive control in terms of arterial stiffness. The lack of control over modifiable RF of patients with hypertension is associated with early vascular aging.

scholarly journals MICROCIRCULATORY SYSTEM OF THE SKIN (DEMONSTRATION MATERIALS OF STUDENTS AND YOUNG SCIENTISTS)

2021 ◽  
Vol 1 (4) ◽  
Author(s):  
Veronika Bocharova ◽  
Mariia Kushnir ◽  
Daria Pedchenko
Keyword(s):  
Blood Vessels ◽  
Scientific Literature ◽  
Structural Components ◽  
Microcirculatory System ◽  
The Subject ◽  
Relationship Of ◽  
The Relationship

The subject of research – the structure of the microcirculatory tract of the skin. The purpose of the work is to provide demonstration materials of students and young scientists of the microcirculatory system of the skin. Even in the modern scientific literature there are many contradictions about the relationship of structural components that form the microcirculatory system of the skin, which dictates the need for further research on the relationship of various blood vessels with other components of the so-called microcirculatory system.Key words: microcirculatory system of skin, demonstration materials.

Endothelial and Smooth Muscle Cells as Antagonists in Vascular Fibrinoysis

1975 ◽  
Author(s):  
V. Noordhoek Hegt
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Blood Vessels ◽  
Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Vascular System ◽  
Muscle Cells ◽  
Vascular Wall ◽  
Vasa Vasorum ◽  
Slide Technique

Endothelial plasminogen activator activity in different types of human blood vessels obtained from fifty necropsies and thirty-five biopsies was detected and localized by means of plasminogen-rich fibrin slides. Great differences in endothelial activator activity were found along and across (vasa vasorum) the wall of the human vascular system.The same blood vessels were simultaneously investigated by a modified fibrin slide technique using plasminogen-free fibrin slides covered by plasmin to detect and localize inhibition of fibrinolysis in the vascular wall. The great variation in plasmin inhibition in different vessels revealed by this “fibrin slide sandwich technique” appeared to be closely associated with the localization and number of smooth muscle cells present in the walls of the vascular system. Strong plasmin inhibition was generally found at sites which showed no activator activity with the regular fibrin slide technique, while areas with a high endothelial fibrinolytic activity mostly revealed no inhibitory capacity.These results indicate that much of the variation in endothelial fibrinolytic activity on fibrin slides is due to inhibitory effects from the surrounding smooth muscle cells rather than to variability in the plasminogen activator content of the endothelium itself.

scholarly journals Maladaptive neuropathological syndrome of blood vessel aging

2019 ◽  
pp. 33-40
Author(s):  
A. A. Artemenkov
Keyword(s):  
Cerebral Cortex ◽  
Blood Vessel ◽  
Blood Vessels ◽  
Cortical Neurons ◽  
Circulatory System ◽  
Vascular Wall ◽  
Modern Human ◽  
Wall Thickening ◽  
Additional Risk Factor ◽  
The Relationship

This article discusses the relationship between maladaptation and blood vessel aging. The work shows that upright posture created an additional load on the circulatory system, and the lifestyle of a modern human is an additional risk factor of cardiovascular diseases. It has been suggested that a disorder of the nervous regulation of vascular tone is the main etiopathogenetic mechanism of morphofunctional changes in blood vessels and their aging. We discussed the statute that vascular reactions in humans is based on the formation of a maladaptive circuit in the cerebral cortex, consisting of a matrix of motor, sensory and associative cortical neurons involved in the maladaptive process. This hypothesis is based on the fact that any irritations entering the cerebral cortex from the periphery (thermal, pain, and others) cause cortical-vascular reflex reactions that change their tonic activity. Based on this principle, a model of vascular aging is further constructed, which is based on the maladaptive damage to all layers of the vascular wall (intima, media and adventitia). The opinion is expressed about the need for early diagnosis and prevention of vascular disorders to maintain human health. In conclusion, it is concluded that if the age of a person is really determined by the age of his blood vessels, then in order to achieve active longevity it is necessary to normalize the relationship in the adaptation-maladaptation-environment. Detailed study of hypertrophy and calcification of blood vessels is needed, since aging always reveals vascular wall thickening and stiffness increase.

The Relationship between Genito-Urinary Hæmorrhage and Diseases of the Vascular System

1933 ◽  
Vol 27 (1) ◽  
pp. 87-94
Author(s):  
A. Clifford Morson
Keyword(s):  
Blood Pressure ◽  
Urinary Tract ◽  
Blood Vessels ◽  
Vascular System ◽  
Arterial Disease ◽  
Vascular Lesion ◽  
Capillary Endothelium ◽  
Sudden Loss ◽  
The Relationship

The diseases of the vascular system which cause hæmorrhage from the genito-urinary tract are:— (1) Those in which changes are noted in the blood and capillary endothelium, and (2) Those in which alterations of a pathological nature are taking place in the walls of both large and small blood-vessels, but in which there is no change in the blood itself. In the first group are the purpuras; in the second arteriosclerosis, hyperpiesis and atheroma. This paper is confined to a discussion of the latter group of diseases in relation to genito-urinary hæmorrhage. Little attention has been paid to sudden loss of blood from the kidney, bladder, or genitalia in support of a diagnosis of a vascular lesion, other than angioma. Hæmorrhage in these cases may be purely renal, vesical, or penile. Investigations consist of examination of the superficial arteries, estimation of the blood-pressure, examination of the blood and cystoscopy. Surgical lesions must be excluded by the usual well-known methods. A careful record has been kept of fifteen cases of arteriosclerosis in which hæmorrhage from the genito-urinary tract has been the predominant manifestation of the disease. Details are given of nine patients with renal, one with vesical and three with urethral hæmorrhage. Two cases of thrombosis of the penis are also included. From a study of the literature here the cases of urethral hæmorrhage and thrombosis of the penis, recorded as due to arterial disease, appear to be unique.

Abstract P161: Blood Pressure And Vascular Stiffness With Increased Body Weight In Young People In The Aspect Of The Obesity Paradox

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Maria Evsevyeva ◽  
Michail Eremin ◽  
Maria Rostovtseva ◽  
Ilona Galkova ◽  
Victoria Kudrjavtseva ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Young People ◽  
Obesity Paradox ◽  
Vascular Stiffness ◽  
Stiffness Index ◽  
High Density Lipoproteins ◽  
Vascular Age ◽  
Diagnostic Complex ◽  
Relationship Of ◽  
The Relationship

Background: The relationship of arterial stiffness, which is marker of vascular age, with the main risk factors (RF) was studied mainly in adults and elderly. Purpose - to evaluate associations of various body mass (BM) with vascular stiffness, blood pressure (BP) and some other RF in young people. Material and Methods: Within the framework of the National Preventive Project "University Territory of Health", 264 students (93 boys and 171 girls) aged 18-25 years were evaluated for BP and profile of metabolic RF - total cholesterol (TC), low-density lipoproteins (LDL), triglycerides (TG), high-density lipoproteins (HDL) and glucose. Vascular stiffness was determined using cardio-ankle vascular index (CAVI), which was measured using diagnostic complex VaSera-1500 (Fucuda Denshi, Japan). Students were divided into groups according to BM-index: 1group - insufficient BM; 2 group - normal BM and 3 group - overweight. Data processing was performed using software package "Statistica 10.0" (StatSoft Inc, USA). Results: It turned out CAVI values in three observation groups, formed by BM indicator, in boys averaged 6.8 ±0.2, 5.9 ± 0.1 and 5.4 ± 0.1, and in girls - 6,1 ± 0,11, 5,9 ± 0,05 and 5,7 ±0,13. In boys, differences between groups on this indicator reached significant level (p = 0,032). At same time, systolic and diastolic BP from first to third group rose in boys by 9 and 2, and in girls - by 11 and 4 mm Hg. TC, LDL and TG also increased from first to third group in boys by 0.5, 0.4 and 0.5, and in girls - by 0.6, 0.7 and 0.65 mmol/l. HDL decreased in these groups in boys by 0.07, and in girls - by 0.37 mmol/l. The glucose level from first to third group increased by 0.12 in boys and 0.14 mmol/l in girls. Conclusion: A decrease in the vascular stiffness index CAVI was found among young people as their BM increased. It is noteworthy that in young people with an increased BM, positive changes in vascular rigidity occur in the presence of negative changes in hemodynamic and metabolic parameters, which are more significantly represented among girls. Further in-depth research is needed to clarify the mechanisms that regulate the relationship between metabolic status of young people and peculiarities of their vascular remodeling.

The state of the vascular system in the children and adolescents presenting with metabolic syndrome

2014 ◽  
Vol 60 (2) ◽  
pp. 8-12 ◽  
Author(s):  
N V Bolotova ◽  
N V Posokhova ◽  
E P Novikova ◽  
E G Dronova ◽  
E A Evseeva
Keyword(s):  
Metabolic Syndrome ◽  
Pulse Wave Velocity ◽  
Children And Adolescents ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Vascular System ◽  
Vascular Wall ◽  
The State ◽  
Simple Obesity ◽  
Maximum Rate Of Rise

It was studied the state of the vascular wall at metabolic syndrome (MS) in children and adolescents. The study included two groups of children: 45 people with MS and 25 patients with simple obesity. With the help of the device Vasotens assessed indicators of vascular stiffness: pulse wave velocity in the aorta, the indices of stiffness and augmentation of the peripheral arteries and the aorta, the maximum rate of rise in blood pressure. The study showed that 70% of children with MS increased arterial stiffness and thickness of the vascular wall. The rigidity of the vascular wall in children with MS revealed a 3.5 times more likely than children with simple obesity. Pulse wave velocity is a predictor of hypertension and has a high correlation with SDS IMT.

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