scholarly journals Nonlinear analysis of fluctuations of microcirculation parameters in symmetrical organs of humans by laser doppler flowmetry

2019 ◽  
Vol 17 (4) ◽  
pp. 33-38 ◽  
Author(s):  
L. V. Mezentseva
Keyword(s):  
Nonlinear Dynamics ◽  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Coefficient Of Variation ◽  
Correlation Dimension ◽  
The Body ◽  
Doppler Flowmetry ◽  
Average Value ◽  
Flow Fluctuations ◽  
The Right

Purpose– the study the nonlinear dynamics of microcirculation parameters in human symmetrical organs.Material and Methods. Parameters of microcirculation were measured in healthy volunteers (aged between 50 and 70 years) by means of laser Doppler flowmetry (LDF). LDF signal transducers were fixed symmetrically on the lower parts of the right and left shoulders (3 cm above the elbow bend). The degree of chaoticity of microcirculation parameters as a nonlinear dynamic process was estimated using Hausdorff’s index, relative entropy and characteristics of phase portraits. Along with components of the amplitude-and-frequency range for blood flow fluctuations (myogenic, neurogenic, respiratory, and cardiac) was estimated and correlations between all characteristics of microcirculation in both sides of the body were done.Results.Asymmetry of correlation relationships of nonlinear dynamics parameters and components of the amplitude-andfrequency range for blood flow fluctuations of right and left sides of the body was revealed. Hausdorff index in the left side correlated not only with the average value of perfusion and with the coefficient of variation in the same side (r1 = –0,68; r2 =–0,51), but also with correlation dimension of chaos in the opposite side (r=0,49). Similarly, entropy in the left side correlated not only with the average value of perfusion and coefficient of variation in the left (r1 =0,43; r2 =0,60), but also with the entropy and correlation dimension of chaos in the right side (r1 =0,48; r2 =–0,41). The neurogenic component in the left side positively correlated with the myogenic component in the same side (r=0,71). A positive correlation was observed between the neurogenic component in right side and myogenic component in the opposite side (r=0,57). Asymmetry of correlation relationships was also revealed for the respiratory and cardiac components.Conclusions. Our results illustrate the specific regulation of blood flow in micro vessels of paired organs, which is associated with functional asymmetry. The physiological mechanisms for this asymmetry require further experimental and clinical studies. 

scholarly journals Body Position Affects Capillary Blood Flow Regulation Measured with Wearable Blood Flow Sensors

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 436
Author(s):  
Andrey A. Fedorovich ◽  
Yulia I. Loktionova ◽  
Elena V. Zharkikh ◽  
Maria A. Mikhailova ◽  
Julia A. Popova ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Body Position ◽  
Blood Perfusion ◽  
The Body ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Postural Changes ◽  
Skin Blood Perfusion ◽  
The Right

In this study we demonstrate what kind of relative alterations can be expected in average perfusion and blood flow oscillations during postural changes being measured in the skin of limbs and on the brow of the forehead by wearable laser Doppler flowmetry (LDF) sensors. The aims of the study were to evaluate the dynamics of cutaneous blood perfusion and the regulatory mechanisms of blood microcirculation in the areas of interest, and evaluate the possible significance of those effects for the diagnostics based on blood perfusion monitoring. The study involved 10 conditionally healthy volunteers (44 ± 12 years). Wearable laser Doppler flowmetry monitors were fixed at six points on the body: two devices were fixed on the forehead, on the brow; two were on the distal thirds of the right and left forearms; and two were on the distal thirds of the right and left lower legs. The protocol was used to record three body positions on the tilt table for orthostatic test for each volunteer in the following sequence: (a) supine body position; (b) upright body position (+75°); (c) tilted with the feet elevated above the head and the inclination of body axis of 15° (−15°, Trendelenburg position). Skin blood perfusion was recorded for 10 min in each body position, followed by the amplitude–frequency analysis of the registered signals using wavelet decomposition. The measurements were supplemented with the blood pressure and heart rate for every body position analysed. The results identified a statistically significant transformation in microcirculation parameters of the average level of skin blood perfusion and oscillations of amplitudes of neurogenic, myogenic and cardiac sensors caused by the postural changes. In paper, we present the analysis of microcirculation in the skin of the forehead, which for the first time was carried out in various positions of the body. The area is supplied by the internal carotid artery system and can be of particular interest for evaluation of the sufficiency of blood supply for the brain.

scholarly journals Laser doppler flowmetry assessment of microcirculation in children of 6–7 years old

2021 ◽  
Vol 20 (3) ◽  
pp. 46-53
Author(s):  
V. I. Kozlov ◽  
V. N. Sakharov ◽  
O. A. Gurova ◽  
V. V. Sidorov
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Lower Limbs ◽  
Doppler Flowmetry ◽  
Flow Modulation ◽  
Left Hand ◽  
Flow Fluctuations ◽  
Ongoing Development

Introduction. The state of the blood flow within the capillaries and close blood vessels is highly important in practice for the revealing of pathogenetic mechanisms of both systemic and local circulatory disorders. Aim of the study was to define the parameters of microcirculation and the level of blood flow fluctuations (flux) in the distal segments of upper and lower limbs (in fingers of hands and toes of feet) in children of 6–7 years old; and to describe the possible differences in the mechanisms of blood flow modulation in boys and girls. Materials and methods. Skin microcirculation was assessed in middle fingers of hands and great toes of feet in children of 6-7 years old (14 girls and 7 boys in prone position) by means of laser doppler flowmetry. Results. The ranges for parameters of microcirculation (PM) for distal segments of upper and lower limbs in children of mentioned age group were defined, also it was shown that the PM are significantly lower in the lower limbs comparing to those of the upper limbs (both in groups of girls and boys). Asymmetry of PM in the feet was not found; the features of right hand-left hand asymmetry for PM in girls and boys are described. The analysis of modulation of blood flow fluctuations (fluxmotions) of different frequencies showed the profound role of vasomotor (myogenic) rhythm for regulation of microcirculation. Conclusion. Increased neurogenic influences on the modulation of fluxmotions in girls of 6-7 years old may be an evidence of the ongoing development of the mechanisms of blood flow regulation, particularly the association with the growth rate of girls is possible.

scholarly journals Investigation of changes in the skin blood microcirculation when performing the hatha yoga breathing technique

2022 ◽  
Vol 20 (4) ◽  
pp. 33-44
Author(s):  
A. V. Frolov ◽  
Yu. I. Loktionova ◽  
E. V. Zharkikh ◽  
V. V. Sidorov ◽  
A. I. Krupatkin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Circulatory System ◽  
Low Frequency ◽  
Brain Perfusion ◽  
The Body ◽  
Laser Doppler ◽  
Regulatory Mechanisms ◽  
Doppler Flowmetry ◽  
Breathing Exercises

Introduction. Yoga breathing exercises improve the ability to significantly reduce the respiratory rate. A decrease of the minute respiration volume results in compensatory reactions of the microcirculatory bed caused by changes in the gas composition. The reaction of the regulatory mechanisms of the microvascular bed can be evaluated by the optical non-invasive laser Doppler flowmetry method. The aim of the study was to assess the tissue microcirculation parameter changes in people performing yoga breathing exercises. Materials and methods. 25 volunteers performed yoga breathing exercises at a frequency of 3 times per minute, 2 times per minute, 1.5 times per minute, 1 time per minute for 5 minutes, and free breathing for 6 minutes before and after breathing exercises. Parameters aimed to defin the reaction of skin microcirculation in different body areas were simultaneously recorded in six sites by laser Doppler flowmetry using a distributed system of wearable analyzers. The parameters of tissue microcirculation recorded by the method of laser Doppler flowmetry were: the index of microcirculation (Im), nutritive blood flow (Imn), the amplitude of myogenic (Am), neurogenic (An), endothelial (Ae), respiratory (Ar) and cardiac (Ac) regulation circuits. Results. Yoga breathing exercises led to increase of microcirculation index at all breathing frequencies. Breathing at a frequency of 1.5 and 1/minute leads to a significant increase in nutritional blood flow. Low-frequency breathing exercises lead to an increase in blood pressure at the lowest breathing rates – 1.5/minute and 1/minute. The most significant changes were achieved at the lowest respiration rates (1 and 1.5/minute), that could be associated with hypoxic-hypercapnic mechanisms. Conclusion. The absence of significant changes in microcirculation parameters after low-frequency respiration during measurements in the supraorbital arteries in both groups characterizes the work of homeostatic mechanisms for maintaining brain perfusion in stressful situations for the body (low-frequency types of respiration, hypercapnia and hypoxia). When measured in the extremities, a change in the effect of the circulatory system regulatory mechanisms was observed; along with an increase in skin perfusion and the nutritional component, it can characterize the compensatory reaction of the microcirculation to respiration change.

scholarly journals Specificity of manifestation of functional asymmetry microcirculation parameters at physical loads on the upper limbs

2019 ◽  
Vol 18 (4) ◽  
pp. 37-44
Author(s):  
L. V. Mezentseva
Keyword(s):  
Blood Flow ◽  
Standing Position ◽  
Functional Asymmetry ◽  
Upper Limbs ◽  
Initial State ◽  
Doppler Flowmetry ◽  
Flow Fluctuations ◽  
Left And Right ◽  
Specific Regulation ◽  
The Right

Purpose – the study the functional asymmetry of oscillatory processes of microcirculatory bed at physical loads on the upper limbs.Material and methods. Microcirculation parameters were measured in 5 healthy volunteers (men aged 50–55 years) by laser Doppler flowmetry (LDF). LDF signal sensors were fixed symmetrically on the lower parts of the right and left shoulders (3 cm above the elbow bend). Physical exercise consisted of machs left or right hand in the standing position for 1 min. Measurements were performed in 3 conditions: 1 – initial state, 2 – immediately after exercise, 3 – 5 min after load termination The changes in the mean perfusion value and the components of the amplitude-frequency spectrum of blood flow fluctuations (myogenic, neurogenic, respiratory and cardiac), as well as the correlation between the changes in all parameters of the right and left sides of the observation were evaluated.Results. Asymmetry of changes in microcirculation parameters and correlations between them under the physical loads on the upper limbs was revealed. It is shown that both left and right machs change the microcirculation parameters of both the left and right sides, and the changes on the left are more pronounced than on the right. It is shown that after the left machs the blood flow on the left and right increases, and after the right machs – reduced. After loads the right side is recovering more slowly than the left.Conclusions. Our results illustrate the specific regulation of blood flow in micro vessels of paired organs, which is associated with functional asymmetry. The physiological mechanisms for this asymmetry require further experimental and clinical studies.

Peculiarities of microcirculation in periodont tissues in children of key age groups sufficient type 1 diabetes. Part II

2019 ◽  
Vol 24 (2) ◽  
pp. 108-119 ◽  
Author(s):  
B. N. Davydov ◽  
D. A. Domenyuk ◽  
S. V. Dmitrienko
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Diabetic Microangiopathy ◽  
Healthy Children ◽  
Doppler Flowmetry

Relevance. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders. Identifcation of microcirculation features of the blood by the method of laser Doppler flowmetry in children with different experience of type 1 diabetes in key age categories.Materials and methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler flowmetry using a laser analyzer for capillary blood flow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood flow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac fluctuations, low efciency and redistribution of blood flow in favor of the nutritive link.Conclusions. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early – compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late – decompensation with passive adaptation, supporting the effectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outflow.

Using reactive hyperemia to investigate the effect of cupping sizes of cupping therapy on skin blood flow responses

2021 ◽  
pp. 1-7
Author(s):  
Xiangfeng He ◽  
Xueyan Zhang ◽  
Fuyuan Liao ◽  
Li He ◽  
Xin Xu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Skin Blood Flow ◽  
Repeated Measures ◽  
Recovery Time ◽  
Reactive Hyperemia ◽  
Cupping Therapy ◽  
Doppler Flowmetry ◽  
Healthy Participants ◽  
Hyperemic Response

BACKGROUND: Various cupping sizes of cupping therapy have been used in managing musculoskeletal conditions; however, the effect of cupping sizes on skin blood flow (SBF) responses is largely unknown. OBJECTIVE: The objective of this study was to compare the effect of three cupping sizes of cupping therapy on SBF responses. METHODS: Laser Doppler flowmetry (LDF) was used to measure SBF on the triceps in 12 healthy participants in this repeated measures study. Three cup sizes (35, 40 and 45 mm in diameter) were blinded to the participants and were tested at -300 mmHg for 5 minutes. Reactive hyperemic response to cupping therapy was expressed as a ratio of baseline SBF. RESULTS: All three sizes of cupping cups resulted in a significant increase in peak SBF (p< 0.001). Peak SBF of the 45 mm cup (9.41 ± 1.32 times) was significantly higher than the 35 mm cup (5.62 ± 1.42 times, p< 0.05). Total SBF of the 45 mm cup ((24.33 ± 8.72) × 103 times) was significantly higher than the 35 mm cup ((8.05 ± 1.63) × 103 times, p< 0.05). Recovery time of the 45 mm cup (287.46 ± 39.54 seconds) was significantly longer than the 35 mm cup (180.12 ± 1.42 seconds, p< 0.05). CONCLUSIONS: Our results show that all three cup sizes can significantly increase SBF. The 45 mm cup is more effective in increasing SBF compared to the 35 mm cup.

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