scholarly journals Use of the synthetic muramyl dipeptide for efficient induction of collagen arthritis and in vitro induction of a monokine, T cell activating factor

Ensho ◽  
1981 ◽  
Vol 1 (2) ◽  
pp. 200-207
Author(s):  
Toshitaka Koga ◽  
Hideaki Iribe
Keyword(s):  
T Cell ◽  
Muramyl Dipeptide ◽  
Collagen Arthritis ◽  
Efficient Induction ◽  
In Vitro Induction

scholarly journals Induction of acetylcholine receptor-specific suppression. An in vitro model of antigen-specific immunosuppression in myasthenia gravis.

1984 ◽  
Vol 159 (1) ◽  
pp. 292-304 ◽  
Author(s):  
S Bogen ◽  
E Mozes ◽  
S Fuchs
Keyword(s):  
T Cell ◽  
Myasthenia Gravis ◽  
Clinical Importance ◽  
Lymphocyte Transformation ◽  
Specific Suppression ◽  
Target Autoantigen ◽  
High Concentrations ◽  
In Vitro Induction

This report describes the in vivo and in vitro induction of murine (AChR)-specific suppressor T cells (Ts) and T cell factors (TsF), and the development of an appropriate assay system for their measurement. The assay described is based on the in vitro Mishell-Dutton culture system. Using this assay, it was shown that the AChR-specific helper cell is an Lyt-2- radiosensitive T cell. Moreover, the proliferating cell measured in the lymphocyte transformation assay was shown to provide AChR-specific T cell help. In vivo induction of Ts cells is achieved by injection of soluble AChR; potent AChR-specific suppression is found in the spleen 1 wk later. In vitro induction of Ts cells involves the primary education of naive splenocytes by culturing them with high concentrations of AChR. Both the in vivo- and in vitro-induced Ts cells were shown to secrete AChR-specific factors that mediate their suppressive effects. The possibility of specifically suppressing the AChR-immune response may be of a particular clinical importance since the AChR is the target autoantigen in the neuromuscular autoimmune disease myasthenia gravis.

scholarly journals An arthritogenic lymphokine in the rat.

1985 ◽  
Vol 162 (5) ◽  
pp. 1531-1545 ◽  
Author(s):  
S M Helfgott ◽  
R Dynesius-Trentham ◽  
E Brahn ◽  
D E Trentham
Keyword(s):  
T Cells ◽  
T Cell ◽  
Knee Joint ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Effector Mechanism ◽  
Collagen Arthritis

A type II collagen-specific arthritogenic lymphokine has been identified in the rat. Arthritogenic factor (AF) is a 65 kD protein generated in vitro by T cells from rats with collagen arthritis, and it induces an erosive, proliferative synovitis when injected into the knee joint of syngeneic naive recipients. Complement does not appear to be required. These data identify a potential T cell-mediated effector mechanism in this model, and suggest that AF may function in other inflammatory synovial diseases.

Efficient Induction of Human CD4 T Cell Lines Reactive with a Self-K-ras-Derived Peptide In Vitro, Using a mAb to CD29

1998 ◽  
Vol 59 (6) ◽  
pp. 343-351 ◽  
Author(s):  
Yoshihiko Tanaka ◽  
Michio Ogawa ◽  
Yasuharu Nishimura ◽  
Sho Matsushita
Keyword(s):  
T Cell ◽  
Cell Lines ◽  
Cd4 T Cell ◽  
Efficient Induction ◽  
T Cell Lines

Histamine inhibition of the in vitro induction of cytotoxic T-cell responses

1980 ◽  
Vol 2 (3) ◽  
pp. 179-190 ◽  
Author(s):  
Anthony Schwartz ◽  
Philip W. Askenase ◽  
Richard K. Gershon
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cytotoxic T Cell ◽  
Cell Responses ◽  
Cytotoxic T Cell Responses ◽  
In Vitro Induction

scholarly journals Two Distinct T Cell Subsets, CD4+and CD8+CD60+, and Their Cytokines Are Required for In Vitro Induction of Human Ragweed-Specific Memory IgE Responses

2008 ◽  
Vol 181 (7) ◽  
pp. 4761-4769 ◽  
Author(s):  
Tamar A. Smith-Norowitz ◽  
Jonathan Silverberg ◽  
Kevin B. Norowitz ◽  
Martin H. Bluth ◽  
Seto Chice ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Subsets ◽  
Specific Memory ◽  
In Vitro Induction

scholarly journals Efficient induction of collagen arthritis by the use of a synthetic muramyl dipeptide

1980 ◽  
Vol 23 (9) ◽  
pp. 993-997 ◽  
Author(s):  
Toshitaka Koga ◽  
Shigeru Sakamoto ◽  
Kauro Onoue ◽  
Shozo Kotani ◽  
Akinobu Sumiyoshi
Keyword(s):  
Muramyl Dipeptide ◽  
Collagen Arthritis ◽  
Efficient Induction
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