scholarly journals Akut REM Uyku Yoksunluğu Oluşturulan Sıçanlarda Uzun dönem Ilımlı Egzersizin Depresif/Anksiyete Benzeri Davranış Üzerine Etkisi

2018 ◽  
Vol 6 (11) ◽  
pp. 1640
Author(s):  
Leyla Şahin
Keyword(s):  
Physical Exercise ◽  
Sleep Deprivation ◽  
Open Field ◽  
Rem Sleep ◽  
Elevated Plus Maze ◽  
Rem Sleep Deprivation ◽  
Elevated Plus Maze Test ◽  
Deprivation Group ◽  
Plus Maze ◽  
Internal And External Factors

Sleep is a physiological process that influenced by internal and external factors and brain is as active as waking in certain periods. REM sleep is demonstrated in the literature that provides psychological relaxation due to more frequent occurrence of psychiatric disorders in sleep deprivation and causes depression / anxiety-like situations. There are studies in the literature indicate that physical exercise may be useful on depressive / anxiety. However, the duration and physical severity of the physical exercise and sleep deprivation affects the results. For this reason, we investigated the effect of long-term exercise on depression / anxiety behavior on acute REM sleep deprived rats. Rats were divided into control (C), exercise (E), REM sleep deprivation (SD) and exercise + REM sleep deprivation (E + SD) (n = 7). For developing REM sleep deprivation, rats were kept in a sleep deprivation tank during a 48-hour period. Exercise was performed with treadmill for 15, 30, 45 and 60 minutes for 4 weeks. Depressive / anxiety behaviors were assessed with open field and elevated plus maze tests. It has been shown that the sleep deprivation group takes less distance in the open field test. It was observed that in the elevated plus maze test, the rats in the sleep deprivation group spent less time on the open-arm compared to the other groups, and the number of entries and exits in this group also decreased. Behavioral test findings show that depressive / anxiety-like effects of sleep deprivation are reduced by moderate treadmill exercise.

Neuropharmacological Activity of Various Fractions Obtained from Solanum aethiopicum (Linn.) Fruit in Mice.

2020 ◽  
Vol 1 (5) ◽  
pp. 12-23
Author(s):  
A.R. Abubakar ◽  
◽  
I.H. Sani ◽  
S. Malami ◽  
A.H. Yaro ◽  
...  
Keyword(s):  
Open Field ◽  
Elevated Plus Maze ◽  
Toxicity Testing ◽  
Aqueous Fraction ◽  
Solanum Aethiopicum ◽  
Elevated Plus Maze Test ◽  
Board Test ◽  
Plus Maze ◽  
Hole Board ◽  
Hole Board Test

Background: Solanum aethiopicum (L.), family Solanaceae, is known as garden eggs. The fruit is used in the treatment of insomnia, diabetes and constipation. Objective: The aim of this study was to evaluate anxiolytic-like activity of fractions obtained from crude methanol extract of Solanum aethiopicum fruit. Method: Acute toxicity testing was conducted according to the OECD guidelines 420 via oral and intraperitoneal routes (ip). n-Hexane (HF), chloroform (CHF), ethyl-acetate (EAF), n-butanol (BF) and residual aqueous fraction (RAF) at doses of 25, 50 and 100 mg/kg ip were experimented using the open field, elevated plus maze, staircase, light dark box and hole-board tests. Results: Results: In open field test, there was statistically significant increase in frequency of central square entry by EAF 25mg/kg, 50mg/kg and 100mg/kg and RAF 25mg/kg, 50mg/kg and 100mg/kg all at p<0.05 compared to distilled water (D/W) group. Elevated plus maze test showed statistically significant increases in open arm entry and duration by CHF 25mg/kg, RAF 25mg/kg and 50mg/kg again at p<0.05. Also, in the staircase test, statistically significant decrease in frequency of rearing with no effect on step climbing was observed by RAF 25mg/kg (p< 0.05) compared to D/W. Light and dark box test produced increased light box entry and duration by EAF 25mg/kg, RAF 25mg/kg and 50mg/ kg at p<0.05. Furthermore, the hole -board test showed statistically significant increases in number of head dips by EAF 50mg/kg and 100mg/kg as well as RAF 25mg/kg, 50mg/kg and 100 mg/kg at p<0.05. Conclusion: The fractions obtained from Solanum aethiopicum fruits possesses anxiolytic-like activity.

scholarly journals Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models

Dose-Response ◽  
2019 ◽  
Vol 17 (4) ◽  
pp. 155932581989126 ◽  
Author(s):  
Hafiz Muhammad Asif ◽  
Abdul Hayee ◽  
Muhammad Rahil Aslam ◽  
Khalil Ahmad ◽  
Abdul Sattar Hashmi
Keyword(s):  
Open Field ◽  
Elevated Plus Maze ◽  
Tail Suspension Test ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Hydroalcoholic Extract ◽  
Elevated Plus Maze Test ◽  
Plus Maze ◽  
Immobility Time ◽  
Dose Dependent

The present work was carried out to assess the Onosma bracteatum anxiolytic and antidepressant properties. Swiss albino mice (male) were fed orally with hydroalcoholic extract at different doses 50, 100, and 200 mg 1 hour prior to test with the standard diazepam and fluoxetine. Anxiolytic and antidepressant activities were evaluated by using open field, elevated plus maze, force swimming, and tail suspension test. Results of open field test showed an increase in number of line crossing as well as number of rearing in dosage-dependent design. Although results of elevated plus maze test evidently showed antianxiety effect of O bracteatum by increasing the time spent in open arms along with decreasing the time spent in closed arms in dosage-dependent way. For the evaluation of antidepressant effect, O bracteatum diminished the immobility time and expanded mobility time in forced swim model in dosage-dependent way. Likewise, O bracteatum expanded time span of mobility along with diminished immobility time in tail suspension method in dosage-dependent way. Outcome demonstrated that plant at the dose of 200 mg/kg body weight showed significant potential which was similar to that standard diazepam and fluoxetine. Hence, O bracteatum may be used as potent natural psychotherapeutic agent against the mental disorders.

scholarly journals The Effect of REM Sleep Deprivation on mTOR Signaling-Induced by Severe Physical Exercise

2019 ◽  
Vol 6 (4) ◽  
Author(s):  
Sarah Mahboubi ◽  
Mohammad Nasehi ◽  
Alireza Imani ◽  
Mitra-Sadat Sadat-Shirazi ◽  
Mohammad-Reza Zarrindast ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Sleep Deprivation ◽  
Rem Sleep ◽  
Mtor Signaling ◽  
Rem Sleep Deprivation

Anxiogenic effect of sleep deprivation in the elevated plus-maze test in mice

2004 ◽  
Vol 176 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Regina H. Silva ◽  
Sonia R. Kameda ◽  
Rita C. Carvalho ◽  
Andr� L. Takatsu-Coleman ◽  
Suzy T. Niigaki ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Elevated Plus Maze ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Anxiogenic Effect ◽  
Plus Maze

scholarly journals Anxiolytic activity of aerial part hydroethanolic extract of Allium ascalonicum Linn. (Liliaceae) in mice

2012 ◽  
Vol 2 (11) ◽  
pp. 448 ◽  
Author(s):  
Abidemi J. Akindele ◽  
Hakeem A. Sanni ◽  
Pamela C. Edeh
Keyword(s):  
Social Interaction ◽  
Open Field ◽  
Aerial Part ◽  
Elevated Plus Maze ◽  
Anxiolytic Activity ◽  
Elevated Plus Maze Test ◽  
Plus Maze ◽  
Hole Board ◽  
Hole Board Test ◽  
Hydroethanolic Extract

Background: Allium ascalonicum Linn. (Liliaceae) is a mildly aromatic annual herb used to flavor food. Ethnobotanical survey revealed application of A. ascalonicumin the treatment of central nervous system (CNS) disorders.  Objective: To investigate the anxiolytic activity of aerial part hydroethanolic extract of A. ascalonicum. Methods: The hole-board, elevated plus maze, light/dark exploration, open field and social interaction tests were used in this study. Groups of mice were treated orally with distilled water (10 ml/kg), diazepam (1 mg/kg), and A. ascalonicum (50-400 mg/kg). Evaluations were done 1 h post-treatment and the duration of observation was mostly 5 min. In the hole-board test, mice were observed for number/duration of head dips and number of sectional crossings. In the elevated plus maze test, the time spent in the open/closed arms and the number of entries by mice were observed. In the light/dark exploration test, the latency of entry into the dark box, time spent in the light and dark compartments, number of rearing and assisted rearing were determined. In respect of the open field test, observations were made for the number of rearing, assisted rearing, and sectional crossings. In the social interaction test, pairs of mice were observed for number of interactions including sniffing, following, and partner grooming. Results: In the hole-board test, A. ascalonicum significantly (p<0.05, 0.01) increased the number/duration of head dips and number of sectional crossings. In the elevated plus maze test, A. ascalonicum significantly (p<0.05) increased the number of entries into the open arm with corresponding reduction in number of entries into the closed arm. In the light/dark exploration test, A. ascalonicum significantly (p<0.05, 0.01) increased the latency of entry into the dark box, time spent in the light box, and number of rearing and assisted rearing. In respect of the open field test, A. ascalonicum significantly (p<0.05, 0.01) increased the number of sectional crossings and rearing. Considering the social interaction test, A. ascalonicum significantly (p<0.05) increased the number of interactions. Peak anti-anxiety effects were mostly observed at the dose of 100 mg/kg. Conclusion: The aerial part hydroethanolic extract of Allium ascalonicum possesses anxiolytic properties. Keywords: Allium ascalonicum, Liliaceae, anxiolytic activity, medicinal plants, traditional medicine.

scholarly journals Behavioural and neurochemical characterisation of the anxiolytic properties of an aqueous extract of Dysphania ambrosioides (L.) Mosyakin and Clemants (Chenopodiaceae) in experimental mice

2021 ◽  
Vol 14 (03) ◽  
pp. 265-276
Author(s):  
Bigued ◽  
Germain Sotoing Taiwe ◽  
Jacqueline Stephanie Kameni Njapdounke ◽  
Joseph Ngaibi ◽  
Yvette Nguezeye ◽  
...  
Keyword(s):  
Open Field ◽  
Aqueous Extract ◽  
Mechanism Of Action ◽  
Elevated Plus Maze ◽  
Aqueous Extracts ◽  
Gaba Concentration ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Brain Gaba

Ethnopharmacological relevance: Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae) is a medicinal plant known for its anxiolytic, antidepressant and anticonvulsant activities in Cameroonian folk medicine. Aim of the study: The aim of this work is to evaluate the anxiolytic effects of Dysphania ambrosioides aqueous extracts and investigate its mechanism of action. Materials and methods: Elevated plus maze test and open field test were used for detecting it anxiolytic properties. The possible mechanism of action of the aqueous extracts were investigated after pretreatment of animals with different antagonists of GABAA complex receptors (5 mg/kg N-methyl-β-carboline-3-carboxamide, 4 mg/kg flumazenil or 2 mg/kg bicuculline) 30 minutes prior to the oral administration of 370 mg/kg Dysphania ambrosioides aqueous extract. Results: Dysphania ambrosioides increased the percentage of entries into and percentage of time in open arms, and reduced rearing, head dipping, and percentage of time in closed arms, in the elevated plus maze. It reduced rearing and defecation, and increased crossing, in the open field. In addition, anxiolytic-like properties of Dysphania ambrosioides were blocked by different antagonists of GABAA complex receptors (N-methyl-β-carboline-3-carboxamide, flumazenil or bicuculline) as examined in elevated plus maze test. Finally, the activity of GABA-T activity was inhibited and the brain GABA concentration was increased by the extracts, respectively. Conclusion: These results suggest that Dysphania ambrosioides possess anxiolytic-like properties in mice that might involve an action on benzodiazepine and/or GABA sites in the GABAA receptor complex or by modulating brain GABA concentration in the central nervous system.

scholarly journals A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals

2021 ◽  
Vol 10 (4) ◽  
pp. 624
Author(s):  
Dimitris Tsoukalas ◽  
Ovidiu Zlatian ◽  
Mihaela Mitroi ◽  
Elisavet Renieri ◽  
Aristidis Tsatsakis ◽  
...  
Keyword(s):  
Open Field ◽  
Field Test ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Centella Asiatica ◽  
The Elderly ◽  
Dependent Manner ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

Ageing is a genetically programmed physiological process that is modulated by numerous environmental factors, associated with decreasing physiological function, decreasing reproductive rate and increasing age-related mortality rate. Maintaining mobility performance and physical function in the elderly is the main objective of the successful ageing concept. In this study, we aimed to evaluate the beneficial effect of a novel nutraceutical formulation containing Centella asiatica L. extract, vitamin C, zinc and vitamin D3 (as cholecalciferol) on motor activity and anxiety with the use of a murine model of old animals, as a means of providing proof for clinical use in the elderly, for enhancing physical strength and improving life quality. Eighteen Sprague Dawley 18 months old male rats were divided into three groups and received corn oil (the control group) or 1 capsule/kg bw Reverse supplement (treatment group 1) or 2 capsules/kg bw Reverse supplement (treatment group 2), for a period of 3 months. The Reverse supplement (Natural Doctor S.A, Athens, Greece) contains 9 mg Centella asiatica L. extract, vitamin C (200 mg as magnesium ascorbate), zinc (5 mg as zinc citrate), vitamin D3 (50 µg as cholecalciferol) per capsule. Before and after the treatment, the motor function and behavioral changes for anxiety and depression were evaluated using the open-field test, elevated plus-maze test and rotarod test. The supplementation with Reverse (Natural Doctor S.A) supplement can improve the locomotor activity in old rats in a dose-dependent manner, as demonstrated by an increase in the latency to leave from the middle square, in the number of rearings in the open field test, in the time spent in the open arms and time spent in the center in the elevated plus-maze test and the latency to all in all three consecutive trials in the rotarod test. Stress also decreased significantly in a dose-dependent manner, following the treatment with Reverse supplement, as was demonstrated by the decrease in the number of groomings at the open field test and time spent in the dark and the number of groomings at the elevated plus-maze test.

scholarly journals GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice

2013 ◽  
Vol 4 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Divya Anchan ◽  
Sara Clark ◽  
Kevin Pollard ◽  
Nandini Vasudevan
Keyword(s):  
Open Field ◽  
Field Test ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Female Mice ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze
Sign in / Sign up

Export Citation Format

Share Document