scholarly journals Effectiveness of photodynamic therapy of a patient with early central lung cancer and cystic fibrosis

2019 ◽  
Vol 8 (3) ◽  
pp. 43-45
Author(s):  
E. S. Borzenko ◽  
I. V. Reshetov ◽  
A. S. Fatyanova ◽  
K. V. Ogdanskaya ◽  
M. M. Gafarov ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cystic Fibrosis ◽  
Photodynamic Therapy ◽  
Energy Density ◽  
Power Density ◽  
Clinical Effect ◽  
Clinical Observation ◽  
Complete Regression ◽  
Dynamic Observation

The authors describe a clinical observation with full clinical effect after multi-course photodynamic therapy of a patient with central lung cancer and cystic fibrosis using Photoditazine. Photoditazine was administered intravenously at a dose of 0.8 mg/kg 2 hours before the irradiation session. Irradiation parameters: power density – 150 mW/cm2, energy density – 200 J/cm2. In total, 3 courses of photodynamic therapy were performed. As a result of the treatment, a complete regression of the tumor was noted. The patient has been under dynamic observation for 2 years after treatment, no relapse was observed.

Clinical observation of next-generation photodynamic therapy (NGPDT) for advanced non-small cell lung cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e19028-e19028
Author(s):  
Li Jun Li
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Clinical Observation ◽  
Lung Tumor ◽  
Remission Rate ◽  
Small Cell ◽  
Next Generation ◽  
Small Cell Lung

e19028 Background: Clinical observation of next-generation photodynamic therapy (NGPDT) for advanced non-small cell lung cancer (NSCLC). Methods: Through pathology or cytology diagnosis, 66 cases of advanced non-small cell lung cancer patients were selected and randomly divided into two groups. The Next Generation Photodynamic Therapy (NGPDT) group had 32 patients. Photosensitizer was administered on a dosage of 2 mg per kilogram of body weight, wherein two-thirds via ultrasonic atomization inhalation and one-third via oral intake. After the irradiation target(s) were determined, optical fiber for laser treatment purposes was guided into lung tumor(s) via interstitial procedure, percutaneous puncture under precious laser navigation, irradiation light intensity was 200 J/cm2, irradiation power was 1,000 mw, activation was then started and lasted for eight to ten minutes, laser irradiation into tumor was two to five centimeters in length, irradiation could be performed phase by phase (sub-paragraph treatment) based on tumor size or irradiations could be performed repeatedly. While in the mean time in the chemotherapy/radiotherapy group (external beam radiotherapy + whole body chemotherapy) 34 cases were observed, 15 MV X ray radiation therapy irradiation field covers primary lung tumor lesion(s) and mediastinal lymphatic drainage area, dosage was 65-70 Gy, on every first day in a week of radiotherapy, 20 mg cisplatin was administered via intravenous application. Results: In the NGPDT group and simultaneous radiotherapy/chemotherapy group, one and two years survival rate were 93.75%, 70.60% and 68.75, 32.35% respectively (P <0.05). The complete remission rate and partial remission rate were 56.20% and 21.30%, rate of the NGPDT group was significantly higher than that of the corresponding radiotherapy and chemotherapy group, the difference was statistically significant (P <0.05). Conclusions: NGPDT can prolong survival in patients with advanced NSCLC, improving their quality of life; it is one of the most effective measures for advanced non-small cell lung cancer treatment.

scholarly journals Analysis of the short-term effect of photodynamic therapy on primary bronchial lung cancer

2020 ◽  
Author(s):  
Cunzhi Lin ◽  
Yuanyuan Zhang ◽  
Qian Zhao ◽  
Pingping Sun ◽  
Zhe Gao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Tumor Cells ◽  
Nuclear Membrane ◽  
Clinical Effect ◽  
Chest Ct ◽  
Apoptotic Cells ◽  
Short Term ◽  
Intercellular Substance ◽  
Number Of Cells

Abstract To analyze the short-term clinical effect of photodynamic therapy on bronchial lung cancer and provide relevant practical experience for its better application in clinical practice. Twenty patients with bronchial lung cancer diagnosed by pathology were treated with photodynamic therapy or interventional tumor reduction combined with photodynamic therapy. Follow-up at 3 months after treatment, the chest CT and bronchoscopy were reexamined. The lesions were observed under a microscope, and the pathological specimens of living tissues were stained with HE and TUNEL to evaluate the short-term clinical effect. The volume of the tumor in the trachea or bronchus was smaller than before and the obstruction improved after the PDT from the chest CT. We could conclude that after PDT, the tumor volume was reduced and the pathological tissue appeared necrotic, the surface was pale, and the blood vessels were fewer while compared with before, and less likely to bleed when touched from the results of the bronchoscopy. HE staining showed that before treatment, there were a large number of tumor cells, closely arranged and disordered, or agglomerated and distributed unevenly. The cell morphology was not clear and the sizes were various with large and deeply stained nucleus, and the intercellular substance was less. After treatment, the number of tumor cells decreased significantly compared with before and the arrangement was relatively loose and orderly. The cells were roughly the same size; the intercellular substance increased obviously and showed uniform staining. The nuclei morphology was incomplete and fragmented, and tumor cells were evenly distributed among the intercellular substance. TUNEL staining showed that the number of cells was large and the nucleus morphology was regular before treatment; the nuclear membrane was clear and only a small number of apoptotic cells could be seen. However, the number of cells decreased and arranged loosely after treatment, with evenly stained cytoplasm. The nuclear morphology was irregular and the nuclear membrane cannot be seen clearly. Apoptotic cells with typical characteristics such as karyopyknosis, karyorrhexis, and karyolysis were common. Photodynamic therapy for bronchial lung cancer can achieve a satisfactory short-term clinical treatment effect and improve the life quality of patients, but the long-term clinical effect remains to be further studied.

scholarly journals Photodynamic therapy in patients with skin metastases of disseminated melanoma

2019 ◽  
Vol 8 (1) ◽  
pp. 24-28
Author(s):  
D. A. Tzerkovsky ◽  
N. A. Petrovskaya ◽  
A. N. Mazurenko
Keyword(s):  
Quality Of Life ◽  
Photodynamic Therapy ◽  
Semiconductor Laser ◽  
Power Density ◽  
Tumor Volume ◽  
Complete Regression ◽  
Skin Melanoma ◽  
Who Criteria

The aim of the study was to evaluate the immediate results of photodynamic therapy (PDT) in patients with intradermal metastases of skin melanoma. The study included 50 patients who received treatment at the department of hyperthermia and photodynamic therapy. The study included 23 (46%) men and 27 (54%) women with an average age of 60.7±10.4 years. PDT of tumors was carried out 3–4 hours after intravenous administration of a chlorine-based photosensitizer (Photolon) in doses of 1.5–3 mg/kg using a semiconductor laser «UPL-PDT» (Lemt, Belarus, λ=660±5 nm). The exposure doses varied from 100 to 400 J/cm2; power density – from 0.2 to 0.9 W/cm2; power – from 0.25 to 1 W and time of PDT of one focus was dependent on the size and location of the tumor and was 5 to 20 minutes. Evaluation of antitumor efficacy of PDT was carried out according to WHO criteria. The terms of follow-up of patients were between 3 and 23 months. At follow-up observation, 1–3 months after the treatment, complete regression of intradermal metastases of skin melanoma was achieved in 9 (18%) patients, partial – in 28 (56%), process stabilization in 8 (16%) and progression in 5 (10%)) patients. The objective effect was achieved in 74% of patients, the therapeutic – in 90%. PDT can be used in the treatment of intradermal metastases of disseminated skin melanoma with palliative purposes and allows reducing the tumor volume, which significantly improves the quality of life of patients.

Endoscopic photodynamic therapy for Stage I lung cancer

1995 ◽  
Vol 16 (Supplement) ◽  
pp. 511-512
Author(s):  
Yoji Ishii ◽  
Michimaro Ejiri ◽  
Takuro Tsukube ◽  
Kiyoko Hirano ◽  
Sumio Nishi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Stage I ◽  
Stage I Lung Cancer

scholarly journals Na0.76V6O15/Activated Carbon Hybrid Cathode for High-Performance Lithium-Ion Capacitors

Materials ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 122
Author(s):  
Renwei Lu ◽  
Xiaolong Ren ◽  
Chong Wang ◽  
Changzhen Zhan ◽  
Ding Nan ◽  
...  
Keyword(s):  
Activated Carbon ◽  
Energy Density ◽  
Power Density ◽  
Cathode Materials ◽  
Low Cost ◽  
Lithium Ion ◽  
High Energy ◽  
Cycling Stability ◽  
High Energy Density ◽  
Artificial Graphite

Lithium-ion hybrid capacitors (LICs) are regarded as one of the most promising next generation energy storage devices. Commercial activated carbon materials with low cost and excellent cycling stability are widely used as cathode materials for LICs, however, their low energy density remains a significant challenge for the practical applications of LICs. Herein, Na0.76V6O15 nanobelts (NaVO) were prepared and combined with commercial activated carbon YP50D to form hybrid cathode materials. Credit to the synergism of its capacitive effect and diffusion-controlled faradaic effect, NaVO/C hybrid cathode displays both superior cyclability and enhanced capacity. LICs were assembled with the as-prepared NaVO/C hybrid cathode and artificial graphite anode which was pre-lithiated. Furthermore, 10-NaVO/C//AG LIC delivers a high energy density of 118.9 Wh kg−1 at a power density of 220.6 W kg−1 and retains 43.7 Wh kg−1 even at a high power density of 21,793.0 W kg−1. The LIC can also maintain long-term cycling stability with capacitance retention of approximately 70% after 5000 cycles at 1 A g−1. Accordingly, hybrid cathodes composed of commercial activated carbon and a small amount of high energy battery-type materials are expected to be a candidate for low-cost advanced LICs with both high energy density and power density.

scholarly journals In Situ Fabrication of Activated Carbon from a Bio-Waste Desmostachya bipinnata for the Improved Supercapacitor Performance

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Gopal Krishna Gupta ◽  
Pinky Sagar ◽  
Sumit Kumar Pandey ◽  
Monika Srivastava ◽  
A. K. Singh ◽  
...  
Keyword(s):  
Activated Carbon ◽  
Energy Density ◽  
Power Density ◽  
Supercapacitor Electrode ◽  
In Situ Fabrication ◽  
Transmission Electron ◽  
Good Energy ◽  
Supercapacitor Performance ◽  
Operating Potential

AbstractHerein, we demonstrate the fabrication of highly capacitive activated carbon (AC) using a bio-waste Kusha grass (Desmostachya bipinnata), by employing a chemical process followed by activation through KOH. The as-synthesized few-layered activated carbon has been confirmed through X-ray powder diffraction, transmission electron microscopy, and Raman spectroscopy techniques. The chemical environment of the as-prepared sample has been accessed through FTIR and UV–visible spectroscopy. The surface area and porosity of the as-synthesized material have been accessed through the Brunauer–Emmett–Teller method. All the electrochemical measurements have been performed through cyclic voltammetry and galvanometric charging/discharging (GCD) method, but primarily, we focus on GCD due to the accuracy of the technique. Moreover, the as-synthesized AC material shows a maximum specific capacitance as 218 F g−1 in the potential window ranging from − 0.35 to + 0.45 V. Also, the AC exhibits an excellent energy density of ~ 19.3 Wh kg−1 and power density of ~ 277.92 W kg−1, respectively, in the same operating potential window. It has also shown very good capacitance retention capability even after 5000th cycles. The fabricated supercapacitor shows a good energy density and power density, respectively, and good retention in capacitance at remarkably higher charging/discharging rates with excellent cycling stability. Henceforth, bio-waste Kusha grass-derived activated carbon (DP-AC) shows good promise and can be applied in supercapacitor applications due to its outstanding electrochemical properties. Herein, we envision that our results illustrate a simple and innovative approach to synthesize a bio-waste Kusha grass-derived activated carbon (DP-AC) as an emerging supercapacitor electrode material and widen its practical application in electrochemical energy storage fields.

scholarly journals SAFETY AND FEASIBILITY STUDY OF PHOTODYNAMIC THERAPY FOR ABLATION OF PERIPHERAL LUNG CANCER

CHEST Journal ◽  
2020 ◽  
Vol 157 (6) ◽  
pp. A239
Author(s):  
S. Bansal ◽  
R. Bechara ◽  
J. Patel ◽  
H. Mehta ◽  
J. Ferguson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Feasibility Study ◽  
Peripheral Lung Cancer ◽  
Peripheral Lung

Ionophobic nanopore enhancing capacitance and charging dynamics in supercapacitor with ionic liquids

2021 ◽  
Author(s):  
Zhongdong Gan ◽  
Yanlei Wang ◽  
Mi Wang ◽  
Enlai Gao ◽  
Feng Huo ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Energy Density ◽  
Power Density ◽  
Porous Electrodes ◽  
Charging Dynamics

Nano-porous electrodes combined with ionic liquids (ILs) are widely favored to promote the energy density of supercapacitors. However, this is always accompanied by the reduced power density, especially considering the...

scholarly journals Novel Lithium-Ion Capacitor Based on a NiO-rGO Composite

Materials ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3586
Author(s):  
Qi An ◽  
Xingru Zhao ◽  
Shuangfu Suo ◽  
Yuzhu Bai
Keyword(s):  
Energy Storage ◽  
Energy Density ◽  
Power Density ◽  
High Power ◽  
Specific Capacity ◽  
Lithium Ion ◽  
High Energy ◽  
Cycle Life ◽  
High Energy Density ◽  
Lithium Ion Capacitor

Lithium-ion capacitors (LICs) have been widely explored for energy storage. Nevertheless, achieving good energy density, satisfactory power density, and stable cycle life is still challenging. For this study, we fabricated a novel LIC with a NiO-rGO composite as a negative material and commercial activated carbon (AC) as a positive material for energy storage. The NiO-rGO//AC system utilizes NiO nanoparticles uniformly distributed in rGO to achieve a high specific capacity (with a current density of 0.5 A g−1 and a charge capacity of 945.8 mA h g−1) and uses AC to provide a large specific surface area and adjustable pore structure, thereby achieving excellent electrochemical performance. In detail, the NiO-rGO//AC system (with a mass ratio of 1:3) can achieve a high energy density (98.15 W h kg−1), a high power density (10.94 kW kg−1), and a long cycle life (with 72.1% capacity retention after 10,000 cycles). This study outlines a new option for the manufacture of LIC devices that feature both high energy and high power densities.

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