With the improvement of the quality of national life, the physical health problem is gradually placed in the same important position as the basic problems such as education, people’s livelihood, and safety. Improving the physical quality of college students and promoting the healthy growth of students are major events in the future of the country and the nation. Therefore, each school will conduct a physical test every year. The use of wireless sensors for data acquisition has played an important role in various fields. Therefore, for the physical health management of college students, this paper proposes to design a sensor system to collect physical measurement data. The measured data is collected through the sensor, such as the XGZP6847 gas pressure sensor to collect students’ vital capacity. Then, the sensor node and the coordinator are connected to the PC through the serial port, respectively, and the CC2530 chip transmits the data to the coordinator through the ZigBee module, establishes communication with the PC through the 2.4G wireless communication module, adopts the strategy of the thread pool to save resources, improves the response speed, and obtains students’ body test data in real time. Taking the data acquisition and transmission of vital capacity and body weight subjects as an example, the system realizes the accurate transmission of the collected test data from the sensor to the terminal, greatly improves the accuracy and real-time body test data acquisition, and reduces the probability of errors in the recording process, and the collected data can be used directly or for secondary development, and it promotes the establishment of college students’ physical health management system.