scholarly journals Cancer Stem Cell Assay for the Treatment of Platinum-Resistant Recurrent Ovarian Cancer

2021 ◽  
Vol 7 (3) ◽  
pp. 1-9
Author(s):  
Pier Paolo Claudio ◽  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Recurrent Ovarian Cancer ◽  
Treatment Selection ◽  
Cytotoxicity Assay ◽  
First Line ◽  
Cell Assay ◽  
First Line Therapy ◽  
Line Therapy

This data indicates that the drug cytotoxicity assay aimed at targeting CSCs may be a useful tool for optimizing treatment selection when first-line therapy fails, and when there are multiple clinically-acceptable and -equivalent treatments available.

Second-line randomized trials in epithelial ovarian cancer

2008 ◽  
Vol 18 (Suppl 1) ◽  
pp. 59-66 ◽  
Author(s):  
J. B. Vermorken
Keyword(s):  
Ovarian Cancer ◽  
Randomized Trials ◽  
Single Agent ◽  
Complete Response ◽  
Recurrent Ovarian Cancer ◽  
First Line ◽  
Symptomatic Disease ◽  
First Line Therapy ◽  
Line Therapy ◽  
Response To Chemotherapy

Important issues in the treatment of patients with recurrent ovarian cancer (ROC) are 1) to delay the time to symptomatic disease, 2) to reduce symptoms in case of symptomatic disease, 3) to optimize quality of life, and 4) to prolong overall survival. However, response assessment and recording of treatment-induced side effects in general get most attention. The likelihood of response to chemotherapy is directly proportional to the length of time between the end of primary chemotherapy and the date of recurrence. Also, the aggressiveness of the recurrence seems related to the prior biological pace of disease progression. For these reasons different disease categories have been identified, ie, platinum/taxane-refractory disease (progressive during first-line stabilization as best response), persistent disease (partial response to first-line therapy), platinum/taxane-resistant disease (clinical complete response [CCR] or no evidence of disease [NED] to/after first line and relapse <6 months), and platinum/taxane-sensitive disease (CCR or NED to/after first line and relapse >6 months). Randomized trials in these different categories did not show a benefit of maintenance or consolidation therapies after first-line therapy but did show differences in tolerability and efficacy (in platinum/taxane-sensitive disease) of different single agents and indicated that in specific circumstances combination chemotherapy is superior to single-agent chemotherapy. However, in all circumstances other aspects such as toxicity (and earlier experienced toxicity), clinical condition, convenience of administration, costs, and patient preference should be considered in the final selection of treatment

First-line Therapy With Donor-derived Human Cytomegalovirus (HCMV)–specific T Cells Reduces Persistent HCMV Infection by Promoting Antiviral Immunity After Allogenic Stem Cell Transplantation

2019 ◽  
Vol 70 (7) ◽  
pp. 1429-1437 ◽  
Author(s):  
Xiang-Yu Zhao ◽  
Xu-Ying Pei ◽  
Ying-Jun Chang ◽  
Xing-Xing Yu ◽  
Lan-Ping Xu ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Human Cytomegalovirus ◽  
Hcmv Infection ◽  
First Line ◽  
Allogenic Stem Cell Transplantation ◽  
First Line Therapy ◽  
Line Therapy

Abstract Background Human cytomegalovirus (HCMV) infection, especially persistent HCMV infection, is an important cause of morbidity and mortality after allogenic stem cell transplantation (allo-SCT). Antiviral agents remain the first-line therapy but are limited by side effects and acquired resistance. Methods We evaluated the safety and efficacy of donor-derived HCMV-specific cytotoxic T cells (CTLs) as a first-line therapy for HCMV infection after allo-SCT and investigated the underlying mechanisms. Results In humanized HCMV-infected mice, first-line therapy with CTLs effectively combated systemic HCMV infection by promoting the restoration of graft-derived endogenous HCMV-specific immunity in vivo. In a clinical trial, compared with the pair-matched, high-risk control cohort, first-line therapy with CTLs significantly reduced the rate of persistent (2.9% vs 20.0%, P = .018) and late (5.7% vs 20.0%, P = .01) HCMV infection and cumulative incidence of persistent HCMV infection (hazard ratio [HR], 0.13; 95% confidence interval [CI], 0.10–0.82; P = .02), lowered 1-year treatment-related mortality (HR, 0.15. 95% CI, 0.11–0.90. P = .03), and improved 1-year overall survival (HR, 6.35; 95% CI, 1.05–9.00; P = .04). Moreover, first-line therapy with CTLs promoted the quantitative and functional recovery of CTLs in patients, which was associated with HCMV clearance. Conclusions We provide robust support for the benefits of CTLs combined with antiviral drugs as a first-line therapy for treating HCMV infection and suggest that adoptively infused CTLs may stimulate the recovery of endogenous HCMV-specific immunity. Clinical trials registration NCT02985775.

Sign in / Sign up

Export Citation Format

Share Document