scholarly journals Amoxicillin secretion by gastric mucosa in Chernobyl nuclear power plant accident recovery workers with atrophic and nonatrophic gastritis undergoing eradication therapy

2020 ◽  
pp. 36-42
Author(s):  
A. O. Sablina ◽  
O. A. Sablin ◽  
S. S. Aleksanin ◽  
G. G. Rodionov ◽  
I. I. Shantyr' ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Power Plant ◽  
Nuclear Power Plant ◽  
Gastric Mucosa ◽  
Gastric Secretion ◽  
Nuclear Power ◽  
Eradication Therapy ◽  
Chernobyl Nuclear Power Plant ◽  
Normal Gastric Mucosa ◽  
H Pylori

Relevance. Today gastric cancer is still one of the oncologic diseases most often leading to death. H. pylori eradication reduces risk of gastric cancer, but its efficacy depends on gastric mucosa state. Atrophy of gastric mucosa is more common in Chernobyl nuclear power plant (CNPP) accident recovery workers than in patients who have not been involved in CNPP accident recovery works. It seems especially important to investigate the features of antibiotics transport to H. pylori colonization area in this contingent.Intention – to determine the features of amoxicillin secretion by gastric mucosa in CNPP accident recovery workers with atrophic and nonatrophic gastritis undergoing H. pylori eradication.Methodology. 65 CNPP accident recovery workers were divided into groups depending on state of gastric mucosa according to endoscopic and histological examination, immunosorbent assay of pepsinogens I and II and gastrin-17 basal serum levels. On the first day of eradication therapy, gastric secretion samples were obtained via nasogastric probe 30, 60, 120, 180 and 240 minutes after oral amoxicillin administration. Drug concentrations in gastric secretion were assessed via liquid chromatography-mass spectrometry.Results and discussion. Amoxicillin concentrations in gastric secretion samples were lower (р < 0.01) in patients with atrophic antral gastritis than in patients with normal gastric mucosa and atrophic fundal gastritis. Patients with fundal atrophy were characterized by lower amoxicillin concentrations 30 and 60 (p = 0.02) minutes after drug intake than in patients with normal gastric mucosa, and higher concentration in the 120th (p < 0.01) and 180th (p = 0.02) minute than in patients with antral atrophy. Amoxicillin concentrations in patients with antral atrophy were lower (p < 0.01) than in non-atrophy group in the 30th, 60th and 120th minute. In the 240th minute, amoxicillin concentrations in patients with fundal atrophy exceeded concentrations in both other groups (p < 0.01). Amoxicillin concentration peak was registered in patients with fundal and antral atrophy in the 180th minute, in patients without atrophy – from the 30th to 120th minute.Conclusion. Atrophy of gastric mucosa is characterized by decreased transport of orally administered amoxicillin from bloodstream to gastric lumen. Depending on gastric mucosa state, amoxicillin concentrations in gastric secretion should be evaluated at different time points after drug administration: in patients with atrophic gastritis – in the 180th minute, in patients without atrophy – in the 120th minute. While predicting the efficacy and choosing H. pylori eradication regimen, morphological and functional state of gastric mucosa should be taken into account.

scholarly journals Large Carnivores of the Chernobyl Nuclear Power Plant Exclusion Zone

2012 ◽  
Vol 46 (3) ◽  
pp. e-21-e-28 ◽  
Author(s):  
M. Shkvyria ◽  
D. Vishnevskiy
Keyword(s):  
Power Plant ◽  
Nuclear Power Plant ◽  
Species Composition ◽  
Nuclear Power ◽  
Chernobyl Nuclear Power Plant ◽  
Large Carnivores ◽  
Exclusion Zone ◽  
Animal Group ◽  
Large Predators

Large Carnivores of the Chernobyl Nuclear Power Plant Exclusion Zone During nine years observations on large carnivores of Exclusion Zone have been carried out. Species composition and the number of large predators in the Exclusion Zone correspond to the regional conditions. The presence of bears and permanent stay of the lynx in the Exclusion Zone was confirmed. Six wolf packs were counted. The use of an anthropogenically transformed areas, the shift of the daily regime of activity and characteristics of the diet are the most specific features of this animal group.

scholarly journals ENVIRONMENTAL PROBLEMS ASSOCIATED WITH DECOMMISSIONING THE CHERNOBYL NUCLEAR POWER PLANT COOLING POND

2010 ◽  
Vol 99 (5) ◽  
pp. 639-648 ◽  
Author(s):  
B. Ya. Oskolkov ◽  
M. D. Bondarkov ◽  
S. P. Gaschak ◽  
A. M. Maksymenko ◽  
V. M. Maksymenko ◽  
...  
Keyword(s):  
Power Plant ◽  
Nuclear Power Plant ◽  
Nuclear Power ◽  
Environmental Problems ◽  
Chernobyl Nuclear Power Plant ◽  
Cooling Pond ◽  
Power Plant Cooling

scholarly journals Depression with auto-aggressive manifestations in victims during a radiation disaster and fighting

2020 ◽  
pp. 23-29
Author(s):  
N. Оtroshchenko ◽  
P. Оtroshchenko
Keyword(s):  
Power Plant ◽  
Nuclear Power Plant ◽  
Medical Care ◽  
Nuclear Power ◽  
Comparison Group ◽  
Main Group ◽  
Chernobyl Nuclear Power Plant ◽  
Treatment Programs ◽  
Comprehensive Treatment ◽  
Joint Forces

Purpose. To increase the level of medical care for depression patients with autoaggressive manifestations (AM) in victims during a radiation disaster and fighting by developing new diagnostic and treatment programs. Material and methods. The object and methods of the study were 70 liquidators of the accident consequences at the Chernobyl nuclear power plant aged from 54 to 65 years old and 45 combatants of the Anti-terroristic operation (Joint forces operation) aged from 25 to 59 years old – comparison group, depression patients with AM, psychosomatic pathology were examined. For the main group and the comparisons group were used clinical and paraclinical methods, division into groups, according to diagnostic and treatment programs, therapy and follow-up from 2 months to 2 years. Results. The main group observed increasing depressive frequency disorders with AM in liquidators of the accident consequences at the Chernobyl nuclear power plant. The examination revealed asthenic – in 34 (48.6 %) patients, anxiety – in 13 (18.6 %), apathetic – in 8 (11.4 %), hypochondriac – in 7 (10 %), dysphoric – in 5 (7.1 %), obsessive-phobic – in 3 (4.3 %) variants of depression with AM. These particular disorders are characterized asthenic, anxiety and apathetic symptoms, progressive course, personality changes with organic and psychosomatic traits, cognitive deficit (р <0,05). In the comparison group, asthenic was found in 13 (28.3 %) patients, anxious in 11 (23.9 %), hypochondriac in 10 (21.7 %), dysphoric in 6 (13 %), and obsessive-phobic – in 3 (6.5 %) and apathetic variants – in 2 (4.4 %) depression with AM. After the participation in the Anti-terroristic operation (Joint forces operation) fighters exhibit depression with AM in combination with psychosomatic and personality traits, changes in the bioelectrical activity of the brain. These particular disorders are characterized asthenic, anxiety, hypochondriac symptoms, personality and psychosomatic traits (р <0,05). Conclusions. The proposed comprehensive treatment and diagnostic program will increase the level of medical care of the liquidators of the accident consequences at the Chernobyl nuclear power plant, combatants of the Anti-terroristic operation (Joint forces operation) and prevent the occurrence of suicide. Key words: depression, autoaggressive manifestations, diagnostics, treatment, prevention, combatants of the Anti-terroristic operation (Joint forces operation), liquidators of the consequences of the Chernobyl accident.

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