A case of primary bilateral breast lymphoma presenting with a painless mass in the left breast

Breast cancer is the most common cancer in women. Patients usually present with a rapidly progressed painless mass in the breast. The first pathological entity to be considered is breast cancer in case of newly developed painless mass, so that radiological and pathological evaluations must be performed. However, some systemic disorders; benign conditions like rheumatological diseases, and also systemic malignancies such as lymphoma, can mimic breast cancer by involving the breast. It is necessary to distinguish between such diseases through a correct diagnosis, because they have very different treatments and prognoses. We present a case diagnosed as bilateral primary breast lymphoma with a palpable mass in a single breast, its clinical and radiological characteristics. This case report suggests that systemic diseases should be considered in the differential diagnosis of breast diseases and breast masses, especially when there is bilaterally involvement, as discussed in this article.

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Primary breast lymphoma in the right breast during treatment for left breast cancer

World Journal of Surgical Oncology ◽

10.1186/1477-7819-5-134 ◽

2007 ◽

Vol 5 (1) ◽

Cited By ~ 7

Author(s):

Shigeyuki Nagata ◽

Ataru Nishimura ◽

Yukio Iwashita ◽

Tadahiko Kinoshita ◽

Kengo Fukuzawa ◽

...

Keyword(s):

Breast Cancer ◽

Left Breast ◽

Primary Breast Lymphoma ◽

Breast Lymphoma ◽

The Right

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Clinical and mammographic profile of patients with breast cancer surgically treated

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.61.03.22 ◽

2015 ◽

Vol 61 (3) ◽

pp. 220-226

Author(s):

Raquel Rodrigues Muradas ◽

Maria Teresa Aquino de Campos Velho ◽

Itamar dos Santos Riesgo ◽

Alexandre Duarte Brum ◽

Raquel Montagner Rossi ◽

...

Keyword(s):

Breast Cancer ◽

Histopathological Examination ◽

Radical Mastectomy ◽

Left Breast ◽

Cross Sectional Study ◽

University Hospital ◽

Research Committee ◽

Cross Sectional ◽

Palpable Mass ◽

Santa Maria

Summary Objective: to analyze the epidemiological, clinical and mammographic profile of women with breast cancer who were treated at the mastology clinic of the University Hospital of Santa Maria and who underwent breast surgery between January 2007 and December 2012. Methods: this was a cross-sectional study, approved by the Ethics in Research Committee. A review of the patients' medical records was performed. The data were then exported to a software program for statistical analysis, namely Minitab 14.1. Results: the patients' profile indicated that they were mostly born and raised in Santa Maria (respectively 11.1%, n=16, and 26.3%, n=68). They were about 55.6 years old (SD±12.3), white (90.2%, n=213), had already given birth and breastfed their children, were nonsmokers, but also overweight (average BMI of 27kg/m2). On physical examination of the first medical consultation, these patients, as described in the records: had a palpable mass (81.1%, n=184) measuring over three centimeters, located in the left breast, precisely in the upper outer quadrant (41.4%, n=81). Mammography (39%, n=109) showed that this lump was classified as BIRADS ® 5 (40%, n=81). On histopathological examination, the lump was diagnosed as an invasive ductal cancer (71.1%, n=191). Surgery was generally a radical mastectomy (84.7%, n=236) with axillary dissection (92.5%, n=222). Conclusion: some of the epidemiological, clinical and mammographic features mentioned above resembled those found in the literature reviewed. However, these patients had advanced disease and underwent non conservative surgical procedures.

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Breast diseases and breast cancer screening in pregnant and puerperals in şanlıurfa province

Medical Science and Discovery ◽

10.36472/msd.v8i2.451 ◽

2021 ◽

Vol 8 (2) ◽

pp. 60-63

Author(s):

Mehmet Patmano ◽

Durmuş Ali Çetin ◽

Tufan Gümüş

Keyword(s):

Breast Cancer ◽

Breast Diseases ◽

First Year ◽

High Fertility ◽

Palpable Mass ◽

Breast Examination ◽

Pregnancy And Lactation ◽

The Mean ◽

The Moment ◽

Self Examination

Objective: Pregnancy-associated breast cancer is breast cancer that occurs during pregnancy or within 1 year after birth. It occurs in one out of 3000-10000 pregnancies and is the most common cancer occurring during pregnancy and the postpartum period. It was aimed to reveal the incidence of pregnancy-associated breast cancer in pregnant and lactating patients in a city with high fertility rates. Methods; Patients who presented with breast pain and palpable mass in the breast in the first year of pregnancy and lactation between December 2018 and November 2020 were prospectively recorded. 314 patients were included in the study. Results; The mean age of the patients was 28.7 ± 6.1 years. 258 (82.1%) of the patients were Turkish and 56 (17.8%) were Syrian nationals. The most common complaints were pain in the breast, palpable mass, redness, and breast swelling. A palpable mass in the breast was detected in 39 (12.4%) patients. As a result of the examinations and tests performed in both patients, a diagnosis of malignancy was made. Conclusion; Breast cancer risk increases in pregnant and breastfeeding patients. To reduce the incidence of breast cancer, it is important to perform a breast examination by a physician before or at the beginning of pregnancy and breast self-examination. From the moment of diagnosis, general surgery, obstetrics and oncology clinics should be followed with a multidisciplinary approach

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Decreased catalase activity and glutathione concentration levels in women patients with breast cancer

10.36295/asro.2020.231371 ◽

2020 ◽

Vol 23 (13) ◽

Author(s):

Ruqayah Ali Salman ◽

Genan Adnan Abdullatef AlBairuty ◽

Omar F. Abdul-Rasheed

Keyword(s):

Breast Cancer ◽

Catalase Activity ◽

Women Patients ◽

Glutathione Concentration ◽

Concentration Levels

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Deep-inspirational breath-hold (DIBH) technique in left-sided breast cancer: various aspects of clinical utility

Radiation Oncology ◽

10.1186/s13014-021-01816-3 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Szilvia Gaál ◽

Zsuzsanna Kahán ◽

Viktor Paczona ◽

Renáta Kószó ◽

Rita Drencsényi ◽

...

Keyword(s):

Breast Cancer ◽

Side Effects ◽

Clinical Utility ◽

Prospective Trial ◽

Conformal Radiotherapy ◽

Free Breathing ◽

Left Breast ◽

Breath Hold ◽

Ipsilateral Lung ◽

Breast Cancer Radiotherapy

Abstract Background Studying the clinical utility of deep-inspirational breath-hold (DIBH) in left breast cancer radiotherapy (RT) was aimed at focusing on dosimetry and feasibility aspects. Methods In this prospective trial all enrolled patients went through planning CT in supine position under both DIBH and free breathing (FB); in whole breast irradiation (WBI) cases prone CT was also taken. In 3-dimensional conformal radiotherapy (3DCRT) plans heart, left anterior descending coronary artery (LAD), ipsilateral lung and contralateral breast doses were analyzed. The acceptance of DIBH technique as reported by the patients and the staff was analyzed; post-RT side-effects including radiation lung changes (visual scores and lung density measurements) were collected. Results Among 130 enrolled patients 26 were not suitable for the technique while in 16, heart or LAD dose constraints were not met in the DIBH plans. Among 54 and 34 patients receiving WBI and postmastectomy/nodal RT, respectively with DIBH, mean heart dose (MHD) was reduced to < 50%, the heart V25 Gy to < 20%, the LAD mean dose to < 40% and the LAD maximum dose to about 50% as compared to that under FB; the magnitude of benefit was related to the relative increase of the ipsilateral lung volume at DIBH. Nevertheless, heart and LAD dose differences (DIBH vs. FB) individually varied. Among the WBI cases at least one heart/LAD dose parameter was more favorable in the prone or in the supine FB plan in 15 and 4 cases, respectively; differences were numerically small. All DIBH patients completed the RT, inter-fraction repositioning accuracy and radiation side-effects were similar to that of other breast RT techniques. Both the patients and radiographers were satisfied with the technique. Conclusions DIBH is an excellent heart sparing technique in breast RT, but about one-third of the patients do not benefit from that otherwise laborious procedure or benefit less than from an alternative method. Trial registration: retrospectively registered under ISRCTN14360721 (February 12, 2021)

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Cystic Encapsulated Papillary Carcinoma in the Male Breast: An Unusual Feature With a Diagnostic Challenge

International Journal of Surgical Pathology ◽

10.1177/10668969211018754 ◽

2021 ◽

pp. 106689692110187

Author(s):

Rongying Li ◽

Karan Saluja ◽

Brenda Mai ◽

Michael Covinsky ◽

Hongxia Sun

Keyword(s):

Papillary Carcinoma ◽

Cyst Wall ◽

Correct Diagnosis ◽

Nipple Discharge ◽

Left Breast ◽

Male Breast ◽

Unusual Feature ◽

Breast Mass ◽

Repeat Biopsy ◽

Bloody Nipple Discharge

Papillary carcinoma in the male breast is uncommon. Here, we report a case of a large encapsulated papillary carcinoma (EPC) in a 62-year-old male. The patient presented with a left breast mass of 1-year duration and bloody nipple discharge for several days. Mammography and breast ultrasonography showed a large left breast mass. The initial biopsy demonstrated fat necrosis with acute and chronic inflammation only. Due to clinical suspicion, a repeat biopsy was performed and revealed scant fragments of papillary carcinoma in a background of inflammation. The patient underwent left total mastectomy. Grossly, the breast contained a 9.0 cm entirely cystic lesion lined by a hemorrhagic thick fibrotic wall. No solid area was identified in the cyst. The entire cyst wall was examined under microscopy; only a few sections with papillary carcinoma were identified. The lesion was confined to the cyst wall; so, a diagnosis of EPC was made. Compared to the previously reported EPC cases of male breast, the lesion of this case was unusually cystic, which making the diagnosis challenging. Therefore, awareness of this unusual feature, repeat biopsy when the pathology result is discordant, and extensive sampling of the lesion are essential for making the correct diagnosis and guiding patient management.

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170 Primary Breast Lymphoma-Mimicking Inflammatory Breast Disease: A Case Report

British Journal of Surgery ◽

10.1093/bjs/znab134.199 ◽

2021 ◽

Vol 108 (Supplement_2) ◽

Author(s):

R Alam ◽

B Basak ◽

A Ahsan ◽

A S Gupta ◽

S Islam ◽

...

Keyword(s):

Breast Carcinoma ◽

B Cell ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Primary Breast Lymphoma ◽

Palpable Mass ◽

Large B Cell Lymphoma ◽

Breast Lymphoma ◽

History Of ◽

Large B Cell

Abstract Primary breast lymphoma (PBL) is an unusual clinical entity accounting for 0.4–0.5% of all breast neoplasms. The usual presentation includes a painless palpable mass similar to that of breast carcinoma. Diffuse large B-cell lymphoma (DLBCL) is the most common identifiable type of PBL based on the histopathological examination. We report an unusual case of 22 years old Bangladeshi woman presented with a 6-month history of a lump on left breast. Although the lump was initially small, it began a rapid growth after 4 months. The swelling was localized and did not show any skin involvement or discharge and as she didn’t have any positive familial history of breast carcinoma her primary attending physician diagnosed it as a case of breast abscess. When local incision and drainage proved ineffective, she was referred to us. After doing an immunohistochemistry from incisional biopsy the diagnosis was confirmed as Diffuse Large B-cell Lymphoma. The patient was treated initially by chemotherapy with CHOP therapy followed by wide local excision. Early and accurate diagnosis of PBL is crucial for selecting the appropriate MDT treatment strategies to avert potentially harmful surgical interventions.

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