scholarly journals Biomarkers of susceptibility and effect in car painters exposed to organic solvents

2020 ◽  
Author(s):  
Marcela Varona-Uribe ◽  
Milciades Ibáñez-Pinilla ◽  
Leonardo Briceno-Ayala ◽  
Diego Herrera ◽  
Lilian Chuaire-Noack ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Somatic Cell ◽  
Organic Solvents ◽  
Cross Sectional Study ◽  
Exposed Group ◽  
Exposure Group ◽  
Sectional Study ◽  
Genotoxic Effects ◽  
Cross Sectional ◽  
Increased Susceptibility

Introduction: Car painters are routinely exposed to organic solvents classified as carcinogenic and mutagenic substances. Objective: To characterize the population susceptibility and evaluate the genotoxic effects of exposure to organic solvents. Methods: A cross-sectional study comparing a group of car painters exposed to organic solvents with a non-exposed group. CYP2E1 polymorphisms and the presence of micronuclei in lymphocytes were determined. Results: One hundred twenty-two workers participated in the study: 62 who worked in car paint shops and were exposed to solvents, and 60 who were not exposed. There were statistically significant differences between the two groups regarding micronucleated cells and nucleoplasmic bridges frequencies (p=0.042 and p=0.046, respectively; exact likelihood ratio). Significant differences were found at the interaction between the CYP2E1 genotype c1c1 and occupational exposure to solvents, with higher frequencies of micronuclei (p= 0.013) and micronucleated cells (p= 0.015). However, when the frequencies of micronuclei, micronucleated cells and nucleoplasmic bridges in the exposure group were compared between the c1c1 and c2c2/c1c2 allele groups of the CYP2E1 polymorphism, statistically significant differences were found. Conclusions: This study confirms that when workers with CYP2E1 polymorphisms, specifically the c1c1 genotype, are exposed to organic solvents, they are more likely to have somatic cell mutations, a condition associated with increased susceptibility to diseases such as cancer

scholarly journals Waterpipe Smoking among Bladder Cancer Patients: A Cross-Sectional Study of Lebanese and Jordanian Populations

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Elio Jabra ◽  
Amal Al-Omari ◽  
Fadi Haddadin ◽  
Walid Alam ◽  
Khawlah Ammar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bladder Cancer ◽  
Occupational Exposure ◽  
Cancer Patients ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Significant Finding ◽  
Waterpipe Smoking ◽  
Sectional Study ◽  
Cross Sectional

Background. Bladder cancer (BC) is the second most reported cancer in Lebanon and the fifth in Jordan. Its risk factors are mainly smoking and occupational exposure to aromatic amines. In these countries where smoking and bladder cancer are highly prevalent, the role of waterpipe smoking (WPS) in bladder cancer is less investigated. We aim to compare two sets of patients between Lebanon and Jordan, focusing on their smoking habits, WP use, occupational exposure, and the grade/invasiveness of their bladder cancer. Methods. This is a cross-sectional study that compares the smoking culture between two sets of populations with bladder cancer, from two different countries. We recruited 274 bladder cancer patients over the 18 years of age at the American University of Beirut Medical Center (AUBMC), and 158 bladder cancer patients over the age of 18 years at the King Hussein Cancer Center (KHCC). Results. 7.7% of Lebanese patients had significantly more positive family history of bladder cancer compared to 13.9% of Jordanian patients ( p = 0.045 ). Another significant finding is that the majority of Lebanese patients 70.7% reported being frequently exposed to secondhand smoking, mainly cigarettes, versus only 48.6% of Jordanian patients ( p < 0.001 ). The increasing smoking trend among Lebanese females is remarkably the highest in the region, which contributed to the overall increase in smoking rates in the country. 17.1% of the Lebanese smoking patients are mainly but not exclusively WP smokers of which 6.3% are daily WP smokers, similarly 17.1% of the Jordanian patients of which 3.2% are daily WP smokers. There were 71.5% of Lebanese patients who had a noninvasive BC versus 40% of Jordanian patients ( p < 0.001 ), and more than one-third reported an occupational exposure to one of the risk factors of BC in both groups. Conclusions. Bladder cancer incidence is on the rise in both Jordan and Lebanon along with different smoking types. It is necessary to impose prevention policies to prevent and control the high smoking prevalence. Bladder cancer invasiveness is higher in Jordan compared to universal data.

scholarly journals Characterization of buccal cell DNA after exposure to azo compounds: a cross-sectional study

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 1053
Author(s):  
Juni Handajani ◽  
Urfa Tabtila ◽  
Nadia Rully Auliawati ◽  
Abdul Rohman
Keyword(s):  
Principal Component ◽  
Cross Sectional Study ◽  
Exposed Group ◽  
Azo Compounds ◽  
Buccal Cell ◽  
Control Group ◽  
Synthetic Dyes ◽  
Sectional Study ◽  
Cross Sectional ◽  
Principle Component

Background: Azo compounds, containing naphthol and diazonium salts, are synthetic dyes widely used in the batik industry. Azo compounds are considered toxic when they are exposed to human tissue. The purpose of this study was to analyze buccal cell DNA exposed to azo compounds in batik workers. Methods: A cross-sectional study involving 20 male subjects divided into two groups (n=10 group), namely azo-exposed and non-exposed (control group). Inclusion criteria were batik workers of the colouring division who have been exposed to azo for at least 5 years. Buccal cells were taken using cytobrush then DNA were isolated from buccal cell. DNA isolation was done by buccal DNA kit, while the purity and concentration of the DNA was determined using spectrophotometer and electrophoresis. Results: The azo-exposed group revealed higher purity DNA than those in the control group. The purity of the DNA in the azo-exposed group and control group was 0.61±0.93 and 0.21±0.09, respectively, while the concentration of DNA was of 59.02 and 19.35 ng/UL, respectively. The ratio at 260/280 nm was 1.84-1.94 (azo-exposed) and 1.85-1.92 (control). Principal component analysis using the first principle component (PC1) and second principle component (PC2) could successfully classify subjects in the control and azo-exposed groups. Conclusion: Characteristics of DNA could be used as an indication of exposure to azo compounds in workers of batik industries.

scholarly journals Association Between Occupational Exposure to Domestic Solid Waste and Dental Caries: A Cross Sectional Study

2021 ◽  
Author(s):  
Mariana Andrade ◽  
Nara Araujo ◽  
Maria Isabel Vianna ◽  
Maria Cristina Cangussu ◽  
Isaac Gomes-Filho ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Solid Waste ◽  
Direct Contact ◽  
Dental Health ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Missing Teeth ◽  
Cross Sectional ◽  
Dmft Index ◽  
Domestic Solid Waste

Abstract This cross-sectional study evaluated the dental caries and its associated factors among domestic waste collectors. A total of 301 adult men who worked for a waste collection corporation were included; 171 men worked in direct contact with domestic solid waste and 130 did not. Sociodemographic data, working and medical history were assessed. The decayed, missing, and filled permanent teeth (DMFT) index was examined. Logistic regression analysis was used to identify factors associated with dental status with a significance level of 5%. The overall mean DMFT score was 8.36 ± 5.64. The mean DMFT, missing teeth (MT), and filled teeth (FT) were significantly higher in workers who did not have any direct contact with waste (p ≤ 0.04). In the logistic analysis, DMFT ≥ 8 was only associated with older age (OR = 8.41 [95% confidence interval (95%CI), 5.01–14.12], p < 0.001). Decayed teeth (DT) ≥ 2 was associated with no previous oral hygiene instruction (OR = 2.70 [1.50–4.81], p = 0.001) and no daily dental flossing (OR = 4.26 [1.92–9.43], p < 0.001). MT ≥ 9 was associated with lower education level (OR = 3.33 [1.57–7.10], p = 0.002). FT ≥ 3 had a negative association with low income (OR = 0.42 [0.25–0.70], p < 0.001) and no daily flossing (OR = 0.42 [0.23–0.76], p = 0.004). Occupational exposure to domestic solid waste was not associated with poor dental status. Instead, age, education, income level, and oral hygiene were associated with dental health status. Missing teeth constituted the major component of the DMFT index. Therefore, prevention and oral rehabilitation programs are necessary to improve dental health.

Occupational exposure influences control of disease in patients with chronic rhinosinusitis

2021 ◽  
Vol 59 (4) ◽  
pp. 380-386
Author(s):  
D.A.E. Dietz de Loos ◽  
S. Ronsmans ◽  
M.E. Cornet ◽  
P.W. Hellings ◽  
V. Hox ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Conservative Therapy ◽  
Cross Sectional Study ◽  
Sinus Surgery ◽  
Sectional Study ◽  
Cross Sectional ◽  
Independent Variables ◽  
The Relationship

Background: Chronic rhinosinusitis (CRS) is a frequent condition that is treated by endoscopic sinus surgery (ESS) when medical treatment fails. Irritating or sensitizing airborne agents can contribute to uncontrolled CRS. A prior study showed a linear correlation between occupational exposure and the number of ESS. Methods: In this cross-sectional study we tested the hypothesis that occupational exposure is a risk for undergoing ESS. We sent questionnaires enquiring occupational exposure in patients with CRS with nasal polyps (CRSwNP) or CRS without nasal polyps (CRSsNP). An expert assessed blindly the reported work exposures to inhaled agents. The relationship between occupational exposure on undergoing ESS was analysed. Results: Among all patients who underwent ESS (n=343), 30% reported a relevant occupational exposure, which is significantly higher than the 4.8% found among CRS patients that underwent no prior sinus surgery (n=21). Besides occupational exposure, self-reported doctor-diagnosed asthma were independent variables contributing to the chance of undergoing ESS. Conclusion: In our study we confirm occupational exposure as a risk factor for uncontrolled CRS, if defined by undergoing ESS. In CRS patients with uncontrolled symptoms, despite maximal conservative therapy, the clinician should explore the possible contribution of occupational exposure.

scholarly journals Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study

2011 ◽  
Vol 10 (1) ◽  
Author(s):  
Hans B Ketelslegers ◽  
Roger WL Godschalk ◽  
Ralph WH Gottschalk ◽  
Ad M Knaapen ◽  
Gudrun Koppen ◽  
...  
Keyword(s):  
At Risk ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Genotoxic Effects ◽  
Cross Sectional

Incense Smoke and Increasing Carotid Intima Media Thickness: A Cross-Sectional Study of the Thai-Vietnamese Community

2018 ◽  
Vol 30 (2) ◽  
pp. 178-187 ◽  
Author(s):  
Rattanee Kammoolkon ◽  
Nutta Taneepanichskul ◽  
Nattaporn Pitaknoppakul ◽  
Somrat Lertmaharit ◽  
Vitool Lohsoonthorn
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional Study ◽  
Exposed Group ◽  
Mean Difference ◽  
Sectional Study ◽  
Cross Sectional ◽  
Media Thickness ◽  
Incense Burning

Incense burning, a source of household indoor air pollution, is possible to effect on cardiovascular system. Our study sought to examine the association of long-term exposure to household incense smoke with increased carotid intima-media thickness (CIMT). A cross-sectional study was conducted 132 adults aged ≥35 years. Participants were stratified into 3 groups by their long-term household incense use; nonexposed group, non–daily exposed group, and daily exposed group. A combined mean CIMT (mean difference = 0.04 mm; P < .01) and combined maximum CIMT (mean difference = 0.09 mm; P < .01) in the daily exposed group had greater than the nonexposed group. The mean CIMT and maximum CIMT of the left common carotid artery in the daily exposed group was significantly greater than the nonexposed group ( P < .01). These findings suggest that incense burning inside the house may be a risk factor for cardiovascular disease morbidity and mortality.

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