Arnika górska jako roślina lecznicza

The pharmacological properties of arnica flowers are mainly due to the action of sesquiterpene lactones and flavonoids. The mechanism of the anti-inflammatory action of Arnicae flos (in vitro studies) is based on the inhibition of the release of pro-inflammatory factors: NF-κB, NF-AT and metabolic products of arachidonic acid. This herbal substance is used only externally in blunt injuries (contusions, sprains, bruises), as well as in muscle and rheumatic pains. Strong antimicrobial properties, equal to the activity of antibiotics, justify the use of arnica flowers in dermatoses.

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Dangguijakyak-San Protects against 1-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-Induced Neuronal Damage via Anti-Inflammatory Action

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2013/976270 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Deok-Sang Hwang ◽

Hyo Geun Kim ◽

Jun-Bock Jang ◽

Myung Sook Oh

Keyword(s):

Neuronal Damage ◽

Cell Damage ◽

Substantia Nigra Pars Compacta ◽

Inflammatory Factors ◽

Dopaminergic Cell ◽

Therapeutic Implications ◽

Anti Inflammatory ◽

Inflammatory Action

Dangguijakyak-san (DJS), a famous traditional Korean multiherbal medicine, has been used to treat gynecological and neuro-associated disease. Recent studies demonstrated that DJS has multiple bioactivities including neuroprotection. In the present study, we were to investigate the effect of DJS and its mechanism in anin vitroandin vivomodel of Parkinson’s disease (PD). In primary mesencephalic culture system, DJS attenuated the dopaminergic cell damage induced by 1-methyl-4-phenylpyridine toxicity, and it inhibited production of inflammatory factors such as tumor necrosis factorα(TNF-α), nitric oxide (NO), and activation of microglial cells. Then, we confirmed the effect of DJS in a mouse PD model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In the pole test, DJS at 50 mg/kg/day for 5 days showed increase of motor activity showing shortened time to turn and locomotor activity compared with the MPTP only treated mice. In addition, DJS significantly protected nigrostriatal dopaminergic neuron from MPTP stress. Moreover, DJS showed inhibition of gliosis in the substantia nigra pars compacta. These results have therapeutic implications for DJS in the treatment of PD via anti-inflammatory effects.

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Effects of dilazep on human platelets and rat vascular tissue: In vitro studies on platelet aggregation, and arachidonic acid oxidation

Pharmacological Research Communications ◽

10.1016/s0031-6989(83)80030-7 ◽

1983 ◽

Vol 15 (6) ◽

pp. 593-602 ◽

Cited By ~ 3

Author(s):

S. Colli ◽

P. Maderna ◽

G. Morazzoni ◽

C. Speroni ◽

E. Tremoli

Keyword(s):

Arachidonic Acid ◽

Platelet Aggregation ◽

Vascular Tissue ◽

Human Platelets ◽

In Vitro Studies ◽

Acid Oxidation

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Inhibitory activity of stilbenes against filamentous fungi

Italian Journal of Food Safety ◽

10.4081/ijfs.2021.8461 ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Luce Mattio ◽

Giorgia Catinella ◽

Marcello Iriti ◽

Lisa Vallone

Keyword(s):

Antifungal Activity ◽

Filamentous Fungi ◽

Antimicrobial Properties ◽

Microbial Infection ◽

Wide Range ◽

Mycotoxigenic Fungi ◽

Wild Strains ◽

Diffusion Assay ◽

Inflammatory Action

Stilbenoids (resveratrol and its derivatives) are secondary metabolites produced by plants as defence mechanism to microbial infection. These compounds are known for their anti-inflammatory action and health benefits in preventing a wide range of disorders (e.g. cancer and cardiovascular diseases). However, their antimicrobial properties are less investigated. A series of 8 stilbenoid compounds were synthesized and their antifungal activity against 19 wild strains of filamentous fungi and yeasts (isolated from the environment and food) was tested in vitro. Using an agar diffusion assay, compounds were tested at the concentration of 100 μg/ml on filamentous fungi and yeasts at 104 CFU/ml. The results showed that tested derivatives possess moderate antifungal activity: in particular, monomeric stilbenoids 3’-hydroxy-pterostilbene and piceatannol, and dimeric stilbenoids (±)-trans-δ-viniferin and pallidol were active against mycotoxigenic fungi.

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In Vivo and In Vitro Studies of Antibiotic Release from and Bacterial Growth Inhibition by Antibiotic-Impregnated Polymethylmethacrylate Hip Spacers

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.50.1.332-335.2006 ◽

2006 ◽

Vol 50 (1) ◽

pp. 332-335 ◽

Cited By ~ 40

Author(s):

Jens Kelm ◽

Thilo Regitz ◽

Eduard Schmitt ◽

Werner Jung ◽

Konstantinos Anagnostakos

Keyword(s):

Wound Healing ◽

Growth Inhibition ◽

Bacterial Growth ◽

Antimicrobial Properties ◽

In Vitro Studies ◽

Antibiotic Release ◽

Bacterial Growth Inhibition

ABSTRACT The antimicrobial properties and the elution characteristics of gentamicin-vancomycin-loaded hip spacers were studied in vivo and in vitro. Vancomycin elution was greater than gentamicin elution. The antibiotic concentrations in vivo were less than those in vitro. Not dependent on implantation duration, growth inhibition by spacers in vitro was observed for 2 weeks. The reason for protracted wound healing cannot be insufficient antibiotic release.

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