KADAR FERITIN SERUM DAN HEMOGLOBIN PADA WANITA PASANGAN  PENGANTIN BARU DI BALI

Serum ferritin and hemoglobin concentration were used to iron deficiency anemia (IDA) tests over population. The prevalence of IDA prevalence in pregnant women were 18% over the world, 37.5% in Asia, and 46.5% in Bali. The iron supplementation that was administrated during pregnancy did not clinically proven to solve the problems. It was predicted that the IDA was existing before pregnant. So, the body iron store must be prepare before pregnancy period. This research aimed to know the serum ferritin and hemoglobin concentration in the new married women in Bali. The design of this research was descriptive cross sectional study and conducted at 276 new married women by multistage sampling method. Every participant was interviewed for characteristic data and taken blood sample to evaluate serum ferritin and hemoglobin. Serum ferritin and hemoglobin were examined by Immulite 2000 Ferritin and Sysmex SF-3000 and the data were analyzed by descriptive analysis. The mean of serum ferritin and hemoglobin concentration are 29.41±20.36 µg/dl and 11.35±0.92 g/dl. The serum ferritin level proportions 20-29 µg/dl, less than 20 µg/dl, and ≥100 µg/dl are 145 (51.9%), 130 (47.1%), and 1(0.4%), eventually. The hemoglobin value <12 g/dl was found in 36.2% population and amount 63.8% population with hemoglobin value ≥12 g/dl. According on iron status, the proportion of anemia was23.6%, proportion of iron deficiency was19.2% and proportion of IDA was14.1%. Based on the result, ferritin in the new married women Bali was mostly low level but hemoglobin concentration was mostly normal. Although, they have problem in the proportion of iron deficiency, anemia and iron deficiency anemia, that were 19.2%, 23.6% and 14.1%, respectively.

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Effect of Maternal Iron Deficiency Anemia on the Iron Store of Newborns in Ethiopia

Anemia ◽

10.1155/2015/808204 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 9

Author(s):

Betelihem Terefe ◽

Asaye Birhanu ◽

Paulos Nigussie ◽

Aster Tsegaye

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Serum Ferritin ◽

Complete Blood Count ◽

Iron Status ◽

Hemoglobin Concentration ◽

Deficiency Anemia ◽

Iron Store ◽

Cross Sectional ◽

Iron Deficient

Iron deficiency anemia among pregnant women is a widespread problem in developing countries including Ethiopia, though its influence on neonatal iron status was inconsistently reported in literature. This cross-sectional study was conducted to compare hematologic profiles and iron status of newborns from mothers with different anemia status and determine correlation between maternal and neonatal hematologic profiles and iron status in Ethiopian context. We included 89 mothers and their respective newborns and performed complete blood count and assessed serum ferritin and C-reactive protein levels from blood samples collected from study participants. Maternal median hemoglobin and serum ferritin levels were 12.2 g/dL and 47.0 ng/mL, respectively. The median hemoglobin and serum ferritin levels for the newborns were 16.2 g/dL and 187.6 ng/mL, respectively. The mothers were classified into two groups based on hemoglobin and serum ferritin levels as iron deficient anemic (IDA) and nonanemic (NA) and newborns of IDA mothers had significantly lower levels of serum ferritin (P=0.017) and hemoglobin concentration (P=0.024). Besides, newborns’ ferritin and hemoglobin levels showed significant correlation with maternal hemoglobin (P=0.018;P=0.039) and ferritin (P=0.000;P=0.008) levels. We concluded that maternal IDA may have an effect on the iron stores of newborns.

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Effect of Vitamin D Replacement on Hemoglobin Concentration in Subjects with Concurrent Iron-Deficiency Anemia and Vitamin D Deficiency: A Randomized, Single-Blinded, Placebo-Controlled Trial

Acta Haematologica ◽

10.1159/000357104 ◽

2014 ◽

Vol 133 (1) ◽

pp. 31-35 ◽

Cited By ~ 16

Author(s):

Basavraj Sooragonda ◽

Sanjay Kumar Bhadada ◽

Viral N. Shah ◽

Pankaj Malhotra ◽

Jasmina Ahluwalia ◽

...

Keyword(s):

Vitamin D ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Serum Ferritin ◽

Controlled Trial ◽

Hemoglobin Concentration ◽

Deficiency Anemia ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Hb Concentration

Background: The effect of vitamin D replacement on hemoglobin (Hb) concentration in subjects with concurrent deficiencies of vitamin D and iron is not known. Methods: We report on an investigator-initiated, randomized, single-blinded, placebo-controlled, 12-week interventional trial. Thirty subjects with iron-deficiency anemia (serum ferritin <15 µg/l) were randomized to an intervention arm (cholecalciferol, i.e. vitamin D3, 0.6 million units i.m. once) or placebo. In all subjects, iron deficiency was corrected with parental iron. Other causes of anemia were excluded with appropriate investigation. The primary end point was a rise in Hb concentration. Results: Baseline parameters of age, BMI, hemogram values and levels of serum ferritin, 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) were similar in the 2 arms. Twelve weeks after vitamin D replacement, there was a significant increase in 25 (OH)D levels (57.7 ± 20.5 vs. 14.1 ± 6.2 ng/ml, p < 0.0001) and a decrease in PTH levels (32.4 ± 16.4 vs. 52.9 ± 18.4 pg/ml, p = 0.003) in subjects in the intervention arm when compared to the placebo arm. However, the increments in serum ferritin and Hb concentration in the intervention and placebo arm did not differ. Conclusion: Vitamin D replacement in subjects with iron-deficiency anemia after iron correction does not improve Hb concentration further.

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Correlation of red cell indices and hemoglobin concentration with serum ferritin among iron deficiency anemia patients

Biomedicine ◽

10.51248/.v39i2.194 ◽

2020 ◽

Vol 39 (2) ◽

pp. 268-273

Author(s):

N. L Sharanya Raj ◽

U Ajay Sharma ◽

M. L Revathi Devi ◽

S. M Purushothama ◽

S. N Manjunath ◽

...

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Serum Ferritin ◽

Hemoglobin Concentration ◽

Developed Countries ◽

Deficiency Anemia ◽

Mean Corpuscular Hemoglobin ◽

Red Cell ◽

Distribution Width ◽

Red Cell Indices

Introduction and Aim: Iron deficiency anemia is the commonest cause of anemia in developing country like India in all age groups. It is most easy to prevent as well as to treat. Its diagnosis and treatment are based on serum ferritin levels in developed countries which is not possible in India at primary healthcare setting. This study was undertaken to explore if red cell indices could replace serum ferritin in detecting iron deficiency. Materials and Methods: Study of association of red cell indices like Mean Corpuscular Volume (MCV), Mean Corpuscular hemoglobin (MCH), Mean Corpuscular hemoglobin Concentration (MCHC), Red cell Distribution Width (RDW) and Hemoglobin concentration (Hb%) with iron deficiency anemia and the correlation of these Red cell indices and Hb% with serum ferritin was done in 220 anemia patients of all age groups with Hb% <12g/dL. Results: Descriptive data showed skewed distribution of serum ferritin. Statistically significant reduction in all red cell indices values among iron deficiency anemia patients and statistically significant correlation of all red cell indices values except red cell distribution width with serum ferritin was found. Conclusion: Unlike developed countries we can use simple estimation of hemoglobin concentration along with red cell indices for diagnosing iron deficiency anemia in primary healthcare setting of India.

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Serum Ferritin and Anemia in Trained Female Athletes

International Journal of Sport Nutrition ◽

10.1123/ijsn.8.3.223 ◽

1998 ◽

Vol 8 (3) ◽

pp. 223-229 ◽

Cited By ~ 17

Author(s):

Michael J. Ashenden ◽

David T. Martin ◽

Geoffrey P. Dobson ◽

Colin Mackintosh ◽

Allan G. Hahn

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Serum Ferritin ◽

Female Athletes ◽

Weight Bearing ◽

Hemoglobin Concentration ◽

Background Information ◽

Deficiency Anemia ◽

Mean Corpuscular Hemoglobin ◽

Ferritin Concentration

The aim of this study was to establish whether extremely low serum ferritin values in female athletes were associated with indications of iron deficiency anemia and whether serum ferritin values were influenced by the type of training or participants' body size. Hematological data collected during 6 years at the Australian Institute of Sport were reviewed to quantify changes in serum ferritin concentration associated with training and to establish whether decrements in serum ferritin were associated with any change in hemoglobin concentration, mean corpuscular volume, or mean corpuscular hemoglobin concentration. Mean serum ferritin concentrations of 7.5 μg ⋅ L−1 were not associated with any indication of iron-deficiency anemia. Serum ferritin declined by approximately 25% with the onset of rigorous daily training (p <.01) whether training was predominantly weight-bearing or non-weight-bearing. Rowers had significantly higher ferritin concentrations than basketball players of similar stature (p = .02). We conclude that considerable background information such as the stage of training, specific sport, and previous blood results should be sought when interpreting serum ferritin concentrations in female athletes.

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PENENTUAN DEFISIENSI BESI ANEMIA PENYAKIT KRONIS MENGGUNAKAN PERAN INDEKS sTfR-F

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v12i1.833 ◽

2018 ◽

Vol 12 (1) ◽

pp. 9

Author(s):

Adang Muhammad ◽

Osman Sianipar

Keyword(s):

Chronic Disease ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Ferritin Level ◽

Diagnostic Value ◽

The Body ◽

Deficiency Anemia ◽

Iron Store ◽

Level Increase ◽

Nutrition Problem

Background: The highest prevalence of nutrition problem due to nutrition deﬁciency is iron deﬁciency. Chronic disease anemia often occurs coincide with iron deﬁciency and both show of low iron serum appearance. Difﬁculty occurs when iron deﬁciency determined in chronic disease anemia by routine parameters. Bone marrow stainning can indicate iron store, but it is invasive. Therefore it needs another more practical parameter that has higher diagnostic value. Objective: To know the more practical parameter that can determine iron deﬁciency in chronic disease anemia Discussion: Ferritin serum indicates iron store in the body, whereas transferin receptor indicates functional of iron uptake in the erythrocyte. Changes of ferritin level due to inﬂammation process are varies. Recent evidence shows different changes of transferin receptor between iron deﬁciency anemia and those in chronic disease anemia. In chronic disease anemia, receptor transferin level increase but not as high as in those who suffer from pure iron deﬁciency anemia. Studies on groups of iron deﬁciency anemia, iron deﬁciency with acute inﬂammation, chronic disease anemia and healthy control population showed signiﬁcance differences of receptor transferin among them. sTrF-R index is an index derived from the calculation of transferin receptor level divided by logarithmic of the ferritin level. The usage of sTfR-F index indicates more signiﬁcance difference as compared to transferin receptor. Its sensitivity and speciﬁcity increase when it is applied to diagnose iron deﬁciency in elderly group. Conclusions: sTfR-F index is more sensitive and specific for the determination of iron deficiency in chronic disease anemia

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The Value of Routine Ferritin Measurement In Blood Donors

Blood ◽

10.1182/blood.v116.21.3353.3353 ◽

2010 ◽

Vol 116 (21) ◽

pp. 3353-3353

Author(s):

Alix O'Meara ◽

Laura Infanti ◽

Jörg Sigle ◽

Martin Stern ◽

Andreas S. Buser

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Serum Ferritin ◽

Blood Donors ◽

Hemoglobin Concentration ◽

Deficiency Anemia ◽

Women Of Childbearing Age ◽

Childbearing Age ◽

Donor Population ◽

The Impact

Abstract Abstract 3353 Iron store depletion is a common side effect of whole-blood donation. Iron loss may lead to iron deficiency symptoms such as fatigue, decreased physical and job performance then gradually result in iron deficiency anemia. As of 2004, routine serum ferritin testing was implemented at our Center. We analyzed the impact of this measure on our donor population with regard to hemoglobin level, anemia occurrence and donor deferral due to low hemoglobin. A total of 160'612 intended donations of 23'557 healthy blood donors at a single institution (Blutspendezentrum beider Basel, Basel, Switzerland) between 1996 and 2009 were analyzed. At each visit, complete blood counts were taken from fingerprick samples and donors were deferred if the capillary hemoglobin concentration proved <133 g/L (m) or <123 g/L (f). From 2004 on, serum ferritin was measured systematically. Upon detection of ferritin levels indicative of iron depletion or iron deficiency anemia, donors were contacted by a blood bank physician and received medical counseling. The further procedure of iron supplementation, donation interval extension or GP referral in the case of abnormal history remained at the physician and donor's discretion.Our donor population consisted of 10'893 males and 12'664 females, 8165 being women of childbearing age (age 18–45). Mean hemoglobin concentration of male donors rose from 151.7 g/L (before 2004) to 153.6 g/L after 2004 (difference 1.9 g/L, 95% CI 1.7 – 1.9 g/L). In women of all ages, the mean hemoglobin concentration increased from 135.7 to 138.3 g/L (difference 2.6 g/L, 95% CI 2.4 – 2.7 g/L) (Figure 1). The hemoglobin concentration of women of childbearing age was 134.2 g/L before 2004 and 137.0 g/L thereafter (difference 2.8 g/L, 95% CI 2.6 – 3.0 g/L). To rule out an alternative cause for the increase in hemoglobin, we assessed the evolution of hemoglobin levels in the periods of 1996–2003 and 2004–2009. In the former period, hemoglobin levels decreased at a mean rate of 0.22 g/L (95% CI -0.19 - -0.26 g/L) per year in male donors, whereas no significant change was seen in female donors (mean change 0.04 g/L, 95% CI -0.01 – 0.09 g/L). In the second period (2004 – 2009), mean hemoglobin levels increased in both male (mean increase per year 0.20 g/L, 95% CI 0.14 – 0.25 g/L) and female donors (mean increase per year 0.16 g/L, 95% CI 0.09 – 0.23 g/L). Before the introduction of routine ferritin measuring, 1.6% (95% CI 1.5 – 1.7%) of donors showed anemia according to WHO definitions (m: Hb<130; f: Hb<120). Anemia occurred in 1.1% of our donors after 2004 (95% CI 1.0 – 1.2%, difference before/after 2004 0.5%, 95% CI -0.6 – -0.3%). Frequency of anemia declined in both male donors (before 2004 0.7%, after 2004 0.5%) and in female donors (before 2004 3.6%, after 2004 2.2%). In the group of women of childbearing age, 4.9% (95% CI 4.6 – 5.3%) were anemic before and 3.1% (95% CI 2.7– 3.4%) after 2004 (difference before/after 2004 -1.8%, 95% CI -1.4 – -2.4%). In all visits to our center before 2004, 2.8% of donors (95% CI 2.7 – 2.9%) were not accepted for phlebotomy due to a hemoglobin count below the mandatory threshold. After 2004, the percentage of rejected donors due to a low hemoglobin count decreased to 1.9% (95% CI 1.8 – 2.0%, difference before/after 2004 -0.9%, 95% CI -0.7 – -1.0%). In particular in the group of women in childbearing age a clear reduction of the rejection rates was noted (before 2004: 7.6% CI 7.2 – 8.1%, thereafter: 4.8% CI 4.4 – 5.2%, difference before/after 2004 -2.8%, 95% CI -2.2 – -3.4%). In conclusion, the introduction of systematic serum ferritin measurements allowed an optimized management of donors with iron deficiency, with efficacious prevention of iron deficiency anemia. This resulted in an increase of mean hemoglobin levels in blood donors particularly in women of childbearing age, the population at highest risk for iron deficiency anemia. Both the incidence of pre-donation anemia and the frequency of donors rejected due to low hemoglobin decreased significantly. Disclosures: No relevant conflicts of interest to declare.

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Evaluation of Reticulated Haemoglobin (CHr) as a diagnostic parameter in Iron Deficiency Anemia

European Journal of Medical and Health Sciences ◽

10.24018/ejmed.2020.2.4.342 ◽

2020 ◽

Vol 2 (4) ◽

Author(s):

C. C. Kariyawasan ◽

D. J. U. S. Samarasekara ◽

N. Vithanage ◽

D. M. C. Dissanayake ◽

S. A. C. D. Ranatunga ◽

...

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Serum Ferritin ◽

Serum Iron ◽

The Body ◽

Deficiency Anemia ◽

Care Hospital ◽

Red Cell ◽

Deficiency State ◽

The Mean

Introduction: Iron deficiency anemia (IDA) is the commonest nutritional deficiency in all parts of the world. In developing countries, the commonest cause is inadequate dietary intake [1]. The red cell indices raise the suspicion of iron deficiency state due to the microcytic, hypochromic changes and the wide red cell distribution width. The iron studies are confirmatory of an iron deficiency state, but are not accurate in the presence of infection, inflammation or malignancy as they are acute phase proteins and are affected in these states making the serum iron studies unreliable under these conditions. The reticulocyte haemoglobin content (CHr) indicates the iron available in the marrow for the production of Hb and are not affected by the above-mentioned situations and therefore has been recommended as a reliable marker of iron status in the body. The value for CHr given in the literature was 25pg [3]. Objectives: General objective was to evaluate the significance of CHr in the diagnosis of IDA. The Specific objectives were to compare CHr with the other conventional iron parameters including serum iron, serum ferritin, TS and TIBC and evaluate any significance of CHr with RBC indices (MCV, MCH and MCHC) and age. Methodology: A retrospective analytical study performed at the Department of Haematology of a Tertiary care hospital in Sri Lanka. Data was obtained from the patient records of those referred to the Haematology department for management of iron deficiency during the period of 9 months commencing from April 2019 to January 2020. Data from 178 adult patients both males and females (16 to 84 years) diagnosed with IDA (S. Ferritin < 20ng/ml) (Hb < 12g/dl in men and Hb <11.5g/dl in women) were randomly selected. In pregnant females the S. Ferritin level considered was <30ng/ml and the Hb level was <11g/dl in the first trimester and 10.5g/dl in the 2nd and third trimester [4]. Blood count and CHr was analyzed using Mindray fully automated analyzer BC 6800, Serum iron and TIBC was measured with Mindray BS 480 and Serum ferritin with Advia Centaur Xp. TS was calculated by dividing serum iron by TIBC and multiplying by 100. A data extraction sheet was used to enter the investigations with the results. Statistical Analysis: Data were double entered and were analyzed using Statistical Package for Social Sciences (SPSS) version 20. Descriptive statistical methods were used to calculate the median and the mean ± standard deviation of Hb, serum iron, serum ferritin, TIBC, TS, MCV, MCH, MCHC and CHr. Pearson’s correlation was used to evaluate the correlation between variables. Coefficient of determination (R Sq) was used to a statistical measure of how close the data are to the fitted regression line. P < 0.05 was considered significant. Conclusion: Significant positive correlations were observed between the CHr and haematological parameters such as Hb, MCV, MCH, and MCHC and biochemical parameters including serum iron, serum ferritin, and TS (p value < 0.001). Negative correlation was seen between the CHr and TIBC and there was no correlation with age. The mean value of CHr was 22.4 ±4.16pg and median was 22.2 pg.

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"EVALUATION OF INTRAVENOUS IRON VERSUS ORAL IRON IN MANAGEMENT OF IRON DEFICIENCY ANEMIA IN PREGNANCY WITH SPECIFIC REFERENCE TO BODY IRON STORE”

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/612 ◽

2013 ◽

Vol 2 (16) ◽

pp. 2750-2755 ◽

Cited By ~ 2

Author(s):

Richa Bhargava ◽

Manju Maheshwari

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Intravenous Iron ◽

Oral Iron ◽

Deficiency Anemia ◽

Specific Reference ◽

Iron Store ◽

Body Iron ◽

Body Iron Store ◽

In Pregnancy

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Effect of Vitamin D Supplements On Hemoglobin Concentration in Patients with Iron Deficiency Anemia and Concurrent Vitamin D Deficiency:A Randomized Single Blind Placebo Controlled Trial

Blood ◽

10.1182/blood.v120.21.5173.5173 ◽

2012 ◽

Vol 120 (21) ◽

pp. 5173-5173

Author(s):

Pankaj Malhotra ◽

Basavaraj GS ◽

Naresh Sachdeva ◽

Jasmina Ahluwalia ◽

Sanjay Bhadada

Keyword(s):

Vitamin D ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Serum Ferritin ◽

Conflicts Of Interest ◽

Controlled Trial ◽

Hemoglobin Concentration ◽

Deficiency Anemia ◽

Controlled Study ◽

Vitamin D Supplements

Abstract Abstract 5173 Background: The effect of vitamin D replacement on hemoglobin concentration in subjects with concurrent iron deficiency anemia and vitamin D deficiency is not known. Methods: In a single blinded randomized placebo controlled study, thirty subjects with iron deficiency anemia (serum ferritin < 15 ug/dl) were randomized to intervention arm (vitamin D 6 lakh IU IM once) or placebo. In all subjects, iron deficiency was corrected with parental iron. All the causes other than iron deficiency were excluded with appropriate investigation. The primary end point was rise in hemoglobin concentration. Results: Baseline age, BMI, hemogram, levels of serum ferritin, 25(OH)D and PTH were similar in both the arms. Twelve weeks after vitamin D replacement, there was significant increase in 25 (OH) D levels and decrease in PTH levels in subjects with intervention arm compared to placebo arm (p<0. 01). The increment in serum ferritin in both the group was similar. There was no further increase in hemoglobin concentration in intervention arm compared to placebo arm. Conclusion: Vitamin D replacement in subjects with iron deficiency anemia after iron correction does not improve hemoglobin concentration further. Disclosures: No relevant conflicts of interest to declare.

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