scholarly journals Platelet-rich plasma in interventional dermatology and trichology: How far have we come?

2021 ◽  
Vol 1 ◽  
pp. 12
Author(s):  
Suruchi Garg ◽  
Anuva Bansal

Platelet-rich plasma (PRP) contains several growth factors and cellular adhesion molecules which promote wound healing, angiogenesis and accelerate the rejuvenation of skin and hair follicles. With its proven regenerative and regrowth potential in a plethora of conditions, PRP has been deemed as the “futuristic elixir.” Current evidence suggests that PRP effectively stimulates angiogenesis, collagen as well as elastin regeneration, and is a safe, easy to prepare, minimally invasive technique with limited downtime, and negligible risk of allergic/hypersensitivity reactions owing to its autologous nature. It has shown excellent results when utilized as monotherapy or in combination with microneedling or ablative lasers in acne scars, post-burn or post-traumatic scars, melasma, striae distensae, chronic ulcers, and lichen sclerosus. PRP injections or PRP combined with microneedling are increasingly being utilized for skin rejuvenation and recently have been utilized to provide non-invasive face lifts. A novel technique combining non-cultured epidermal cell suspension suspended in PRP results in superior repigmentation outcomes in case of vitiligo. Use of PRP alone or in combination with hair transplant in androgenetic alopecia is another well-researched indication and its use has been successfully extrapolated to indications such as alopecia areata, chronic telogen effluvium, and cicatricial alopecia. In spite of its established efficacy in such a vast number of indications, PRP should be used with utmost caution. These growth mediators exert their own endocrine, paracrine, and enzymatic effects, the complete influence of which still remains a mystery and only years of experience, in the times to come will unravel the absolute power of our “mighty dragon warrior.”

Author(s):  
S.L. Erlandsen

Cells interact with their extracellular environments by means of a variety of cellular adhesion molecules (CAM) and surface ligands. In many instances, CAMs interact in a sequential temporal fashion which suggests that these adhesion molecules may occupy or be polarized to various membrane microdomains on the cell surface. Detection of CAMs can be accomplished by a variety of methods including immunofluorescent microscopy and flow cytometry, and by the use of immunocytochemical markers (i.e. colloidal gold) in electron microscopy. The development of high resolution field emission SEM in the mid 1980's and the Autrata modification of the YAG detector for backscatter electron detection at low voltage has greatly facilitated the recognition of colloidal gold probes for detection of surface CAMs. Low voltage FESEM with Bse imaging provides increased resolution of cell surface topography (~3nm at 3-4 keV) which can be observed in 3-dimensions, and simultaneously permits detection/high spatial resolution of immunogold label by atomic number contrast.


2006 ◽  
Vol 26 (5) ◽  
pp. 437-444 ◽  
Author(s):  
Jacek Rysz ◽  
Ewa Majewska ◽  
Robert A. Stolarek ◽  
Maciej Banach ◽  
Aleksandra Ciałkowska-Rysz ◽  
...  

1995 ◽  
Vol 65 (12) ◽  
pp. 838-847 ◽  
Author(s):  
A. F. Breidahl ◽  
M. J. Hickey ◽  
A. G. Stewart ◽  
P. G. Hayward ◽  
W. A. Morrison

2005 ◽  
Vol 23 (2) ◽  
pp. 106-112 ◽  
Author(s):  
Yu-Sen Peng ◽  
Chih-Kang Chiang ◽  
Shih-Ping Hsu ◽  
Mei-Fen Pai ◽  
Kuan-Yu Hung ◽  
...  

2006 ◽  
Vol 155 (6) ◽  
pp. 1270-1274 ◽  
Author(s):  
M. Caproni ◽  
W. Volpi ◽  
B. Giomi ◽  
D. Torchia ◽  
E. Del Bianco ◽  
...  

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Ning Zhang ◽  
Yong-Ping Wu ◽  
Sheng-Jun Qian ◽  
Chong Teng ◽  
Shuai Chen ◽  
...  

Platelet-rich plasma (PRP) therapy is a recently developed technique that uses a concentrated portion of autologous blood to try to improve and accelerate the healing of various tissues. There is a considerable interest in using these PRP products for the treatment used in bone deficiency healing. Because PRP products are safe and easy to prepare and administer, there has been increased attention toward using PRP in numerous clinical settings. The benefits of PRP therapy appear to be promising, and many investigators are exploring the ways in which this therapy can be used in the clinical setting. At present, the molecular mechanisms of bone defect repair studies have focused on three aspects of the inflammatory cytokines, growth factors and angiogenic factors. The role of PRP works mainly through these three aspects of bone repair. The purpose of this paper is to review the current evidence on the mechanism of the effect of PRP in bone deficiency healing.


Blood Reviews ◽  
1990 ◽  
Vol 4 (4) ◽  
pp. 211-225 ◽  
Author(s):  
K. Yong ◽  
A. Khwaja

Author(s):  
Kerry Heitmiller ◽  
Jordan V. Wang ◽  
Robert D. Murgia ◽  
Nazanin Saedi

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