scholarly journals MONITORING OF ANAEROBIC PATHOGENS RESISTANCE IN PATIENTS WITH SURGICAL SKIN AND SOFT TISSUE INFECTIONS

2021 ◽  
Vol 19 (2) ◽  
pp. 166-169
Author(s):  
S. D. Fedzianin ◽  
◽  
V. K. Okulich ◽  
E. L. Lokteva ◽  
◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antibiotic Therapy ◽  
High Activity ◽  
Soft Tissue Infections ◽  
Empirical Antibiotic Therapy ◽  
Anaerobic Infection ◽  
Test Systems ◽  
Anaerobic Infections

Background: The problem of treating anaerobic infections in surgery continues to be relevant. Aim: To develop a protocol for empirical antibiotic therapy of anaerobic infection in patients with surgical skin and soft tissue infections. Material and methods: A total of 191 patients were examined. Identification and assessment of pathogens sensitivity was performed on the АТВ Expression analyzer. In addition, we used the ID-ANA and AB-AN test systems, developed by us. Results: In the structure of anaerobes, bacteroids, peptococci and peptostreptococci continue to occupy the leading positions. No changes in the resistance of anaerobes to most antibiotics were found. There is an increase in the resistance of peptococci and peptostreptococci to clindamycin. Metronidazole, imipenem, meropenem retain high activity. Conclusions: If anaerobic infection is suspected, it is recommended to prescribe metronidazole, and imipenem and meropenem as reserve drugs.

Empirical antibiotic therapy of complicated skin and soft tissue infections in dermatological practice

2011 ◽  
Vol 152 (7) ◽  
pp. 252-258
Author(s):  
Andrea Magyar ◽  
Edina Garaczi ◽  
Edit Hajdú ◽  
Lajos Kemény
Keyword(s):  
Soft Tissue ◽  
Antibiotic Therapy ◽  
Streptococcus Pyogenes ◽  
Anaerobic Bacteria ◽  
Empirical Therapy ◽  
Soft Tissue Infections ◽  
Empirical Antibiotic Therapy ◽  
Gram Negative ◽  
First Choice ◽  
Complicated Skin

Erysipelas is an acute bacterial infection of the skin predominantly caused by Streptococcus pyogenes. According to the international classification complicated erysipelas belongs to the complicated skin and soft tissue infections. Complicated infections are defined as severe skin involvement or when the infection occurs in compromised hosts. These infections frequently involve Gram-negative bacilli and anaerobic bacteria. Aims: The aim of this study was to compare the efficacy of the empirical antibiotic therapy for the patients who were admitted to the Department of Dermatology and Allergology, University of Szeged. Methods: The empirical therapy was started according to a previously determined protocol. The data of 158 patients with complicated skin and soft tissue infections were analyzed and the microbiology culture specimens and the isolates were also examined. Results and conclusions: The results show that penicillin is the first choice for the treatment of erysipelas. However, the complicated skin and soft tissue infections require broad-spectrum antibiotics. Orv. Hetil., 2011, 152, 252–258.

scholarly journals 289. Impact of Clinician Specialty on the Use of Oral Antibiotic Therapy for Definitive Treatment of Uncomplicated Bloodstream Infections

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S144-S145
Author(s):  
Jasmine R Marcelin ◽  
Mackenzie R Keintz ◽  
Jihyun Ma ◽  
Erica J Stohs ◽  
Bryan Alexander ◽  
...  
Keyword(s):  
Social Media ◽  
Soft Tissue ◽  
Infectious Diseases ◽  
Antibiotic Therapy ◽  
Bloodstream Infections ◽  
Definitive Treatment ◽  
Oral Antibiotic ◽  
Soft Tissue Infections ◽  
Gram Positive ◽  
Oral Antibiotic Therapy

Abstract Background No established guidelines exist regarding the role of oral antibiotic therapy (OAT) to treat uncomplicated bloodstream infections (uBSIs) and practices may vary depending on clinician specialty and experience. Methods An IRB-exempt web-based survey was emailed to Nebraska Medicine clinicians caring for hospitalized patients, and widely disseminated using social media. The survey was open access and once disseminated on social media, it was impossible to ascertain the total number of individuals who received the survey. Chi-squared analysis for categorical data was conducted to evaluate the association between responses and demographic groups. Results Of 275 survey responses, 51% were via social media, and 94% originated in the United States. Two-thirds of respondents were physicians, 16% pharmacists, and infectious diseases clinicians (IDC) represented 71% of respondents. The syndromes where most were comfortable using OAT routinely for uBSI were urinary tract infection (92%), pneumonia (82%), pyelonephritis (82%), and skin/soft tissue infections (69%). IDC were more comfortable routinely using OAT to treat uBSIs associated with vertebral osteomyelitis and prosthetic joint infections than non-infectious diseases clinicians (NIDC), but NIDC were more likely to report comfort with routine use of OAT to treat uBSIs associated with meningitis and skin/soft tissue infections. IDC were more likely to report comfort with routine use of OAT for uBSIs due to Enterobacteriaceae and gram-positive anaerobes, while NIDC were more likely to be comfortable with routinely using OAT to treat uBSIs associated with S. aureus, coagulase-negative staphylococci and gram-positive bacilli. In one clinical vignette of S. aureus uBSI due to debrided abscess, 11% of IDC would be comfortable using OAT vs 28% of NIDC; IDC were more likely to report routinely repeating blood cultures (99% vs 83%, p< 0.05). Figure 1: Clinician comfort using oral antibiotic therapy to treat uncomplicated bacteremia due to specific syndromes Figure 2: Clinician comfort using oral antibiotic therapy to treat uncomplicated bacteremia due to specific organisms Conclusion Considerable variation in comfort using OAT for uBSIs among IDC vs NIDC exists, highlighting opportunities for IDC to continue to demonstrate their value in clinical practice. Understanding the reasons for variability may be helpful in creating best practice guidelines to standardize decision making. Disclosures All Authors: No reported disclosures

scholarly journals Relationship between Adherence to Oral Antibiotics and Postdischarge Clinical Outcomes among Patients Hospitalized with Staphylococcus aureus Skin Infections

2016 ◽  
Vol 60 (5) ◽  
pp. 2941-2948 ◽  
Author(s):  
Samantha J. Eells ◽  
Megan Nguyen ◽  
Jina Jung ◽  
Raul Macias-Gil ◽  
Larissa May ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Antibiotic Therapy ◽  
Clinical Response ◽  
Clinical Outcomes ◽  
Hospital Discharge ◽  
Oral Antibiotic ◽  
Soft Tissue Infections ◽  
Oral Antibiotics ◽  
Oral Antibiotic Therapy

ABSTRACTSkin and soft tissue infections are common and frequently recur. Poor adherence to antibiotic therapy may lead to suboptimal clinical outcomes. However, adherence to oral antibiotic therapy for skin and soft tissue infections and its relationship to clinical outcomes have not been examined. We enrolled adult patients hospitalized with uncomplicated skin and soft tissue infections caused byStaphylococcus aureuswho were being discharged with oral antibiotics to complete therapy. We fit the participants' pill bottles with an electronic bottle cap that recorded each pill bottle opening, administered an in-person standardized questionnaire at enrollment, 14 days, and 30 days, and reviewed the participants' medical records to determine outcomes. Our primary outcome was poor clinical response, defined as a change in antibiotic therapy, new incision-and-drainage procedure, or new skin infection within 30 days of hospital discharge. Of our 188 participants, 87 had complete data available for analysis. Among these participants, 40 (46%) had a poor clinical response at 30 days. The mean electronically measured adherence to antibiotic therapy was significantly different than the self-reported adherence (57% versus 96%;P< 0.0001). In a multivariable model, poor clinical response at 30 days was associated with patients having lower adherence, being nondiabetic, and reporting a lack of illicit drug use within the previous 12 months (P< 0.05). In conclusion, we found that patient adherence to oral antibiotic therapy for a skin and soft tissue infection after hospital discharge was low (57%) and associated with poor clinical outcome. Patients commonly overstate their medication adherence, which may make identification of patients at risk for nonadherence and poor outcomes challenging. Further studies are needed to improve postdischarge antibiotic adherence after skin and soft tissue infections.

scholarly journals Skin and Soft-Tissue Infections after Injury in the Ocean: Culture Methods and Antibiotic Therapy for Marine Bacteria

1999 ◽  
Vol 164 (3) ◽  
pp. 198-201 ◽  
Author(s):  
Keven C. Reed ◽  
Mark C. Crowell ◽  
Melva D. Castro ◽  
Mary L. Sloan
Keyword(s):  
Soft Tissue ◽  
Antibiotic Therapy ◽  
Marine Bacteria ◽  
Soft Tissue Infections ◽  
Culture Methods

scholarly journals An unusual pathogen in ambulatory care: two cases of Scedosporium soft tissue infections presenting as “unresponsive cellulitis”

2016 ◽  
Vol 15 (2) ◽  
pp. 88-91
Author(s):  
Patrick Lillie ◽  
◽  
Gary Peter Misselbrook ◽  
Claire P Thomas ◽  
◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antibiotic Therapy ◽  
Ambulatory Care ◽  
Soft Tissue Infection ◽  
Outpatient Setting ◽  
Immunocompromised Patients ◽  
Soft Tissue Infections ◽  
Important Condition ◽  
Initial Antibiotic Therapy ◽  
The Uk

Soft tissue infections with Scedosporium spp. are an uncommon but serious and emerging cause of infection in immunocompromised patients. Acute Medical Units (AMUs) in the UK are increasingly managing patients with cellulitis in an outpatient setting, therefore acute physicians should be aware of some of the more uncommon causes of soft tissue infection, particularly in patients not responding to initial antibiotic therapy. We present two cases of Scedosporium presenting to the AMU as cellulitis not responding to initial antibiotic therapy and outline the assessment and management of this important condition.

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