scholarly journals Early diagnosis of cervical cancer in the Republic of Bashkortostan: a pilot project

Author(s):  
А.Ф. Ахметгалеева ◽  
Р.И. Султанова ◽  
О.И. Машков ◽  
В.Л. Ахметова ◽  
М.В. Мельникова ◽  
...  

В рамках пилотного проекта сплошного организованного комбинированного скрининга рака шейки матки (РШМ) было обследовано 29084 жительниц г.Уфы в возрасте от 30 до 39 лет с использованием технологии ВПЧ Дайджен-тест (Digene-тест, QIAGEN) с последующим цитологическим исследованием ВПЧ позитивных женщин. При проведении лабораторного обследования положительный результат был выявлен в 2991 случае, что составило 9,8% всех обследованных. Из них у 274 пациентов в результате дообследования были выявлены предраковые изменения шейки матки, а у 19 - карциномы на I стадии. Данное исследование является первым опытом в России по ранней диагностики РШМ. 29,084 Ufa residents were examined for cervical cancer using HPV technology Digene-test (Digene-test, QIAGEN), as part of a pilot project of organized combined screening, followed by cytological examination of HPV positive women. Women were 30-39 years old. Positive results were detected in 2991 cases, which is 9.8% of all examined women. Precancerous changes in the cervix was revealed in 274 patients, and carcinomas - in 19 patients.

2020 ◽  
pp. 8-12
Author(s):  
Anatoliy M. Kovalenko ◽  
◽  
Nazar V. Yavnikov ◽  
Maksim V. Petropavlovskiy ◽  
Albina G. Isaeva ◽  
...  

The aim of the research is to use the early diagnosis of cattle leukemia virus-infected animals using serological and molecular genetic methods, as well as to determine the significance of PCR in detecting BLV infected calves. The studies were carried out in the leukemia laboratory of the department for monitoring and forecasting of infectious diseases of the Ural Federal Agrarian Research Center, at the department of infectious and invasive pathology of the Belgorod State Agrarian University named after V.Ya. Gorin, as well as in 20 livestock agricultural enterprises of the Tyumen, Chelyabinsk, Kurgan, Belgorod regions and the Republic of Bashkortostan. The studies were carried out in the framework of the 160th direction of the FNI Program of State Academies of Sciences for 20132020 on the topic «Development of theoretical foundations for the creation and implementation of a monitoring, diagnostic, treatment and wellness program for the protection of animals from epizootically significant infectious diseases» The system of anti-leukemic health measures using complex serological and hematological testing helps to reduce the number of RID+ animals and hematologically sick individuals for a 6-month period by 32.0% and 6.28%, respectively. The use of the polymerase chain reaction method contributes to the detection of an additional 18 to 39% of calves from 15 days of age, infected with the virus of bovine leukemia, in dysfunctional leukemia livestock enterprises. In a PCR study of cows, 29% to 54% of individuals infected with BLV can be detected. This indicates the need for consistent use of serological studies and the importance of molecular genetic tests for the detection of BLV infected calves.


2020 ◽  
Vol 56 (2) ◽  
pp. 12-15
Author(s):  
N. S. IGISSINOV ◽  
Zh. B. TELMANOVA ◽  
G. S. IGISSINOVA ◽  
Z. A. BILYALOVA ◽  
D. M. KULMIRZAYEVA

About 800 thousand new cases of cervical cancer (CC) are predicted, and it is expected that about 460 thousand women will die from this pathology, according to the forecasts of the International Agency for Research on Cancer in 2040. To this aim, an analysis studying the indicators of the cancer service for CC also allows us to evaluate the effectiveness of anti-cancer measures in the Republic of Kazakhstan. Aim: Evaluate some indicators of the cancer service at CC in Kazakhstan for 2009-2018. Materials and methods. The research material was data from the Ministry of Health of the Republic of Kazakhstan – annual form No.7 and 35 regarding CC (ICD10–C53) for 2009-2018 – incidence, mortality, early diagnosis, neglect, morphological verification. A retrospective study using descriptive and analytical methods of biomedical statistics was used as the main method. Results and discussion. For 2009-2018, 16,441 new cases of CC were registered in the Republic for the first time, and 6,461 women died from this disease. The crude CC incidence rate increased from 16.3±0.4‰ (2009) to 19.5±0.5‰ in 2018 (p=0.000). In dynamics, mortality rates from CC tended to decrease from 8.4±0.3‰ (2009) to 6.4±0.3‰ in 2018 (р=0.000). The research of the study period reveals a trend: early diagnosis indicators (specific weight of patients with I-II stage) improved from 79.8% (2009) to 88.1% in 2018, and accordingly the specific weight of neglected patients significantly decreased with stage III (from 15.4% to 8.9%) and with stage IV (from 3.4% to 2.7%). The morphological verification indicators for CC remained virtually unchanged, remaining fairly high 99.2% and 99.3%, respectively, in 2009 and 2018. Conclusion. An analysis of the indicators of the cancer service in CC revealed an improvement in morphological verification and early diagnosis, a decrease in neglect and mortality rates, which is undoubtedly associated with regular anti-cancer activities in Kazakhstan, in particular CC screening.


Author(s):  
Д.А. Шаповалова ◽  
А.В. Тюрин ◽  
Р.И. Хусаинова

Остеоартрит (ОА) - наиболее распространенное многофакторное заболевание суставов. Одним из вероятных факторов риска развития ОА является недифференцированная дисплазия соединительной ткани (нДСТ) - генетически детерминированное нарушение структуры соединительной ткани, в том числе и в суставах. Вопрос о коморбидности ОА с нДСТ чрезвычайно актуален, и решение данной задачи будет способствовать разработке подходов ранней диагностики ОА в целях профилактики заболевания. Osteoarthritis (OA) is a common multifactorial joint disease. Undifferentiated connective tissue dysplasia (uCTD) is a genetically determined lesion of the connective tissue structures, including joints, and it can be one of the factors, predisposing to development of OA. Solving the problem of comorbidity OA and uCTD signs will contribute to the early diagnosis and preventive of OA.


Author(s):  
Victorov V. V. ◽  
◽  
Sharafutdinov M. A. ◽  
Mukhamadeeva O. R. ◽  
Pavlova M. Yu. ◽  
...  

2020 ◽  
Vol 0 (6) ◽  
pp. 13-19
Author(s):  
Guzel Gumerova ◽  
Georgiy Gulyuk ◽  
Dmitry Kucher ◽  
Anatoly Shuravilin ◽  
Elena Piven

Data of long-term researches (2015–2018) in southern forest-steppe zone of the Republic of Bashkortostan, is justified theoretically and experimentally the mode of irrigation of potatoes on leached chernozems of unsatisfactory, satisfactory and good ameliorative condition of irrigated lands. For the growing periods of potatoes with different heat and moisture supply, the number of watering, the timing of their implementation, irrigation and irrigation norms are established. On lands with unsatisfactory meliorative state the number of irrigation depending on weather conditions of potato vegetation period varied from 0 to 3 (1.5 on average) with average irrigation norm – 990 m3/ha. With satisfactory meliorative state of lands the number of irrigation on average increased from 0 to 4 (2.3 on average) with irrigation norm – 1305 m3/ha. On lands with good meliorative state the number of irrigation was the highest – from 1 to 5 (3 on average) with average irrigation irrigation norm is 1653 m3/ha. It was noted that in the dry periods of potato vegetation the greatest number of watering was carried out (3–5 watering), and in the wet periods (2017) watering was not carried out except for the area with a good reclamation state, where only one irrigation was carried out by the norm of 550 m3/ha. Water consumption of potato was studied in dynamics as a whole during the growing season and the months of the growing season depending on weather conditions of vegetation period and land reclamation condition of irrigated lands, as well as in the control (without irrigation). The lowest total water consumption was in the area without irrigation and averaged 226.8 mm. In irrigated areas, its values increased to 319-353.4 mm. The average daily water consumption varied from 2.12 to 3.3 mm. The highest rates of potato water consumption were observed in June and July, and the lowest – in May and August. In the total water consumption of potatoes on the site without irrigation, the largest share was occupied by atmospheric precipitation and in addition to them the arrival of moisture from the soil. Irrigation water was used in irrigated areas along with precipitation, the share of which was 30.2–46.1 %.


2020 ◽  
Vol 99 (4) ◽  
pp. 405-411
Author(s):  
Elena Ju. Gorbatkova

Introduction. The important factors affecting health and performance of young people are the conditions of education, in particular, a comfortable microclimate in the classrooms of higher educational institutions. Materials and methods. In view of the urgency of this problem, an analysis was made of the microclimate parameters of educational organizations of different profiles (Ufa city, the Republic of Bashkortostan). 294 classrooms were studied in 22 buildings of 4 leading universities in Ufa. A total of 3,822 measurements were taken to determine the parameters of the microclimate. The analysis of ionizing radiation in the aerial environment of classrooms. There was performed determination of radon and its affiliated products content. In order to assess the conditions and lifestyle of students of 4 higher educational institutions of the city of Ufa, we conducted an anonymous survey of 1,820 students of I and IV years of education. Results. The average temperature in the classrooms of all universities studied was 23.9±0.09 C. The average relative humidity in all classrooms was 34.2 ± 0.42%. Analysis of ionizing radiation (radon and its daughter products decay) in the aerial environment of the classrooms and sports halls located in the basement determined that the average annual equivalent equilibrium volumetric activity of the radon daughter products (EROA ± Δ222Rn) ranged from 28 ± 14 to 69 ± 34.5 meter, which meets the requirements established by SanPiN. Conclusion. The hygienic assessment of the microclimate parameters of educational institutions of various profile revealed a number of deviations from the regulated norms. The results indicate the need to control the parameters of the microclimate, both from the administration of universities, and from the professors. According to the results of the study, recommendations were prepared for the management of higher educational institutions in Ufa.


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