Activation of brown adipose tissue in the human body

2021 ◽  
pp. 87-91
Author(s):  
A.V. Efremova ◽  
V.A. Alekseev ◽  
L.I. Konstantinova ◽  
E.D. Okhlopkova ◽  
E.I. Semenova ◽  
...  
Author(s):  
Liubov N. Afanaskina ◽  
Svetlana N. Derevtsova ◽  
Lyudmila V. Sindeeva ◽  
Elena A. Hapilina ◽  
Nadezhda N. Medvedeva

Obesity is one of the most common diseases, the proportion of which is increasing annually today in Russia. Not only adults but also adolescents and children are at risk. Excessive body weight leads to the development of metabolic syndrome and related complications - diseases of the circulatory, musculoskeletal, immune and other systems, to premature aging of the human body. Until this disease has become an epidemic, researchers around the world are trying to find methods to combat it. For these purposes, various types of adipose tissue in the human body, their importance, morphology and biology, the possibility of further use of the results to solve this problem are comprehensively studied. The article provides an overview of current data on the morphological features of white, brown and beige adipose tissue at the tissue and cellular levels.The importance of specific proteins for the detection of different types of human adipose tissue is described. The biology and physiology of brown adipose tissue, which is of great importance in the implementation of various metabolic processes in the organism, is characterized. The need for further study of the role of brown adipose tissue for its possible promising use in the treatment of obesity is shown.


2021 ◽  
Vol 1 (19) ◽  
pp. 358-359
Author(s):  
E. Kotenkova

White and brown adipose tissue is present in the human body and is well described. As well as the effect of the type of fat on human health, in particular obesity, type 2 diabetes, insulin tolerance. The presence and distribution of different types of fat in pigs has not been adequately described. As well as the factors contributing to the "browning" of white fat and the ability to influence this process in pigs.


2020 ◽  
Vol 477 (7) ◽  
pp. 1261-1286 ◽  
Author(s):  
Marie Anne Richard ◽  
Hannah Pallubinsky ◽  
Denis P. Blondin

Brown adipose tissue (BAT) has long been described according to its histological features as a multilocular, lipid-containing tissue, light brown in color, that is also responsive to the cold and found especially in hibernating mammals and human infants. Its presence in both hibernators and human infants, combined with its function as a heat-generating organ, raised many questions about its role in humans. Early characterizations of the tissue in humans focused on its progressive atrophy with age and its apparent importance for cold-exposed workers. However, the use of positron emission tomography (PET) with the glucose tracer [18F]fluorodeoxyglucose ([18F]FDG) made it possible to begin characterizing the possible function of BAT in adult humans, and whether it could play a role in the prevention or treatment of obesity and type 2 diabetes (T2D). This review focuses on the in vivo functional characterization of human BAT, the methodological approaches applied to examine these features and addresses critical gaps that remain in moving the field forward. Specifically, we describe the anatomical and biomolecular features of human BAT, the modalities and applications of non-invasive tools such as PET and magnetic resonance imaging coupled with spectroscopy (MRI/MRS) to study BAT morphology and function in vivo, and finally describe the functional characteristics of human BAT that have only been possible through the development and application of such tools.


2011 ◽  
Vol 6 (S 01) ◽  
Author(s):  
M Merkel ◽  
A Bartelt ◽  
K Brügelmann ◽  
J Heeren

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
K Krause ◽  
M Kranz ◽  
V Zeisig ◽  
N Klöting ◽  
K Steinhoff ◽  
...  

2020 ◽  
Author(s):  
G Lenihan-Geels ◽  
F Garcia-Carrizo ◽  
C Li ◽  
M Oster ◽  
A Prokesch ◽  
...  

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