scholarly journals Can early administration of fibrinogen improve post partum hemorrhage? A prospective observational study (preliminary results)

2016 ◽  
Author(s):  
Kolsi Kamel
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Post Partum ◽  
Early Administration ◽  
Preliminary Results ◽  
Post Partum Hemorrhage

AF.131 CHROMOENDOSCOPY FOR DETECTING DYSPLASIA IN IBD PATIENTS: PRELIMINARY RESULTS FROM A SINGLE-CENTRE, PROSPECTIVE OBSERVATIONAL STUDY

2021 ◽  
Vol 53 ◽  
pp. S197
Author(s):  
M.V. Lenti ◽  
F. De Grazia ◽  
M. Bardone ◽  
F. Borrelli De Andreis ◽  
S. Maimaris ◽  
...  
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Single Centre ◽  
Preliminary Results

Quality of life (QoL) and symptoms evaluation in metastatic breast cancer (MBC) patients (pts) treated with eribulin: Preliminary results of a prospective observational study.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e12031-e12031
Author(s):  
Teresa Gamucci ◽  
Lucia Mentuccia ◽  
Silvia Quadrini ◽  
Luca I. Moscetti ◽  
Patrizia Vici ◽  
...  
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Metastatic Breast ◽  
Her2 Positive ◽  
Microtubule Inhibitor ◽  
Preliminary Results ◽  
Kaplan Meier ◽  
Trial Outcome Index ◽  
Third Line ◽  
Outcome Index

e12031 Background: Eribulin (E) is a nontaxane microtubule inhibitor currently indicated for third-line chemotherapy (CHT) of MBC. To evaluate its tolerability and impact on QoL and symptoms improvement in MBC pts, from April 2012, we conducted a prospective observational study. Methods: Pts pretreated with anthracycline (A) and taxane (T) who has received 2 CHT lines for MBC, scheduled to be treated with E were considered eligible. Pts complete the Edmonton Symptoms Assessment Scale (ESAS) at each cycle and the Functional Assessment of Cancer Therapy-Breast (FACT-B) every 2 cycles. Outcome of QoL included the FACT-B total score, FACT-General (FACT-G) score and the Trial Outcome Index (TOI) score. Groups of data were analyzed using ANOVA and the Friedman test. Kaplan-Meier method was used for survival calculation. Overall Survival was calculated by the Kaplan-Meier product-limit method. Results: 25 consecutive MBC pts entered the study. Median age 65 (range 31-77), PS (ECOG) 0-1 96%, 24% had triple-negative MBC, 70% ER/PgR positive and 5% HER2 positive. All pts were pretreated with A and T, 19 (76%) also with capecitabine. Median cycles 6 (range 3-13), 36% received more than 6 cycles. Five pts are to early for evaluation. Of the 20 evaluable pts main toxicity were: alopecia G1 58% and G2 42%, asthenia G2 40% peripheral neuropathy G2 25% neutropenia G2 0% and G3-G4 10%.At a median follow-up of 6 months 16% of pts achieved partial response (PR) 44% stable disease (SD) and 20% progressive disease; disease control rate (PR+SD ≥ 6 m) occurred in 40% of pts. Median PFS is 5 m (95% CI, 4-6) currently 70% of pts are alive. Data of ESAS and QoL are reported in table. Conclusions: Our preliminary results shows that treatment with E is associated with a significant improvement of ESAS scores (p=0.03) mainly in responders pts (p=0.02) and with a good maintenance of QoL with expected and manageable toxicities. Data collection is ongoing and update results will be presented. [Table: see text]

Influence of Various Modes of Delivery on Mother-infant Bonding: A Prospective Observational Study

2019 ◽  
Vol 15 (4) ◽  
pp. 295-300
Author(s):  
Vidyashree Ganesh Poojari ◽  
Akhila Vasudeva ◽  
Vidya Sudha
Keyword(s):  
Observational Study ◽  
Cesarean Delivery ◽  
Vaginal Delivery ◽  
Postpartum Period ◽  
Prospective Observational Study ◽  
Post Partum ◽  
Elective Cesarean Delivery ◽  
Emergency Cesarean ◽  
Bonding Failure ◽  
Elective Cesarean

Background: Mother-infant bonding has tremendous implications for the child's future development. The difficulties that some mothers have in establishing an emotional bond with their newborns often referred to as impaired bonding or bonding failure are an essential focus in the postpartum period. Therefore, it is important to identify predictive factors for bonding failure and to intervene at an early stage for the better mental health care of mothers as well as infant. Objective: To determine the effect of various modes of delivery on the mother-infant bonding. Methods: Prospective observational study performed on low-risk singleton pregnancy who delivered at term. Mother-to-Infant Bonding Scale (MIBS; Taylor et al., 2005), a validated self-report test was used to measure mother's feelings towards her baby within three days of delivery and at the end of six weeks postpartum period. Total score ranges from 0 to 24. A total MIBS score of ≥ 2 is established as cut-off indicating “poor bonding”. MIBS score of 0 and 1 is considered as “good bonding”. The mean bonding score among the 3 groups was compared. Results: Elective cesarean delivery group had 112 participants, 115 were Emergency cesarean group and 107 were vaginal delivery group. Immediately after the delivery (MIBS 1), the proportion of women with poor bonding among Emergency cesarean group was 34.8% when compared to proportion of women with poor bonding among Elective cesarean (11.6%) and Vaginal delivery (13%). This was statistically significant (p-value 0.01). When we followed up these mothers at 6 weeks post-partum checkup, the MIBS scoring (MIBS-2) consistently improved among the three groups. However, proportion of women with poor bonding still remained high at 16.5% among the Emergency cesarean group. Conclusion: Mode of delivery has a significant impact on MIBS. In this study, unplanned cesarean delivery was associated with a high incidence of poor mother to infant bonding. Poor bonding was commoner in this group even at 6 weeks post-partum, compared to those undergoing a successful vaginal delivery and a planned elective cesarean delivery.

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