Solid State Structural Aspects of Solid Self-microemulsifying Drug Delivery Systems (SMEDDS) during Digestion

In the past decades, nanosized drug delivery systems (DDS) have been extensively developed and studied as a promising way to improve the performance of a drug and reduce its undesirable side effects. DDSs are usually very complex supramolecular assemblies made of a core that contains the active substance(s) and ensures a controlled release, which is surrounded by a corona that stabilizes the particles and ensures the delivery to the targeted cells. To optimize the design of engineered DDSs, it is essential to gain a comprehensive understanding of these core–shell assemblies at the atomic level. In this review, we illustrate how solid-state nuclear magnetic resonance (ssNMR) spectroscopy has become an essential tool in DDS design.

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Fast understanding of phases and phase separation in liquid crystal drug delivery systems using deuterium solid-state NMR

Solid State Nuclear Magnetic Resonance ◽

10.1016/j.ssnmr.2020.101642 ◽

2020 ◽

Vol 106 ◽

pp. 101642

Author(s):

Anuji Abraham ◽

Eric Chan ◽

Hyunsoo Park

Keyword(s):

Drug Delivery ◽

Liquid Crystal ◽

Phase Separation ◽

Solid State ◽

Solid State Nmr ◽

Drug Delivery Systems ◽

Delivery Systems

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Influence of drug polarity upon the solid-state structure and release properties of self-emulsifying drug delivery systems in relation with water affinity

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2009.01.008 ◽

2009 ◽

Vol 71 (1) ◽

pp. 73-78 ◽

Cited By ~ 8

Author(s):

O. Chambin ◽

T. Karbowiak ◽

L. Djebili ◽

V. Jannin ◽

D. Champion ◽

...

Keyword(s):

Drug Delivery ◽

Solid State ◽

Drug Delivery Systems ◽

Delivery Systems ◽

State Structure ◽

Solid State Structure ◽

Water Affinity

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Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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