Comparison of the Solubilization Properties of Polysorbate 80 and Isopropanol/Water Solvent Systems for Organic Compounds Leached from Pharmaceutical Packaging Configurations

2016 ◽  
Author(s):  
Steven Zdravkvoic
Keyword(s):  
Organic Compounds ◽  
Polysorbate 80 ◽  
Water Solvent ◽  
Solvent Systems

Preparation of Ultra-Fine Clarithromycin Particles by Anti-Solvent Recrystallization

2016 ◽  
Vol 680 ◽  
pp. 534-537 ◽  
Author(s):  
Jing Xu
Keyword(s):  
Volume Ratio ◽  
Acetone Solution ◽  
Ultrafine Powders ◽  
Precipitation Temperature ◽  
Temperature And Precipitation ◽  
Water Solvent ◽  
Acetone Water ◽  
Ft Ir ◽  
Solvent Systems ◽  
The Mean

Ultrafine drug powders have higher bioavaibability than the larger signed particles. Ultrafine powders of clarithromycin were produced by anti-solvent recrystallization with the acetone - water solvent systems. The effects of volume ratio of clarithromycin acetone solution to anti-solvent, stirring speed, precipitation temperature and precipitation time on the preparation process were investigated. The results show that ultrafine powders can be yielded and well-controlled under the following optimal conditions: the volume ratio of clarithromycin acetone solution to anti-solvent 1:10, stirring speed 900 r/min, precipitation temperature 20°C, and precipitation time 10 min. The ultrafine powders with the rod-shape and the mean diameter of 1.8μm with the narrow distribution were successfully obtained. The yield of drug powders is more than 83%. The powders were analyzed with FT-IR and metalloscope. The purity of drug powders is more than 98%, according with Chinese Pharmacopoeia. The operation of the experiment was very simple, and the powders were separated easily.

Sol–gel synthesis of YAG/Al2O3 long fibres from water solvent systems

2000 ◽  
Vol 20 (5) ◽  
pp. 561-567 ◽  
Author(s):  
Kiyoshi Okada ◽  
Takayuki Motohashi ◽  
Yoshikazu Kameshima ◽  
Atsuo Yasumori
Keyword(s):  
Sol Gel ◽  
Water Solvent ◽  
Solvent Systems ◽  
Sol Gel Synthesis

scholarly journals Using water–solvent systems to estimate in vivo blood–tissue partition coefficients

2015 ◽  
Vol 9 (1) ◽  
Author(s):  
Caitlin E. Derricott ◽  
Emily A. Knight ◽  
William E. Acree ◽  
Andrew SID Lang
Keyword(s):  
Partition Coefficients ◽  
Water Solvent ◽  
Solvent Systems

Bioreduction of Ethyl 3-Oxobutanoate with Immobilized Baker’s Yeast in Organic-Water Solvent Systems

1989 ◽  
Vol 18 (8) ◽  
pp. 1517-1518 ◽  
Author(s):  
Yoshinobu Naoshima ◽  
Tadashi Nishiyama ◽  
Yoshihito Munakata
Keyword(s):  
Baker’S Yeast ◽  
Baker's Yeast ◽  
Water Solvent ◽  
Solvent Systems

Liquid−Liquid Equilibria of Butyric Acid in Water + Solvent Systems with Trioctylamine as Extractant

2001 ◽  
Vol 46 (3) ◽  
pp. 735-745 ◽  
Author(s):  
Erika Sabolová ◽  
Štefan Schlosser ◽  
Ján Marták
Keyword(s):  
Butyric Acid ◽  
Water Solvent ◽  
Solvent Systems

scholarly journals Impacts of Extraction Methods and Solvent Systems in the Assessment of Toxic Organic Compounds in a Solid Matrix

2016 ◽  
Vol 1 (1) ◽  
pp. 23 ◽  
Author(s):  
K. E. Ugwu ◽  
P. O. Ukoha
Keyword(s):  
Organic Compounds ◽  
Extraction Method ◽  
Environmental Concern ◽  
Soxhlet Extraction ◽  
Solvent System ◽  
Extraction Methods ◽  
Solid Matrix ◽  
Binary Solvent ◽  
Solvent Mixtures ◽  
Solvent Systems

Polycyclic Aromatic Hydrocarbons (PAHs) are among the listed persistent organic compounds (POP) which are pollutants of environmental concern due to their toxicity. This study evaluated soxhlet and ultrasonic extraction methods using a three-solvent system (acetone+dichloromethane+n-hexane) in order to compare the ability of the techniques to extract selected PAHs in raw coals collected from a coal mine in Okobo-Enjema, Nigeria. Then, binary solvent mixtures consisting of acetone+dichloromethane; dichloromethane+n-hexane; and acetone+n-hexane, were compared with the ternary solvent system for their ability to extract the target PAHs by soxhlet extraction method. The extracts were quantitatively analysed for sixteen PAHs using Gas Chromatography-Mass Spectrometer (GC-MS). Sonication extraction method extracted higher number of PAHs, required fewer amount of solvents, shorter time of extraction and less energy consumption compared to soxhlet extraction, which extracted higher amount of the target PAHs. The total amount of PAHs determined ranged from 0.02 mg/kg to 0.20 mg/kg in the various solvents' mixtures. The ternary mixture extracted larger quantities of the target toxic PAHs. This report will assist in the choice of analytical methods and solvent systems for environmental studies.

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