Design of Experiments to Evaluate Use of Chitosan-Tripolyphosphate as a Sustained Release Agent in Directly Compressible Tablets

2016 ◽  
Author(s):  
Colin Pinto
Keyword(s):  
Design Of Experiments ◽  
Sustained Release ◽  
Release Agent

Pregelatinized glutinous rice starch as a sustained release agent for tablet preparations

2010 ◽  
Vol 80 (2) ◽  
pp. 453-459 ◽  
Author(s):  
Jomjai Peerapattana ◽  
Pennapa Phuvarit ◽  
Voranuch Srijesdaruk ◽  
Detpon Preechagoon ◽  
Arom Tattawasart
Keyword(s):  
Sustained Release ◽  
Rice Starch ◽  
Release Agent ◽  
Glutinous Rice

Effect of hydrogen peroxide on the sustained release of 99mTc-labeled cytarabine in melanoma of C57 mice by ECT imaging pharmacology.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15569-e15569
Author(s):  
Yan Han ◽  
Qiang Fu ◽  
Baofa Yu ◽  
Keyword(s):  
Hydrogen Peroxide ◽  
Treatment Group ◽  
Sustained Release ◽  
Residence Time ◽  
Tumor Model ◽  
Intratumoral Injection ◽  
Control Group ◽  
Release Agent ◽  
Mouse Tumors ◽  
Long Time

e15569 Background: To investigate the residence time of 99mTc-labeled cytarabine in mouse tumors under ECT imaging. Methods: The subcutaneous solid tumor model of mice was established by injection of melanoma cell suspension into the left forelimb of C57 mice. The tumor-bearing mice were divided into treatment group and control group when the longest diameter of the tumor was 5-8 mm. Group 3 only. The mice in the control group were given intratumoral injection of 0.1 ml of 99mTc-labeled cytarabine solution, and the mice in the treatment group were given intratumoral injection 0.1 ml 99mTc labeled cytarabine combined with hydrogen peroxide solution at 0.25 h, 0.5 h, 1 h. After 2 hours and 19 hours of administration, the radioactivity intensity values were observed by SPECT Apx-409 ECT phenomenon equipment. Results: The T/W values of ECT imaging in 3 mice in the treatment group were higher than those in the control group at 0.25 h, 0.5 h, 1 h, 2 h and 19 h. The T/W values of ECT imaging decreased in the treatment group at different time points. The amplitude was lower, and the T/W values in each period were higher than those in the control group. Conclusions: The sustained release agent hydrogen peroxide can significantly increase the residence time of 99mTc-labeled cytarabine in the tumor. It is speculated that hydrogen peroxide has a positive effect on prolonging the drug action time of cytarabine and improving the effect of killing tumor cells. It showed that H2O2 can hold the Ara-C for a long time in tumor.

Crosslinked Starch as Sustained Release Agent

1990 ◽  
Vol 16 (7) ◽  
pp. 1091-1108 ◽  
Author(s):  
N. Visavarungroj ◽  
J. Herman ◽  
J. P. Remon
Keyword(s):  
Sustained Release ◽  
Release Agent

Screening of the Repellent Activity of 12 Essential Oils Against Adult German Cockroach (Dictyoptera: Blattellidae): Preparation of a Sustained Release Repellent Agent of Binary Oil-γ-CD and its Repellency in a Small Container

2020 ◽  
Vol 113 (5) ◽  
pp. 2171-2178
Author(s):  
Ke Huang ◽  
Dan Zhang ◽  
Jing-Jing Ren ◽  
Rui Dong ◽  
Hua Wu
Keyword(s):  
Sustained Release ◽  
Essential Oils ◽  
Chemical Constituents ◽  
Weight Ratio ◽  
Positive Control ◽  
Repellent Activity ◽  
Release Agent ◽  
Stirring Time ◽  
Oil Mixtures ◽  
Elsholtzia Ciliata

Abstract Cockroaches are important sanitary pests and very difficult to control worldwide. With public concern about traditional insecticides, cockroach control agents should be environmentally friendly, highly efficient, and economical. In this article, 12 essential oils were screened to test their repellent effect against Blattella germanica. To develop essential oils as repellent agents, the oils were further examined in binary synergistic combinations. Ilex chinensis Sims (Sapindales: Aquifoliaceae) oil, Lavandula spp (Tubiflorae: Labiatae) oil, and Elsholtzia ciliata (Thunb.) Hyland (Tubiflorae: Labiatae) oil showed excellent repellent activities with lower RD50 (repellency dose for 50% of treated adults) values of 218.634, 154.590, and 223.989 µg/cm2, respectively, compared to those of other oils and the positive control. The I. chinensis oil and E. ciliata oil (weight ratio of 1:1.41) combination also displayed a remarkable synergistic effect against B. germanica. Their cotoxicity coefficient was 214.4. The major chemical constituents in E. ciliata and I. chinensis oils were respectively 3,7-dimethyl-1, 6-octadien-3-ol and methyl salicylate. The binary oil mixtures were formulated as a sustained release agent with γ-CD. The optimal preparation should be an 8:1 ratio of γ-CD to oils, with a 1 h stirring time, 50°C stirring temperature, and 1:12 ratio of γ-CD to ddH2O. The results of this study suggest that sustained release of binary oil-γ-CD exhibited a prolonged repellent activity (10 h) against B. germanica. This sustained-release agent could be further investigated and developed as a novel repellent preparation.

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